Prezcobix® (darunavir/cobicistat) tablets for HIV-1 treatment

What Prezcobix® Is and How It Works

Prezcobix® combines darunavir 800 mg and cobicistat 150 mg in one tablet. It is an HIV-1 protease inhibitor boosted with a pharmacokinetic enhancer. The usual dose is one tablet once daily with food. It is taken with other antiretrovirals. Many patients compare prices, including prezcobix without insurance, to plan monthly costs.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba, meeting Canadian pharmacy standards. Licensed pharmacists review each prescription before dispensing. We ship brand and generic medicines at Canadian prices, and we also carry OTC health products.

Prezcobix® works by blocking the HIV-1 protease enzyme. Darunavir prevents viral protein processing, and cobicistat slows darunavir metabolism. This increases darunavir levels throughout the day. The combination helps reduce viral load when used as part of a complete regimen. The product is indicated for adults and adolescents who meet weight and resistance criteria and require once-daily boosted darunavir.

We source through licensed and vetted partner pharmacies internationally when appropriate, offering authentic brand medicines, a broad selection, and affordable pricing.

Drug class and mechanism: darunavir is a protease inhibitor; cobicistat is a CYP3A inhibitor used as a booster. Route: oral tablets. Strength: prezcobix 800 150 mg. Consult the official prezcobix package insert and prezcobix prescribing information for full details from the manufacturer.

Dosage and Usage

• Take one Prezobix® tablet (darunavir 800 mg/cobicistat 150 mg) once daily with food.
• Swallow tablets whole. Do not chew, crush, or split.
• Use only with other antiretroviral medicines as prescribed. Do not use as monotherapy.
• Not recommended for patients with known darunavir resistance-associated substitutions.
• Missed dose: if less than 12 hours have passed, take the dose with food. If more than 12 hours, skip and resume the regular schedule.
• Do not take with strong CYP3A inducers or contraindicated drugs. Review all medicines and supplements for interactions.

• Storage: store tablets at 20–25°C (68–77°F); excursions 15–30°C (59–86°F).
• Keep tablets in the original bottle with the desiccant. Close the cap tightly to protect from moisture.
• Keep out of reach of children and pets.
• For travel, carry your medication in your hand luggage. Keep your original labeled bottle for screening.
• Avoid leaving your tablets in a hot car or direct sunlight.

Benefits and Savings

Prezcobix® offers once-daily dosing with food, which supports adherence. The booster component helps maintain effective darunavir exposure across the dosing interval. Patients often see steady viral load declines when used with a compatible backbone.

Ordering from YouDrugstore can lower the prezcobix cost compared to typical US pharmacy prices. Many customers save 60–80% versus common US retail. Savings can still be strong for patients paying without insurance, and multi-month supplies often reduce the per-month price.

Our team supports easy reorders and friendly customer-service chat during posted office hours. Pharmacists are available to address medication questions related to your prescription.

Side Effects and Safety

• Common: diarrhea, nausea, abdominal pain, headache, rash, fatigue.
• Changes in labs: increased cholesterol or triglycerides, elevated liver enzymes, increased serum creatinine (from cobicistat’s effect on tubular secretion).
• Serious: severe skin reactions, liver problems, pancreatitis, immune reconstitution syndrome.
• Renal concerns: risk increases when used with tenofovir disoproxil fumarate; monitor renal function as directed.
• Metabolic effects: new or worsened hyperglycemia or fat redistribution may occur.
• Bleeding: increased bleeding in patients with hemophilia has been reported.

Contraindicated with strong CYP3A inducers (such as rifampin, carbamazepine, phenobarbital, phenytoin, St. John’s wort). Contraindicated with drugs highly dependent on CYP3A clearance (such as lurasidone, pimozide, triazolam, oral midazolam, ergot derivatives, and certain statins like simvastatin and lovastatin). Review the prezcobix prescribing information for a full list.

Use caution in patients with sulfonamide allergy, since darunavir contains a sulfonamide moiety. Monitor for hepatic events, especially with hepatitis B or C coinfection. Severe hepatic impairment is generally not recommended. Cobicistat may lower measured eGFR by blocking creatinine secretion without affecting true GFR.

Pregnancy: cobicistat-boosted regimens may have reduced drug exposure in pregnancy. Management often uses alternatives during pregnancy based on guidelines.

Onset Time

With appropriate background therapy, many patients see viral load declines within 2–4 weeks. CD4 count changes can take longer. Achieving and maintaining suppression depends on baseline viral load, resistance profile, adherence, and companion antiretrovirals.

Compare With Alternatives

Prezcobix® provides a boosted protease inhibitor option. Some patients consider long-acting cabotegravir and rilpivirine injections, such as Apretude® Injectable Suspension paired with long-acting rilpivirine, for maintenance therapy after achieving suppression. Suitability depends on virologic history, resistance, and access to clinic visits.

Another option is the NNRTI rilpivirine, available as Edurant®, used with other agents for selected patients with low baseline viral load and stable disease. Single-tablet regimens such as Odefsey® (emtricitabine/rilpivirine/tenofovir alafenamide) offer once-daily convenience for appropriate candidates. A darunavir-based single-tablet alternative is Symtuza (not all strengths may be stocked).

Choice among these options weighs resistance, drug interactions, food requirements, comorbidities, and adherence preferences.

Combination Therapy

Prezcobix® must be used with other antiretrovirals. It is often paired with two NRTIs, such as emtricitabine with tenofovir alafenamide or tenofovir disoproxil fumarate, when clinically appropriate. Avoid combining with other boosted regimens. Do not coadminister with ritonavir or other cobicistat-containing products.

Significant interactions occur with anticonvulsants, rifamycins, certain macrolides, azoles, pulmonary hypertension drugs, sedative-hypnotics, and some statins. Dose adjustments or alternative therapies may be needed. Review the full interaction tables in the official labeling and consult current HIV treatment guidelines for specific pairs.

Patient Suitability and Cost-Saving Tips

Suitable candidates include adults and adolescents who meet weight criteria and have no known darunavir resistance-associated substitutions. Patients with severe hepatic impairment are generally not candidates. Those with a history of severe sulfonamide reactions may need added caution. Pregnancy may warrant a switch to a different darunavir-based regimen.

Compare the prezcobix price and prezcobix cost with other options if out-of-pocket expenses are a concern. Multi-month supplies can lower your per-month spend, and our team can set gentle reorder reminders so you never run short. For current offers and bulk options, see our prezcobix coupon page.

If you are new to treatment or evaluating regimens, explore condition pages like Hiv and Hiv Infection for general context. For interaction awareness, read Drug Interactions The Top Interactions That Should Be On Your Radar. For testing awareness, see National Hiv Testing Day 2025 Get Tested Know Your Status.

If paying cash, some patients look at prezcobix cash price, prezcobix out of pocket, or prezcobix price without insurance comparisons to plan their budget.

Authoritative Sources

See the Janssen Prescribing Information for Prezcobix for complete dosing, contraindications, and interactions. Review the Health Canada Product Monograph for Canadian guidance. The FDA label for Prezcobix provides additional safety and pharmacology data.

You can order Prezcobix® from YouDrugstore with a valid prescription. Our team supports secure checkout and prompt, express shipping to your address.

Content is for informational purposes and does not replace professional medical advice. Always follow your prescriber’s directions and the patient information provided with the medication. Seek urgent care for signs of a severe reaction or overdose.