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Eldepryl® Tablets for Parkinson's Disease
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What Eldepryl Is and How It Works
Selegiline is a selective MAO-B inhibitor used for Parkinson’s disease. It helps increase and prolong dopamine activity in the brain, which may support movement control. Many people compare options like selegiline 5 mg without insurance to manage out-of-pocket spending and access care with US delivery from Canada. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.
Eldepryl® is often added to levodopa/carbidopa when symptoms are not fully controlled. It can also be used in early disease for certain patients, based on prescriber judgment. The treatment slows dopamine breakdown by inhibiting monoamine oxidase B. By reducing dopamine metabolism, it can modestly improve motor symptoms such as stiffness and slowness.
This medicine is taken by mouth and absorbed through the gastrointestinal tract. Food may interact with dosing schedules; follow your prescriber’s directions and the official label. If you are exploring therapies within Parkinsons Disease or broader Neurology care pathways, your clinician will tailor a plan to your needs.
Typical safety precautions include avoiding certain interacting medicines and watching for insomnia, nausea, or dizziness. Because this therapy is adjunctive for many, your overall regimen and timing matter. Review all medicines, vitamins, and herbal products with your healthcare professional.
Who It’s For
This therapy is indicated for Parkinson’s disease, particularly as an adjunct to levodopa/carbidopa when response fluctuates. Some adults with early symptoms may also be considered for monotherapy under clinician guidance. Patients who cannot take MAO inhibitors, who use certain interacting antidepressants, or who have specific medical conditions should avoid this medicine unless a prescriber deems it appropriate.
Those considering generic selegiline 5 mg should discuss prior psychiatric history, blood pressure issues, and any history of peptic ulcer disease or arrhythmias. People with severe hepatic impairment may need alternative options. If you also manage mood symptoms, see our category on Depression for educational resources.
Dosage and Usage
Follow the exact instructions on your prescription label. For adjunct therapy, clinicians often divide the daily dose and give it with breakfast and lunch to help reduce insomnia. Swallow tablets with water. Do not change your dose or schedule without your prescriber’s guidance.
If you also take levodopa/carbidopa, your prescriber may adjust that regimen based on response and tolerability. The goal is to improve wearing-off while limiting adverse effects such as dyskinesia or lightheadedness. Selegiline 5 mg tablet references appear on many prescriptions; your label will state the dose and frequency for you.
Alcohol may worsen dizziness or blood pressure changes. Stand up slowly to reduce the chance of lightheadedness. If you experience increased involuntary movements, report them to your healthcare professional. Always check the product insert for administration details when uncertain.
Strengths and Forms
Oral tablets are commonly supplied in a 5 mg strength. Availability may vary by manufacturer and market. Some patients may encounter different packaging or imprinting, depending on the supplier and country of origin. Eldepryl 5 mg tablets are a well-known reference presentation; your dispensed product may be an equivalent generic.
Other formulations, such as orally disintegrating tablets or transdermal patches, are separate products with distinct dosing and indications. This page focuses on oral tablets for Parkinson’s disease. Your prescriber will select the appropriate form based on your clinical goals.
Missed Dose and Timing
If you miss a dose, take it when you remember unless it is late in the day. If it is near your next scheduled time, skip the missed dose and resume your regular schedule. Avoid doubling up to make up for a missed tablet. Taking doses late in the day may increase the chance of insomnia. If you are unsure, consult the patient information insert or contact your prescriber.
Storage and Travel Basics
Store tablets in the original container, closed tightly, and kept dry. Protect from excess heat and humidity. Keep out of reach of children and pets. Do not store in the bathroom. When you travel, carry your medicine and a copy of your prescription in your hand luggage.
For longer trips, bring extra tablets and a simple dosing reminder. Keep the container label visible for airport screening. If your regimen includes selegiline oral 5 mg and other Parkinson’s medicines, use a checklist to stay organized. If you have questions about carrying supplies, ask your pharmacist before you leave.
Benefits
As a selective MAO-B inhibitor, this therapy may improve motor symptoms by sustaining dopamine levels in the brain. It can offer adjunct support to reduce wearing-off with levodopa. Morning and midday dosing can help minimize sleep disturbance for many patients, which may be convenient for daytime routines. Tablets are small and easy to take without special devices, making daily use straightforward for most.
Side Effects and Safety
Common side effects include:
- Insomnia or vivid dreams
- Nausea or stomach upset
- Dizziness or orthostatic lightheadedness
- Dry mouth
- Headache
- Increased involuntary movements when combined with levodopa
Serious but less common risks include severe hypertension with contraindicated drug combinations, serotonin syndrome when combined with certain antidepressants, and psychiatric changes such as agitation or hallucinations. Report chest pain, severe headache, confusion, or new hallucinations right away. If you notice unusual bleeding, rash, or signs of allergic reaction, stop the medicine and seek urgent care. People sensitive to stimulatory effects may need earlier dosing or a different therapy.
Some patients may see blood pressure changes, especially when standing. Rise slowly and stay hydrated unless told otherwise. Those with cardiovascular disease should be monitored. Selegiline hcl 5 mg appears in many prescriptions; your safety monitoring remains individualized.
Drug Interactions and Cautions
Do not take this therapy with other MAO inhibitors, meperidine, tramadol, St. John’s wort, or linezolid. Risk of serotonin syndrome exists with SSRIs, SNRIs, TCAs, and certain other antidepressants. A washout period is typically required when switching. Tyramine interactions at recommended oral doses are less likely than with nonselective MAO inhibitors, but follow labeling guidance on diet and symptom monitoring.
