Seroquel XR® Extended-Release Tablets for Schizophrenia

This extended-release quetiapine tablet is used for schizophrenia and bipolar disorder. It releases medicine slowly to support once-daily dosing. Below, you will find practical details on use, safety, and access.

What Seroquel XR® Is and How It Works

This medicine belongs to the atypical antipsychotic class and treats certain mood and thought disorders. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing. We provide US delivery from Canada on approved orders, with options for people paying without insurance. Quetiapine XR helps balance dopamine and serotonin activity in the brain. The extended-release matrix releases the medicine gradually, which may reduce peak-related drowsiness for some people. The treatment is taken once daily, typically in the evening, to keep levels steady.

Quetiapine fumarate extended-release acts on multiple receptors, including 5-HT2 and D2. This activity may help with hallucinations, delusions, mood symptoms, and sleep-wake rhythms in the approved conditions. Learn more about related treatments in our Antipsychotics category.

Who It’s For

This treatment is indicated for adults with schizophrenia. It is also used for bipolar disorder, including manic and depressive episodes, and as add-on therapy for major depressive disorder when prescribed by a clinician. People with dementia-related psychosis should not use it, due to increased mortality risk. The medicine may not be suitable if you have a history of severe low white blood cell counts, uncontrolled diabetes, significant heart rhythm problems, or severe liver impairment.

If you experience psychotic symptoms or mood episodes, your clinician may consider this therapy after an evaluation. Read more about the condition in Schizophrenia and Bipolar Disorder. For background, see What Is Schizophrenia. If you have suicidal thoughts, seek immediate help. Antidepressant use can increase suicidal thinking in young people; close monitoring is important when used as adjunctive therapy for depression.

Dosage and Usage

Follow your prescriber’s instructions and the product label. Take the tablet once daily in the evening, with or without a light meal. Swallow whole; do not cut, crush, or chew. Avoid grapefruit products unless your clinician says otherwise. Titration is common to reach a target dose suited to the indication and your response. Some patients start at Quetiapine XR 50 mg during titration as directed. For schizophrenia and bipolar disorder, the total daily dose is adjusted over several days to the maintenance range. If used with certain other medicines, your prescriber may adjust the dose.

Do not stop suddenly without medical advice. Dizziness or drowsiness can occur; use caution driving until you know how you respond. Alcohol and other sedatives can increase sleepiness. If you miss doses often or feel over-sedated, speak with your healthcare professional about timing and schedule.

Strengths and Forms

This product is available as extended-release tablets. Availability may vary by manufacturer and timing. Many adults stabilize at Seroquel XR 300 mg depending on the indication and clinical response.

• XR tablets: 50 mg
• XR tablets: 150 mg
• XR tablets: 200 mg
• XR tablets: 300 mg
• XR tablets: 400 mg

Color and imprint can differ by manufacturer. Your prescriber and pharmacist will match the strength to your treatment plan.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is close to the next dose. If it is almost time for the next dose, skip the missed tablet and resume your regular schedule. Do not double the dose. If you miss more than one dose, ask your clinician for guidance. For refills approved by your prescriber, you can request Seroquel XR online through your account.

Storage and Travel Basics

Store at room temperature in the original container. Protect from moisture and excessive heat. Keep out of reach of children and pets. Close the cap securely after each use. When traveling, carry tablets in your hand luggage with the labeled pharmacy container. Bring a copy of your prescription or a photo of the label. Stay consistent with your dosing time as you cross time zones. Do not store tablets in a hot car or a damp bathroom. If a tablet looks damaged or discolored, ask your pharmacist before use.

Benefits

The extended-release design supports once-daily use, which can simplify routines. The treatment covers schizophrenia symptoms and certain mood symptoms in bipolar disorder under approved indications. As an add-on for major depressive disorder, it may help when first-line antidepressants are not enough. Nighttime dosing can fit people who experience daytime sedation. Continuous 24-hour coverage may help reduce peaks and troughs in drug levels.

If you want more context on how antipsychotics are used, see Psychosis And Antipsychotics.

