Praluent® (alirocumab) Injectable Pens for High LDL Cholesterol

What Praluent® Is and How It Works

Praluent® (alirocumab) is a PCSK9 monoclonal antibody used with diet and other lipid-lowering therapies to reduce low-density lipoprotein cholesterol (LDL-C). Adults with primary hyperlipidemia, including heterozygous familial hypercholesterolemia, and those with clinical atherosclerotic cardiovascular disease may be candidates. You can compare Praluent price and pen strengths on this page, then place your order when ready. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

This medicine binds to PCSK9 and prevents it from degrading LDL receptors on the liver. More LDL receptors clear more LDL-C from the blood. Many patients see 45–60% additional LDL reductions when Praluent is added to maximally tolerated statins, with or without ezetimibe.

Praluent comes as single-dose prefilled pens or syringes for subcutaneous injection. Common regimens include 75 mg every 2 weeks (75 mg/mL) or 150 mg every 2 weeks (150 mg/mL). Some use a 300 mg dose every 4 weeks. Prescribers adjust dosing based on LDL-C response and treatment goals.

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Dosage and Usage

• Starting dose: Often 75 mg injected subcutaneously every 2 weeks along with ongoing lipid-lowering therapies.
• Titration: If LDL-C reduction is insufficient, dosing may increase to 150 mg every 2 weeks, or switch to 300 mg every 4 weeks.
• Administration sites: Abdomen, thigh, or upper arm. Rotate sites. Avoid scars, bruised areas, and 5 cm (2 inches) around the navel.
• Before injection: Remove one pen from the fridge and let it reach room temperature (about 30–40 minutes). Do not heat externally.
• Check the solution: It should be clear to slightly opalescent and colorless to pale yellow, with no particles. Do not use if cloudy or discolored.
• Do not shake the pen or syringe.
• Clean the skin with an alcohol swab. Remove the needle cap when ready to inject.
• Inject as directed by the device instructions. Press and hold the pen in place until the indicator shows completion.
• 500 mg or multi-injection equivalents are not used; do not combine doses in one syringe.
• Missed dose (every 2 weeks): If the dose is missed and it has been 7 days or less since the scheduled date, inject as soon as possible and resume the original schedule. If more than 7 days have passed, skip the missed dose and take the next dose on the original schedule.
• Missed dose (every 4 weeks): If the dose is missed and it has been 7 days or less since the scheduled date, inject as soon as possible and start a new 4-week schedule from the new date. If more than 7 days have passed, skip the missed dose and inject on the next planned date.
• Sharps disposal: Place used pens or syringes in a puncture-resistant sharps container.

• Store pens refrigerated at 2–8 °C in the original carton. Protect from light.
• Do not freeze. If frozen, do not use.
• Once removed from the fridge, a pen can be kept at room temperature up to 25 °C for up to 30 days. Do not return it to the fridge. Discard if not used within 30 days.
• Do not expose to heat or direct sunlight. Do not shake.
• Travel: You can carry pens in an insulated bag with cold packs. Keep them with you, not in checked luggage. Bring your prescription and a sharps travel container.
• Shipping: Your order ships with prompt, express, cold-chain handling.

Benefits and Savings

Praluent provides strong LDL-C lowering when statin therapy alone is inadequate or not tolerated at higher doses. In outcomes trials, adding alirocumab to optimized background therapy reduced cardiovascular events in high-risk patients. The pen format supports steady dosing at home, with every-2-week or every-4-week schedules to fit daily life.

There is no approved Praluent generic at this time. The brand is available in 75 mg/mL and 150 mg/mL strengths. Many shoppers compare praluent cost per month across strengths and dosing frequencies. Factors that influence praluent pen cost include strength, number of pens per pack, and dispensing fees. You can also review alirocumab price trends and the cost of praluent injection relative to alternatives.

Buying from a Canadian pharmacy often brings 60–80% savings versus typical US prices. This may help those comparing praluent injection cost or a praluent 75 mg mL pen price against local retail rates. Multi-month supplies can lower the effective monthly cost when allowed by your prescription. You can set simple reorder reminders in your account to avoid gaps.

praluent coupon information is posted on our promotions page when a site-wide deal is active.

Manufacturer programs, such as a praluent patient assistance program or praluent savings card, may be available through the brand owners; eligibility and terms vary. Coverage matters like praluent cost Medicare plans or copay details depend on each insurer’s policy.

Side Effects and Safety

• Injection site reactions (redness, pain, bruising, itching)
• Nasopharyngitis or upper respiratory tract symptoms
• Influenza-like illness
• Cough or sore throat
• Back pain or myalgia
• Rash or pruritus

Serious hypersensitivity reactions are uncommon but can occur, including allergic reactions that may require medical attention. Discontinue if severe allergy occurs. Use caution in patients with significant hepatic impairment, as data are limited. This product is not mixed with other medicines in the same syringe.

Onset Time

LDL-C starts to decline within 1–2 weeks of the first dose. Most of the effect appears by about 4 weeks on a stable regimen. After dose changes, clinicians often recheck lipids in 4–8 weeks to guide further titration. Cardiovascular risk reduction follows sustained LDL lowering over months of continued therapy.

Compare With Alternatives

Repatha (evolocumab) is another PCSK9 monoclonal antibody. It offers similar LDL-C lowering and is administered every 2 weeks or monthly, depending on the dose. Choice between PCSK9 options can reflect device preference, dosing, access, and formulary factors.

High-intensity statins remain first-line for many patients. For example, Crestor® (rosuvastatin) provides potent LDL reduction and is often combined with non-statin agents when targets are not met. If statins are not tolerated or are insufficient, adding a PCSK9 inhibitor is considered.

Other options include ezetimibe and bempedoic acid. A traditional statin such as Lovastatin may suit moderate-risk scenarios or serve as a component in combination therapy. Discuss praluent alternatives with a prescriber when tailoring lipid-lowering strategies, including potential ezetimibe combinations.

Combination Therapy

• With statins: Common and effective for high-risk patients; monitor lipid response and statin tolerance.
• With ezetimibe: Adds further LDL-C reduction when goals are not met with statin alone.
• With bempedoic acid (where appropriate): An option when statin intolerance limits escalation.
• Lifestyle measures: Ongoing diet and exercise plans complement pharmacotherapy for long-term risk reduction.

Patient Suitability and Cost-Saving Tips

Adults with primary hyperlipidemia who need more LDL-C lowering despite maximally tolerated statins, or who cannot use higher statin doses, may be candidates. Those with established cardiovascular disease often benefit from intensive lipid lowering. Individuals with a history of severe hypersensitivity to alirocumab or its components should not use this medicine.

Evidence in severe hepatic impairment is limited. Safety in pregnancy and breastfeeding is not established; prescribers weigh risks and benefits. Pediatric use varies by jurisdiction; consult the local product labeling. The praluent drug class (PCSK9 inhibitors) does not require routine laboratory monitoring beyond periodic lipid measurements, as directed by the care team.

To manage expenses, compare pack sizes and dosing schedules for a clear view of praluent 75 mg mL pen needs per month. Multi-pack orders can reduce the per-month rate when regulations and prescriptions allow. You can enable reorder reminders in your account so you have time to upload a new prescription if needed. If you are evaluating praluent how to use materials, the device guide and praluent package insert included with your shipment provide step-by-step instructions.

Authoritative Sources

FDA Prescribing Information for Praluent (alirocumab)

Manufacturer HCP Page: Praluent (alirocumab)

Health Canada Drug Product Database: Praluent

Order Praluent® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This content is for educational purposes only and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and the supplied product labeling.