Nucala® Prefilled Auto-Injector for Severe Eosinophilic Asthma

Nucala® is a prescription biologic used as add-on maintenance therapy for severe eosinophilic asthma and related conditions. This page explains how the prefilled auto-injector works, who it is for, and how to store and use it safely. It also outlines access for US delivery from Canada, including options if you pay without insurance.

What Nucala Is and How It Works

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine contains mepolizumab, a monoclonal antibody that targets interleukin-5. By binding IL-5, it lowers eosinophil counts, which can help reduce asthma exacerbations and symptoms in eosinophil-driven disease. It is used as an add-on therapy and does not replace rescue inhalers or oral steroids prescribed for acute events.

The treatment is indicated for severe eosinophilic asthma, eosinophilic granulomatosis with polyangiitis (EGPA), hypereosinophilic syndrome (HES), and as add-on maintenance for chronic rhinosinusitis with nasal polyps in adults. It is not for sudden breathing problems or status asthmaticus.

If you want background on airway disease, see our overview of Asthma and learn how care plans are tailored inside the Respiratory category.

Who It’s For

Prescribers may consider mepolizumab in people with eosinophil-driven disease who continue to flare despite high-dose inhaled therapy and other controllers. Adults with EGPA or HES may also be candidates as add-on therapy. Children and adolescents may be eligible for asthma under age-specific guidance.

People with active parasitic infections should be treated before starting this therapy. Those with a history of severe hypersensitivity to mepolizumab or any component should not receive it. Talk with your clinician about pregnancy, breastfeeding, and vaccine plans before starting therapy.

Some patients search for terms like Buy mepolizumab autoinjector, but use only the product and schedule your prescriber recommends.

Learn more about related conditions: EGPA and Hypereosinophilic Syndrome.

Dosage and Usage

Follow the dosing plan on your prescription. Many adults with severe eosinophilic asthma receive one subcutaneous injection every 4 weeks. For certain conditions, clinicians may prescribe multiple injections given back-to-back on the same day, every 4 weeks. Children’s dosing and devices differ; use only what is supplied for the intended age group.

Administration basics:

• Pick a site: abdomen, thigh, or upper arm if someone else gives it.
• Let the device come to room temperature as directed in the Instructions for Use.
• Inspect the window and solution; do not use if the device looks damaged.
• Rotate sites with each injection; avoid areas that are tender, bruised, or scarred.
• Do not inject through clothing. Keep the device pressed for the full time listed in the guide.

If your prescriber plans to lower oral steroids, this should be gradual and supervised. Do not change other medicines without clinical guidance.

Strengths and Forms

Common presentations include:

• Prefilled auto-injector: 100 mg/mL single-use device for subcutaneous injection.
• Prefilled syringe options, including a 40 mg format for certain pediatric patients.

Availability can vary by country and device type.

Missed Dose and Timing

If a scheduled injection is missed, take it when remembered, then resume the regular 4-week interval from the new date unless your clinician instructs otherwise. Do not double a dose to make up for a missed one. Keep a calendar or reminder to support on-time dosing.

Storage and Travel Basics

Store the device in the refrigerator in its original carton to protect it from light. Do not freeze. If needed, keep at room temperature for a limited time as described in the official Instructions for Use, then discard if that window is exceeded.

For travel, pack devices in an insulated bag with cold packs as directed, and keep them with you rather than in checked baggage. Bring a copy of your prescription and a note describing your injector and sharps container. Keep out of reach of children and pets.

Pen Handling and Sharps Disposal

Wash hands and prepare a clean surface. When ready, remove the cap straight off and do not recap. Place the device firmly against the skin at the chosen site and activate as instructed. Wait until the indicator shows the injection is complete before lifting away.

After use, place the device into an FDA-cleared sharps container or a puncture-resistant household container if permitted locally. Do not throw loose injectors into household trash. Follow your community’s rules for sharps disposal.

