Prometrium® Capsules for Endometrial Protection and Secondary Amenorrhea

What Prometrium® Is and How It Works

Prometrium is oral micronized progesterone used in women who need progesterone support. It helps protect the uterine lining when estrogen is prescribed after menopause, and it treats secondary amenorrhea by triggering a withdrawal bleed. Strengths include 100 mg and Prometrium 200 mg oral capsule options. Many people compare prometrium price and look for Prometrium without insurance to manage ongoing therapy costs. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

We also work with licensed, vetted partner pharmacies internationally to offer authentic brands, a broad selection, and affordable pricing.

Progesterone binds progesterone receptors in the uterus. It transforms a proliferative endometrium into a secretory state and, when withdrawn, causes a bleed. With estrogen therapy, progesterone lowers the risk of estrogen-induced endometrial hyperplasia.

Prometrium is a capsule formulation, sometimes called Prometrium progesterone capsules or Prometrium progesterone pills. It is not a tablet; references to Prometrium tablets usually point to the capsule product. It is different from over-the-counter progesterone cream. Oral Prometrium is often taken at bedtime because it may cause drowsiness.

Dosage and Usage

• Endometrial protection with estrogen therapy: 200 mg at bedtime for 12 days each 28-day cycle.
• Secondary amenorrhea: 400 mg daily (200 mg twice daily) for 10 days.
• Regimens using 100 mg may be prescribed in select cases based on individual response.
• Take capsules whole with water; do not crush or open.
• Because the capsule contains peanut oil, avoid use in anyone with a peanut allergy.
• A missed dose may be taken when remembered unless it is near the next dose. Skip the missed dose if it is almost time for the next dose. Do not double doses.
• Dizziness or drowsiness can occur; bedtime dosing helps reduce daytime sedation.

• Store at 20–25 °C (68–77 °F); short excursions 15–30 °C (59–86 °F) are acceptable.
• Keep in original packaging away from heat, moisture, and direct sun.
• When traveling, carry in hand luggage with a copy of the prescription.
• Do not leave capsules in a parked car or near heaters.
• If flying, keep medicine with you; avoid checked baggage extremes.

Benefits and Savings

Micronized progesterone Prometrium offers endometrial protection for people using estrogen therapy after menopause. It supports predictable cycles in secondary amenorrhea and can reduce unopposed estrogen exposure. Many patients prefer this natural progesterone option because it mirrors endogenous progesterone. The capsule is taken once daily at bedtime during scheduled days, which keeps routines simple.

Buying from Canada can lower Prometrium cost. You may see 60–80% savings versus typical US prices, especially on multi-month supplies. If paying without insurance, choosing larger quantities can further lower the per-month Prometrium 200 mg cost.

For current promotions, the phrase prometrium coupon may appear on our offers page when available.

Side Effects and Safety

• Common: dizziness, drowsiness, headache, breast tenderness, bloating, abdominal discomfort.
• Other: mood changes, irritability, nausea, vomiting, back pain, joint or muscle aches, vaginal spotting or bleeding.
• Skin: rash or itching.
• Fluid retention and mild swelling can occur.

Serious risks are uncommon but can include blood clots, vision changes, severe headache, chest pain, shortness of breath, jaundice, severe allergic reaction, or depression. Do not use Prometrium with a history of peanut allergy, active or past clotting disorders, undiagnosed vaginal bleeding, severe liver disease, or known/suspected hormone-sensitive cancers unless directed by a prescriber. Combination estrogen-progestin therapy may increase risks of cardiovascular events, stroke, and breast cancer compared with estrogen alone.

Onset Time

For secondary amenorrhea, a withdrawal bleed typically starts 3 to 7 days after the last capsule. Regularity often improves over one to two cycles. When used with estrogen therapy, endometrial protection begins with the first course. Light spotting may occur in early cycles as the lining stabilizes. Sedation can appear within the first few doses and often improves with consistent bedtime dosing.

Compare With Alternatives

Medroxyprogesterone acetate (often known by its brand Provera) is a synthetic progestin used for similar indications. It is taken as a tablet and can be effective for endometrial protection and amenorrhea, though some patients prefer micronized progesterone.

Norethindrone acetate is another progestin option. It offers reliable endometrial protection with estrogen therapy but has a different side-effect profile. Individual response varies, so prescribers choose based on goals and tolerability.

Some patients use transdermal estrogen with oral Prometrium rather than a combined patch. For example, estradiol patches like Estradot® Vivelle Dot can be paired with progesterone capsules. Oral estrogens such as Premarin® may also be combined with Prometrium for postmenopausal therapy, when a uterus is present. Choice depends on symptoms, convenience, and medical history.

Combination Therapy

• With oral estrogens (e.g., conjugated estrogens): add Prometrium 200 mg at bedtime for 12 days each cycle to reduce endometrial hyperplasia risk.
• With estradiol patches: cycle Prometrium on days 15–26 or as directed to protect the endometrium.
• For amenorrhea protocols: prescribers may adjust the daily dose (100–400 mg) and duration to induce a withdrawal bleed.
• If daytime sedation occurs, consolidate dosing at bedtime when appropriate.

Patient Suitability and Cost-Saving Tips

Candidates include postmenopausal patients with a uterus who are using estrogen therapy and people with secondary amenorrhea who need cyclic progesterone to restart bleeding. Those with undiagnosed vaginal bleeding, active thrombosis, severe liver disease, or known/suspected breast or genital tract cancer generally should not use progesterone therapy unless instructed by their clinician. Prometrium contains peanut oil, so it is contraindicated in peanut allergy.

Prometrium for menopause is intended to protect the uterine lining; it does not treat all menopausal symptoms by itself. For abnormal uterine bleeding, clinicians sometimes use oral Prometrium to stabilize the lining and to help control heavy bleeding, based on individualized plans. Prometrium natural progesterone differs from progestins such as medroxyprogesterone or norethindrone, and responses may vary.

Managing Prometrium cost can be straightforward. Bulk purchases and multi-month supplies often reduce the monthly Prometrium price. Set up simple reorder reminders so therapy stays on track. Patients paying Prometrium without insurance often choose 90-day fills to lower shipping cost per month. If comparing Prometrium 100 mg versus 200 mg per-capsule pricing, consider the total daily dose and days per cycle.

Authoritative Sources

AbbVie Prescribing Information: Prometrium Capsules

FDA/DailyMed: Progesterone (Prometrium) Capsules

Health Canada Drug Product Database: Prometrium

Order Prometrium® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This page is educational and does not replace personalized medical advice from your healthcare professional.