Antipsychotics that block dopamine can reduce benefit. If nausea management is needed, options that do not strongly block central dopamine may be preferred; speak with your prescriber. Review every prescription and nonprescription product with your healthcare professional to avoid harmful combinations. For background reading on interacting medicines, see articles like Fluoxetine Side Effects and Trifluoperazine Uses, and digestion-focused Domperidone Tablet.
What to Expect Over Time
Response varies by person and stage of Parkinson’s. Early on, some patients notice modest improvement in stiffness or wearing-off. When combined with levodopa, dose timing may be fine-tuned by your prescriber. Sleep changes can occur, so earlier administration often helps. Keep a simple symptom diary to share at follow-up visits. Consistent daily use and regular check-ins support steady control and safety assessments.
Compare With Alternatives
For many patients, the backbone of therapy remains levodopa/carbidopa. Your clinician may adjust that regimen alongside an MAO-B inhibitor. Another MAO-B option is rasagiline, which has similar class effects with its own labeling guidance. Explore options like Levodopa Carbidopa and Azilect with your prescriber to understand differences in dosing, interactions, and suitability.
Pricing and Access
We offer Canadian-sourced tablets with transparent listings so you can compare pack sizes. Check the selegiline 5 mg price on the product page and review available manufacturers. You can track current availability and select the quantity that fits your refill plan. Ships from Canada to US options are shown at checkout. If you’re looking for savings, review our Promotions page for any current offers. Our encrypted checkout helps protect your information.
Availability and Substitutions
Supply can vary by manufacturer. If a specific brand is unavailable, your prescriber may approve an equivalent generic. Pharmacists may contact your clinician to discuss alternatives when necessary. We do not promise restock dates, but we will display real-time availability on the product page so you can plan refills with your healthcare professional.
Patient Suitability and Cost-Saving Tips
Good candidates can swallow tablets, tolerate MAO-B inhibition, and have a plan for interaction management. Those with active peptic ulcer disease, severe hepatic impairment, or recent use of contraindicated antidepressants may not be suitable. If sleep disruption occurs, earlier dosing may help, as advised by your prescriber.
To reduce costs, consider multi-month supplies when appropriate and allowed by your prescription. Set reminder alerts so you do not run out unexpectedly. Discuss therapeutic goals and any side effects during follow-ups to avoid waste from unnecessary changes. If you experience affordability barriers, ask your clinician whether a lower-cost equivalent could meet your needs.
Questions to Ask Your Clinician
- Where does this medicine fit with my current Parkinson’s plan?
- What signs suggest dose timing needs adjustment?
- Which medicines or supplements should I stop before starting this therapy?
- How should I handle new insomnia or vivid dreams?
- When should I report dizziness or blood pressure changes?
- Could an alternative MAO-B inhibitor be a better fit for me?
Authoritative Sources
DailyMed: Selegiline HCl Tablets
DailyMed: Rasagiline Reference
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How does selegiline work in Parkinson’s disease?
Selegiline is a selective monoamine oxidase B (MAO-B) inhibitor. By inhibiting MAO-B, it slows the breakdown of dopamine in the brain. That can help stabilize dopamine levels and support movement control. It is often added to levodopa/carbidopa when symptoms fluctuate. Some patients may use it earlier in therapy, based on prescriber judgment. The exact plan depends on your overall regimen, symptom pattern, and tolerability.
What are common side effects with selegiline tablets?
Common effects include insomnia, nausea, dry mouth, dizziness, and sometimes increased involuntary movements when combined with levodopa. Vivid dreams may occur. Blood pressure can dip when standing, so stand up slowly. Serious but less common effects include serotonin syndrome with interacting drugs or significant agitation. Report chest pain, confusion, new hallucinations, or severe headache promptly to a healthcare professional.
Can I take selegiline with antidepressants?
Many antidepressants interact and can raise the risk of serotonin syndrome when used with MAO inhibitors. SSRIs, SNRIs, and tricyclics often require washout periods before starting or stopping therapy. Never start, stop, or switch these medicines without medical supervision. Your prescriber will review your current regimen and determine safe intervals. Always check the patient information and seek professional guidance before combining therapies.
When should I take doses during the day?
Follow your prescription label. Many patients take morning and midday doses to reduce sleep disturbance. Late-day dosing can increase insomnia for some. If you also take levodopa/carbidopa, timing may be adjusted by your prescriber to help control wearing-off. Do not change your schedule on your own. If you miss a dose, skip it if it is close to the next dose and resume your usual plan.
Do I need to change my diet while on this medicine?
At recommended oral doses, tyramine-related food restrictions are less likely than with nonselective MAO inhibitors. Still, follow label guidance and your clinician’s advice. Report severe headache, palpitations, or unusual symptoms after eating aged or fermented foods. If you have questions about specific items, ask your pharmacist. Always read the package insert for the most current dietary cautions.
What interactions should I avoid with selegiline?
Avoid other MAO inhibitors, meperidine, tramadol, linezolid, and St. John’s wort. Many antidepressants can interact; washout periods are typically required when switching. Antipsychotics that block dopamine may reduce benefit. Review every prescription, OTC product, and supplement with your healthcare professional. This helps prevent serious reactions and preserves symptom control.
How should I store my tablets at home and when traveling?
Keep tablets in a closed, dry container at room temperature, away from humidity. Do not store in a bathroom. When traveling, carry your medicine and a copy of your prescription in your hand luggage. Keep labels visible for screening. Bring a small buffer supply and a dosing reminder so you stay on schedule. If you have questions about packing medicines, consult your pharmacist in advance.
