Salofalk® Rectal Suspension (Mesalamine) for Ulcerative Colitis

What Salofalk® Is and How It Works

Salofalk® Suspension is a mesalamine (5-aminosalicylic acid) rectal enema used to treat mild to moderate ulcerative colitis in the distal colon and rectum, including proctosigmoiditis. Each single-use bottle typically contains 4 g mesalamine in 60 mL. It is used rectally once daily, often at bedtime. Many people compare prices for Salofalk Suspension without insurance to manage ongoing therapy costs. YouDrugstore is a licensed Canadian pharmacy based in Manitoba, and our pharmacists review every valid prescription before dispensing.

Mesalamine works topically on the intestinal lining to reduce local inflammation. It blocks inflammatory mediators such as prostaglandins and leukotrienes in the colonic mucosa. The rectal route delivers medication directly to the affected area and limits systemic exposure. That can improve tolerability compared to some oral options for distal disease.

We partner with licensed, vetted international pharmacies to expand selection and keep pricing affordable, while dispensing only authentic brand medications sourced through approved channels.

Dosage and Usage

Salofalk® Suspension is for rectal use only. Typical adult dosing follows local product labeling.

• Usual dose: one 4 g/60 mL enema once daily, preferably at bedtime.
• Shake the bottle well for 30 seconds to resuspend the medication.
• Lie on the left side with the left leg straight and right knee bent.
• Gently insert the applicator tip into the rectum and squeeze slowly.
• Aim to retain the enema overnight or for as long as possible.
• Treatment courses often run several weeks; some regimens step down to every other night if directed by a clinician.
• Missed dose: use when remembered unless it is close to the next dose; do not use two enemas the same day.

Storage and travel tips:

• Store at room temperature per label; protect from freezing and excessive heat.
• Keep bottles upright in the original box to protect the applicator tips.
• When traveling, pack in a padded pouch inside your carry-on to avoid crushing.
• Do not use if the bottle is leaking, discolored, or the suspension does not resuspend after shaking.

Follow the prescriber’s instructions and the patient leaflet that comes with the product. Do not ingest. Keep out of reach of children and pets.

Benefits and Savings

Rectal mesalamine can reduce bleeding, urgency, and diarrhea in distal ulcerative colitis. Local delivery treats inflamed tissue directly. Many patients see symptom relief and improved mucosal healing with consistent use during a treatment course.

Buying from a Canadian pharmacy can reduce out-of-pocket costs. Typical savings range from 60% to 80% compared to common US retail pricing. Those paying without insurance often find the rectal suspension more affordable through cross-border pharmacy services. You can order online or by phone, and our friendly customer-service chat is available during posted office hours for ordering support.

YouDrugstore offers brand and generic medicines at Canadian prices and also carries OTC health products. Pharmacists can address medication questions by phone during office hours.

Side Effects and Safety

Most people tolerate rectal mesalamine well. Some effects are local and mild. Serious reactions are less common but require medical attention.

• Common: rectal discomfort, abdominal cramping, gas, mild diarrhea or constipation, nausea, headache.
• Less common: urgency after dosing, dizziness, rash or itching.
• Serious: severe abdominal pain, persistent bloody diarrhea, high fever, chest pain, shortness of breath, severe headache, signs of kidney problems (swelling, reduced urine), pancreatitis (severe upper abdominal pain), liver issues (yellowing of skin/eyes), or blood disorders (unusual bruising).
• Allergy: stop the medication and seek care if angioedema, hives, or anaphylaxis occur.

People with known salicylate allergy, severe kidney or liver disease, or certain stomach or bowel obstructions may not be candidates. Mesalamine can rarely worsen colitis (mesalamine-induced acute intolerance). Review all medicines and supplements with a clinician to check for interactions, including with azathioprine, 6-mercaptopurine, and warfarin.

Onset Time

Some patients notice symptom easing within several days. Full response can take two to four weeks of nightly use. Continue as prescribed through the course unless a clinician advises otherwise.

Compare With Alternatives

Rectal mesalamine products vary by formulation and reach. Enemas deliver medication up to the splenic flexure, which is useful for left-sided disease. Suppositories treat the rectum and may suit disease limited to the distal 5–15 cm.

If inflammation is confined to the rectum, a suppository such as Salofalk® Suppositories or Pentasa® Suppositories may be considered by prescribers. For more extensive left-sided disease, the enema suspension can provide broader coverage.

Oral mesalamine can complement rectal therapy when disease extends proximally. Some regimens combine rectal and oral 5-ASA, such as pairing the enema with Salofalk® tablets, to improve outcomes in selected cases. Corticosteroid rectal foams or enemas are another option for short-term control when 5-ASA alone is not enough. Choice depends on disease extent, severity, and tolerance.

Combination Therapy

Clinicians may pair rectal mesalamine with oral 5-ASA for additive benefit in distal and left-sided ulcerative colitis. Short courses of rectal or oral corticosteroids may be used for flares. Some patients require immunomodulators or biologics for moderate to severe disease. The specific plan, duration, and step-down schedule are individualized by the treating specialist.

Patient Suitability and Cost-Saving Tips

Rectal suspension suits patients who can retain an enema and have disease extending beyond the rectum. Those with only proctitis might prefer suppositories due to ease and coverage. People with significant mobility or dexterity limitations may need assistance or a different form.

To lower costs, consider a multi-month supply when appropriate. Larger fills can reduce the per-month price. You can set simple reorder reminders in your account so you do not run short during a treatment course. If you need deals, see our Salofalk Suspension coupon page for current offers and bulk options.

For background on related conditions, you may find our condition pages on Ulcerative Colitis and Proctosigmoiditis helpful. If symptoms overlap with other gastrointestinal issues, read our educational article Ibs What Is Ibs Causes Symptoms Treatment. Abdominal pain location can vary; our piece on The Abdomen Part Iii The Right Lower Quadrant offers general context. People paying with no insurance can still access Canadian pricing through our platform.

Authoritative Sources

For full prescribing details, consult official references:

• Health Canada Drug Product Database (DPD)
• US FDA mesalamine enema prescribing information (Rowasa)
• Dr. Falk Pharma information on mesalamine products

YouDrugstore offers secure ordering at Canadian prices with pharmacist review of your prescription. Our team supports your refill planning, and we ship to the United States with prompt, express, cold-chain shipping where required.

This content is for general information only and does not replace professional medical advice. Always follow your prescriber’s directions and the product’s patient leaflet. Seek medical care for severe or worsening symptoms or suspected adverse reactions.