Osphena® Tablets for Painful Intercourse Due to Menopause

What Osphena® Is and How It Works

Osphena (ospemifene) is a selective estrogen receptor modulator used by postmenopausal women to treat moderate to severe dyspareunia and bothersome vaginal dryness linked to vulvar and vaginal atrophy. It is taken as an oral tablet once daily with food. Many patients compare the Osphena price and value when choosing where to fill their prescription, including those seeking Osphena without insurance.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. We also source through licensed, vetted international partner pharmacies so you receive authentic brand medications, a broad selection, and competitive pricing.

Osphena acts as an estrogen agonist in vaginal tissues. It helps thicken and lubricate the vaginal epithelium, easing pain with intercourse and reducing dryness. It does not provide systemic estrogen and has tissue-selective activity. The usual course involves daily use only for as long as treatment is needed. The goal is symptom control at the lowest effective duration.

Osphena tablets are one strength for daily dosing. This therapy is indicated for women for whom local or other options are not acceptable or effective. Prescribers may review personal risk factors before starting therapy.

Dosage and Usage

• The usual dose is 60 mg by mouth once daily.
• Take with food at the same time each day.
• Swallow the tablet whole with water; do not split, crush, or chew.
• If a dose is missed, take it when remembered on the same day. Skip it if it is almost time for the next dose. Do not double doses.
• Do not combine with systemic estrogens or other SERMs unless a prescriber advises and monitors therapy.
• Tell the prescriber about all medicines, including fluconazole, ketoconazole, or rifampin, which can change exposure.

• Store tablets at 20–25°C (68–77°F); short excursions 15–30°C (59–86°F) are acceptable.
• Keep in the original container, tightly closed, and protect from moisture.
• Store out of reach of children and away from bathrooms or hot cars.
• For travel, keep your tablets in carry-on luggage with the pharmacy label.
• If crossing time zones, aim to take your dose at the usual local time once daily.
• Do not freeze or expose to excessive heat.

Benefits and Savings

Osphena helps reduce pain during intercourse by improving vaginal mucosa thickness and lubrication. Many patients also report less dryness and improved comfort over time. A once-daily oral tablet offers convenience for those who prefer not to use vaginal creams or inserts.

Ordering through a Canadian online pharmacy can lower the Osphena cost. Typical savings range from 60–80% versus common U.S. prices. This can be helpful if paying Osphena cash price or purchasing Osphena without insurance. Multi-month supplies can reduce the per-month cost, and periodic reorder reminders help you stay on track.

For extra savings, see our Osphena coupon options when available.

You can buy Osphena online from YouDrugstore or order Osphena by phone during posted hours. We ship to the U.S. using prompt, express, cold-chain shipping when required by the product.

Side Effects and Safety

• Hot flushes
• Vaginal discharge or genital discharge
• Muscle spasms
• Increased sweating
• Headache
• Mild breast discomfort
• Spotting or light bleeding
• Rash or pruritus

Serious risks are uncommon but can occur. Osphena has estrogen agonist effects on the endometrium and may increase the risk of endometrial cancer; any unexpected vaginal bleeding requires prompt evaluation. The medicine may increase the risk of stroke, deep vein thrombosis, and pulmonary embolism. It is contraindicated in women with undiagnosed genital bleeding, known or suspected estrogen-dependent neoplasia, active or past thromboembolic disease, or who are pregnant. Caution is advised in those with cardiovascular risk factors or severe liver impairment. Strong CYP3A4 or CYP2C9 inhibitors may increase exposure; rifampin may reduce it.

Onset Time

Many patients notice some improvement in vaginal comfort within 4 weeks of daily use. Pain during intercourse often continues to improve by 8 to 12 weeks as the vaginal epithelium becomes thicker and better lubricated. Benefits are maintained with continued daily therapy. If symptoms recur after stopping, prescribers may consider reinitiating therapy for the shortest duration consistent with treatment goals.

Compare With Alternatives

Local estrogen therapy is a common alternative. A topical cream such as Premarin® Vaginal Cream delivers estrogen directly to vaginal tissue and can be effective for dryness and dyspareunia. Some patients prefer local treatment when systemic exposure needs to be minimized.

Transdermal estradiol patches provide systemic estrogen and are often used for broader menopausal symptoms like hot flashes, with or without progestin in women with a uterus. Options include patches such as Estradot® Vivelle Dot. These may help genitourinary symptoms but involve systemic estrogen exposure.

A non-estrogen local option is intravaginal prasterone (dehydroepiandrosterone), used to treat moderate to severe dyspareunia. Over-the-counter vaginal moisturizers and lubricants can be added to improve comfort during intercourse.

Combination Therapy

• Regular use of vaginal moisturizers for baseline hydration.
• Water-based or silicone lubricants during intercourse for added comfort.
• Pelvic floor physical therapy when pelvic muscle tension contributes to pain.
• Cognitive or sex therapy support for pain-related anxiety or avoidance.
• Do not combine Osphena with systemic estrogens, other SERMs, or estrogen agonists unless a prescriber directs and monitors therapy.
• Review all medicines and supplements to reduce interaction risks.

Patient Suitability and Cost-Saving Tips

Osphena is intended for postmenopausal women with moderate to severe dyspareunia or significant vaginal dryness due to vulvar and vaginal atrophy. It can suit patients who prefer an oral option or who did not achieve adequate relief with nonprescription moisturizers or lubricants.

It may not be appropriate for those with a history of breast cancer or other estrogen-dependent cancers, undiagnosed vaginal bleeding, active or past deep vein thrombosis, pulmonary embolism, stroke, or myocardial infarction. It is not for pregnancy or breastfeeding. Caution is needed with severe hepatic impairment and in smokers or those with multiple thromboembolic risk factors.

To manage costs, you can purchase a larger supply when permitted to lower the per-month Osphena cost. Watch for Osphena deals and simple bulk-price promotions. If paying the Osphena cash pay rate, comparing pharmacies can help. Reorder reminders from YouDrugstore help you avoid gaps in therapy. Patients paying Osphena without insurance often benefit most from Canadian pricing.

Authoritative Sources

Official Osphena patient and prescriber information

FDA Prescribing Information for Osphena (ospemifene)

Health Canada Drug Product Database search

Order Osphena® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This content is for educational purposes only and does not replace professional medical advice, diagnosis, or treatment.