Pifeltro® Tablets for HIV-1

Pifeltro® is a non-nucleoside reverse transcriptase inhibitor used with other antiretrovirals to treat HIV-1. It offers once-daily dosing and a streamlined regimen. This page explains how the medicine works, who may be a candidate, and how to handle storage and travel. It also outlines access options with US delivery from Canada and what to consider if you pay cash, including Pifeltro without insurance.

What Pifeltro Is and How It Works

Pifeltro® contains doravirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI). It helps block the reverse transcriptase enzyme that HIV uses to replicate. When paired with other active agents, it supports durable viral suppression as directed by your prescriber.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine is taken as part of a complete antiretroviral regimen. It does not cure HIV, but it can reduce viral load when you take it consistently. The treatment can be taken with or without food, which adds flexibility to daily routines. For a broader view of therapies in this class, explore our Antivirals and HIV Medicines categories.

Who It’s For

This therapy is indicated for adults and eligible adolescents as part of combination treatment for HIV-1. It may be started in treatment-naïve patients or used to switch from a stable regimen in patients without known resistance to doravirine. Your healthcare professional will confirm suitability based on your history, current regimen, and resistance testing when available.

People with significant liver disease, a history of hypersensitivity to components, or who take strong enzyme inducers should discuss risks. Talk to your prescriber if you are pregnant, planning pregnancy, or breastfeeding. Pifeltro prescription tablets are not used alone; they are prescribed with other antiretrovirals.

For condition context and resources, visit our HIV page and see background reading like HIV Testing Day.

Dosage and Usage

The usual schedule is once daily as part of a complete regimen. Standard labeling supports administration with or without food, at the same time each day for consistent levels. If your prescriber provides special directions due to other medicines, follow those instructions closely and refer to the official label.

Ask about timing with other pills to simplify routines. Using a daily reminder can help keep your plan on track. If you have questions about doravirine 100 mg within your regimen, consult the package insert or your clinician for the most current guidance.

Always take this medicine exactly as prescribed. Do not stop or change your therapy without medical advice, as interruptions can lead to resistance.

Strengths and Forms

The product is supplied as film-coated oral tablets. A commonly available strength is Pifeltro 100 mg. Packaging and availability can vary by market and by lot. Your order will match what your prescriber specifies on your prescription.

If you are seeking regimens, you may also read about combination options in our article Key Facts.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day. If it is close to your next dose, skip the missed dose and resume your regular schedule. Do not double up to make up for a missed tablet. Set reminders or use a pillbox to support steady use.

Traveling across time zones can disrupt routines. Plan ahead by discussing timing with your prescriber before trips. Keep a simple chart for local times so you stay on track without taking extra doses.

Storage and Travel Basics

Store tablets at room temperature in the original container, away from excess heat and moisture. Keep the bottle tightly closed and out of reach of children and pets. Do not store in a bathroom cabinet with high humidity.

When traveling, pack enough supply in your carry-on. Keep the pharmacy label intact to avoid delays at security. Bring your prescription or a copy of your medication list. If a trip extends, arrange refills early so you do not run out.

Avoid leaving the medicine in a hot car or direct sunlight. If your travel involves long transits, use a small organizer and set phone reminders. For more on medication planning and interaction awareness, see Top Interactions.

Benefits

This NNRTI offers once-daily dosing with or without food, which simplifies routines. It fits into combination therapy and is compatible with many backbone agents when prescribed appropriately. The tablet form is discreet and portable for work or travel.

Consistent use as part of a complete regimen may help maintain viral suppression over time. The class is an option for patients who cannot take other classes due to tolerability or interaction concerns, based on prescriber judgment.

Side Effects and Safety

• Headache or dizziness, usually mild
• Nausea or abdominal discomfort
• Tiredness or sleep changes
• Abnormal dreams
• Rash or skin irritation

Serious reactions are uncommon but can include severe rash, liver problems, mood changes, or allergic reactions. Seek urgent care for symptoms of hypersensitivity such as widespread rash, fever, blisters, or swelling. People with underlying liver disease should be monitored as advised. Report bothersome effects to your prescriber or pharmacist.

Drug Interactions and Cautions

Doravirine is metabolized by CYP3A. Strong inducers such as rifampin, carbamazepine, phenytoin, and St. John’s wort can lower levels and may reduce effectiveness. Some azole antifungals, macrolides, and antiepileptics may require careful review. Always provide a full list of prescription medicines, over-the-counter products, and herbal supplements.

Alcohol use, significant liver disease, and pregnancy require individualized discussion. If you switch therapies, your clinician may confirm prior resistance tests. Do not start, stop, or replace other antiretrovirals without professional guidance.

What to Expect Over Time

With steady use as part of a complete regimen, viral load may decline and remain suppressed per lab goals set by your clinician. You may not feel different day to day, so lab monitoring becomes the best indicator that the plan is working. Keep all appointments and share any side effects or adherence challenges early.

Build a simple routine: same time each day, alarms, and a visible pillbox. If you travel or your schedule changes, plan ahead so doses remain consistent.

Compare With Alternatives

Doravirine is one option within modern antiretroviral therapy. Some patients use fixed-dose combinations that include doravirine with other agents. Others may be managed with different classes, such as integrase inhibitor–based regimens, depending on history and resistance.

Pre-exposure prevention is distinct from treatment; for prevention strategies, see Apretude®. For HIV-associated wasting, adjunctive therapy may involve Serostim® in selected cases under specialist care. For background on a doravirine-containing combination, read Key Facts.

Pricing and Access

Canadian pharmacy sourcing can offer competitive pricing for branded antiretrovirals. You can review doravirine price on the product page and compare options for self-pay. We show current availability and provide clear checkout steps. If you use insurance for related care, ask your prescriber about documentation that may help with reimbursement claims.

Orders include US shipping from Canada with transparent fees shown at checkout. For periodic offers, visit our Promotions page. Your prescription is required; dispensing occurs only after verification is complete.

Availability and Substitutions

If stock is limited, your prescriber may recommend an appropriate alternative regimen from the same or another class. We do not guarantee restock dates. When substitutions are considered, your clinician reviews your prior therapy, resistance profile, and potential interactions to keep your plan stable.

If you plan to buy doravirine tablets and cannot find your usual supply, contact your prescriber early to avoid gaps. Category options for context include HIV Medicines and Antivirals.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults and eligible adolescents who need an NNRTI as part of combination treatment. It may not be appropriate for patients with known resistance to doravirine, those using strong enzyme inducers, or people with severe liver disease without careful monitoring. Share your full medication list at each visit.

To reduce doravirine cost, consider multi-month supplies if your prescriber approves. Align refills with lab visits to avoid missed doses. Use calendar reminders and request a refill notification before you run low. Keep your prescription details current so your order processes smoothly. A brief note on privacy and safety: encrypted checkout is used to protect your information.

Questions to Ask Your Clinician

• Daily schedule fit: What time should I take my doses?
• Background agents: Which medicines should I pair with this tablet?
• Interaction risks: Do any of my current drugs reduce its levels?
• Lab monitoring: How often will you check my viral load?
• Side effects: Which symptoms should prompt a call?
• Travel plans: How should I manage time-zone changes?
• Switching therapy: What signs suggest I may need a change?

Authoritative Sources

Manufacturer Prescribing Information

DailyMed Drug Label

Health Canada Drug Product Database

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