Orgovyx® (relugolix) for Advanced Prostate Cancer: Uses, Dosing, Safety

What Orgovyx® Is and How It Works

Orgovyx® (relugolix) is an oral gonadotropin-releasing hormone (GnRH) receptor antagonist used for advanced prostate cancer. It helps lower testosterone quickly, which suppresses tumor growth. Patients and caregivers often compare Orgovyx cost and convenience with injectable options when choosing long-term androgen deprivation therapy.

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Orgovyx is indicated for adult men with advanced prostate cancer, including metastatic and nonmetastatic disease where androgen deprivation therapy is appropriate. This medicine belongs to the GnRH antagonist drug class. It directly blocks the pituitary GnRH receptor, lowering luteinizing hormone and follicle-stimulating hormone. This rapidly reduces testicular testosterone production without the initial hormone surge seen with agonists.

Relugolix is taken by mouth once daily. The standard regimen uses an initial loading dose, then maintenance dosing. Orgovyx 120 mg is the tablet strength, and most patients continue treatment long term as part of a prostate cancer treatment plan. The relugolix brand name is Orgovyx, and there is no approved Orgovyx generic at this time.

In the HERO study, relugolix achieved medical castration levels quickly and maintained suppression effectively over 48 weeks. Orgovyx FDA approval came in 2020, and Health Canada approval followed. For detailed Orgovyx prescribing information, see the links below.

Dosage and Usage

• Loading dose: 360 mg on Day 1 (three Orgovyx 120 mg tablets taken together).
• Maintenance dose: 120 mg (one tablet) once daily thereafter at about the same time.
• Administration: Swallow tablets whole with water. Take with or without food. Do not crush or chew.
• Missed dose (same day): Take as soon as remembered on that day.
• Missed dose (>12 hours or next day): Skip the missed dose. Resume the regular schedule the next day.
• Interruption: If therapy is interrupted for more than 7 days, restart with a 360 mg loading dose, then 120 mg daily.
• Drug interactions: Avoid combined P-gp and strong CYP3A inducers (for example, carbamazepine, St. John’s wort). If a P-gp inhibitor cannot be avoided, take Orgovyx first and separate dosing by about 6 hours.
• Consistency: Take at the same time each day to maintain steady testosterone suppression.

• Storage: Store at 20–25 °C (68–77 °F). Excursions permitted 15–30 °C (59–86 °F). Keep tablets in the original bottle with the desiccant. Protect from moisture.
• Travel: Keep tablets in your carry-on. Bring the pharmacy label and prescription. Avoid leaving medicine in a hot car. Use a pill case only within the country; for border crossings, keep the original bottle.
• Handling: Do not split, crush, or chew the tablets. Keep out of reach of children and pets.

Benefits and Savings

Orgovyx offers oral dosing without injections, so many patients find it simpler to use daily. As a GnRH antagonist, relugolix lowers testosterone without a flare. This is helpful for symptomatic bone metastases where a temporary rise in testosterone could worsen pain or spinal cord compression.

Clinical data show rapid onset of castration-level testosterone and consistent suppression with continued therapy. In HERO, more patients on relugolix maintained castration from Day 29 through Week 48 compared with leuprolide. Testosterone recovery after stopping Orgovyx may also occur earlier than with certain depot agonists, which can matter when treatment plans change.

Ordering Orgovyx tablets from Canada often lowers monthly spend. Patients commonly see 60–80% savings versus typical U.S. prices, helping reduce the overall cost of Orgovyx therapy over time. Multi-month supplies can lower the per-month Orgovyx price further.

For promotions, see the current Orgovyx coupon options on our promotions page.

You can also review our overview of cancer treatments in this article: Cancer Drugs List Common Medications And Their Uses.

