Odefsey® Tablets for HIV-1 Treatment (emtricitabine/rilpivirine/tenofovir alafenamide)

What Odefsey® Is and How It Works

Odefsey® is a complete antiretroviral regimen for HIV‑1. Each film‑coated Odefsey tablet combines emtricitabine (FTC), rilpivirine (RPV), and tenofovir alafenamide (TAF). It is taken by mouth once daily with a meal. It treats HIV‑1 in adults and adolescents who are new to therapy with certain baseline factors, or who are virologically suppressed on a stable regimen. Many patients look for Odefsey without insurance to manage ongoing therapy costs.

Rilpivirine is a non‑nucleoside reverse transcriptase inhibitor. Emtricitabine and tenofovir alafenamide are nucleos(t)ide reverse transcriptase inhibitors. Together they block the viral reverse transcriptase enzyme and reduce viral replication. TAF delivers tenofovir efficiently at lower blood levels than TDF, which supports kidney and bone safety in many patients.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba. Orders are reviewed by licensed pharmacists before dispensing, and you can order online with support from our friendly customer‑service chat during posted office hours. We offer brand and generic medicines at Canadian prices, along with common OTC health products.

We source medicines from licensed, audited partner pharmacies and distributors, so you receive authentic brands with reliable quality and broad availability at fair pricing.

Ask your prescriber if Odefsey® is suitable for your HIV‑1 treatment plan, then you can buy Odefsey online from our pharmacy team with a valid prescription.

Dosage and Usage

• Recommended dose: one Odefsey® tablet by mouth once daily with a meal.
• Swallow whole. Do not chew, crush, or split.
• Consistent daily dosing helps maintain viral suppression.
• Missed dose: if within about 12 hours of the usual time, take with a meal as soon as possible. If more than 12 hours, skip the missed dose and take the next dose at the regular time.
• Vomiting: if vomiting occurs within 4 hours of the dose, consider taking another tablet. If after 4 hours, do not take an extra dose.
• Acid‑reducing agents: avoid proton pump inhibitors. If needed, take H2‑receptor blockers at least 12 hours before or 4 hours after Odefsey®. Take antacids at least 2 hours before or 4 hours after Odefsey®.

• Storage: store at 20–25 °C (68–77 °F). Keep in original bottle with desiccant. Protect from moisture.
• Travel: pack enough tablets for the full trip plus a few extra days. Keep in carry‑on to avoid loss. Carry the prescription label for customs and security checks.
• Reordering: set a reminder so you do not run out. You can use our reorder prompts under your account.

Benefits and Savings

Odefsey® offers once‑daily dosing in a single small tablet, taken with a meal. TAF supports kidney and bone safety compared with older TDF‑based combinations. Many patients maintain suppression when switching from a stable regimen that has no history of resistance to its components. Convenience can improve adherence, and steady adherence supports long‑term outcomes.

Ordering through YouDrugstore can lower the Odefsey price. Many customers report 60–80% savings versus typical US prices. Those savings can help patients who pay out of pocket or manage therapy without insurance. Our team can discuss packaging, supply length, and prescription details to help with a smooth shipment.

We meet Canadian pharmacy standards for dispensing and safety checks, and our pharmacists can address medication questions related to your prescription during posted hours.

Side Effects and Safety

• Common: headache, nausea, diarrhea, dizziness, fatigue, insomnia, abnormal dreams.
• Laboratory changes: increases in total cholesterol and LDL, creatinine rise due to tubular secretion effects, and mild transaminase changes.
• Less common: rash, depression or mood changes, sleep disturbance.
• Serious: severe skin reactions, significant liver problems, lactic acidosis, renal impairment, fractures or bone pain, marked depressive symptoms, or suicidality. Seek urgent care for severe reactions.
• Hepatitis B: emtricitabine and tenofovir have HBV activity. Severe acute exacerbations of HBV can occur if treatment stops. Monitor clinically and with labs in patients with HBV coinfection.
• Drug interactions: Odefsey drug interactions are important to review. Avoid strong CYP3A inducers such as rifampin, carbamazepine, oxcarbazepine, phenobarbital, phenytoin, and St. John’s wort. Coadministration with proton pump inhibitors is contraindicated. Use H2 blockers and antacids only with spacing, as above. Macrolides, azoles, and other agents may require monitoring.

This is not a complete list. Review the full prescribing information and discuss your full medication list with a clinician.

Onset Time

Most patients see viral load decline within weeks of starting Odefsey®. Time to suppression varies by baseline viral load, adherence, resistance profile, and coexisting conditions. Many achieve significant reductions by 4–8 weeks, with continued improvement over 12–24 weeks and beyond.

Compare With Alternatives

Juluca is a two‑drug maintenance regimen (dolutegravir/rilpivirine) indicated for virologically suppressed adults with no history of failure and no known resistance to its components. It removes NRTIs, which may suit patients with certain tolerability needs. See how this option differs by reviewing Juluca®.

Kaletra (lopinavir/ritonavir) is an older boosted protease inhibitor‑based regimen. It often requires combination with two NRTIs and can increase gastrointestinal and lipid‑related side effects. Some patients maintain suppression on it, but many newer regimens offer simpler dosing and improved tolerability. Learn more under Kaletra®.

Cabotegravir injection (Apretude) is used for HIV‑1 pre‑exposure prophylaxis, not for treatment. It may suit prevention needs for people at risk who test HIV‑negative. Treatment and prevention serve different goals and require different products.

Combination Therapy

Odefsey® is a complete regimen and should not be taken with other antiretroviral medicines. Confirm that any added medicines do not duplicate components or interact with rilpivirine’s acid and CYP3A profile. Non‑HIV medicines may be used as needed with appropriate interaction checks.

Patient Suitability and Cost-Saving Tips

Odefsey® may be used for adults and adolescents meeting indication criteria. It is approved for patients with viral load ≤100,000 copies/mL and CD4 counts that support the safety of rilpivirine at start. It is also used for patients who are already virologically suppressed on a stable regimen with no known resistance to its components.

Renal function matters. TAF can support bone and renal safety versus TDF in many patients. Odefsey® is not recommended in severe renal impairment. Avoid use with proton pump inhibitors. Use H2 blockers and antacids only with the required spacing. Review potential interactions before changes. Our article on interactions, Drug Interactions The Top Interactions That Should Be On Your Radar, offers practical insights.

Test for hepatitis B before starting, since FTC and TAF have HBV activity. Monitor closely if therapy stops, as HBV flares can occur. For testing awareness and prevention topics, you can read National Hiv Testing Day 2025 Get Tested Know Your Status.

To help with costs, consider a multi‑month supply when appropriate, which can lower the per‑month Odefsey tablet cost. We offer reorder reminders so refills arrive on time. For current Odefsey coupons and bulk options, visit our promotions page. If paying without insurance, compare Odefsey cash price options and ask our team about available discounts.

Explore condition pages for more context, including Hiv and Hiv 1 Infection. These pages offer general information and links to treatments used for HIV‑1 care.

Authoritative Sources

Gilead Odefsey product information

Health Canada Drug Product Database: Odefsey

FDA Prescribing Information for Odefsey

Ready to get started? Order Odefsey® from YouDrugstore for caring service, Canadian pricing, and secure dispensing by licensed pharmacists. You can place an order online or by phone where available. We offer prompt, express shipping to the US and support through customer‑service chat during posted office hours.

Disclaimer: This content is for general educational purposes only and is not medical advice. Always consult your prescriber and the official prescribing information for individualized guidance. If you experience severe side effects or signs of an allergic reaction, seek emergency care.