Repatha® Injection for High LDL Cholesterol

Repatha is a prescription injection that helps lower LDL cholesterol. It is used with diet and other lipid-lowering medicines to reduce cardiovascular risk in appropriate patients. This page explains how it works, who it’s for, and how to use it. It also outlines options for Repatha cost without insurance and how it Ships from Canada to US.

What Repatha Is and How It Works

Repatha® contains evolocumab, a monoclonal antibody that targets PCSK9. By blocking PCSK9, the treatment increases LDL receptors on the liver, which helps clear “bad” cholesterol from the blood. It can be used alone or with statins and other therapies when additional LDL reduction is needed.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine belongs to the PCSK9 inhibitor class. It is given under the skin and does not require routine lab monitoring at the time of each dose, though your clinician will order lipid panels to track progress. People sometimes compare options or research Repatha injection price, but your prescriber’s guidance on suitability is the first step.

If you also take a statin, your clinician may continue that agent. The therapy may be considered for adults with atherosclerotic cardiovascular disease or certain inherited cholesterol disorders where LDL goals are not met on maximally tolerated statins and diet.

Who It’s For

This medicine is indicated for adults with primary hyperlipidemia, including heterozygous familial hypercholesterolemia, to reduce LDL cholesterol. It is also used to reduce the risk of cardiovascular events in people with established atherosclerotic disease. Certain pediatric patients with familial hypercholesterolemia may also be candidates as outlined in the official label.

Do not use this treatment if you have a known serious allergy to evolocumab or any component of the injection. Discuss pregnancy, plans to become pregnant, or breastfeeding with your prescriber. Always review your medical history and current medicines with a healthcare professional before starting therapy.

Dosage and Usage

Typical adult dosing for primary hyperlipidemia is one injection every two weeks or one larger monthly dose. For homozygous familial hypercholesterolemia, schedules may differ; your clinician will follow the official label and your situation. Do not change your dose without medical advice.

Inject subcutaneously into the thigh, abdomen, or upper arm. Rotate sites with each use. Let the pen or device warm to room temperature as directed before injecting. Do not shake the device. Check the solution visually when applicable and do not use if it is cloudy, discolored, or contains particles. If you also take statins or ezetimibe, continue those unless your prescriber advises otherwise.

Follow any training provided with the device. If you are unsure about technique, ask your pharmacist or healthcare professional for guidance rather than guessing.

Strengths and Forms

Availability may vary by market. Common presentations include the SureClick autoinjector and a single-use infusor with on-body device. Published strengths include a 140 mg/mL prefilled autoinjector and a 420 mg/3.5 mL on-body infusor. Your clinician will select the form that matches your prescribed schedule and your ability to self-administer.

For the most current Repatha Canadian pricing and in-stock presentations, check the product page before you order. If you have questions about pens versus infusors, our team can clarify features and handling steps.

Missed Dose and Timing

If you miss a dose, the general approach is to take it when you remember and then consult the schedule recommended on the official label for your dosing frequency. If the next planned dose is near, you may need to skip the missed dose. Because rules differ by dosing interval, check the patient information leaflet or ask your prescriber for advice specific to your schedule. Avoid doubling doses.

Storage and Travel Basics

Keep the product refrigerated in its original carton, protected from light. Do not freeze. When label guidance permits, you may store it at room temperature for a limited time; do not return it to the refrigerator after it has been kept at room temperature. Keep out of reach of children and pets.

For travel, use an insulated bag with a cool pack, and avoid direct contact between the device and ice packs. Carry your prescription or a copy of your medication label when flying. Place the medicine in your carry-on to prevent exposure to extreme temperatures in checked luggage. If unsure about storage windows during trips, speak with your pharmacist.

Pen Handling and Sharps Disposal

Review the instructions for the pen or on-body infusor before use. Wash your hands, prepare the site, and allow the device to reach room temperature as directed. Do not shake the pen. After injecting, place used pens or needles into an FDA-cleared sharps container. Do not throw used devices in household trash. When the container is nearly full, follow local rules for disposal or ask your pharmacist about take-back options.

