Repatha® (evolocumab) injection for lowering LDL cholesterol

What Repatha Is and How It Works

Repatha® (evolocumab) is a PCSK9 inhibitor used to lower LDL cholesterol. It is approved for adults with atherosclerotic cardiovascular disease and for certain patients with familial hypercholesterolemia. It is given as a subcutaneous injection using a prefilled autoinjector or syringe. Dosing is every two weeks or once monthly, depending on the regimen prescribed. Many people compare Repatha cost across pharmacies, and those assessing repatha cost without insurance often find Canadian pricing helps reduce out-of-pocket spend.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba. Orders are reviewed by licensed pharmacists before dispensing to meet Canadian pharmacy standards. We offer brand and generic medicines at Canadian prices and also carry OTC health products.

Repatha® works by blocking the PCSK9 protein. This action increases LDL receptors on liver cells and improves clearance of LDL from the blood. LDL can fall up to about 60% when Repatha® is added to statins. Cardiovascular outcome trials show reduced risk of heart attack, stroke, and revascularization in appropriate patients.

For sourcing and quality, we partner only with licensed, vetted international pharmacies when needed, providing authentic brand medications at competitive prices and a broad selection.

Dosage and Usage

Typical adult dosing is 140 mg every two weeks or 420 mg once monthly. The total monthly dose is equivalent by either schedule. Use the prefilled autoinjector or prefilled syringe as directed by the manufacturer instructions provided with each pack.

• Take the carton out of the fridge 30 minutes before injection to warm.
• Check the solution. It should be clear to pale yellow with no particles.
• Choose an injection site: thigh, abdomen (not near the navel), or upper arm.
• Rotate sites with each dose to reduce skin irritation.
• Clean the skin with an alcohol swab and let it dry.
• Use the device as instructed. Do not shake the syringe or pen.
• Dispose of needles and devices in an approved sharps container.

Missed dose guidance depends on timing and schedule. If a biweekly dose is missed and it is within seven days, take it as soon as possible and keep the original schedule. If more than seven days have passed, start a new schedule from the day the dose is taken. If a monthly dose is missed and it is within seven days, take it as soon as possible and keep the original schedule; beyond seven days, start a new monthly schedule from that day. Review the current manufacturer Medication Guide for full instructions.

• Store Repatha® in a refrigerator at 2–8 °C (36–46 °F) in the original carton.
• Do not freeze. If it has been frozen, do not use it.
• You may keep a single carton at room temperature (up to 25 °C/77 °F) in the original carton for up to 30 days; do not return it to the fridge.
• Keep away from heat and light. Do not shake.
• For travel, use an insulated bag with cold packs. Keep the carton dry and avoid direct contact with ice.

Benefits and Savings

Repatha® provides strong LDL reduction on top of diet and maximally tolerated statins. Trials report up to about 60% additional LDL lowering and improved goal attainment. Outcome data show fewer myocardial infarctions, strokes, and revascularizations in high-risk patients when added to guideline-based therapy.

The SureClick autoinjector is designed for at-home use. Most injections take seconds, and dosing can be biweekly or monthly to suit the regimen prescribed. Many patients appreciate predictable LDL reductions even when statin response is limited or when statins are not tolerated.

Ordering from YouDrugstore helps patients access Canadian pricing. Typical savings are 60–80% compared with many US pharmacy prices. This can be important for those facing high costs without insurance. Our team can coordinate orders, answer product questions during posted hours, and send gentle reorder reminders on request.

Side Effects and Safety

Many people tolerate Repatha® well. Some experience mild or temporary effects, often at the injection site. Report persistent or severe reactions to a healthcare professional.

• Common: injection site redness, pain, or bruising; nasopharyngitis; influenza; back pain; cough; mild dizziness; mild nausea.
• Less common: rash; hives; joint pain; muscle aches.
• Serious but uncommon: signs of hypersensitivity or anaphylaxis (trouble breathing, swelling of face or throat, severe rash); severe injection site reactions.

People with a history of serious allergy to evolocumab or excipients should not use Repatha®. Safety in pregnancy and breastfeeding is not well established; discuss risks and benefits with a clinician. Keep an updated list of all medicines and supplements. This helps clinicians check for overlapping adverse effects with other lipid-lowering drugs.

Onset Time

LDL cholesterol often begins to fall within one to two weeks of the first dose. Near-maximal LDL reduction is usually seen by about four weeks on a stable regimen. Cardiovascular risk reduction accrues over longer periods with continued therapy and risk-factor control. Lab monitoring schedules are set by the treating clinician.

Compare With Alternatives

Statins remain first-line therapy for most patients with high LDL. Many patients continue a statin while using Repatha®. For example, Crestor® (rosuvastatin) provides strong LDL lowering and has outcome benefits. Ezetimibe is another oral option that can add modest additional LDL reduction.

Other injectable options include alirocumab (another PCSK9 inhibitor) and inclisiran, a small interfering RNA given every six months after initial loading. Dosing schedules, storage needs, and costs differ. Repatha® offers flexible biweekly or monthly dosing with broad outcome data, and it may be preferred when rapid and large LDL reductions are needed or when specific cardiovascular indications are present.

Combination Therapy

Repatha® is often combined with a maximally tolerated statin, with or without ezetimibe. This strategy helps high-risk patients reach lower LDL targets. It is also used in heterozygous and homozygous familial hypercholesterolemia where baseline LDL is very high. Treatment plans, including lifestyle and other medicines, are individualized by the prescriber based on goals and tolerance.

Patient Suitability and Cost-Saving Tips

Repatha® may fit adults with established atherosclerotic cardiovascular disease who need further LDL reduction, those with familial hypercholesterolemia, or those who cannot tolerate adequate statin doses. It can be appropriate after diet and statin optimization when LDL remains above target. A clinician will confirm indications, dosing frequency, and monitoring.

To manage expenses, compare biweekly and monthly regimens, and consider multi-month orders to lower per-month costs. Our team can set up gentle reorder reminders so you do not run out. Check our current offers and bulk pricing before placing an order. For promotions, see our repatha coupon options and other deals when available.

You can browse condition pages such as High Cholesterol and Cardiovascular Risk Reduction to learn more about related therapies and goals. Patients comparing total costs often review the cost of repatha without insurance against plan copays and deductibles to choose the most affordable path.

Authoritative Sources

Amgen Repatha product information

Health Canada Drug Product Database: Evolocumab

FDA Prescribing Information for Repatha (evolocumab)

YouDrugstore offers caring support from a licensed Canadian pharmacy. Pharmacists review prescriptions prior to dispensing, and customer-service chat is available during posted office hours. Order with confidence and receive prompt, express, cold-chain shipping to preserve product integrity.

This information is educational and does not replace advice from a healthcare professional. Always follow the prescribing clinician’s directions and the manufacturer’s Instructions for Use included with your medication.