Retevmo® Capsules for RET+ Non-Small Cell Lung Cancer

This prescription therapy targets cancers driven by RET gene changes. It is used for certain non-small cell lung and thyroid cancers. This page explains dosing basics, safety, and Retevmo price without insurance, with US shipping from Canada.

What Retevmo Is and How It Works

Retevmo® (selpercatinib) is a selective RET kinase inhibitor. It blocks signaling in tumors with RET fusions or mutations, which may slow or stop cancer cell growth. The medicine is taken by mouth and can be used in metastatic or advanced disease when tumors show RET alterations confirmed by testing.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This treatment is approved for adults with RET fusion-positive non-small cell lung cancer and for adults and children with medullary thyroid cancer or RET fusion-positive thyroid cancer, per official labeling. It may be used whether or not patients received prior systemic therapy. Clinical teams use imaging and lab results to assess response over time.

Learn more about related conditions in our resources: Non Small Cell Lung Cancer, Medullary Thyroid Cancer, and Cancer.

Who It’s For

This medicine is for patients whose tumors test positive for a RET gene alteration. It is indicated in metastatic RET fusion-positive NSCLC, advanced or metastatic RET-mutant medullary thyroid cancer, and RET fusion-positive thyroid cancer that requires systemic therapy. It is not for tumors without RET alterations. People with uncontrolled hypertension, significant heart rhythm problems, or severe liver issues need careful evaluation before starting. Those who are pregnant, planning pregnancy, or breastfeeding should discuss risks and contraception timing with a clinician.

Dosage and Usage

Take the capsules twice daily about 12 hours apart. Swallow whole with water; do not open or crush. You may take it with or without food, but follow guidance if you use acid-reducing medicines. Avoid grapefruit.

Acid-reducing agents can affect absorption. Avoid proton pump inhibitors when possible. If you use an H2 blocker, take this medicine either 2 hours after or 10 hours before the H2 blocker. For antacids, separate doses by at least 2 hours.

Your healthcare professional will select a dose based on age, weight, and safety monitoring. If your care team changes the dose or pauses treatment for side effects, follow their instructions and the official label. Do not make changes on your own.

Strengths and Forms

The product is available as oral capsules in commonly supplied strengths of 40 mg and 80 mg. Availability may vary by country and manufacturer lot. Ask your prescriber which strength and quantity are appropriate for your plan.

People often compare selpercatinib 40 mg price when considering multi-bottle fills. Always align quantity with your prescriber’s directions and monitoring schedule. If your regimen changes, your pharmacist can coordinate the next appropriate fill.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember unless your next dose is due within 6 hours. If vomiting occurs after a dose, do not take an extra capsule; take the next dose at the regular time. Keep doses spaced consistently to support steady exposure. When in doubt, review the Patient Information and ask your care team.

Storage and Travel Basics

Store the capsules at room temperature in the original container with the desiccant. Keep the bottle tightly closed to protect from moisture. Store out of reach of children and pets. Do not store in bathrooms or near sinks.

For travel, carry it in your hand luggage with the prescription label attached. Bring a copy of your prescription and clinic contact details. Use a simple schedule reminder on your phone to keep dosing regular across time zones. If your plans change, do not double up doses to catch up.

Benefits

This targeted therapy focuses on the RET pathway identified in tumor testing. Oral dosing may reduce clinic visits compared with infusions. It can be used after certain prior treatments, giving clinicians another option for RET-driven disease. The capsule format also allows flexibility for home use under a prescriber’s supervision.

Side Effects and Safety

Common effects can include dry mouth, diarrhea or constipation, fatigue, swelling, rash, headache, cough, and changes in liver tests. Blood pressure can rise during therapy. Lab monitoring and pressure checks help track these issues.

Serious risks include liver injury, severe hypertension, QT prolongation, bleeding, allergic reactions, and interstitial lung disease. Wound healing issues can occur; your surgeon may advise pausing around procedures. In pediatric patients, growth plate changes have been reported. Contact your clinician right away for chest pain, fainting, severe shortness of breath, unusual bleeding, yellowing skin or eyes, or sudden swelling.

