Aldactazide® (spironolactone/hydrochlorothiazide) tablets for edema and hypertension

What Aldactazide® Is and How It Works

Spironolactone hydrochlorothiazide is a fixed-dose combination used for edema and high blood pressure. It pairs spironolactone, a potassium-sparing aldosterone blocker, with hydrochlorothiazide, a thiazide diuretic. Together, they help remove extra fluid, reduce swelling, and lower blood pressure. Many people look for Spironolactone HCTZ without insurance to manage out-of-pocket costs.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. We also source through licensed, vetted partner pharmacies worldwide to provide authentic brands and a wide range of generics at affordable prices.

Spironolactone blocks aldosterone in the kidney’s distal tubules. This reduces sodium and water reabsorption and helps retain potassium. Hydrochlorothiazide acts earlier in the nephron to increase sodium and water excretion. The combination limits potassium loss while enhancing diuresis. Tablets are typically available as 25 mg/25 mg and 50 mg/50 mg strengths. Your prescriber sets your dose based on diagnosis, kidney function, and lab results.

For hypertension, this medicine can be used alone or with other agents. For edema from heart failure, liver cirrhosis, or certain kidney conditions, it helps reduce fluid overload. The usual dosing cadence is once daily with food. Some patients may split dosing to improve tolerance.

Dosage and Usage

• Confirm your prescribed strength (for example, 25/25 mg or 50/50 mg) before you start.
• Take tablets with food to improve spironolactone absorption and reduce stomach upset.
• Take in the morning to limit nighttime urination. If twice daily, take the second dose mid-afternoon.
• Your prescriber may adjust dose every 2–4 weeks based on blood pressure, edema, and lab results.
• Do not use salt substitutes containing potassium unless your prescriber approves.
• Missed dose: take it when remembered unless it is close to the next dose. Do not double up.
• Lab monitoring may include potassium, sodium, magnesium, creatinine, and uric acid.
• Limit alcohol. Rise slowly from sitting to reduce dizziness or lightheadedness.

• Store tablets at 20–25 °C (68–77 °F) in a dry place. Brief excursions 15–30 °C (59–86 °F) are acceptable.
• Keep in the original, tightly closed container. Protect from moisture and direct light.
• Do not store in bathrooms or cars. Avoid freezing or excessive heat.
• For travel, carry in your hand luggage with the pharmacy label. Bring enough for the whole trip plus extra days.
• Use a daily reminder to avoid missed doses. Keep out of reach of children and pets.

Benefits and Savings

This combination offers two actions in one tablet. Hydrochlorothiazide helps remove fluid and lower blood pressure, while spironolactone counters potassium loss and provides added antihypertensive benefit. Many patients see steadier potassium levels compared with thiazide alone. Once-daily dosing simplifies routines for hypertension and edema care.

Ordering through our Canadian online pharmacy helps you access consistent pricing and selection. Typical savings versus US pharmacy prices can reach 60–80%. Multi-month quantities and bulk order promotions can further lower your per-month Spironolactone HCTZ cost. Reorder reminders make staying on therapy easier. This can help if you pay the Spironolactone HCTZ cash price.

To explore current offers, visit our Spironolactone HCTZ coupon page. No codes are needed.

Side Effects and Safety

• Increased urination, especially after starting or dose changes
• Dizziness, lightheadedness, low blood pressure
• Headache, fatigue, muscle cramps
• Nausea, abdominal discomfort, diarrhea or constipation
• Electrolyte changes: low sodium or magnesium; high potassium
• Skin rash or photosensitivity; use sun protection
• Elevated uric acid that may trigger gout in predisposed people
• Breast tenderness or enlargement (gynecomastia), menstrual changes, reduced libido

Serious effects are uncommon but include high potassium (weakness, slow or irregular heartbeat), severe dehydration or low sodium, kidney problems, and rare severe skin reactions. Do not use with anuria, acute kidney failure, Addison’s disease, or known hyperkalemia. Use caution with ACE inhibitors, ARBs, NSAIDs, potassium supplements, or high-potassium diets. Discuss pregnancy or plans to conceive; spironolactone has antiandrogenic effects and the combination is generally avoided during pregnancy. Limit use while breastfeeding unless approved by your prescriber.

Onset Time

Diuretic effects begin within hours of the first dose. Swelling usually improves over several days as fluid balance adjusts. Blood pressure changes are often seen within 1–2 weeks, with full effect by 4–6 weeks. Lab values like potassium and creatinine may shift during the first few weeks, so early monitoring is routine after dose changes.

Compare With Alternatives

Some patients do well on spironolactone alone, especially when potassium preservation is a priority. If your prescriber prefers a single-agent approach, you can view Spironolactone options.

For hypertension, thiazide-like diuretics such as chlorthalidone can be considered. Angiotensin receptor blockers are also common first-line agents. If you need an ARB, you can compare with Valsartan, which is often paired with a separate diuretic when more control is needed.

Beta blockers and calcium channel blockers are alternatives or add-ons depending on your cardiac profile. The choice depends on coexisting conditions, side-effect tolerance, and target blood pressure.

Combination Therapy

• ACE inhibitor or ARB: often used in hypertension or heart failure; monitor potassium and kidney function closely.
• Loop diuretic (for example, furosemide): may be added for difficult edema; adjust doses to avoid dehydration.
• Calcium channel blocker: complements blood pressure control without affecting electrolytes.
• Beta blocker: consider for heart rate control or post-MI care, with attention to blood pressure.
• Potassium supplements: usually not needed; avoid unless your prescriber directs otherwise.
• NSAIDs: minimize use; they can blunt diuretic effect and raise kidney risk.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with essential hypertension or edema from heart failure, cirrhosis (with careful monitoring), or certain kidney conditions where diuresis is needed and potassium preservation is helpful. It can be useful in resistant hypertension.

People who should avoid this medicine include those with hyperkalemia, Addison’s disease, anuria, severe kidney impairment, or known spironolactone/hydrochlorothiazide hypersensitivity. Use caution with a history of gout, low sodium, or significant dehydration. HCTZ can rarely trigger sulfonamide-type reactions. Older adults may need slower titration and closer lab follow-up.

To reduce costs, consider a larger supply if your dose is stable. Multi-month fills often reduce the per-tablet Spironolactone HCTZ price. Set up simple reorder reminders so you never run out. If you are uninsured, ask our team about options that fit Spironolactone HCTZ without insurance budgets. Your prescriber can sometimes streamline monitoring visits once stable, which can lower overall care costs.

Authoritative Sources

Review full details in these official resources:

Pfizer product information for Aldactazide

Health Canada Drug Product Database: Aldactazide listing

FDA Prescribing Information: spironolactone and hydrochlorothiazide tablets

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This material is for educational purposes only and does not replace your prescriber’s advice. Always follow your healthcare professional’s directions for diagnosis, treatment, and monitoring.