Side Effects and Safety

• Common effects: hot flashes, fatigue, musculoskeletal pain, diarrhea, constipation, headache.
• Other reported: decreased libido, erectile dysfunction, weight changes, night sweats, increased glucose or lipids.
• Gastrointestinal: nausea, abdominal discomfort.
• Blood pressure changes may occur in some patients.
• Cardiac: possible QT interval prolongation. Monitor if at risk.

Serious but less common risks include cardiovascular events, severe hypersensitivity, and marked QT prolongation, particularly in patients with congenital long QT syndrome or those taking QT-prolonging antiarrhythmics. Use caution with strong CYP3A inducers and P-gp modulators. Orgovyx is contraindicated in pregnancy; it can cause fetal harm. Women should not take this medication. Discuss concomitant therapies and monitoring with the prescribing clinician.

Onset Time

Relugolix begins suppressing testosterone quickly. In clinical trials, many patients reached castrate levels within days, with most achieving castration by Day 29. Prostate-specific antigen (PSA) often starts to decline within the first 2–4 weeks, and symptom improvement may follow as disease stabilizes.

When stopping Orgovyx, testosterone recovery can begin within weeks. Some men return to baseline over 1–3 months, though timelines vary by age, duration of therapy, and baseline function.

Compare With Alternatives

GnRH agonists (leuprolide, goserelin): These depot injections reduce testosterone after an initial surge. The flare may worsen bone pain or urinary symptoms briefly. Agonists are dosed monthly to every six months and may suit patients who prefer in-clinic injections.

Injectable GnRH antagonist (degarelix): Degarelix avoids the flare and is given as a subcutaneous injection with a loading dose, then monthly maintenance. Orgovyx offers similar antagonist benefits but in an oral, once-daily tablet.

Androgen biosynthesis inhibitor: Abiraterone acetate is often added for metastatic disease. See Zytiga® for information on this oral option typically combined with prednisone and ongoing androgen deprivation.

Other systemic options include androgen receptor inhibitors (enzalutamide, apalutamide) or chemotherapy (docetaxel), chosen based on disease stage, symptoms, and prior treatments. For broader context, review our Cancer category.

Combination Therapy

• ADT (Orgovyx) plus abiraterone/prednisone for metastatic hormone-sensitive disease; monitor liver tests and blood pressure.
• ADT plus enzalutamide or apalutamide for nonmetastatic castration-resistant or metastatic settings, per guidelines.
• ADT plus docetaxel for selected high-volume metastatic hormone-sensitive disease.
• ADT with radiation in localized high-risk disease or to palliate symptoms in metastatic settings.
• Bone-protective agents (zoledronic acid or denosumab) for men at risk of skeletal events.

Patient Suitability and Cost-Saving Tips

Orgovyx may suit adults needing medical castration who prefer an oral therapy or who should avoid an initial testosterone flare. It may also be considered when quicker testosterone recovery after discontinuation is desired. Adherence to daily dosing is essential.

Orgovyx may not be appropriate for patients with severe uncontrolled cardiac disease, congenital long QT syndrome, significant drug interaction risks, or those unable to take oral medicines reliably. Women and children should not take relugolix. The prescriber will weigh benefits, risks, interactions, and monitoring needs for each patient.

Cost-conscious patients compare Orgovyx 120 mg tablet pricing across pharmacies. There is no approved Orgovyx generic; the cost of Orgovyx reflects brand-only availability. Ordering from Canada may reduce monthly expenses. You can choose a multi-month supply to reduce the per-month cost, and you can set simple reorder reminders so you do not run out during ongoing therapy.

You can place your order online, upload the prescription, and track shipment updates. We offer brand and generic medicines at Canadian prices and also carry OTC products for supportive care during treatment.

Authoritative Sources

Orgovyx Manufacturer Product Page

Health Canada Drug Product Database

FDA Prescribing Information for Orgovyx

Order Orgovyx® from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This content is educational and does not replace professional medical advice. Always consult a qualified healthcare provider about diagnosis, treatment options, and medicine safety.