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Pentasa® suppositories are a rectal 5-ASA medicine used to calm inflammation in the lower bowel. This guide explains how the therapy works, who it fits, and safe use basics for your order. We support US delivery from Canada, including options for those paying pentasa suppositories without insurance.

What Pentasa Is and How It Works

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

The brand contains mesalamine, an anti-inflammatory agent that acts locally in the rectum. It reduces production of inflammatory mediators in the intestinal lining. That action helps ease bleeding, urgency, and rectal discomfort linked to ulcerative proctitis.

Rectal 5-ASA products, including generic mesalamine suppositories, deliver medication to the site of inflammation. Systemic exposure is low compared to many oral agents. This approach can be useful when disease is confined to the distal bowel.

Use this medicine only with a valid prescription and guidance from a healthcare professional. For broader background on the condition, see our category page for Ulcerative Colitis.

Who It’s For

This treatment is indicated for mild to moderate ulcerative proctitis, when inflammation is limited to the rectum. Clinicians may also use rectal 5-ASA therapy as part of a regimen for distal colitis. People with known salicylate hypersensitivity, severe kidney disease, or severe liver impairment should avoid the product unless a prescriber advises otherwise.

Those with a history of mesalamine intolerance or severe allergic reactions should discuss risks with a prescriber. If symptoms extend higher into the colon, a rectal suspension or oral therapy may be considered. Explore related options in our Gastrointestinal section.

Dosage and Usage

Follow your prescriber’s specific instructions and the official patient information. Many adults are directed to insert one suppository once daily at bedtime. Your clinician may adjust therapy based on response and tolerance.

Wash hands, unwrap the unit, and, if needed, moisten it with cool water for comfort. Lie on your side and gently insert the suppository past the anal sphincter, pointed end first. Try not to evacuate the dose for at least one to three hours, or as instructed by your clinician.

Typical short-course therapy lasts several weeks, with ongoing assessment of symptoms and tolerability. If your provider has combined therapies, follow the sequence they recommend. Some patients are prescribed mesalamine 1000 mg suppositories in the evening while using other medicines during the day.

If rectal irritation occurs, contact your prescriber for advice. Do not discontinue prescribed therapy without professional guidance.

Strengths and Forms

Availability can vary by jurisdiction. Common presentations include:

• Mesalamine rectal suppositories: 1 g unit dose

Other rectal forms, such as suspensions or foams, are used when disease extends beyond the rectum. Some patients start with Mesalamine tablets or a rectal suspension if their clinician recommends a different route. The choice depends on disease location and severity. This section includes a strength reference; dosing remains individualized by your prescriber.

For those whose disease is localized, clinicians may choose pentasa 1g suppositories to focus medication where needed. Product packaging and count may differ by supplier and market.

Missed Dose and Timing

If you miss a dose, insert it when you remember unless it is close to the next scheduled dose. Do not use extra suppositories to make up for a missed dose. Consistent use as directed can help maintain symptom control. If frequent doses are missed, speak with your clinician about strategies to support adherence.

Storage and Travel Basics

Keep units in their original packaging until use. Store at room temperature and protect from moisture. Keep out of reach of children and pets. Do not use damaged or melted units; contact your pharmacist for guidance if this occurs.

When traveling, pack enough supply in your carry-on. Bring your prescription label and a copy of your treatment plan. For longer trips, set reminders on your phone to support consistent use. If you have questions about handling while away from home, our team can assist your planning.

Benefits

Rectal 5-ASA therapy targets the inflamed rectal mucosa directly. This localized approach may reduce systemic exposure compared to many oral treatments. For some patients, nightly dosing is convenient and can align with routine. The treatment can be used alone or alongside oral medicines per your clinician’s plan.

When disease is confined to the rectum, topical therapy may minimize unnecessary exposure of unaffected areas. Discuss your goals and symptom patterns with your prescriber to tailor therapy and monitoring.

