Nucala® Pre-filled Auto Injection: Uses, Dosing, Storage, and Savings

What Nucala® Is and How It Works

Nucala Pre-filled Auto Injection contains mepolizumab, a monoclonal antibody that targets interleukin-5 (IL-5). It helps control severe eosinophilic inflammation in asthma and related conditions. You can order Nucala Pre-filled Auto Injection online from our pharmacy, and many patients compare Nucala Auto Injection without insurance to Canadian pricing for budget planning. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and prescriptions are reviewed by licensed pharmacists before dispensing. We work with licensed, vetted international partner pharmacies to supply authentic brand medicines with broad selection and fair pricing.

Mepolizumab binds IL-5 and prevents it from activating eosinophils. Lower eosinophil counts can reduce airway inflammation, asthma exacerbations, sinus polyp growth, and disease flares in certain eosinophilic disorders. Nucala is given as a subcutaneous injection once every four weeks. Indications include add-on maintenance treatment of severe eosinophilic asthma (ages 6 years and older; the pre-filled auto injector is generally used by adults and adolescents able to self-inject), eosinophilic granulomatosis with polyangiitis (EGPA) in adults, hypereosinophilic syndrome (HES) in patients aged 12 years and older, and adults with chronic rhinosinusitis with nasal polyps (CRSwNP). Nucala does not treat acute bronchospasm or sudden breathing problems.

Dosage and Usage

• Standard dosing: 100 mg subcutaneously every 4 weeks for severe eosinophilic asthma and CRSwNP.
• EGPA dosing: 300 mg every 4 weeks (administered as three separate 100 mg injections given consecutively at the same visit).
• HES dosing: 300 mg every 4 weeks (three separate 100 mg injections).
• Each pre-filled auto injector delivers 100 mg/1 mL of mepolizumab for subcutaneous injection.
• Appropriate patients may self-inject after training; others may be injected by a caregiver or healthcare professional.
• Injection sites: abdomen (avoid 5 cm around the navel), thigh, or upper arm (upper arm only if a caregiver administers). Rotate sites.
• Missed dose: administer as soon as possible, then resume the regular every-4-weeks schedule. Consult the prescriber if timing is unclear. Do not give a double dose.
• Device steps (general): remove the autoinjector from the carton; allow it to reach room temperature for about 30 minutes; inspect the liquid (clear to opalescent, colorless to pale yellow, no particles); do not shake; clean the site; place and activate the autoinjector as instructed; hold until the indicator confirms completion; dispose of the used device in a sharps container.

• Refrigerated storage: 2–8°C (36–46°F) in the original carton; protect from light; do not freeze.
• Room-temperature window: once removed from the fridge, keep at or below 30°C (86°F) and use within 7 days; do not return to refrigeration; discard if left out longer than allowed.
• Handling: do not shake; do not heat or microwave; allow to warm naturally for 30 minutes before injection.
• Travel: keep in the original carton; use cold packs to maintain 2–8°C; do not place the device directly on ice; carry in hand luggage; avoid freezing during flights.
• After use: place autoinjectors in an approved sharps container; follow local rules for disposal.

Benefits and Savings

Nucala can reduce severe asthma exacerbations, improve symptom control, and lower oral steroid use and cumulative steroid exposure. In CRSwNP, it can reduce polyp size and nasal congestion and decrease the need for sinus surgery. In EGPA and HES, it helps reduce relapses and disease flares and supports steroid-sparing strategies. The once-monthly schedule and home injection option add convenience.

Ordering from a Canadian pharmacy can offer meaningful savings. Many patients pay 60–80% less than typical US prices. Options exist even if purchasing Nucala Auto Injection without insurance. Multi-month supplies and bulk promotions may reduce the per-month cost. We also offer gentle reorder reminders so you can stay on schedule.

Looking for offers? See current promotions with the Nucala Pre-filled Auto Injection coupon.

