Repatha® (evolocumab) for Lowering LDL Cholesterol

What Repatha® Is and How It Works

Repatha is the brand name for evolocumab, a PCSK9 inhibitor. It is a prescription biologic used to lower LDL cholesterol in adults with primary hyperlipidemia and to reduce cardiovascular risk in those with established atherosclerotic disease. It is also used in certain patients with familial hypercholesterolemia. Many people compare repatha cost and repatha price when choosing a mail-order option, and some ask about repatha cost without insurance. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

This medicine is given as a subcutaneous repatha injection at home. It binds to PCSK9 and increases LDL receptor recycling in the liver. More LDL receptors clear more LDL particles from the bloodstream, so LDL-C drops quickly and deeply. Typical dosing is 140 mg every 2 weeks or 420 mg once monthly. Both options provide similar LDL reduction when taken as prescribed.

Repatha comes as a SureClick 140 mg/mL autoinjector and as a prefilled syringe. The monthly 420 mg dose is usually given as three 140 mg injections in a row within 30 minutes. The older Pushtronex on-body infusor (repatha pushtronex 420 mg 3.5 ml) is discontinued in many regions. Our sourcing uses licensed, vetted partner pharmacies globally to supply authentic brand medications at competitive pricing with a broad selection.

Repatha is not a statin. Many patients take it with a maximally tolerated statin and diet changes. It is not a treatment for high triglycerides alone, and it does not replace emergency care for heart symptoms.

Dosage and Usage

• Usual adult dose: 140 mg subcutaneously every 2 weeks, or 420 mg once monthly.
• Familial hypercholesterolemia dosing may differ; follow the prescriber’s plan.
• Sites: abdomen, thigh, or upper arm. Rotate sites. Avoid tender, bruised, or scarred areas.
• Let the pen/syringe come to room temperature for 30 minutes. Do not warm with heat.
• Check the solution. It should be clear to slightly yellow, without particles. Do not use if cloudy or discolored.
• Wash hands. Clean the skin with an alcohol swab and let it dry.
• For SureClick: remove cap, place on skin at 90 degrees, press and hold until the window shows complete dose and the click stops. See the device guide for full steps.
• For prefilled syringe: pinch skin, insert at 45–90 degrees, and inject steadily until empty.
• Monthly 420 mg dose: give three 140 mg injections back-to-back within 30 minutes.
• Missed dose, every-2-weeks regimen: if within 7 days of the missed dose, inject as soon as possible and resume the original schedule. If more than 7 days late, skip the missed dose and take the next dose on the original day.
• Missed dose, monthly regimen: if within 7 days of the missed dose, inject as soon as possible and continue monthly on the original date. If more than 7 days late, inject and start a new monthly schedule from that date.
• Do not shake the device. Do not inject through clothing.
• Ask your provider or pharmacist for in-person training if you are new to self-injection. If unsure, review the repatha how to inject instructions in the patient guide that comes with your device.

• Refrigerate at 2–8 °C (36–46 °F) in the original carton to protect from light.
• Do not freeze. If frozen, do not use.
• Room temperature: keep at 20–25 °C (68–77 °F) for up to 30 days. Once at room temperature, do not return to the fridge. Discard if not used within 30 days.
• Do not shake. Protect from heat. Keep out of reach of children.
• Travel: use an insulated cooler with ice packs. Do not place the device directly on ice. Keep the carton and labeling for security checks.
• Shipping: we use prompt, express, cold-chain shipping to maintain proper temperature.

Benefits and Savings

Repatha lowers LDL cholesterol by about 55–65% when added to a statin. In clinical trials, it reduced heart attack, stroke, and coronary revascularization in patients with established atherosclerotic cardiovascular disease. It works fast and offers flexible dosing every 2 weeks or monthly. The SureClick device helps make the repatha shot quick and simple at home.

Buying from a Canadian pharmacy can offer meaningful savings. Many customers see 60–80% savings compared to typical US prices. This can lower the repatha cost per injection and the overall repatha medication cost. Patients also ask about repatha cost without insurance; our team can provide current pricing so you can compare the cost of repatha injection against local options.

Looking for extra deals? See our repatha coupon page for current promotions.

We offer reorder reminders, and multi-month supplies can reduce per-month costs when available. Bulk promotions may also lower the repatha sureclick 140 mg ml price over time.

Side Effects and Safety

• Common: nasopharyngitis, upper respiratory tract infection, flu-like symptoms, back pain.
• Injection-site reactions: redness, swelling, pain, bruising, or itching.
• Gastrointestinal: mild nausea or diarrhea.
• Dizziness or fatigue.
• Allergic reactions: rash or hives.

Serious reactions are uncommon. Report signs of hypersensitivity, such as swelling of the face, lips, tongue, or throat (angioedema), or trouble breathing. Neurocognitive events are rare. Repatha does not cause low blood sugar and has no known interaction with insulin or sulfonylureas that would increase hypoglycemia risk. Tell your clinician about all medicines and supplements you take.

Onset Time

LDL-C begins to drop within the first week after starting evolocumab injection. The full effect is often seen by 4 weeks as steady-state levels are reached. Cardiovascular risk reduction builds over months with continued therapy and background risk-factor control. Your prescriber will monitor lipids and adjust your overall regimen as needed.

Compare With Alternatives

Statins such as Crestor® (rosuvastatin) are first-line for LDL lowering and event reduction. Many patients use Repatha with a statin when LDL remains above goal or when a statin alone is not tolerated at higher doses.

Ezetimibe blocks intestinal cholesterol absorption and is often added before or along with a PCSK9 inhibitor. It provides an extra 15–25% LDL reduction and is taken orally once daily.

Alirocumab (Praluent) is another PCSK9 inhibitor given by subcutaneous injection with similar LDL reduction. Inclisiran (Leqvio) is a small interfering RNA given every 6 months after initial doses; it lowers PCSK9 production in the liver. For broader reading on risks and targets, see our condition page on High Cholesterol.

Combination Therapy

• With statins: common and evidence-based for high-risk patients; monitor lipids regularly.
• With ezetimibe: adds further LDL reduction; useful when goals are not met on statin alone.
• With apheresis: in select familial hypercholesterolemia cases under specialist care.
• No glucose-lowering effects: no dose changes are needed to prevent hypoglycemia.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with primary hyperlipidemia or mixed dyslipidemia who need more LDL reduction despite diet and statin therapy, and those with clinical ASCVD who need further risk reduction. It is also used for familial hypercholesterolemia. Repatha is not for those with known serious hypersensitivity to evolocumab or any component of the product.

Discuss use if you are pregnant, planning pregnancy, or breastfeeding. Safety data are limited. Pediatric use varies by indication and age; specialist guidance is recommended. If you have active liver disease, an alternate plan may be considered, though Repatha is not hepatotoxic like some agents. It does not require routine liver enzyme monitoring solely due to its use.

To manage costs, ask about larger fills when available, as multi-month supplies can lower your monthly spend. Set a reorder reminder so you do not miss doses. If you are comparing the cash price for repatha at local pharmacies, you can contact us to review options and see how our pricing compares. If relevant to your coverage, we can discuss repatha cost without insurance during a quote.

Authoritative Sources

Amgen Repatha patient information and device guides

Health Canada Drug Product Database: Repatha (evolocumab)

FDA Prescribing Information for Repatha (evolocumab)

Order Repatha® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This material is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s instructions and the device’s Instructions for Use.