Prometrium® Capsules for Secondary Amenorrhea

Prometrium is an oral micronized progesterone used for menstrual support and hormone therapy. It can treat secondary amenorrhea and helps protect the uterus when taking estrogen. Many people look for options that may be more affordable without insurance.

What Prometrium Is and How It Works

Prometrium® is micronized progesterone that acts like the hormone your body naturally produces. It supports a predictable uterine lining and helps oppose estrogen in postmenopausal therapy. We provide US delivery from Canada for eligible prescriptions. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine works by binding progesterone receptors in the uterus and other tissues. It stabilizes the endometrium and can trigger a scheduled withdrawal bleed in secondary amenorrhea. Some people take micronized progesterone 200 mg at bedtime because it may cause drowsiness.

Who It’s For

This treatment is used for secondary amenorrhea as directed by a prescriber. It is also used with estrogen therapy in postmenopausal women who have a uterus to reduce the risk of endometrial hyperplasia. People with peanut allergy should not take this product because some capsules contain peanut oil. Those with undiagnosed vaginal bleeding, active blood clots, liver disease, or a history of hormone-sensitive cancer should avoid it unless a clinician determines otherwise. If a Progesterone 200 mg capsule is prescribed, follow the label provided with your medication.

Dosage and Usage

Follow your prescriber’s schedule and the product label. For secondary amenorrhea, a common regimen is one capsule nightly for a short cycle, often 10 days. For endometrial protection with estrogen therapy, a typical schedule is one capsule at bedtime for 12 days of a 28-day cycle. Take with food if it helps your stomach, and swallow the capsule whole. Many are advised to take it at bedtime to minimize dizziness or drowsiness during the day. If you are instructed to use a Prometrium 200 mg capsule, do not change your dose without consulting your prescriber.

Tips to support safe use:

• Bedtime dosing preferred if you feel sleepy after a dose
• Keep a calendar for cycle days when used with estrogen
• Do not crush or open the capsule
• Avoid alcohol before bedtime if you feel sedated
• Report unexpected vaginal bleeding to your clinician

Strengths and Forms

This therapy is available as oral capsules in commonly published strengths such as 100 mg and 200 mg. Availability can vary by manufacturer and lot. Some pharmacies may stock brand and generic options. If you are seeking generic progesterone 200 mg capsules, availability may differ by region and supplier.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is close to your next dose. If it is almost time for the next dose, skip the missed dose and resume your schedule. Do not take two doses at once. For cyclic regimens, note where you are in the cycle and ask your prescriber if you are unsure how to proceed. To keep therapy on track and avoid gaps, set reminders and plan ahead for a Prometrium 200 mg refill if that is the strength you use.

Storage and Travel Basics

Store capsules at room temperature away from heat, moisture, and direct light. Keep them in the original container, tightly closed, and out of reach of children and pets. Do not store in a bathroom. When you travel, pack your prescription in your carry-on with a copy of your prescription label. Use a small pill organizer only if it will not be exposed to excess heat or humidity. If crossing borders, carry your prescription details and your prescriber’s contact information.

Benefits

This treatment supports a stable uterine lining for scheduled cycles in secondary amenorrhea. With estrogen therapy, it helps protect the endometrium in those with a uterus. Bedtime dosing can make daytime sedation less likely. Oral capsules are convenient and familiar to many users. Generic options may be available depending on supply.

Side Effects and Safety

Common side effects can include:

• Drowsiness or dizziness
• Headache
• Bloating or abdominal discomfort
• Nausea
• Breast tenderness
• Mood changes

Serious effects are less common but require urgent attention. These may include chest pain, sudden shortness of breath, severe headache, vision changes, weakness on one side, leg swelling or pain, or jaundice. Unexpected vaginal bleeding should be evaluated. There is a known risk of blood clots, stroke, and certain cancers with combined estrogen-progestin therapy; your prescriber will weigh risks and benefits. Do not use this therapy during pregnancy unless your clinician specifically instructs you otherwise; this product is not indicated for use in pregnancy.

Drug Interactions and Cautions

Tell your prescriber and pharmacist about all medicines, vitamins, and herbal supplements you take. Strong CYP3A4 inducers, such as rifampin, carbamazepine, phenytoin, and St. John’s wort, may lower progesterone levels. Strong CYP3A4 inhibitors, such as ketoconazole, may increase exposure. Alcohol and other sedatives can increase drowsiness. If you have liver impairment, blood clot history, hormone-sensitive cancers, or peanut allergy, discuss risks before use. When combined with estrogen, your clinician will monitor for adverse effects and adjust your plan if needed.

What to Expect Over Time

Some patients notice drowsiness early on, which often improves with bedtime dosing. In secondary amenorrhea, a scheduled withdrawal bleed may occur after a completed cycle. When used with estrogen therapy, it helps maintain endometrial protection during the days it is taken. Your clinician may review symptoms, blood pressure, and any bleeding changes over time. Adherence to the dosing schedule supports consistent results. If you miss doses or stop early, protection of the uterine lining may be reduced.

Compare With Alternatives

Other progestins such as medroxyprogesterone acetate are sometimes used for similar purposes; your prescriber will choose based on your medical history and goals. Some estrogen options that may be paired with progesterone include transdermal patches and topical gels. For example, patches such as Estradot Vivelle Dot or gels like Estrogel may be used as part of a combined regimen when appropriate. Choice depends on symptoms, tolerance, and clinician guidance.

Pricing and Access

We offer Canadian pharmacy pricing with transparent checkout. For questions on brand or generic availability, our team can help you compare options. If you are researching Prometrium 200 mg price, you can review live availability and current offers on the product page. Patients asking about Prometrium 200 mg Canadian pricing can see updated details before placing an order. Ships from Canada to US with prescription validation. Looking for promotions? See current offers on our Promotions page.

Availability and Substitutions

Supply can vary by market and manufacturer. If a specific strength or brand is not in stock, your prescriber may recommend a therapeutically appropriate alternative. Any substitution should match your treatment goals and be reviewed by your clinician before dispensing.

Patient Suitability and Cost-Saving Tips

Good candidates include postmenopausal women with a uterus who are taking systemic estrogen and require endometrial protection, and patients with secondary amenorrhea whose clinician recommends a progestin cycle. Those with peanut allergy, active clotting disorders, severe liver disease, or undiagnosed vaginal bleeding are usually not candidates.

Ways to manage costs and simplify refills:

• Ask about multi-month supplies if allowed
• Set refill reminders in your phone
• Compare brand and generic availability
• Bundle related items to reduce separate fees
• Use your order history to reorder quickly

Explore related topics such as Amenorrhea and broader Women’s Health options. For educational reading on estrogen choices, see Premarin Vs Estradiol. To learn about vaginal progesterone comparisons, read Does Endometrin Delay Your Period. For general background, see Progesterone Pills And Its.

Questions to Ask Your Clinician

• Which regimen fits my condition and goals
• What signs of side effects should I watch for
• Is bedtime dosing best for me
• How long should I continue this cycle
• Which lab or exams will you monitor
• Do my other medicines interact with this

Authoritative Sources

Review official information before use:

• FDA DailyMed: Prometrium Capsules
• Health Canada DPD
• Manufacturer Prescribing Information

Ready to proceed? Add to cart for US shipping from Canada with express shipping and temperature-controlled handling when required. This page is educational and does not replace advice from your healthcare professional.