Side Effects and Safety

• Common: injection-site pain, redness, swelling, or itching.
• Headache or back pain.
• Fatigue.
• Upper respiratory tract infections, sinusitis, or sore throat.
• Rare: hypersensitivity reactions, including rash, hives, or angioedema.

Serious allergic reactions, including anaphylaxis, can occur. Seek emergency care if symptoms such as chest tightness, wheeze, dizziness, or swelling develop after an injection. Herpes zoster (shingles) has been reported. Parasitic (helminth) infections may worsen; treat active infections before starting. Nucala is not for relief of acute bronchospasm or status asthmaticus. Discuss pregnancy and breastfeeding questions with a clinician.

Onset Time

Biologic effects on eosinophil counts occur quickly, but clinical improvements appear over weeks. Many patients notice asthma symptom gains within 4–8 weeks, with fewer exacerbations during the first 1–3 months. Lung function and control can continue to improve beyond that window. For CRSwNP, congestion and polyp size may improve within the first 1–3 months and build with continued dosing. In EGPA and HES, reduced relapses and steroid-sparing benefits often emerge during the first few months and stabilize with ongoing therapy.

Compare With Alternatives

Fasenra (benralizumab) targets the IL-5 receptor and depletes eosinophils by antibody-dependent cell-mediated cytotoxicity. It is given every 4 weeks for the first three doses, then every 8 weeks. Some prefer less frequent maintenance dosing; others prefer Nucala’s established data across asthma, EGPA, HES, and CRSwNP.

Dupixent (dupilumab) blocks IL-4/IL-13 signaling and is used for type 2 inflammatory asthma and CRSwNP. It can help when allergic and eosinophilic pathways overlap. It has a different dosing schedule and injection technique.

Omalizumab (Xolair) is an anti-IgE therapy for allergic asthma with elevated IgE and perennial allergen sensitization. It requires dose adjustments based on weight and IgE level and has a distinct safety profile.

Conventional therapies may still be required. Oral corticosteroids such as Winpred can control flares in EGPA and severe asthma but carry long-term risks. Older bronchodilators, including theophylline like Theo La, are sometimes used in refractory asthma but require monitoring and offer less targeted control than IL-5 biologics.

Combination Therapy

• Use with high-dose inhaled corticosteroid/long-acting beta-agonist (ICS/LABA) regimens; many patients can reduce exacerbations while maintaining standard inhalers.
• Oral steroid tapering in EGPA/HES may be possible; taper plans should be supervised to avoid relapse.
• CRSwNP: combine with saline irrigations and intranasal corticosteroids to support sinus outcomes.
• Allergen management and trigger avoidance remain important in asthma care.
• Vaccination planning, including zoster, should be individualized by the healthcare provider.

Patient Suitability and Cost-Saving Tips

Suitable candidates often have elevated eosinophils and frequent exacerbations despite high-dose ICS/LABA, or require maintenance steroids. Adults with EGPA or CRSwNP, and adolescents or adults with HES may benefit if criteria are met. The pre-filled auto injector is intended for patients able to self-inject or with a trained caregiver.

Nucala is not appropriate for acute bronchospasm, those with known hypersensitivity to mepolizumab or excipients, or patients with untreated helminth infection. Pediatric dosing for children 6–11 with severe eosinophilic asthma differs and often uses a different presentation than the auto injector.

Cost planning tips: request a multi-month supply when possible to lower per-dose shipping and take advantage of bulk purchase promotions. Set reorder reminders so you do not miss the every-4-weeks schedule. Many patients ask about the Nucala Auto Injection no insurance option or cash price; Canadian pricing can help reduce out-of-pocket costs.

Authoritative Sources

Nucala (mepolizumab) official site and patient resources

Health Canada Drug Product Database: Nucala (mepolizumab)

FDA Prescribing Information for Nucala (mepolizumab)

Order Nucala® from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This page is for educational purposes only and does not replace advice from your healthcare professional.