Pentasa® Suppositories for Ulcerative Proctitis Relief

What Pentasa® Is and How It Works

Pentasa suppositories contain mesalazine (mesalamine), an anti-inflammatory 5‑aminosalicylic acid (5‑ASA). They act locally in the rectum to calm inflammation and ease bleeding, urgency, and pain in mild to moderate ulcerative proctitis. Many people buy pentasa suppositories to support remission and reduce flare symptoms.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. We also work with licensed, vetted international partner pharmacies to offer authentic brand medicines, wide selection, and affordable options. If you need a pentasa 1g suppository without insurance, we can ship discreetly after your prescription is verified.

Pentasa mesalazine suppositories are placed rectally, not taken by mouth. The medicine blocks inflammatory mediators like prostaglandins and leukotrienes in the colonic mucosa. Typical strengths are 500 mg and 1 g. Most treatment courses run for several weeks, and some patients continue on a maintenance schedule per prescriber guidance. Pentasa suppositories for ulcerative colitis are made by Ferring and are sometimes listed as Pentasa suppositories 1g mesalazine Ferring.

Suppositories focus treatment where disease is most active. For symptoms extending above the rectum (proctosigmoiditis), a rectal enema or foam may reach higher.

Dosage and Usage

• Usual adult dose: 1 g once daily at bedtime, or 500 mg twice daily. Follow the exact directions on the prescription label.
• For induction of remission in ulcerative proctitis, courses often last 2 to 8 weeks before reassessment.
• For maintenance, prescribers may continue 1 g nightly or adjust the schedule to sustain remission.
• Rectal use only. Do not swallow.
• How to insert: wash hands; remove the foil; if needed, slightly moisten the tip; lie on the left side with the top leg bent; gently insert the pointed end into the rectum; remain lying for 10–15 minutes to help retention.
• Best given at bedtime to increase contact time in the rectum.
• Missed dose: if the next dose is not soon, insert when remembered. If close to the next dose, skip the missed dose. Do not use two doses at once.
• If the suppository is expelled soon after insertion, another dose may be required. Follow prescriber advice for this situation.
• Do not cut or divide a suppository.

• Storage: keep in the original packaging at 15–25 °C (59–77 °F). Protect from moisture and heat. Do not freeze.
• Travel: carry in a cool, dry place. Avoid leaving in a hot car. Use an insulated pouch in warm weather.
• Keep out of reach of children and pets.
• On the road: bring enough doses for your trip plus a few extra. Pack your prescription details for security checks.
• Disposal: follow local guidance. Do not flush unused medicines.

Benefits and Savings

Pentasa rectal therapy treats inflammation directly at the site of disease. Patients often see less rectal bleeding, fewer bowel movements, and improved urgency. Local delivery can reduce systemic exposure compared with some oral or steroid options.

Convenience matters. Once-nightly dosing is common with pentasa 1g suppositories, and 500 mg twice-daily plans are simple to follow. Clear instructions support consistent use, and the compact format is easy to store and travel with.

You may see 60–80% savings compared with typical US pricing through Canadian pharmacy access. Ask about the pentasa suppositories 1g price and the pentasa suppository price for the strength prescribed. We also list the pentasa 1g suppository cost and pentasa suppositories cash price transparently at checkout. Savings can be meaningful for patients paying without insurance.

Multi-month supplies and occasional bulk promotions can lower the per-month spend, and reorder reminders help you avoid gaps in therapy. For current offers, see our pentasa suppository coupon page.

Side Effects and Safety

• Common: rectal discomfort, mild cramping, gas, nausea, headache, dizziness, or constipation/diarrhea.
• Less common: rash, fatigue, joint pain, or flu-like symptoms.
• Local effects: temporary burning or the urge to pass stool after insertion.

Serious but uncommon risks include allergic reactions to salicylates, pancreatitis, liver enzyme changes, blood disorders, and kidney effects (including interstitial nephritis). Worsening colitis can occur rarely. People with kidney or liver disease, or a history of salicylate allergy, need prescriber guidance and monitoring. Report chest pain, severe abdominal pain, persistent fever, blood in urine, or marked fatigue promptly.

Onset Time

Symptom relief can begin within 3 to 7 days. Rectal bleeding and urgency often improve first. Many patients reach clear benefit by 2 weeks, and mucosal healing may continue over 4 to 8 weeks. Maintenance schedules support sustained remission and reduce relapse risk when therapy is continued as directed.

Compare With Alternatives

For disease that extends higher than the rectum, an enema can coat a larger area. The same active ingredient is available as an enema; see Pentasa® Enema for proctosigmoiditis coverage.

Oral mesalazine can complement rectal therapy, especially when inflammation involves more of the colon. A comparable brand is Salofalk®, offered in tablets and granules to reach the colon from above.

Rectal corticosteroids, such as budesonide enemas or foam, can be used for short courses during flares when 5‑ASA alone is not enough. Steroids can work quickly, but long-term use is limited by systemic effects, so many patients return to 5‑ASA for maintenance.

Combination Therapy

• Rectal plus oral mesalazine to treat both distal and more proximal inflammation.
• Suppository at bedtime with a daytime 5‑ASA enema if disease extends into the sigmoid colon.
• Short course of rectal corticosteroid added during a flare, then tapered off.
• If using thiopurines or biologics, prescribers may keep mesalazine for mucosal support.
• Regular lab monitoring may be advised when combining therapies that can affect blood counts or renal function.

Patient Suitability and Cost-Saving Tips

Pentasa supp is intended for adults with mild to moderate ulcerative proctitis. It is not for infections or for people with known salicylate hypersensitivity. Caution is needed with significant kidney or liver impairment. During pregnancy or breastfeeding, prescribers weigh benefits and risks; mesalazine is often considered when the benefits outweigh potential risks.

Those unable to retain rectal preparations may need a different form. People with extensive colitis often require oral therapy in addition to rectal treatment. Always follow the dose and duration set by your prescriber and report new or severe symptoms.

To manage costs, consider a multi-month supply if appropriate. Larger quantities can reduce the per-month price and simplify planning. Use refill reminders so you do not run out, and compare the pentasa suppositories 1g deal listings for current promotions. If paying out of pocket, ask about options for a pentasa 1g suppository without insurance at checkout. You can also order pentasa suppositories online by phone support during posted hours if you prefer.

Authoritative Sources

Ferring Pharmaceuticals: Pentasa product information

Health Canada Drug Product Database: Mesalazine (5‑ASA) listings

FDA Label: Mesalamine Rectal (Canasa) prescribing information

Order Pentasa® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express handling.

This content is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and the patient leaflet that comes with the medicine.