Pentasa® Enema for Ulcerative Colitis

Pentasa Enema is a mesalamine rectal suspension used for ulcerative colitis affecting the distal colon. It targets local inflammation in the lining of the bowel. This page helps you understand how it works, who it suits, and how to use it correctly.

What Pentasa Is and How It Works

Pentasa® enema contains mesalamine, a 5-aminosalicylic acid that acts locally in the colon. It reduces inflammatory mediators in the mucosa. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing. We offer US delivery from Canada and options that can work without insurance. The medicine is designed to coat the rectum and sigmoid colon, where it can help calm inflammation linked to active disease.

Mesalamine is not a steroid. It works on the surface of the bowel and has minimal systemic absorption when used rectally. The formulation is intended to be retained to maximize contact time with inflamed tissue.

Who It’s For

This treatment is indicated for mild to moderate ulcerative colitis involving the rectum and left colon, including proctitis and proctosigmoiditis. Pentasa Enema may be used alone or with oral therapy when a prescriber recommends combined treatment. People with known hypersensitivity to salicylates or aminosalicylates should not use it. Those with significant kidney or liver disease require careful evaluation by a clinician before starting.

Tell your healthcare professional about past reactions to aspirin, sulfasalazine, or mesalamine products. Share your full medication list and medical history, including any history of pancreatitis or blood disorders.

Dosage and Usage

Use exactly as directed by your prescriber and the official label. Many regimens involve one rectal dose at bedtime to improve retention. Your clinician may adjust duration based on your response. Administration tips can help with comfort and consistency.

• Prepare position: lie on the left side with the left leg straight.
• Shake the bottle well to mix the suspension evenly.
• Gently insert the applicator tip; do not force it.
• Squeeze steadily to instill the full amount, unless directed otherwise.
• Remain lying for several minutes to help the liquid spread and stay.

Some patients are prescribed a mesalamine enema 4g in other brands or regions; follow the specific strength and schedule provided for your product. Avoid oral laxatives near dosing unless your prescriber instructs you. If rectal irritation occurs, contact your healthcare professional.

Strengths and Forms

The product is commonly available in single-use bottles. Availability can vary by country and distributor. In Canada, a frequent presentation is Pentasa enema 1g 100ml. Foam rectal formulations exist in some markets, sometimes referred to as Pentasa foam enema, which may be used when a smaller volume is desired. Your prescriber will select a form that matches your disease location and tolerance.

Missed Dose and Timing

If you miss a dose, use it when you remember unless it is close to the next scheduled time. Do not double up to make up for a missed dose. Keeping a daily routine, such as bedtime use, improves retention and consistency. If nighttime dosing is difficult, ask your clinician about an alternative schedule.

Storage and Travel Basics

Store at room temperature as directed on the label. Protect from excessive heat and keep the bottles upright in their packaging until use. Do not freeze. Keep out of reach of children. When traveling, carry this medicine in original packaging with your prescription details. Place it in your carry-on to avoid extreme temperatures. A simple note from your prescriber and a copy of your prescription can ease security checks.

Benefits

Rectal 5-ASA therapy acts where symptoms start, which can reduce urgency and rectal bleeding in active distal disease. Nightly use can be convenient for many people because the liquid is retained while sleeping. Compared with systemic therapies, local treatment may limit whole-body exposure. A generic mesalamine enema option may be appropriate when allowed by your prescriber and pharmacy.

Side Effects and Safety

Common effects can include:

• Rectal discomfort or cramping
• Gas or bloating
• Nausea or headache
• Urgency after dosing
• Mild dizziness

Serious but uncommon reactions may include allergic reactions, chest pain, pancreatitis, liver concerns, blood disorders, or kidney issues. Stop the medicine and seek urgent care if you develop signs of severe allergy such as hives, facial swelling, or trouble breathing. Blood and kidney monitoring may be recommended for some patients. If you have worsening abdominal pain, persistent fever, or significant bleeding, contact your clinician promptly.

Drug Interactions and Cautions

Share all medicines and supplements with your prescriber. Caution is advised with nephrotoxic agents that can affect the kidneys. Use with azathioprine or 6-mercaptopurine may increase the risk of blood effects. Report use of anticoagulants, high-dose NSAIDs, or other salicylate-containing products. Do not use if you are allergic to aspirin-like drugs. If you are pregnant, planning pregnancy, or breastfeeding, discuss potential risks and benefits with your healthcare professional.

What to Expect Over Time

It can take consistent nightly use for the bowel lining to calm. Some people notice stool changes or less bleeding as inflammation eases. The response can vary. Keep using as prescribed even if you feel better, unless your clinician changes the plan. Contact your prescriber if symptoms persist or worsen. People using Pentasa enema 1g may continue with a maintenance plan after induction, guided by clinical evaluation.

Compare With Alternatives

Other rectal 5-ASA options include suppositories, which target the rectum, and other mesalamine suspensions used in different strengths. For more extensive disease, oral mesalamine can be combined with rectal therapy as directed by a prescriber. Discuss which form aligns with your symptoms, tolerance for volume, and daily routine.

Pricing and Access

Canadian pharmacy pricing may lower your Pentasa enema price compared to some local cash-pay rates. You can review current options and see what fits your prescription. Ships from Canada to US with mail-order convenience. For potential savings on future orders, see our promotions. Checkout uses encrypted processes for security.

Availability and Substitutions

Supply can vary by pack size and distributor. If a specific presentation is unavailable, your prescriber may recommend a therapeutic alternative within the same class. Some patients consider a Pentasa enema online purchase through our pharmacy after their clinician has sent a prescription. When appropriate, pharmacists can discuss whether a compatible generic is available in your region.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults with mild to moderate distal ulcerative colitis. It may not be suitable for those with severe renal impairment or salicylate allergy. Ask your clinician about combining rectal and oral therapy when symptoms extend beyond the rectum. Consider longer refill intervals if you are stable, which can reduce fees and fewer shipments. Setting reminders helps maintain adherence. If your plan does not cover this therapy, review multi-pack options and compare the Pentasa enema cash price with potential generic alternatives. Upload your prescription early so pharmacists can clarify any questions before fulfilment.

Questions to Ask Your Clinician

• Right fit: Is a rectal suspension appropriate for my disease location?
• Dose plan: How long should I use nightly dosing before reassessment?
• Combination: Should I add an oral 5-ASA or suppository for better coverage?
• Side effects: What reactions require lab tests or an urgent check-in?
• Lifestyle: Any tips to improve retention and reduce bedtime urgency?
• Monitoring: Do I need kidney or liver blood tests while on treatment?

Authoritative Sources

Health Canada Drug Product Database

FDA DailyMed

Takeda Canada Medicines

Ready to proceed with YouDrugstore? Start your order with prompt US shipping from Canada and temperature-controlled handling when required. This information is not a substitute for medical advice; always follow your prescriber and the official label.