Selegiline Tablets and Eldepryl® Equivalence for Parkinson’s Support

What Selegiline Is and How It Works

Selegiline (selegiline hydrochloride) is a selective monoamine oxidase type B (MAO‑B) inhibitor used with levodopa/carbidopa to help manage motor fluctuations in Parkinson’s disease. It slows the breakdown of dopamine in the brain. That helps extend the effect of levodopa and may reduce “off” time. Oral selegiline tablets are typically 5 mg; many people use selegiline 5mg twice daily, as directed by their prescriber.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. We also work with licensed, vetted international partner pharmacies to supply authentic brands and a broad selection at affordable pricing.

Selegiline tablets are for human use. Oral selegiline is not the same as the transdermal system used for depression. In most regions, the tablet form is indicated as adjunct therapy in Parkinson’s disease. If you see terms like selegiline for depression or selegiline depression dosage, that usually refers to the patch, not the 5 mg tablet.

You can order selegiline online from Canada. We offer generic selegiline hydrochloride tablets at Canadian prices. If you compare selegiline price options, generics often provide strong value versus brands such as Eldepryl or Zelapar (orally disintegrating tablets).

Dosage and Usage

• Typical starting dose with levodopa/carbidopa: 5 mg once daily or 5 mg twice daily with breakfast and lunch. The usual maximum is 10 mg per day in divided doses.
• Your prescriber may lower your levodopa dose after starting selegiline to limit dyskinesia, nausea, or dizziness.
• Take selegiline tablets in the morning and at midday to reduce insomnia risk. Swallow tablets with water. Do not crush ODT products like Zelapar.
• Missed dose: take it when remembered if it is not late in the day. Skip it if near the next dose. Do not double doses.
• Drug and food interactions: at tablet doses up to 10 mg/day, tyramine restrictions are not usually required, but avoid very high-tyramine foods if advised. Do not combine with other MAO inhibitors.
• Washout periods: allow at least 14 days after stopping selegiline before starting most serotonergic antidepressants; allow 5 weeks after fluoxetine before starting selegiline. Your prescriber sets exact timing.

• Store at 20–25°C (68–77°F); keep in a dry place away from moisture and light.
• Keep in the original, child‑resistant container. Close the cap tightly after each use.
• Do not store in the bathroom. Do not freeze.
• When you travel, carry selegiline pills in your hand luggage with your prescription label.
• For long trips, bring extra doses and a copy of your prescription. No refrigeration is needed.

Benefits and Savings

Adding selegiline hydrochloride tablets to levodopa can modestly improve motor symptoms and extend “on” time. Some people can lower their levodopa dose after stabilization, which may reduce dyskinesia. Morning and midday dosing support daytime symptom control while limiting sleep disruption. Selegiline tablets are small and easy to store, with simple dosing.

Ordering selegiline for sale from Canada can reduce your medication spend. Many patients see 60–80% savings versus typical US pharmacy costs. Generic selegiline tablets help lower monthly out‑of‑pocket selegiline cost while maintaining the same active ingredient as branded Eldepryl. You can compare selegiline price per strength, including 5 mg or selegiline 10 mg where available.

Side Effects and Safety

• Nausea or upset stomach
• Dry mouth
• Headache
• Insomnia if taken later in the day
• Dizziness or orthostatic hypotension
• Agitation or anxiety
• Hallucinations or confusion (more often in older adults or with higher levodopa doses)
• Worsening dyskinesia when combined with levodopa/carbidopa
• Rhinitis or sore throat

Serious but uncommon risks include serotonin syndrome when combined with serotonergic drugs (SSRIs, SNRIs, tricyclics, MAOIs, linezolid, methylene blue, St. John’s wort), hypertensive reactions with certain sympathomimetics or high‑tyramine exposure, and severe interactions with meperidine, tramadol, methadone, or dextromethorphan. People with Parkinson’s disease have an increased melanoma risk; regular skin checks are recommended by many prescribers. Hypoglycemia can occur if selegiline is used with agents that lower blood glucose, but the risk is most relevant when insulin or sulfonylureas are part of the regimen.

Onset Time

Some patients notice smoother levodopa response within 1–2 weeks of starting selegiline tablets. Meaningful changes in “on/off” time often become clearer over 2–6 weeks as dosing stabilizes and levodopa adjustments are made. If your prescriber reduces levodopa, expect a gradual change over several weeks.

Compare With Alternatives

Rasagiline is another once‑daily MAO‑B inhibitor for Parkinson’s disease. It has similar benefits with a simpler dosing schedule. Some patients switch from selegiline to rasagiline for convenience or tolerability preferences.

Safinamide is a reversible MAO‑B inhibitor (availability varies by country). It offers adjunctive benefit for “off” episodes and may have additional glutamate‑modulating effects. Suitability depends on regional approvals and individual response.

Other adjuncts include catechol‑O‑methyltransferase (COMT) inhibitors such as entacapone or opicapone, and amantadine for dyskinesia. Your prescriber tailors choices to symptom pattern, age, and side‑effect profile.

If your main need is treatment for major depressive disorder rather than Parkinson’s, alternatives may include Wellbutrin Xl® (bupropion) or Rexulti® (brexpiprazole) as adjunct therapy, depending on clinical history. Selegiline tablets are generally not used for depression; the transdermal patch is a different product and dosing paradigm.

Combination Therapy

• With levodopa/carbidopa: common pairing; consider lowering levodopa dose to reduce dyskinesia or orthostatic symptoms.
• With COMT inhibitors (entacapone/opicapone): can further extend levodopa effect; monitor for increased dyskinesia.
• With dopamine agonists (pramipexole, ropinirole, rotigotine): improves motor control; watch for hallucinations or impulse‑control symptoms.
• With amantadine: may help dyskinesia; monitor for insomnia and confusion in older adults.
• Avoid with SSRIs, SNRIs, TCAs, MAOIs, linezolid, methylene blue, dextromethorphan, meperidine, tramadol, methadone, or St. John’s wort due to interaction risks.

Patient Suitability and Cost-Saving Tips

Oral selegiline use is intended for adults with Parkinson’s disease who need adjunct therapy to levodopa/carbidopa. It is not usually used as monotherapy in advanced disease. People with a history of uncontrolled hypertension, significant arrhythmias, active peptic ulcer disease, severe hepatic impairment, or psychosis may not be good candidates. Safety in pregnancy or breastfeeding is not established; prescribers weigh risks carefully.

Selegiline hydrochloride tablets are for humans only. Queries like selegiline dogs dosage or selegiline use in dogs relate to veterinary products and require a veterinarian’s prescription and guidance. Do not give human tablets to animals unless specifically directed by a licensed veterinarian.

To manage selegiline cost, consider larger fills when appropriate. A multi‑month supply can lower the per‑month price, and bulk promotions may reduce overall spend. Set a simple reorder reminder so you do not run short. You can compare selegiline tablets by strength (such as selegiline hcl 5 mg) and form to match your prescription and budget. If you need a different strength, your prescriber may adjust; do not split or alter doses without guidance.

Authoritative Sources

Health Canada Drug Product Database: Eldepryl (selegiline hydrochloride)

FDA Prescribing Information: Selegiline Orally Disintegrating Tablets (Zelapar)

Parkinson’s Foundation: MAO‑B Inhibitors overview

Order Selegiline from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This material is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s instructions and the patient information that comes with your medication.