Benefits

This therapy is add-on maintenance designed to help reduce exacerbations, oral steroid exposure, and symptoms in eosinophil-driven disease when used as prescribed. Self-injection at home or in clinic can reduce visits for administration once you are trained. Regular scheduling every 4 weeks can support routine and adherence.

Side Effects and Safety

Common effects may include:

• Headache
• Injection-site reactions
• Back pain
• Fatigue
• Upper respiratory symptoms

Serious reactions are uncommon but can include hypersensitivity, swelling of the face or tongue, breathing difficulty, or hives. Seek urgent care for signs of anaphylaxis. Herpes zoster has been reported; ask about vaccination where appropriate. Treat helminth infections before starting, and pause therapy if a parasitic infection does not respond to treatment.

When used with insulin or sulfonylureas, the risk of hypoglycemia is not a known class issue for this agent; however, always monitor for symptoms tied to your other therapies.

Drug Interactions and Cautions

Mepolizumab is not known to have significant CYP-mediated drug interactions. Still, tell your clinician about all medicines, biologics, and supplements. Live vaccines are generally avoided with many immunomodulators; ask your prescriber for specific guidance. Do not stop or taper oral steroids without direction. This therapy does not treat acute bronchospasm.

What to Expect Over Time

Many people notice gradual changes in control markers, such as fewer exacerbations and improved symptom days, after consistent use. Keep using your controller inhalers and rescue inhaler as prescribed. Track your symptoms, inhaler use, and any side effects in a diary. Share this information during visits so your plan can be adjusted safely and effectively. Terms like Nucala cost per autoinjector often arise during planning; discuss affordability with your care team and pharmacy.

For additional background on respiratory wellness, explore our article Respiratory Care Week 2025 and this Severe Asthma overview.

Compare With Alternatives

Other add-on options for eosinophilic or allergic airway disease include biologics that target different pathways. Selection depends on biomarkers, comorbidities, and prior response. Your prescriber may also consider allergen immunotherapy for sensitized adults with rhinitis that worsens asthma control.

Related options we offer include Acarizax (dust mite sublingual tablets for eligible patients) and Lupin Tiotropium (a long-acting bronchodilator for maintenance in obstructive lung disease). Pricing varies across classes; searches like Mepolizumab autoinjector price reflect this. Compare choices with your clinician.

Pricing and Access

We provide transparent Canadian pricing with options for prescription review and fulfilment. Terms such as Nucala autoinjector price and Mepolizumab price without insurance are common; final amounts depend on your prescribed device and quantity. You can view current pricing and request a quote. For seasonal offers, see our Promotions.

Ordering supports US shipping from Canada with discreet packing. You can upload your prescription during checkout or have your clinic send it to us.

Availability and Substitutions

Supply can vary by device type. If a particular presentation is unavailable, your prescriber may recommend a suitable alternative from the same class or another pathway. If you plan to Order Nucala online, ensure the device on your prescription matches the item in your cart before placing the request.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults and some adolescents with eosinophil-driven disease who still flare on high-level inhaled therapy. It may not be appropriate for people with prior anaphylaxis to the product or with untreated parasitic infections. Always review your history and goals with your clinician.

Cost planning tips:

• Multi-month fills: ask your prescriber if a longer supply is appropriate for steady therapy.
• Refill reminders: set calendar alerts to avoid gaps.
• Discuss affordability: ask about the Nucala refill price and alternatives if needed.
• Coordinate benefits: your clinic and our team can help you understand coverage documents.

Questions to Ask Your Clinician

• Is my eosinophil level consistent with this therapy?
• Which device is right for me, and can I self-inject?
• How should we handle oral steroid changes over time?
• What symptoms or side effects should prompt a call?
• Which vaccines should I get before starting?
• How long should I continue before we reassess control?

Authoritative Sources

Nucala Patient Site

DailyMed: Mepolizumab

Health Canada DPD

Ready to proceed? Place your request with cold-chain shipping, Ships from Canada to US, and secure checkout. This information is educational and does not replace your prescriber’s advice.