Nordimet® Injection Pre-filled Pen for Rheumatoid Arthritis

Nordimet® is a prefilled methotrexate pen used once weekly for certain autoimmune conditions. This page explains the Methotrexate prefilled pen, how it works, dosing, safety, and access with US delivery from Canada for those paying without insurance.

What Nordimet Is and How It Works

This medicine contains methotrexate, a disease-modifying antirheumatic drug. It reduces overactive immune activity that drives joint and skin inflammation. The treatment inhibits folate-dependent enzymes, which can slow the immune processes that damage joints and skin.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Clinicians use methotrexate in low weekly doses for long-term control. The pen delivers a set dose under the skin. Many patients use folic acid alongside therapy to help limit certain adverse effects if recommended by a prescriber.

Who It’s For

This treatment is used to manage active rheumatoid arthritis in adults. It is also used for severe, recalcitrant psoriasis when other options are unsuitable or inadequate. Some patients with psoriatic arthritis may also be candidates under specialist care. See our condition pages on Rheumatoid Arthritis and Psoriasis for broader context on care.

People who should not use this therapy include those who are pregnant or planning pregnancy, breastfeeding, or with severe liver disease, significant kidney impairment, blood dyscrasias, or immunodeficiency. Alcohol misuse and chronic liver problems increase risk. Always review individual risks and monitoring needs with a healthcare professional.

Dosage and Usage

This medicine is taken once weekly on the same day each week. Use the Nordimet subcutaneous injection pen only as directed by your prescriber. Do not take extra doses, and do not change your schedule without medical guidance.

Use a new pen for each weekly dose. Inject into the abdomen or thigh, avoiding the navel and any irritated skin. Rotate sites. Clean the area before use. Check the solution and pen window; do not use if the solution looks cloudy, contains particles, or the device appears damaged.

General steps: let the pen reach room temperature, remove the cap, place against the skin at a 90-degree angle, press and hold until the window confirms completion, then remove and apply gentle pressure with cotton or gauze. Read the patient leaflet for full device instructions.

Strengths and Forms

The pen is available in multiple fixed-dose presentations to match prescribed weekly dosing. Availability may vary by country and stock. Common options include:

• 7.5 mg
• 10 mg
• 12.5 mg
• 15 mg
• 17.5 mg
• 20 mg
• 22.5 mg
• 25 mg

Your prescriber selects the appropriate weekly dose and may adjust over time based on response and safety labs. If prescribed, a Methotrexate 15 mg prefilled pen may be used among other strengths listed above.

Missed Dose and Timing

If a weekly dose is missed, take guidance from your prescriber or the product leaflet. In general, take the missed dose when remembered unless it is close to your next scheduled dose. Do not take two doses within a short interval. If unsure, skip the missed dose and contact your healthcare professional for advice.

Storage and Travel Basics

Store the pens in the original carton to protect from light. Keep at typical room temperature as directed on the label. Do not freeze. Keep out of reach of children and pets. Do not use after the expiration date.

For travel, pack pens in carry-on luggage with the carton and leaflet. Bring a copy of your prescription and a travel letter if available. Keep sharps supplies with your kit. If you cross time zones, pick a weekly day that works and stay consistent. Dispose of used pens properly at your destination.

Pen Handling and Sharps Disposal

Review the device guide before first use. A nurse or pharmacist can demonstrate technique. Practice on a teaching pad if you are offered training.

After injecting, place the used pen into an approved sharps container. Do not recap, crush, or throw into household trash. When the container is full, follow local guidance for disposal at pharmacies or community programs. For general tips on pen injections, see How To Inject Mounjaro and How To Use Ozempic.

Benefits

Weekly dosing can improve adherence compared with daily tablets for some patients. Subcutaneous delivery may reduce stomach upset versus higher-dose oral options. A single-use preset pen simplifies steps and may reduce dosing errors. Many people appreciate at-home administration, which can fit regular routines.

Side Effects and Safety

• Gastrointestinal upset: nausea, stomach pain, or diarrhea
• Mouth sores or sore throat
• Headache or dizziness
• Fatigue or malaise
• Injection-site redness or discomfort
• Temporary hair thinning

Serious risks can include low blood counts, liver toxicity, lung problems, severe skin reactions, and infection risk. Stop the medicine and seek urgent help if you develop signs of an allergic reaction, shortness of breath, persistent cough, jaundice, severe rash, or unusual bleeding. Alcohol can increase liver risk. Regular blood tests are usually required. A prescriber may recommend folic acid to help limit certain effects.

Drug Interactions and Cautions

Important interactions include trimethoprim or trimethoprim/sulfamethoxazole, certain antibiotics such as penicillins, and some NSAIDs at high doses, which can increase methotrexate levels. Proton pump inhibitors and some antiepileptics may also interact. Avoid live vaccines while using immunosuppressive therapy. Discuss all medicines, vitamins, and herbal supplements with your healthcare professional. Use effective contraception during treatment and for the advised period after the last dose.

What to Expect Over Time

Symptoms often improve gradually with consistent weekly dosing and routine monitoring. Lab checks help your clinician balance effectiveness and safety. If side effects occur, many are manageable by adjusting timing, hydration, folic acid use if directed, or supportive care. Do not stop treatment abruptly without medical advice.

Compare With Alternatives

Biologic TNF inhibitors are options when conventional therapy is insufficient. Etanercept is given by subcutaneous injection using a different mechanism; see Enbrel® Pre Filled Syringe for a commonly used agent. An oral targeted synthetic DMARD, tofacitinib, is another option under specialist supervision; learn more at Xeljanz® XR. Prescribers choose based on disease activity, comorbidities, monitoring needs, and prior response.

Pricing and Access

Canadian pharmacy pricing may offer savings compared with some US cash options. If you want to compare Nordimet injection cost with your local cash-pay rate, review our product page for current details. You can also review choices if you plan to Buy methotrexate injection pen for a weekly regimen. We provide transparent information on supply, device format, and options that fit a specialist’s prescription. Ships from Canada to US for qualified orders. See current offers on our Promotions page when available.

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Availability and Substitutions

Supply can vary by strength and package size. If a selected presentation is unavailable, a prescriber may recommend an alternative dose or a different therapy. If a device style is changed by the manufacturer, your pharmacist will confirm that instructions still match your prescription. Prescription required and verified before dispensing.

Patient Suitability and Cost-Saving Tips

This therapy suits patients who benefit from weekly dosing and prefer subcutaneous administration. It may be unsuitable for those with significant liver disease, heavy alcohol use, active infections, or pregnancy. Discuss planned vaccinations and family planning with your clinician before starting.

To reduce pharmacy trips, consider multi-month supplies if your prescriber approves. Set reminders for weekly dosing and for reorders. Ask about generics or alternative device formats if clinically appropriate. Self-pay patients sometimes look for a Methotrexate pen without insurance; review options with your prescriber to maintain safe monitoring and continuity of care.

Questions to Ask Your Clinician

• Starting dose and weekly schedule: what is planned and why?
• Monitoring: which labs and how often?
• Folic acid: recommended dose and timing?
• Alcohol limits: what is safe for my situation?
• Vaccinations: which should be updated before therapy?
• Side effects: which require urgent attention?
• Alternatives: when to consider a biologic or targeted oral?

Authoritative Sources

FDA DailyMed: Methotrexate Injection

Health Canada: Drug Product Database

Manufacturer: Nordic Pharma

Ready to proceed? Order Nordimet pen online with prompt US shipping from Canada. Always follow your prescription and the official patient leaflet. This information is educational and not a substitute for medical advice.