Salofalk® Suspension for Ulcerative Colitis

Rectal mesalamine suspension treats mild to moderate ulcerative colitis affecting the distal colon and rectum. This page explains what it is, how it works, and how to use it safely. You can access US delivery from Canada, even if paying without insurance.

What Salofalk Is and How It Works

Salofalk® is a rectal mesalamine (5-aminosalicylic acid) medicine used to reduce inflammation in ulcerative proctitis and left-sided disease. It releases anti-inflammatory action directly at the mucosa, where it can help calm symptoms like rectal bleeding, urgency, and cramping. The mechanism involves local inhibition of cyclooxygenase and lipoxygenase pathways, which may reduce prostaglandin and leukotriene production in the colon.

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Many people know this treatment by its class rather than brand. In practice, Salofalk Suspension reaches inflamed tissue via rectal administration, limiting systemic exposure compared to some oral options. It is commonly used for distal disease, including proctosigmoiditis, and can be combined with oral therapy when a prescriber recommends dual routes.

Who It’s For

This medicine is indicated for adults with mild to moderate ulcerative colitis limited to the rectum and sigmoid colon. It is often considered when symptoms include rectal bleeding, tenesmus, and urgency. People with a history of hypersensitivity to salicylates or mesalamine should avoid it. Those with severe kidney or liver impairment, or a history of myocarditis or pericarditis linked to 5-ASA, require careful evaluation by a prescriber before use. Generic mesalazine rectal suspension may be prescribed when clinically suitable.

Dosage and Usage

The usual regimen follows the official label and your prescriber’s instructions. Many adults use one enema at bedtime. Shake the bottle well until the contents look uniform. Lie on your left side with the left leg straight and right knee bent. Gently insert the applicator tip into the rectum and squeeze the bottle steadily. Try to empty the full contents. Remain on your side for several minutes to help retain the dose.

If your clinician advises a different schedule, follow that guidance. The label may allow alternative timing when bedtime use is not possible. Mesalamine rectal suspension 4g 60mL is commonly retained overnight for best effect. Always read the patient leaflet that comes with your pack.

Strengths and Forms

This product is typically supplied as single-use enemas. A commonly published presentation is 4 g mesalamine in 60 mL suspension per bottle, often packed in multi-bottle cartons. Availability may vary by market and lot. We also carry related rectal 5-ASA options when appropriate, including Mesalamine for prescribers who prefer a different form.

Missed Dose and Timing

If you forget a dose, use it when you remember unless it is close to the next scheduled administration. Do not use two enemas at once to catch up. Aim for consistent daily use while your prescriber is treating a flare. If you often cannot retain the enema, speak with your healthcare professional about technique or timing.

Storage and Travel Basics

Store the bottles at room temperature as directed on the label. Keep them in the original carton to protect from light, and do not freeze. Keep out of reach of children and pets. For travel, pack unopened bottles upright in a sealable pouch to prevent leakage. Place your prescription or a copy of the label in your carry-on. When crossing borders, allow extra time for security screening. If you are away from home, set reminders so you use the dose at a consistent hour, ideally before sleep.

Benefits

Rectal 5-ASA therapy delivers medication to the site of inflammation in distal ulcerative colitis. This approach may reduce systemic exposure compared with certain oral options and can be used alongside tablets if a prescriber recommends combination therapy. Nightly administration supports routine use. Many patients appreciate that enemas target symptoms like rectal bleeding and urgency where they occur.

Side Effects and Safety

• Rectal discomfort or irritation
• Abdominal pain or cramping
• Urgency or tenesmus
• Gas or bloating
• Nausea or headache

Serious effects are uncommon but can include hypersensitivity reactions, kidney issues, pancreatitis, liver problems, blood disorders, or myocarditis/pericarditis. Stop the medicine and seek medical attention if you develop severe abdominal pain, chest pain, unexplained rash, facial swelling, difficulty breathing, dark urine, or unusual bruising. People allergic to salicylates or who had reactions to sulfasalazine or mesalamine should discuss risks carefully.

Drug Interactions and Cautions

Tell your prescriber about all medicines and supplements you use. Caution is advised with nephrotoxic agents, because 5-ASA can rarely affect renal function. Concomitant use with azathioprine or 6-mercaptopurine may increase the risk of blood dyscrasias; monitoring may be needed. Warfarin and other anticoagulants warrant care due to potential changes in bleeding risk. Report new or worsening symptoms promptly, including fever, chest pain, or persistent diarrhea.

What to Expect Over Time

Symptoms can improve gradually with regular nightly use. Retaining the enema for longer may help outcomes, as directed by your clinician. Stay consistent and keep follow-up appointments so your response can be assessed. If your prescriber adjusts therapy, changes are typically based on your symptom pattern, tolerance, and endoscopic findings. Order mesalamine enema from Canada when you and your clinician decide to continue therapy, and set reminders to avoid gaps.

Compare With Alternatives

Other rectal options may be appropriate depending on disease location and response. For another 5-ASA enema, some clinicians consider Pentasa Enema. For a corticosteroid foam option, Uceris Rectal Foam may be used in select cases. Your prescriber will choose based on severity, location, and tolerability.

Pricing and Access

See current pricing on this page. Costs can vary by pack size and market supply. We support US shipping from Canada with straightforward checkout. If you are comparing options, look at the total per-bottle value rather than only the carton size. For coupons or current offers, visit our Promotions page. Our site uses encrypted checkout for your protection.

Availability and Substitutions

Stock can vary. If an item is unavailable, your prescriber may recommend a therapeutically appropriate alternative. Generic mesalazine rectal suspension may be an option if permitted and available. You can also review related therapy in our Ulcerative Colitis and Gastrointestinal sections for broader context.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with distal disease who can use and retain enemas. It may not suit people with significant renal or hepatic impairment, known 5-ASA hypersensitivity, or severe systemic illness. Ask your prescriber if multi-month fills are appropriate to reduce per-shipment costs. Align refills with your follow-up schedule so you do not run out. Salofalk price without insurance can differ by pack and source; many buyers compare total cost per dose. If paying out of pocket, consider setting calendar reminders to reorder before the last week of supply.

Questions to Ask Your Clinician

• Ideal dosing time: bedtime or another schedule?
• How long should I try this therapy before reassessment?
• Can I combine rectal 5-ASA with an oral 5-ASA?
• What signs suggest I should stop and call you?
• How do we monitor kidney function with this treatment?
• What are my alternatives if retention is difficult?

Authoritative Sources

Health Canada Drug Product Database

FDA DailyMed

Dr. Falk Pharma

Ready to proceed? Place your order with express service. Ships from Canada to US, with temperature-controlled handling when required. This information is not medical advice; always follow your prescriber and the official label.