Pentasa® Enema (mesalamine) for Ulcerative Colitis and Proctosigmoiditis

What Pentasa® Is and How It Works

Pentasa® Enema contains mesalamine (5-aminosalicylic acid). It is used to treat mild to moderate ulcerative colitis limited to the rectum and left side of the colon, including proctitis and proctosigmoiditis. The rectal suspension delivers anti-inflammatory action directly to the inflamed lining. Dosing is usually once daily at bedtime during active flares. Some patients also use a maintenance schedule. People sometimes search for pentasa enema uninsured or pentasa enema tanpa asuransi when comparing options.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. We meet Canadian pharmacy standards, and a licensed pharmacist reviews each prescription before dispensing. We offer brand and generic medicines at Canadian prices and also carry OTC health products. When sourcing, we also work with licensed, audited partner pharmacies abroad to supply authentic brands at fair prices and a broad selection.

Dosage and Usage

The enema is available in different strengths, such as 1 g per 100 mL and 4 g per 60–100 mL, depending on the product supplied. Always follow the prescriber’s directions and the product label.

• Starting dose: Many regimens use 1 g or 4 g rectally at bedtime for 3–6 weeks during a flare.
• Titration: Some patients reduce to every other night or a lower dose once symptoms improve, as directed by the prescriber.
• Preparation: Shake the bottle to resuspend the medication. Warm to room temperature in the hands for comfort. Do not heat with appliances.
• Administration: Lie on the left side with the right knee bent. Insert the applicator gently and instill the full contents unless told otherwise.
• Retention: Holding the enema for at least 30 minutes and ideally overnight helps the medicine coat the distal colon.
• Missed dose: If a dose is missed, use it when remembered unless it is near the next dose. Do not double the next dose.

Storage and travel tips:

• Store at 15–25 °C. Protect from freezing and excessive heat.
• Keep bottles in the original carton to protect from light.
• When you travel, pack spares and a sealed bag for disposal. Keep the enema upright and cushioned in luggage.
• Check expiry dates before you order and before travel.

Benefits and Savings

Pentasa® Enema treats inflammation at the site of disease. Rectal delivery provides high local concentrations with limited systemic absorption compared with oral therapy. It is effective for bleeding, urgency, and rectal pain in distal ulcerative colitis and proctosigmoiditis. Many patients see improvements in stool frequency and rectal bleeding during induction therapy.

Ordering from YouDrugstore is simple. You can place your order online, and our team is available through customer-service chat during posted office hours to help with questions about your order or account. You may save 60–80% compared with typical US prices, including if paying without insurance.

Side Effects and Safety

Most people tolerate mesalamine well, but side effects can occur. This summary does not replace medical advice. Speak with a healthcare professional about risks and monitoring.

• Common: Rectal discomfort, urgency, abdominal cramping, gas, mild nausea, headache, or dizziness.
• Less common: Fever, rash, fatigue, insomnia, or back pain.
• Serious but rare: Worsening colitis, acute intolerance syndrome, pancreatitis, liver problems, kidney problems (interstitial nephritis), myocarditis or pericarditis, blood disorders, or severe skin reactions. Stop therapy and seek medical care if severe symptoms occur.
• Allergy: Do not use in patients allergic to mesalamine or salicylates (aspirin).
• Interactions: Monitor when used with azathioprine or 6-mercaptopurine (risk of myelosuppression). Use caution with nephrotoxic agents and NSAIDs. Tell the prescriber about all medicines and supplements.
• Monitoring: Renal function monitoring may be recommended before and during treatment.
• Special populations: Use in pregnancy or breastfeeding only if the benefits outweigh risks, under medical guidance.

Onset Time

Symptom relief may begin within several days to two weeks. Bleeding and urgency often improve first. Full benefit can build over two to four weeks. Response varies based on disease extent, dose, and adherence.

Compare With Alternatives

Rectal mesalamine is available in several forms. Choice depends on disease location, tolerance, and convenience.

For very distal disease limited to the rectum, suppositories may be suitable. See Pentasa® Suppositories for patients whose symptoms are confined to the rectum.

For left-sided colitis extending beyond the rectum, enemas reach further into the sigmoid and descending colon. Products vary by strength, such as pentasa 1g enema and pentasa enema 4g. Some patients prefer a foam formulation for easier retention; pentasa foam enema availability varies by market.

A corticosteroid enema or foam can be considered when 5-ASA alone is not adequate or rapid relief is needed. Budesonide rectal therapy has more systemic steroid effects than mesalamine but less than oral prednisone. See Entocort® Enema for a steroid-based option in selected cases.

Oral 5-ASA helps treat more extensive colitis or maintain remission. Some patients use both oral and rectal 5-ASA. See our Mesalamine page to compare oral strengths and tablet forms.

Combination Therapy

Combining rectal and oral mesalamine can increase mucosal exposure for left-sided disease. Some patients receive a rectal enema nightly plus an oral mesalamine tablet regimen for induction. A prescriber may add a short course of rectal or oral corticosteroids if symptoms persist, then taper steroids as inflammation improves. Do not change therapy without medical guidance.

Patient Suitability and Cost-Saving Tips

Pentasa® Enema is intended for mild to moderate distal ulcerative colitis, including proctitis and proctosigmoiditis. It is not a treatment for infections or constipation. People with a salicylate allergy, severe kidney or liver disease, or a history of mesalamine intolerance may not be candidates. Always confirm the diagnosis, especially when symptoms overlap with IBS; our article Ibs What Is Ibs Causes Symptoms Treatment explains key differences. Learn more about the condition on Ulcerative Colitis and Proctitis.

Ways to manage costs:

• Order a multi-month supply when appropriate to lower the per-month cost.
• Use reorder reminders in your account so you do not run out during maintenance.
• Compare available strengths, such as pentasa enema 1g 100ml and higher-dose options, with your prescriber to balance efficacy and value.
• Check promotions before you place your order. See current pentasa enema discount and bulk options.
• Our team can explain invoice details and help you submit receipts if you seek reimbursement when buying without insurance.

Authoritative Sources

For detailed prescribing and safety information, see these official resources:

• Ferring Canada Pentasa product information
• Health Canada Drug Product Database
• FDA prescribing information repository for mesalamine rectal products

You can order from YouDrugstore with confidence. We are a licensed Canadian pharmacy, and your prescription is checked by a pharmacist before dispensing. Place your order online, and we provide prompt, express, cold-chain shipping to the US when needed. Customer-service chat is available during posted office hours if you need help with your order.

Disclaimer: This content is for general information only and does not replace professional medical advice. Always speak with a licensed healthcare provider about diagnosis, treatment choices, and dosing for your situation. Read the patient leaflet supplied with the product.