Side Effects and Safety

• Rectal discomfort or irritation
• Abdominal pain or cramping
• Headache
• Nausea or gas
• Rash or itching

Serious reactions are uncommon but can include mesalamine intolerance syndrome, pancreatitis, kidney issues, liver problems, severe allergic reactions, and blood dyscrasias. Stop the medicine and seek care immediately if you develop severe abdominal pain, chest pain, shortness of breath, swelling of the face or throat, or dark urine. Those with kidney disease require careful monitoring. Report new or worsening symptoms promptly.

Drug Interactions and Cautions

Tell your clinician about all medicines you use, including over-the-counter products and supplements. Notable interactions may involve azathioprine or 6-mercaptopurine, which can increase risk of blood count abnormalities. Use caution with other nephrotoxic agents. Discuss NSAID use and any known salicylate sensitivity before starting therapy.

People with a history of severe skin reactions, myocarditis, or pericarditis with 5-ASA should avoid rechallenge unless a specialist advises it. If you are pregnant or breastfeeding, consult your healthcare professional to weigh potential benefits and risks.

What to Expect Over Time

Many people notice gradual symptom changes as the rectal lining calms. Bowel urgency and bleeding may improve with steady use. Your prescriber may check progress after several weeks and adjust your plan based on response. Keep using the medicine as directed even if symptoms lessen, unless a clinician tells you to stop.

Adherence helps the treatment work as intended. Consider setting reminders, pairing use with bedtime routines, and keeping extra supplies packed for travel.

Compare With Alternatives

Other rectal therapies may be considered when disease location or response differs. Another mesalamine brand option is Salofalk® Suppositories. For steroid-based topical therapy, some prescribers use Uceris® Rectal Foam to address inflammation extending beyond the rectum. The appropriate choice depends on your medical history and disease distribution.

Pricing and Access

We offer competitive Canadian rates and transparent listings to help you compare options. Look for pentasa suppositories canadian pricing when reviewing product details. You can also check pentasa suppository price alongside alternatives to understand typical self-pay ranges.

Orders include US shipping from Canada with tracking. Prescription details are verified before fulfilment, and we provide encrypted checkout for your security. For current deals and seasonal savings, visit our Promotions page. If you prefer related therapies, browse Dicyclomine Hcl for cramps, Prednisone for systemic use when indicated, and Trimebutine for motility symptoms as directed by your clinician.

Availability and Substitutions

Supply can vary by supplier and market demand. If this item is temporarily unavailable, your prescriber may suggest another mesalamine brand or a different rectal form. For broader options, view our Gastrointestinal category or discuss alternatives such as a suspension or foam with your clinician.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with distal disease and intact rectal tone who can retain suppositories. It may not be appropriate for people with severe renal impairment or known 5-ASA allergies. Share your full medication list and medical history with your prescriber before starting.

To reduce pharmacy runs, consider multi-month supplies if your prescription allows. Set refill reminders on your phone, and keep a small reserve for travel. Comparing formulations can also help align therapy with your budget. For digestive education, see IBS What Is IBS and Does Metformin Cause Diarrhea for related reading.

Questions to Ask Your Clinician

• Is topical 5-ASA right for my disease location?
• How long should I continue rectal therapy before reassessment?
• What signs suggest intolerance or an adverse reaction?
• Can I combine this with oral therapy, and how should I time doses?
• How often should my kidney function be monitored?
• What steps help reduce irritation during insertion?
• When should I consider a different rectal form or an oral alternative?

Authoritative Sources

Ferring Canada: Pentasa

Health Canada Drug Product Database

FDA DailyMed: Mesalamine (Rectal)

Storage and Travel Links

Explore treatment categories and related options: Ulcerative Colitis and Mesalamine for additional context.

Place your order at YouDrugstore with prompt, express shipping and temperature-controlled handling when required. Ships from Canada to US. This information is educational and not a substitute for professional medical advice; always follow your prescriber’s instructions.