Piqray® Tablets for HR+/HER2- Breast Cancer

Piqray® is alpelisib, a PI3K inhibitor used with fulvestrant for certain advanced breast cancers. This page explains how the treatment works, who it may suit, and practical use. We also outline access options, including US delivery from Canada, and ways to manage costs without insurance.

What Piqray Is and How It Works

Alpelisib blocks the PI3K-alpha pathway that can drive tumor growth in HR-positive, HER2-negative, PIK3CA-mutated breast cancer. It is taken by mouth once daily and used with fulvestrant. The medicine is intended for adults whose disease has progressed after endocrine therapy. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This therapy reduces signaling that tumor cells use to survive and multiply. It may help slow disease progression when combined with standard hormone blockade. Effects and tolerability can vary, so your healthcare professional will guide ongoing monitoring.

Who It’s For

This medicine is indicated for postmenopausal women and men with HR-positive, HER2-negative, PIK3CA-mutated, advanced or metastatic breast cancer, after progression on endocrine therapy. Testing for a PIK3CA mutation is required before starting.

People with poorly controlled diabetes, a history of severe skin reactions, or active pneumonitis may not be suitable. Those with significant kidney or liver concerns, or prior severe hypersensitivity to alpelisib or excipients, should discuss risks with a prescriber. Review your full medical history and all medicines before use.

Dosage and Usage

Standard labeling describes once-daily dosing with food, taken at approximately the same time each day. Tablets should be swallowed whole with water; do not split, crush, or chew. Piqray is used together with fulvestrant, administered by a clinician. If you are unsure about timing or dose changes, follow your prescriber’s directions and the official label.

Take the treatment with a meal to support absorption and reduce stomach upset. Keep hydrated and watch for skin or glucose changes. Your care team may schedule regular checks, including blood sugar and other lab work, especially early in therapy. Avoid starting new supplements or interacting prescriptions without professional advice.

Strengths and Forms

Alpelisib is supplied as film-coated oral tablets in multiple strengths to support individualized dosing. Common presentations include:

• 50 mg tablets
• 150 mg tablets
• 200 mg tablets

Availability may vary by pack size and strength. Your prescriber will choose the tablet combination that aligns with your current plan.

Alpelisib 150 mg tablets are often part of daily dose adjustments when needed. Always confirm the exact strength on your prescription and package before taking a dose.

Missed Dose and Timing

If you miss a dose, the label generally advises taking it the same day if there is adequate time remaining in your normal schedule. If it is nearly time for the next dose, skip the missed dose and take the next dose at the usual time. If you vomit after a dose, do not take an extra tablet. Resume at the next scheduled time. When uncertain, follow the official patient information or contact your healthcare professional.

Storage and Travel Basics

Store tablets at room temperature and in the original blister packaging to protect from moisture. Keep out of reach of children and pets. Do not remove tablets from blisters until you are ready to take them. Avoid excessive heat, humidity, and direct sunlight.

When traveling, keep your medicine in carry-on baggage with the pharmacy label attached. Pack enough supply for your trip plus extra days. Bring a copy of your prescription and your prescriber’s contact details. For international travel, check local rules for carrying prescription medicines.

Pen Handling and Sharps Disposal

Not applicable. This product is an oral tablet and does not require pen handling or sharps disposal.

Benefits

This therapy targets a specific pathway that may contribute to tumor growth in the indicated setting. When paired with fulvestrant, it can provide an option after prior endocrine therapy has stopped working. Oral dosing offers convenience at home, with one daily administration.

Buy alpelisib tablets via a prescription when your clinician recommends this option. Keep consistent daily habits, such as taking the dose with food, to support adherence. Your care team can adjust treatment if side effects occur.

