Orilissa® Tablets for Endometriosis Pain

Orilissa® is a prescription oral medicine for managing endometriosis pain. This page explains how the treatment works, who may benefit, and how to use it safely. It also outlines ways to pay for Orilissa® without insurance.

What Orilissa Is and How It Works

Elagolix is the active ingredient in this medicine. It is a gonadotropin-releasing hormone (GnRH) antagonist that lowers ovarian hormone production. By reducing estrogen levels, it can help lessen pelvic pain, painful periods, and discomfort with intercourse related to endometriosis. You can access this therapy with US delivery from Canada through our pharmacy service. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

The treatment begins working by competitively blocking GnRH receptors in the pituitary, which decreases LH and FSH. Lowering these signals reduces estradiol and minimizes endometriosis-related pain symptoms. Its effect is reversible, and hormone levels return to baseline after stopping.

Who It’s For

This medicine is indicated for adults with moderate to severe endometriosis pain. It may be considered when pain persists despite NSAIDs or other options. It is not for use in pregnancy or for children. People with known osteoporosis, severe liver disease, or a history of severe hypersensitivity to components should avoid it. Your prescriber will also consider mood history, bleeding patterns, and bone health before starting therapy.

Use reliable birth control during treatment and for a short period after stopping. Non-hormonal methods are preferred. Estrogen-containing contraceptives may reduce effectiveness and are generally not recommended while taking this therapy.

Dosage and Usage

Elagolix dosing follows labeled regimens. A common schedule is one tablet taken around the same time each day. Another regimen uses a twice-daily schedule for patients with more severe symptoms. Your prescriber will choose the schedule that fits your needs and liver function. Swallow tablets with water, with or without food.

General tips:

• Take doses at consistent times to support steady effect.
• Avoid taking more tablets than prescribed.
• Use non-hormonal contraception during treatment.
• Keep regular follow-ups to monitor symptoms and safety.

If you have questions about timing, ask your healthcare professional and follow the official label.

Strengths and Forms

This product is supplied as film-coated tablets. Available strengths include:

• Elagolix 150 mg tablets
• Also available as 200 mg tablets

Availability may vary by strength and pack size. Packaging and tablet color can differ by market.

Missed Dose and Timing

If you experience an Orilissa missed dose, take the tablet as soon as you remember on the same day. If it is nearly time for the next dose, skip the missed dose and resume your usual schedule. Do not take two doses at once. For twice-daily schedules, take the next dose at the regular time. If you miss doses often, set reminders or use a pill organizer.

Storage and Travel Basics

Store tablets at room temperature in the original container, away from moisture. Keep the bottle tightly closed and out of reach of children and pets. When traveling, carry your medicine in your hand luggage with the original labeled pharmacy container. Bring a copy of your prescription or a clinic note if you expect security screening. Try to keep your schedule consistent across time zones and use phone alarms to help.

Benefits

This therapy can help reduce endometriosis-related pain, including painful periods, pelvic discomfort, and pain during intercourse. As an oral option, it avoids injections and can be stopped if adverse effects occur. Flexible labeled durations allow shorter courses for severe symptoms or longer courses for ongoing management as directed by your prescriber.

Side Effects and Safety

Common effects may include:

• Hot flushes or night sweats
• Headache or fatigue
• Nausea or decreased appetite
• Difficulty sleeping
• Mood changes or irritability
• Irregular periods or lighter bleeding

More serious risks can include decreased bone mineral density, liver enzyme elevations, and depression or suicidal thoughts in rare cases. Tell your clinician right away if you notice yellowing of the skin, severe abdominal pain, unusual bleeding, or mood changes. It is contraindicated in pregnancy. Use effective contraception and stop the medicine if pregnancy occurs. Seek medical advice if you think you are pregnant.

Drug Interactions and Cautions

Some medicines can change how this treatment works or increase side effects. Interactions of concern include:

• Strong OATP1B1 inhibitors such as cyclosporine or gemfibrozil
• Strong CYP3A inhibitors or inducers that may alter levels
• P-gp substrates where monitoring may be needed
• Estrogen-containing contraceptives, which may reduce effectiveness
• Herbal products like St. John’s wort

Limit alcohol if it worsens dizziness or nausea. Review all medicines, vitamins, and supplements with your prescriber before starting. Do not change doses without guidance.

What to Expect Over Time

Many people notice pain relief after starting therapy, though the degree and timing can vary. Periods may become lighter, irregular, or stop during treatment. Some symptoms may ebb and flow as your hormone levels adjust. Your prescriber may monitor liver tests, mood, and bone health during longer courses. If pain returns after stopping, your clinician may reassess options.

Compare With Alternatives

Other approved options include progestins such as Dienogest and GnRH agonists like leuprolide or goserelin. Agonists lower estrogen by a different pathway and may require add-back hormones to help limit bone loss. For background on GnRH agonists, see our overview: Zoladex Cost. You can also explore the condition page for Endometriosis to compare therapies by class and goals.

Pricing and Access

Elagolix tablets price can vary by strength and quantity. Canadian pricing may offer meaningful savings for US patients paying cash. Orders Ships from Canada to US with pharmacy dispensing by our team. To see current options, sign in to view availability and request a quote. For offers and seasonal deals, visit Promotions. Your checkout is encrypted, and our team confirms each prescription before processing.

Availability and Substitutions

Supply can fluctuate by pack size and market. If your preferred option is unavailable, your prescriber may suggest a different strength, a class alternative, or a follow-up plan. We cannot provide restock dates, but we will show in-stock choices when you sign in. Review the Womens Health category for related medicines.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with moderate to severe endometriosis pain who are not pregnant and have acceptable liver function and bone health. It may not suit those with osteoporosis, severe hepatic impairment, or untreated depression. Review mental health history and fracture risk before starting. Use non-hormonal birth control while taking this medicine and for a short time after stopping.

Ways to save and stay on track:

• Ask about multi-month fills if appropriate
• Align refills with appointment dates
• Set calendar reminders for dosing
• Choose the schedule that fits your routine
• Discuss generic or class alternatives if costs are a barrier

Questions to Ask Your Clinician

• Which dosing schedule fits my symptoms and liver function?
• How will we monitor bone health and mood over time?
• What birth control should I use during treatment?
• Which medicines or supplements should I stop or avoid?
• How long should I stay on therapy before reassessment?
• What signs mean I should contact the clinic right away?

Authoritative Sources

• AbbVie Orilissa Prescribing Information
• FDA DailyMed: Orilissa
• Health Canada Drug Product Database

Ready to get started? Place your request with YouDrugstore for prompt US shipping from Canada. This information is not medical advice; always follow your prescriber and the official label.