Drug Interactions and Cautions

Tell your care team about all medicines and supplements. Strong CYP3A inhibitors or inducers can alter levels. Avoid St. John’s wort. Use caution with other agents that prolong the QT interval. Separate antacids, and carefully time H2 blockers as noted. Limit grapefruit. Alcohol may worsen dizziness or blood pressure effects.

Inform your clinician about heart disease, liver disease, bleeding risks, upcoming surgery, and pregnancy plans. Use effective contraception during treatment and for the recommended time after the last dose per labeling.

What to Expect Over Time

Clinicians often schedule imaging and labs at regular intervals to gauge benefit and safety. Many effects, like blood pressure changes or liver enzyme elevations, can appear early and may be managed with supportive care or dose adjustments. Symptom diaries and consistent dosing help your team make decisions. If treatment is paused, follow your prescriber’s plan for restarting to minimize risks.

Educational reading on evolving care approaches: Immunotherapy For Cancer and Common Types Of Cancer. For lung health awareness, see Lung Cancer Awareness.

Compare With Alternatives

For lung cancers with different drivers, other targeted options may be used. EGFR-altered NSCLC may be treated with Tagrisso. ALK-positive disease may use Xalkori. These are not substitutes for RET-driven tumors but illustrate how therapy selection follows biomarkers. Discuss selpercatinib price and insurance coverage with your care team when comparing options across mutation types.

Pricing and Access

We show transparent information to help you and your clinician plan around selpercatinib cost. Pricing can vary by strength, quantity, and market supply. We support prescription verification and encrypted checkout. If your plan allows, multi-bottle fills can reduce refill frequency and may lower per-bottle charges compared with single fills. Our team can work with your prescriber for refill coordination.

Canadian pricing with US delivery from Canada helps many patients access therapy with consistent sourcing. Ask your insurer about specialty pharmacy requirements and prior authorization. If you use manufacturer support programs, your prescriber may need to submit documentation. We can coordinate dispensing once the prescription is received and verified.

If you and your clinician choose the higher strength, you can review selpercatinib 80 mg price in the product options before placing an order. Your final selection should match the dose and schedule on your prescription.

Availability and Substitutions

Supply may vary. If a specific pack size is not available, your prescriber may recommend an alternative strength or schedule adjustment using the same active ingredient. For therapy changes, your oncology team will guide transitions based on response, tolerance, and current guidelines. You may also choose to order Retevmo capsules once your prescription is on file and verified.

Patient Suitability and Cost-Saving Tips

Patients who benefit most have confirmed RET alterations and can attend routine monitoring. Those with uncontrolled cardiac conditions or significant liver impairment may need closer oversight. Take capsules consistently and keep a simple log for doses and side effects.

To manage expenses, ask your prescriber if a 60- to 90-day supply makes sense for stability and fewer co-pays. Align refill dates with scan schedules to avoid surplus if therapy changes. Consider using a health savings account for out of pocket cost if eligible. If you plan to buy selpercatinib capsules on a recurring schedule, enable reminders so you never miss a refill window. Discuss monthly cost expectations early; your care team may help with assistance resources for self pay price or cash price situations.

Questions to Ask Your Clinician

• RET testing: Which assay confirmed my tumor’s RET status?
• Dose plan: What schedule and strength are recommended for me?
• Monitoring: How often will labs, ECGs, and imaging be done?
• Interactions: How should I handle acid reducers or other medicines?
• Side effects: Which symptoms should prompt an urgent call?
• Surgery: When should I pause therapy before a procedure?
• Family planning: What contraception and timing do you recommend?

Authoritative Sources

Eli Lilly (Manufacturer)FDA DailyMedHealth Canada DPD

Pricing and Access

Ready to proceed? You can place your order with prompt, express, temperature-controlled handling when required. Ships from Canada to US. Prescription required. This content is for general information and does not replace medical advice; always follow your prescriber and the official label.