Side Effects and Safety

• High blood sugar
• Diarrhea
• Rash or itching
• Nausea or vomiting
• Decreased appetite
• Stomatitis or mouth sores
• Hair thinning
• Fatigue

Serious risks can include severe hyperglycemia or ketoacidosis, severe skin reactions, pneumonitis, and hypersensitivity. Seek urgent care for breathing difficulty, extensive rash, fever, severe dehydration, confusion, or signs of high blood sugar. Your prescriber may order baseline and periodic blood glucose tests. If you use insulin or sulfonylureas, the combination can increase hypoglycemia risk when glucose-lowering regimens are adjusted; close monitoring is recommended.

For background reading on endocrine partners, see Exemestane Side Effects.

Drug Interactions and Cautions

Tell your prescriber about all medicines, vitamins, and herbal products. Strong enzyme inducers may lower alpelisib exposure. Caution is advised with agents that can raise blood sugar, including certain steroids. If you are being treated for diabetes, your clinician may adjust your existing plan when starting this therapy. Avoid starting new products without checking interactions. Alcohol may worsen stomach upset or glucose changes for some people.

What to Expect Over Time

Your clinician will assess response through clinical evaluation and imaging at appropriate intervals. Many side effects, such as rash or diarrhea, can appear early and may be managed with supportive care or dose adjustments if needed. Blood sugar elevations may occur; monitoring helps guide management. Keep a simple diary for symptoms, doses taken, and questions to discuss at your next visit. Adherence to daily dosing and scheduled labs supports safe use.

Compare With Alternatives

Several treatments are used in HR-positive, HER2-negative advanced breast cancer. Options may include an AKT inhibitor such as Truqap Capivasertib, or hormone blockade with Fulvestrant. CDK4/6 inhibitors like Verzenio are also used in appropriate patients per guidelines. Your prescriber will match therapy to biomarker status, prior treatments, and tolerance.

Order Piqray online only with a valid prescription and under the care of your oncology team. If insurance coverage is limited, ask about support programs or clinic-based resources.

Pricing and Access

Canadian pricing can offer savings compared with typical US cash-pay rates. Check our site for current Piqray price and available pack options. You can review availability, strength options, and submit your prescription for review. We provide US delivery from Canada with careful handling and tracking. For potential offers, visit our Promotions page. Encrypted checkout helps protect your information during purchase.

If you prefer to research before ordering, compare options in our condition pages such as Breast Cancer and the broader Cancer category.

Availability and Substitutions

Supply can vary by strength and pack. If a specific presentation is unavailable, your prescriber may suggest an alternative plan based on your treatment goals. Alpelisib price considerations differ by strength and quantity; review the listing and contact our team if you need help interpreting options. We cannot promise restock dates, but we will share current inventory status on the product page.

For background on endocrine partners sometimes used in this setting, you may also find Exemestane 25 Mg helpful.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults with the indicated mutation after disease progression on endocrine therapy. It may not be appropriate if you have a history of severe cutaneous reactions, active lung inflammation, or significant uncontrolled metabolic conditions. Your prescriber will weigh benefits and risks based on your history and lab results.

To manage out-of-pocket costs, consider multi-month fills if appropriate, and set refill reminders so you do not run short. Ask your clinic about assistance programs. Compare Canadian pricing with local quotes to understand potential savings. Piqray online pharmacy access can support self pay planning when coverage is limited. Keep all medicines in one order when possible to reduce separate handling fees.

Questions to Ask Your Clinician

• Is my tumor confirmed to have a PIK3CA mutation?
• How will we monitor blood sugar and skin during treatment?
• What signs mean I should call the clinic right away?
• How does this option fit with my prior therapies and goals?
• Which supportive medicines can help with rash or diarrhea if needed?
• Are there access programs or financial counseling resources available?

Authoritative Sources

• Novartis Piqray Prescribing Information
• FDA DailyMed: Piqray
• Health Canada Drug Product Database: Alpelisib

Ready to proceed? Place your order with prompt US delivery from Canada. All items ship with temperature-controlled handling when required. This information is educational and not a substitute for your prescriber’s advice.