Benefits

This therapy helps lower LDL cholesterol when statins and diet are not enough. It can be used with other lipid-lowering agents and has infrequent dosing compared with daily tablets. The class may suit people who cannot tolerate higher doses of statins. Discuss the potential LDL reduction, the convenience of every-two-week or monthly schedules, and your treatment goals with your clinician. People researching PCSK9 inhibitor price should also weigh suitability, dosing comfort, and monitoring needs.

Side Effects and Safety

• Injection-site reactions such as redness, pain, or bruising
• Nasopharyngitis or upper respiratory symptoms
• Back pain or joint discomfort
• Flu-like symptoms or cough
• Allergic reactions including rash or hives

Serious allergic reactions are uncommon but possible. Seek immediate care for severe rash, swelling of the face or throat, trouble breathing, or chest tightness. Report persistent injection-site issues to your healthcare professional. If your LDL becomes very low, your prescriber may reassess your regimen based on clinical guidance. Always read the Medication Guide and full Prescribing Information.

Drug Interactions and Cautions

The injection is a monoclonal antibody and has no well-known drug-drug interactions with common lipid-lowering tablets. It is often taken alongside statins or ezetimibe. Still, tell your prescriber about all medicines, vitamins, and supplements you use. Inform clinicians if you receive LDL apheresis. Discuss pregnancy and breastfeeding considerations before starting therapy. Do not use the product if it has been frozen, overheated, or mishandled during storage.

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What to Expect Over Time

Many patients see LDL cholesterol changes after consistent use, as measured by routine lipid panels. Your clinician will set targets and check labs to guide ongoing therapy. It may take several weeks of steady dosing to understand your response and adjust your overall plan. Keep your diet and exercise plan in place. Set reminders for injections, and keep backup supplies on hand so you do not miss doses.

Compare With Alternatives

Another PCSK9 inhibitor option is Praluent (alirocumab), which also targets PCSK9 and is given subcutaneously. Dosing and device features differ, so discuss comfort and frequency with your prescriber.

Inclisiran, branded as Leqvio, is a small interfering RNA that reduces PCSK9 production and is administered less often after initial doses. It is a different class and may be considered when appropriate. Your clinician can help compare options based on your profile and lipid goals.

Pricing and Access

Canadian pharmacy pricing may help some patients manage out-of-pocket expenses with US delivery from Canada. Check our site for current Repatha price and see how costs compare with your local options. You can also review Evolocumab price to understand pricing across forms. If you use discount programs, insurance, or manufacturer support, compare those approaches with our posted rates.

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Availability and Substitutions

Stock can vary by form and strength. If your prescribed device is not available, your prescriber may recommend an alternative presentation in the same class or another therapy that meets your LDL goals. Ask your clinician before switching products or changing your schedule. For reference, people sometimes compare Evolocumab injection price when weighing device options and dosing frequency.

Patient Suitability and Cost-Saving Tips

Good candidates often include adults with atherosclerotic cardiovascular disease or familial hypercholesterolemia who need further LDL reduction beyond diet and statins. People with a history of severe hypersensitivity to components should avoid it. If you have injection concerns, ask about training or an office-administered option.

To lower costs, consider multi-month fills where allowed, which can reduce per-shipment fees. Set refill reminders aligned with your dosing interval. Compare cash-pay, card programs, and any support you may receive. If you use a high-deductible plan, checking list price versus pharmacy cash rates may help you choose the most practical path for your situation.

Questions to Ask Your Clinician

• LDL goals: What targets are right for me?
• Regimen fit: Every two weeks or monthly, which suits my routine?
• Combination plan: Should I keep my statin and add ezetimibe?
• Device choice: Pen versus on-body infusor, which is best for me?
• Monitoring: How often will my lipid panel be checked?
• Travel: How should I store and carry doses safely?

Authoritative Sources

FDA Prescribing Information

DailyMed: Evolocumab

Health Canada Drug Product Database

For related reading, see our article on cholesterol basics: The Skinny On High Cholesterol, and explore the High LDL Cholesterol and Cardiovascular categories. If your clinician suggests adjunct therapy, you can review medicines like Ezetimibe or statin options such as Crestor.

Ready to proceed? Order from YouDrugstore with US shipping from Canada and prompt, express, cold-chain shipping. Always use as directed by your prescriber.

This information is educational and does not replace advice from your healthcare professional. Consult the official label for complete directions and risks.