Retevmo® (selpercatinib) Capsules for RET‑Driven Cancers

What Retevmo® Is and How It Works

Retevmo® (selpercatinib) is a targeted RET kinase inhibitor. It treats certain RET fusion-positive non-small cell lung cancer (NSCLC), RET-mutant medullary thyroid cancer (MTC), and some RET fusion-positive thyroid cancers that have progressed or need systemic therapy. The capsules are usually taken twice daily. Strengths include 40 mg and 80 mg, so retevmo 80mg is a common option. Many people ask about Retevmo price and retevmo cost without insurance when planning a course of therapy.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba. We meet Canadian pharmacy standards, and prescriptions are reviewed by licensed pharmacists before dispensing. We offer brand and generic medicines at Canadian prices, and you can order online or by phone. Our customer-service chat is available during posted office hours for ordering help.

To keep supply predictable and pricing fair, we also work with licensed, vetted international partner pharmacies to source authentic brand medications, giving you a broad selection at affordable rates. Retevmo received retevmo fda approval for specific RET-driven cancers, and Health Canada has also authorized its use in approved indications.

Dosage and Usage

Your prescriber will confirm the exact schedule. Retevmo® is typically taken twice a day, about 12 hours apart, and therapy continues as long as it is effective and tolerated.

• Swallow the capsules whole with water; do not crush or open.
• Take at the same times each day to keep steady levels.
• You can take it with or without food; avoid grapefruit products.
• If you miss a dose and it is close to the next one, skip the missed dose.
• If you vomit after a dose, do not take an extra capsule; wait for the next dose.
• Tell your care team about all medicines and supplements to check for interactions.

Storage and travel tips:

• Store at room temperature 20–25°C (68–77°F); brief 15–30°C excursions are acceptable.
• Keep capsules in the original, tightly closed container with the desiccant.
• Protect from moisture and keep out of reach of children and pets.
• When traveling, keep medication in your carry-on with the pharmacy label, bring extra for delays, and avoid leaving it in hot cars.

Benefits and Savings

Retevmo® targets the RET pathway that can drive tumor growth. In clinical studies, many patients with RET fusion-positive NSCLC or RET-altered thyroid cancers achieved meaningful responses, including durable control and activity in some brain metastases. Results vary by cancer type and prior therapy.

Ordering through YouDrugstore offers convenience and consistent supply. Many customers see 60–80% savings versus usual US prices. If you are comparing retevmo price without insurance, our Canadian pricing and multi-month options can make ongoing treatment more affordable.

Side Effects and Safety

All medicines can cause side effects. Your care team will monitor blood tests and blood pressure during therapy.

• Common: dry mouth, diarrhea, constipation, fatigue, edema, rash, mouth sores, abdominal pain, headache, cough, joint or muscle pain, and increased blood pressure.
• Laboratory changes: elevated liver enzymes, creatinine changes, changes in electrolytes or blood counts.
• Serious: liver injury, hypertension crises, QT interval prolongation, hemorrhage, hypersensitivity reactions, interstitial lung disease/pneumonitis, wound-healing issues, and impaired fertility risk.
• Seek urgent care for signs of severe allergic reaction, chest pain, severe shortness of breath, fainting, severe bleeding, or yellowing of the skin/eyes.

Tell your prescriber if you are pregnant, planning pregnancy, or breastfeeding. Effective contraception is usually advised during treatment and for a period after the last dose, according to the retevmo prescribing information.

Onset Time

Response timelines vary. Many oncology teams schedule the first assessment scan around 6–8 weeks. Some patients experience symptom improvement sooner, while others need several cycles before changes are evident. Continue taking the medication as directed unless your prescriber advises a change.

Compare With Alternatives

Other RET-targeted therapy includes pralsetinib (Gavreto), which has a similar indication profile. Choice between agents considers prior therapy, side effect profiles, drug interactions, and your treatment history. For medullary thyroid cancer, multi-kinase inhibitors such as cabozantinib and vandetanib can be options when appropriate. In NSCLC, immunotherapy or chemotherapy may be used before, after, or instead of targeted therapy if the tumor profile or clinical course warrants.

Your oncology team will select the most suitable approach for your cancer subtype and prior treatments. You can also browse other oncology treatments available at YouDrugstore, such as Bavencio® and Zytiga®, which treat different cancers. To explore more conditions, see our Cancer category.

Combination Therapy

Retevmo® is often used alone. It may be sequenced with radiation, surgery, immunotherapy, or chemotherapy over a full treatment course, depending on response and tolerance. Drug interactions matter: strong CYP3A inhibitors or inducers can change selpercatinib exposure, and some anticoagulants or antiplatelet agents may increase bleeding risk. Your prescriber may adjust dosing or avoid certain combinations as outlined in the retevmo uspi.

Patient Suitability and Cost-Saving Tips

Retevmo® is considered for adults and some adolescents with confirmed RET fusions or RET mutations, depending on the cancer type. Doctors usually confirm RET status using validated tests. Ongoing monitoring often includes liver tests, blood pressure checks, and electrocardiograms in some cases. If you have uncontrolled hypertension, significant liver disease, or a history of bleeding, your team will weigh risks and benefits carefully.

Cost-saving tips:

• Ask your prescriber about a 60–90 day supply; larger fills can lower your per-month cost and reduce shipping fees.
• Turn on reorder reminders so you never run out.
• Compare Retevmo price across quantities to see where you save most.
• Some patients explore the retevmo patient assistance program from Eli Lilly; eligibility and support vary by country and insurance status.

For current promotions and bulk options, see our retevmo coupon page. If you are budgeting for retevmo cost without insurance, our team can help you compare package sizes and plan refills. For general reading on side-effect management, you might find Common Darzalex Side Effects And Tips To Manage Them helpful, and Understanding Calquence Medication For Cancer Treatment offers background on targeted therapy concepts. You can also learn about mechanisms in Darzalex Mechanism Of Action How It Treats Multiple Myeloma.

Authoritative Sources

For complete details, see the FDA Prescribing Information (USPI) for Retevmo, the Health Canada Drug Product Database entry, and the Eli Lilly Retevmo patient and HCP site. These resources cover dosing, interactions, warnings, and retevmo fda approval history.

You can order Retevmo® online from YouDrugstore with support from our pharmacy team. We provide prompt, express, cold-chain shipping through trusted carriers, and we pack your order carefully. Our customer-service chat is available during posted office hours if you need help placing an order.

This content is educational and not a substitute for professional medical advice. Always follow your prescriber’s guidance and the current product monograph. Availability, pricing, and packaging may change without notice.