Prometrium® (Progesterone) Capsules for Menopause and Uterine Bleeding

What Prometrium Is and How It Works

Prometrium® is oral micronized progesterone. It is prescribed to protect the uterine lining during estrogen therapy, to treat secondary amenorrhea, and to help manage abnormal uterine bleeding. It comes as 100 mg and prometrium 200 mg capsules. YouDrugstore is a licensed Canadian pharmacy in Manitoba, and our pharmacists review prescriptions before dispensing. We offer Canadian pricing and friendly customer-service chat during posted office hours. Many shoppers compare Prometrium choices and Prometrium cost without insurance to plan a budget.

Progesterone balances the effects of estrogen on the endometrium. It converts a proliferative lining to a secretory lining and supports a predictable withdrawal bleed. The capsule uses micronized progesterone for steadier absorption, and drowsiness can occur, so many regimens use bedtime dosing.

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Dosage and Usage

Your prescriber sets the exact schedule based on your diagnosis and goals. Typical oral regimens include cyclic therapy with estrogen, continuous therapy with estrogen, or short courses for amenorrhea.

• Menopausal HRT endometrial protection: 200 mg at bedtime for 12 days of a 28‑day cycle, or 100 mg at bedtime daily when a continuous schedule is chosen.
• Secondary amenorrhea: commonly 200–400 mg at bedtime for 10 days to induce a withdrawal bleed.
• Abnormal uterine bleeding: dose and duration vary by cause and clinical plan.
• Swallow capsules whole with water. Bedtime dosing can reduce dizziness or drowsiness felt during the day.
• Missed dose: take when remembered unless it is near the next dose. Do not double up.

Storage and travel

• Store at 20–25 °C (68–77 °F) in the original container. Protect from moisture.
• Do not freeze. Avoid leaving capsules in a parked car or near heat sources.
• When traveling, keep in your carry-on with your prescription label and a copy of your medication list.
• Keep out of reach of children and pets.

Benefits and Savings

Prometrium® helps protect the endometrium when you take estrogen for menopausal symptoms. It supports regular, predictable withdrawal bleeding in amenorrhea. It can also reduce unopposed estrogen effects in the uterus. Many patients find bedtime dosing simple and well tolerated.

Ordering through YouDrugstore gives you access to Canadian prices, often 60–80% less than typical U.S. retail. We offer brand and generic options when available. You can order online, and our team can help during posted hours. If you pay out of pocket, you can still find meaningful savings without insurance.

Side Effects and Safety

Most effects are mild and improve with time or dose changes. Bedtime dosing can help reduce daytime drowsiness.

• Common: dizziness, sleepiness, headache, breast tenderness, mood changes, bloating, abdominal discomfort.
• Less common: vaginal bleeding or spotting, nausea, diarrhea or constipation, joint pain, fatigue.
• Serious: blood clots, chest pain, shortness of breath, severe headache, vision changes, jaundice, severe depression, allergic reactions (hives, swelling, breathing trouble). Seek urgent care if these occur.

Prometrium® contains peanut oil. It is contraindicated in patients with a peanut allergy. It is not for use in pregnancy unless directed for specific reproductive protocols. Caution is needed in patients with a history of thromboembolic disease, hormone‑dependent cancers, liver disease, or unexplained vaginal bleeding.

Some medicines can alter progesterone levels, including certain anti‑seizure drugs and rifampin. Alcohol and other sedatives may increase drowsiness. Review all medicines and supplements with your prescriber.

For a deeper look at tolerability, see our article Progesterone Pills And Its Side Effects.

Onset Time

Many people notice sedation within the first few doses. For amenorrhea courses, a withdrawal bleed usually occurs within a few days after finishing a 10‑day regimen. When used with estrogen for endometrial protection, benefits begin in the first cycle and continue with ongoing use. Changes in heavy bleeding can take one or more cycles based on the cause.

Compare With Alternatives

Medroxyprogesterone acetate (Provera) is a synthetic progestin given in similar cyclic or short‑course schedules. It can be effective but has a different side‑effect profile. Some patients prefer micronized progesterone for tolerability and a more physiologic hormone.

Norethindrone is another oral progestin option. It is sometimes used for abnormal uterine bleeding or endometrial protection. Dosing and side effects differ from micronized progesterone.

Vaginal progesterone (e.g., inserts or gel) provides local delivery. It is often used in fertility care or for luteal support. It may cause local irritation but less systemic drowsiness.

For menopausal vaginal pain with intercourse, estrogen‑free therapy such as Osphena® may be considered for suitable patients. For contraception needs, a combined hormonal option such as Nuvaring® may be discussed with a clinician. These are not substitutes for Prometrium® when progesterone is required for endometrial protection or amenorrhea.

If you are comparing vaginal options, our article Does Endometrin Delay Your Period offers general insights on timing and bleeding expectations.

Combination Therapy

Prometrium® is often paired with systemic estrogen for menopausal symptom control. The progesterone component reduces the risk of endometrial hyperplasia from unopposed estrogen in patients with a uterus. It may also be included in fertility protocols to support the luteal phase. Use only within a supervised plan set by your prescriber. Avoid combining with other progestins unless instructed, as duplication can raise side effects without added benefit.

Patient Suitability and Cost-Saving Tips

Candidates include patients on estrogen therapy who retain a uterus, those with secondary amenorrhea needing a withdrawal bleed, and some with abnormal uterine bleeding. It is generally avoided in patients with peanut allergy, active or past clots, severe liver disease, or certain hormone‑sensitive cancers.

To lower costs, consider a multi‑month supply when appropriate, which can reduce the per‑month price. You can turn on reorder reminders so you never run short. For current promotions and bulk options, see our promotions page for any prometrium coupon opportunities.

If you are researching conditions, you can read more about Menopausal Symptoms and Abnormal Uterine Bleeding. For cycle restoration topics, see Secondary Amenorrhea. Our customer-service chat is available during posted office hours if you need ordering support.

Authoritative Sources

FDA Prescribing Information for Prometrium (label PDF)

Health Canada Drug Product Database

DailyMed listing for Prometrium and progesterone capsules

YouDrugstore offers caring service from a Canadian pharmacy team. Pharmacists review prescriptions before dispensing. Order online at your pace, and we ship to the U.S. with prompt, express, cold-chain shipping.

This information is educational and does not replace guidance from your healthcare provider. Always follow your prescriber’s directions and your pharmacy label.