Side Effects and Safety

• Sleepiness or fatigue
• Dizziness or lightheadedness
• Dry mouth or constipation
• Increased appetite and weight gain
• Indigestion or nausea
• Headache

Serious but less common risks include high blood sugar, changes in cholesterol, low blood pressure on standing, abnormal movements (tardive dyskinesia), neuroleptic malignant syndrome, low white blood cell counts, seizures, and eye lens changes. There is an increased risk of death in elderly patients with dementia-related psychosis. Antidepressant use in young people can increase suicidal thoughts; monitoring is important when used as adjunctive therapy for depression. Combining with insulin or sulfonylureas may raise hypoglycemia risk indirectly by appetite changes; monitor glucose if you have diabetes.

Drug Interactions and Cautions

Strong CYP3A4 inhibitors (such as ketoconazole, clarithromycin, some HIV protease inhibitors) can raise levels. Strong CYP3A4 inducers (such as carbamazepine or phenytoin) can lower levels. Your prescriber may adjust therapy when these are used together. Avoid grapefruit unless your clinician agrees. Use caution with other medicines that cause drowsiness, lower blood pressure, or prolong the QT interval. If you have diabetes, heart disease, a history of fainting, seizures, or liver problems, tell your clinician before starting. Report signs of severe rash, fever, rigid muscles, confusion, suicidal thoughts, or uncontrolled movements right away.

What to Expect Over Time

Your clinician will usually increase the dose over several days to improve tolerability. Sleepiness can occur early and often improves with time and dose adjustments. Mood, thinking, and behavior changes may be gradual. Keep a simple log of sleep, appetite, and energy to share at follow-up visits. Regular checks of weight, blood sugar, and lipids are common. If side effects affect daily life, contact your prescriber; adjustments or supportive measures may help.

Compare With Alternatives

Many patients do well on the same active ingredient in a different brand or as a generic. Ask your prescriber whether the once-daily generic formulation could suit your plan, such as Quetiapine XR.

Another option in the atypical class is aripiprazole, which has a different receptor profile and dosing approach. Some people prefer it due to activating properties, while others do not. Review whether it fits your history with your prescriber. See Aripiprazole for details.

Pricing and Access

We list current options so you can compare Seroquel XR price and generics when available. With Canadian pricing and US delivery from Canada, many patients see meaningful out-of-pocket savings. You can review strength options and quantity choices in your account, then proceed to checkout.

Looking for deals? See our latest offers on the Promotions page. We support secure, encrypted checkout. Final costs depend on dose, quantity, and manufacturer.

Availability and Substitutions

Supply can vary by strength and manufacturer. Your prescriber may consider the Generic for Seroquel XR if it suits your treatment plan. If a specific strength is unavailable, your clinician may recommend a different tablet strength or an alternative in the same class. We cannot provide restock dates, but we will display available options on the product page.

Patient Suitability and Cost-Saving Tips

This treatment could be appropriate if you need once-daily maintenance for schizophrenia or bipolar disorder and can tolerate potential drowsiness or metabolic changes. It may not be a good fit if you have uncontrolled diabetes, a history of severe orthostatic hypotension, or are at high risk for QT prolongation. Pregnant or breastfeeding patients should discuss risks and benefits with their prescriber.

To manage expenses, consider larger fills when stable, use refill reminders, and compare generic options. People maintained on Quetiapine XR 200 mg may be able to schedule multi-month refills after the prescriber confirms stability. Keep your profile current so our team can coordinate prescription renewals in time.

Questions to Ask Your Clinician

• Indication and goals: Which symptoms are we targeting first?
• Dose plan: How will we titrate, and when will we reassess?
• Monitoring: What labs or weight checks should I expect?
• Side effects: What should I report right away?
• Interactions: Are any of my medicines a concern?
• Alternatives: Would a different atypical fit my history better?
• Duration: How long might I continue maintenance therapy?

Authoritative Sources

Seroquel XR Prescribing Information (AstraZeneca)FDA DailyMed: Quetiapine Fumarate Extended-ReleaseHealth Canada Drug Product Database

Ready to proceed? Add your prescription and place your order for express US shipping from Canada, with temperature-controlled handling when required. This information is not a substitute for professional medical advice; always follow your prescriber’s guidance.