Praluent® Injection for High Cholesterol

This prescription injection helps lower LDL cholesterol in adults who need more than diet and statins. It supports long-term risk reduction for certain heart conditions. This page explains how it works, who it may suit, and how to order with US delivery from Canada. It also covers typical access for praluent without insurance.

What Praluent Is and How It Works

Praluent® is alirocumab, a PCSK9 inhibitor. It helps your liver remove more LDL cholesterol from the blood. It is used along with diet and, often, a statin. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine binds to PCSK9 proteins and helps keep LDL receptors available. More receptors mean more LDL is cleared. The treatment is given by subcutaneous injection with a prefilled pen.

Who It’s For

This therapy is for adults with atherosclerotic cardiovascular disease needing further LDL reduction. It is also for adults with familial hypercholesterolemia. Your prescriber may consider it when statins and diet are not enough.

People with a history of severe hypersensitivity to components should not use it. Discuss pregnancy and breastfeeding plans with your healthcare professional. Review your cardiovascular goals and background therapy. You can learn more about the condition at High Cholesterol and Familial Hypercholesterolemia categories.

Some patients use it with other lipid-lowering options. Your prescriber may evaluate add-on therapy such as Atorvastatin, Rosuvastatin, or Ezetimibe based on your goals.

Dosage and Usage

Follow the dosing schedule on your prescription. In general, this therapy is injected under the skin on a regular schedule, either every two weeks or once monthly. Your prescriber will choose a starting schedule and may adjust if more LDL reduction is needed.

Read the patient information and Instructions for Use before your first dose. Wash and dry your hands. Choose an injection site on the thigh, abdomen, or upper arm if a caregiver injects it. Rotate sites with each dose and avoid areas that are tender, bruised, or scarred. Allow time for the pen to reach room temperature as directed in the guide. Do not shake, do not freeze, and do not use if the solution is cloudy or discolored.

If you are unsure about timing or technique, contact your prescriber or pharmacist. Do not change your schedule without medical guidance.

Strengths and Forms

This treatment is supplied as single-use prefilled pens for subcutaneous injection. Commonly available concentrations include 75 mg/mL and 150 mg/mL. Availability may vary by market and lot. Your prescription will specify the presentation.

Missed Dose and Timing

If you miss a dose, check how much time has passed. When the label instructions allow a window, take it as soon as possible within that window and then resume your regular schedule. If you miss the window, skip the missed dose and take the next dose at the usual time. Do not take extra injections to make up for a missed dose. If you are unsure, consult the official patient leaflet or your healthcare professional.

Storage and Travel Basics

Keep pens in their original carton to protect from light. Store unopened pens in the refrigerator unless your label states otherwise. Do not freeze. When traveling, use an insulated bag with cold packs to keep within recommended temperatures, and keep pens away from direct contact with ice. Once a pen has been out of refrigeration for the allowable period listed in the patient leaflet, do not return it to the fridge. Keep out of reach of children and pets.

Carry your prescription or a travel letter if flying. Place pens and supplies in your carry-on. At your destination, store as directed. If you have questions about handling, speak with your pharmacist.

Pen Handling and Sharps Disposal

Use each prefilled pen one time only. Check the window and expiration date before use. After injecting, place the used pen in a FDA-cleared sharps container. If you do not have one, use a heavy-duty household container with a tight-fitting, puncture-resistant lid. Follow local or state rules for disposal. Keep containers away from children and pets. Never share your pen with anyone, even if the needle has been changed. Do not recap or reuse needles.

Benefits

PCSK9 inhibition can provide additional LDL lowering on top of diet and statins. The class works independently of statin pathways, so it may help when statins alone are not enough. Prefilled pens offer at-home dosing on a schedule aligned to your goals. This approach may support long-term lipid management when combined with lifestyle changes and other therapies as advised.

Side Effects and Safety

• Injection site reactions such as redness, itching, or swelling
• Upper respiratory symptoms including nasopharyngitis
• Flu-like symptoms or cough
• Muscle aches

Serious allergic reactions can occur, though they are uncommon. Stop the medicine and seek urgent care for symptoms like trouble breathing, widespread rash, or severe swelling. Report persistent or worsening effects to your prescriber. People on multiple lipid-lowering therapies should be monitored to ensure LDL does not fall too low.

Drug Interactions and Cautions

Few drug interactions are known for this class. Still, tell your prescriber about all medicines, supplements, and herbal products you take. Use caution when combining with other potent LDL-lowering treatments. Discuss plans for pregnancy or breastfeeding. People with a history of severe hypersensitivity to components should not use it. For broader heart health topics, see Cardiovascular resources and the article The Skinny On High Cholesterol.

What to Expect Over Time

Your clinician will monitor LDL levels and adjust therapy if needed. Some people see changes on routine labs after staying consistent with the schedule. Keep appointments and continue background therapies unless advised otherwise. If you experience side effects, discuss options to improve tolerability. Lifestyle steps such as diet, exercise, and smoking cessation remain important. Regular review supports long-term risk reduction.

Compare With Alternatives

Other options include PCSK9-targeted or siRNA-based therapies. Repatha is another PCSK9 inhibitor with a similar mechanism and prefilled devices. Leqvio uses small interfering RNA to reduce PCSK9 production and is given less frequently in a clinic. When comparing choices, discuss goals, dosing schedules, and alirocumab cost with your prescriber.

Pricing and Access

We list transparent options so you can compare praluent price across available packs. You can also review alirocumab price to understand typical cash-pay levels. Ordering is straightforward with a valid prescription, and your information is protected with encrypted checkout. We provide US shipping from Canada for eligible orders. Your prescriber can send us the script directly, or you can upload it during checkout.

If you use insurance, confirm coverage and prior authorization needs with your plan. For self-pay, many people coordinate fills around lab visits to streamline care. Check our site for current availability before you place an order.

Availability and Substitutions

Supply can vary by strength and pack size. If an item is unavailable, your prescriber may recommend a therapeutically appropriate alternative. Discuss device preference, dose schedule, and alirocumab injection price when considering substitutions. We cannot guarantee restock dates, but our team can help you review in-stock options on the site.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults who need significant LDL reduction beyond diet and statins. It may not be appropriate for people with a known allergy to ingredients. To help manage praluent cost, consider multi-month supplies when approved by your prescriber. Set refill reminders tied to your injection schedule. Keep a spare pen on hand when traveling. Ask your clinician about optimizing background therapy to meet LDL goals with the fewest products necessary.

Questions to Ask Your Clinician

• LDL targets: What is my goal and how will we track it?
• Schedule fit: Which dosing interval best suits my routine?
• Background therapy: Which statin or add-on should I keep?
• Side effects: What symptoms should I report right away?
• Travel: How should I pack pens for flights and road trips?
• Follow-up: When should I repeat labs and check in?

Authoritative Sources

• Manufacturer Information
• FDA DailyMed Prescribing Information
• Health Canada Drug Product Database

Ready to proceed? Place your order at YouDrugstore for temperature-controlled handling when required and prompt, express, cold-chain shipping that Ships from Canada to US. Always use as directed by your prescriber. This content is educational and not a substitute for medical advice or the official label.