Odefsey® Tablets for HIV-1 Infection

This prescription treats HIV-1 in adults and certain adolescents. Ships from Canada to US for convenient access and transparent options, even without insurance. This guide explains how it works, who it may suit, important safety points, and how to arrange supply.

What Odefsey Is and How It Works

Odefsey® combines three antiretrovirals in one tablet. It belongs to the class often described as emtricitabine, rilpivirine, and tenofovir alafenamide working together to suppress HIV-1. As Emtricitabine rilpivirine tenofovir alafenamide tablets, the components act at different steps in the viral lifecycle. Emtricitabine and tenofovir alafenamide are nucleoside/nucleotide reverse transcriptase inhibitors. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor. Together, they help reduce viral replication when taken as directed with food.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine is taken once daily with a meal. A proper meal improves rilpivirine absorption. Consistent daily dosing supports durable viral suppression alongside regular lab monitoring per your prescriber’s plan. Avoid stopping therapy without medical guidance, as viral rebound and resistance may occur.

Learn more about the condition in our HIV category.

Who It’s For

This treatment is indicated for adults and certain adolescents who meet label criteria. It may be used in people new to therapy who have no known resistance to rilpivirine and a baseline viral load within label thresholds. It is also used as a switch option for individuals who are already suppressed on a stable regimen without prior treatment failure or resistance substitutions to the included agents.

Those with significant drug interactions, a history of rilpivirine resistance, or certain stomach-acid conditions may not be good candidates. People with chronic hepatitis B should not stop this treatment without medical advice because flares can occur after discontinuation. Severe kidney disease or certain concurrent medicines may require another option.

Dosage and Usage

Odefsey dosage is one tablet by mouth once daily with a meal. A real meal is required for reliable absorption. Swallow the tablet whole with water. If you have difficulty swallowing, speak with your prescriber before making changes; do not crush or split unless your clinician confirms it is appropriate per the official label.

Acid-reducing medicines can affect rilpivirine absorption. Proton pump inhibitors are not recommended. H2-receptor antagonists and antacids require careful timing relative to your dose; see the Interactions section and the product leaflet for details.

Keep to a consistent dosing time each day. Use a reminder system, such as a phone alarm or a pill organizer. If you are switching from another regimen, follow the plan provided by your prescriber to maintain suppression.

Strengths and Forms

This product is supplied as film‑coated tablets in bottles. The fixed dose contains emtricitabine 200 mg, rilpivirine 25 mg, and tenofovir alafenamide 25 mg in each tablet. Availability and packaging may vary by market. Ask our team if you have questions about the current presentation.

Many people prefer the simplicity of Odefsey tablets as a single-tablet regimen. For other options in this class, browse our Antivirals category.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember with a meal. If it is close to your next scheduled time, skip the missed dose and resume your regular schedule. Do not take two doses at the same time. If you vomit shortly after taking a dose, the patient leaflet describes when a replacement dose may be needed; ask your prescriber if you are unsure.

Storage and Travel Basics

Store tablets at room temperature in the original, tightly closed bottle. Keep the desiccant in the container to protect from moisture. Do not store in the bathroom or near heat sources. Keep out of reach of children and pets.

When traveling, carry your medicine in your hand luggage with a copy of your prescription. Pack enough for your trip and a small buffer in case of delays. Keep dosing times consistent across time zones when possible. If crossing time zones, your prescriber can help plan timing adjustments.

Benefits

This medicine provides complete HIV-1 therapy in one daily tablet. Taking it with food supports reliable absorption, which helps maintain viral suppression when used consistently. A single-tablet option can simplify routines compared with multi-pill regimens, which may support adherence for some people.

Side Effects and Safety

• Headache
• Nausea or stomach discomfort
• Diarrhea
• Tiredness
• Trouble sleeping or abnormal dreams
• Mood changes, including depressed mood
• Rash

Most effects are mild and settle with continued use. Serious reactions can occur and require prompt medical attention. Rare but important risks include severe skin reactions, liver problems, lactic acidosis, depressive disorders, and kidney issues. If you have hepatitis B, stopping treatment can lead to serious flare‑ups. Contact your prescriber right away if you notice yellowing of the skin or eyes, severe rash, dark urine, unusual fatigue, or thoughts of self‑harm.

Read the Medication Guide and Patient Information leaflet for a full list of possible effects. Report any unexpected symptoms to your clinician.

Drug Interactions and Cautions

Some medicines reduce rilpivirine levels, while others can raise them. Strong enzyme inducers, certain anticonvulsants, rifamycins, and products containing St. John’s wort may reduce effectiveness. Macrolide antibiotics, azole antifungals, and some other agents can increase exposure.

Proton pump inhibitors are not recommended. With H2 blockers, separate timing as described in the label. Antacids containing aluminum, magnesium, or calcium also require spacing. Discuss all prescription medicines, over‑the‑counter products, vitamins, and herbal supplements with your prescriber before starting this treatment.

If you have questions about Odefsey and antacids, review the official patient leaflet and see our overview on interactions in Drug Interactions.

What to Expect Over Time

With consistent daily dosing and a meal, many people maintain viral suppression on this regimen. Your prescriber will monitor viral load, CD4 counts, liver and kidney labs, and overall tolerance. If lab results change or side effects develop, they may adjust your plan. Do not stop therapy on your own, especially if you have hepatitis B, as flares can occur.

Build the dose into a routine meal and set reminders. Keep follow‑up appointments to review labs and discuss any concerns. If your circumstances change, such as new medicines or dietary shifts, update your care team.

Compare With Alternatives

Other complete regimens may be suitable depending on your history and lab criteria. Options include:

• Delstrigo as another single‑tablet regimen with different components
• Isentress used with companion agents for a tailored two‑drug backbone approach

For background reading on another single‑tablet regimen, see our article Genvoya Medication Uses. These are general examples; your prescriber will recommend a regimen based on resistance testing, prior therapy, and comorbidities.

Pricing and Access

Many patients compare sources to manage the Odefsey price. With US shipping from Canada, you can view Canadian pricing and request a quote before ordering. Final amounts depend on quantity, dispensing fees, and your prescription details.

Looking for a coupon? Check our current Promotions. You can complete checkout online through our encrypted platform. If you have coverage, your plan may have its own rules; we support cash‑pay orders as well.

Availability and Substitutions

Supply can vary. If the tablets are temporarily unavailable, your prescriber may recommend a clinically appropriate alternative. We cannot guarantee restock dates, but our team can discuss options your clinician might consider.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults and eligible adolescents who meet label criteria and can take it with a meal daily. It may not suit those requiring proton pump inhibitors or those with known rilpivirine resistance. People with advanced kidney disease or significant liver problems need careful evaluation.

To help manage costs, consider multi‑month fills when appropriate, set refill reminders, and review your therapy plan during routine check‑ins. Ask your prescriber about generic alternatives in your regimen class if relevant. If you are budgeting out of pocket, request a quote to compare options and plan your total expenses.

Questions to Ask Your Clinician

• Is this single‑tablet option appropriate for my baseline viral load and history?
• How should I time doses with meals and other medicines?
• What lab tests and follow‑ups will you monitor on this regimen?
• What signs of side effects should I watch for and report?
• How should I handle missed doses or vomiting after a dose?
• Do my current medicines interact with this treatment?
• What is our plan if my viral load changes?

Authoritative Sources

Gilead Odefsey Prescribing InformationFDA DailyMed: OdefseyHealth Canada Drug Product Database: Odefsey

Ready to request your prescription fill? Place your order online for prompt, express shipping. This information is educational and does not replace your clinician’s advice.