Parnate® (tranylcypromine) tablets for major depressive disorder

What Parnate Is and How It Works

Parnate® is the brand name for tranylcypromine. It is an oral antidepressant in the monoamine oxidase inhibitor (MAOI) class. It treats major depressive disorder, including cases that have not responded to other medicines. Tablets are taken by mouth, usually in divided doses during the day. People often compare brands and the Parnate price when planning long-term therapy, including those paying cash such as parnate without insurance.

Tranylcypromine irreversibly blocks monoamine oxidase A and B. This increases serotonin, norepinephrine, and dopamine in the brain. Higher levels can improve mood, energy, and motivation. MAOIs require specific food and drug precautions. A prescriber decides if this medicine is suitable and how long to continue therapy.

YouDrugstore is a licensed Canadian pharmacy in Manitoba that meets Canadian pharmacy standards. Pharmacists review each valid prescription before dispensing and support safe use. We ship brand and generic medicines to the US at Canadian prices and also carry common OTC health products.

We source from licensed, vetted partner pharmacies and distributors so you receive authentic brands, a wide selection, and consistent affordability.

Dosage and Usage

• Starting dose: many adults start with 10 mg twice daily.
• Titration: increase by 10 mg per day at intervals, as tolerated, to 30 mg per day in divided doses.
• Usual range: 30–40 mg per day in two doses. Some patients need up to 60 mg per day.
• Administration: take tablets during daytime to reduce insomnia risk. Avoid late-evening doses.
• Missed dose: if a dose is missed, skip it if close to the next dose. Do not double doses.
• Dietary rules: follow a low-tyramine diet to reduce hypertensive crisis risk. Avoid aged cheeses, cured meats, fermented soy, sauerkraut, yeast extracts, and tap beers.
• Drug interactions: do not combine with SSRIs, SNRIs, other MAOIs, many antidepressants, meperidine, dextromethorphan, linezolid, or certain sympathomimetics. Respect washout periods when switching.
• Driving and alcohol: use caution with tasks requiring alertness. Avoid alcohol that is high in tyramine or interacts with blood pressure.

• Storage: store at 20–25 °C (68–77 °F) in a dry place. Keep tablets in the original container.
• Travel: keep tablets in carry-on luggage. Bring extra doses and your prescription. Protect from heat, moisture, and light.
• Reorders: use your account to set friendly reminders so you do not run out.

Benefits and Savings

Parnate® can help when other antidepressants have not worked well enough. It may be useful for certain depressive patterns such as atypical features, as clinically assessed. Some people experience improved mood, reduced ruminations, and better daily function. It is taken as tablets, which supports simple daily routines.

Ordering through YouDrugstore gives access to Canadian pricing. Many patients report 60–80% savings compared to typical US retail costs. Savings can help those paying without insurance, and multi-month supplies can lower the per-month cost when appropriate. Customer-service chat is available during posted office hours if you need help with ordering or account questions.

Side Effects and Safety

• Common: insomnia, dry mouth, constipation, dizziness, orthostatic hypotension, headache, restlessness, tremor, edema, weight changes, sexual dysfunction.
• Less common: paresthesias, blurred vision, nausea, sweating, skin rash.
• Serious: hypertensive crisis with severe headache, chest pain, palpitations, neck stiffness, or confusion; serotonin syndrome with agitation, fever, muscle rigidity, and rapid heart rate; liver enzyme elevations.
• Diet and interactions: excess tyramine intake can trigger sudden blood pressure spikes. Many medicines are incompatible. Linezolid and methylene blue can interact dangerously.
• Switching rules: washout periods are required when moving to or from other antidepressants. Prescribers set timelines to avoid interactions.

Report unusual symptoms promptly and seek urgent care for signs of hypertensive crisis or serotonin syndrome. Always share a full medication and supplement list with the prescriber and pharmacist.

Onset Time

Some symptom relief may appear within one to three weeks. Sleep and energy can shift first, with mood gains following. A full response may need several weeks at a stable dose. Prescribers monitor progress and adjust dosing based on response and tolerability.

Compare With Alternatives

Many patients try an SSRI before an MAOI. Escitalopram is commonly chosen for its once-daily dosing and broad evidence. It lacks tyramine diet restrictions but can cause sexual side effects and may not help after multiple prior trials.

Cipralex® Lexapro is a brand option of escitalopram. It offers consistent quality control and similar efficacy to generics. People who prefer branded therapy sometimes choose it for continuity.

Fluvoxamine is another SSRI option that can support mood and certain anxiety symptoms. It can interact with many medicines through CYP pathways. Compared with SSRIs, tranylcypromine brings dietary rules and interaction limits but can provide strong benefit in resistant depression when supervised.

Combination Therapy

Tranylcypromine should not be taken with other antidepressants, certain pain medicines, or serotonergic agents. Psychotherapy, such as cognitive behavioral therapy, can be used alongside medication. Structured sleep, activity planning, and social support can complement treatment goals. Any add-on therapy should be reviewed with the prescriber to avoid interactions.

Patient Suitability and Cost-Saving Tips

Parnate® may suit adults with major depressive disorder who have not responded to other approaches. It is not appropriate for people with certain conditions, such as pheochromocytoma, or those taking incompatible medicines. Careful adherence to the low-tyramine diet is essential. Prescribers weigh risks and benefits based on history and current symptoms.

To manage costs, consider longer supplies when appropriate. Reorder reminders help keep therapy on track. If you are comparing options, check our current prices and ask about bulk promotions. For current deals and bulk options, see our parnate coupon page.

Explore related topics in our condition pages for Depression and Anxiety. For broader reading on antidepressant tolerability, see our articles on Fluoxetine Side Effects Patient Guide To Safe Use and Fluoxetine For Anxiety How It Boosts Mood And Reduces Worry. People paying parnate without insurance can still access Canadian pricing through YouDrugstore and compare total costs.

Authoritative Sources

Review official prescribing and safety information before starting treatment. See the FDA Prescribing Information for tranylcypromine, the Tranylcypromine in the Drug Product Database, and the DailyMed tranylcypromine label.

YouDrugstore makes it simple to upload a prescription and place your order. Our team provides careful dispensing and discreet packaging, with prompt, express, cold-chain shipping where required. Reach out during posted office hours if you need help with your account or delivery preferences.

This information is not a substitute for medical advice. Always speak with a qualified healthcare professional about diagnosis, treatment choices, and potential interactions. Use medicines only as prescribed.