Stivarga® (regorafenib) Tablets for mCRC, GIST, and HCC

What Stivarga Is and How It Works

Stivarga® (regorafenib) is an oral multikinase inhibitor used in oncology. It is indicated for adults with metastatic colorectal cancer (mCRC) previously treated with standard therapies, unresectable or metastatic gastrointestinal stromal tumor (GIST) after imatinib and sunitinib, and hepatocellular carcinoma (HCC) previously treated with sorafenib. The usual form is a stivarga 40 mg tablet, taken once daily on a cycle schedule. Many people search for stivarga cost without insurance when planning long courses of care, and our team can help with options.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba. Orders are reviewed by licensed pharmacists before dispensing, and you can order online or by phone during posted hours at Canadian prices.

Stivarga® targets multiple kinases involved in tumor growth and blood-vessel formation, including VEGFR, PDGFR, KIT, and RAF. By blocking these pathways, regorafenib can slow cancer cell proliferation and reduce tumor blood supply. Tablets are taken by mouth with a low-fat meal. Treatment follows 28-day cycles with dosing on days 1 through 21.

We work with licensed, vetted partner pharmacies internationally so brand medicines are authentic, the selection is broad, and pricing stays affordable.

Dosage and Usage

Follow your oncology team’s plan. The information below reflects typical guidance from product labeling.

• Starting dose: 160 mg once daily (four 40 mg tablets) for 21 days, then 7 days off, in 28‑day cycles.
• Administration: take after a low‑fat meal at the same time each day; swallow tablets whole with water.
• Dose adjustments: may reduce to 120 mg, then 80 mg, if side effects require it.
• Missed dose: if a dose is missed, take it the same day when remembered; do not take two doses on the same day to make up for a missed dose.
• Vomiting after a dose: do not take an extra dose; resume the next scheduled dose.

• Storage: store at 20–25 °C (68–77 °F); short excursions 15–30 °C are allowed.
• Keep tablets in the original bottle with the desiccant. Tightly close the cap to protect from moisture.
• Travel: keep the bottle in carry‑on luggage. Avoid heat, humidity, and direct sunlight.
• Avoid grapefruit products and St. John’s wort due to interactions.

Always check the strength on the bottle label. Stivarga® comes as film‑coated tablets. Common listings include bayer stivarga, stivarga tablet, stivarga tab 40mg, and stivarga 40mg price details for different pack sizes.

Benefits and Savings

Regorafenib offers a targeted option in later treatment lines. In mCRC, it has shown improvements in progression‑free survival versus placebo. In GIST after prior lines, it can help control disease and delay progression. In HCC previously treated with sorafenib, it provides another oral therapy choice. Individual response varies by cancer type and prior therapy, and published stivarga success rate figures depend on trial criteria.

Ordering from a Canadian pharmacy can lower total treatment costs. Typical savings range from 60–80% compared to many US pharmacy prices. We also support patients managing expenses without insurance by offering transparent pricing and flexible supply options.

You can compare stivarga price options on our site, view stivarga discount offers when available, and choose multi‑month supplies when approved. Our customer‑service chat is available during posted office hours to help with ordering steps.

Side Effects and Safety

Side effects are common with targeted oncology therapy. Your healthcare team will monitor labs and symptoms, especially early in treatment.

• Common: hand‑foot skin reaction, fatigue, diarrhea, decreased appetite, weight loss, hypertension, dysphonia, rash, oral soreness, abdominal pain, fever, nausea.
• Laboratory changes: elevated liver enzymes, bilirubin changes, electrolyte changes.
• Serious: hepatotoxicity and liver failure, severe bleeding, gastrointestinal perforation or fistula, myocardial ischemia/infarction, hypertensive crisis, reversible posterior leukoencephalopathy syndrome (RPLS), infections, poor wound healing.

Liver function tests are often checked every two weeks during the first two months, then monthly or as directed. Use caution with anticoagulants and antiplatelet drugs due to bleeding risk. Avoid strong CYP3A4 inducers (such as rifampin) and strong inhibitors when possible; your prescriber may adjust therapy if needed. Do not use during pregnancy, and use effective contraception during treatment and for the recommended time after the last dose. Breastfeeding is not recommended during use.

Onset Time

Regorafenib starts acting on kinase pathways soon after dosing. Clinical benefit appears over weeks to months and is assessed by scans, labs, and symptoms. Some patients notice fatigue or hand‑foot symptoms in the first cycle. Tumor response and stabilization timelines vary by diagnosis, prior therapy, and overall health.

Compare With Alternatives

For mCRC after multiple prior regimens, Lonsurf (trifluridine/tipiracil) is an oral option. In HCC, sorafenib or lenvatinib are used earlier, and cabozantinib is another later‑line choice. For GIST, imatinib and sunitinib are standard before regorafenib.

Different cancers require different medicines. If you are exploring other targeted or hormonal therapies, you can also review Zytiga® and immunotherapy options such as Bavencio® while working with your care team on the right plan.

Combination Therapy

Stivarga® is usually used as monotherapy in its labeled settings. It often follows prior chemotherapy, targeted agents, or immunotherapy. Combination approaches are under study, but approved use is typically single‑agent with dose adjustments based on tolerance. Report all medicines, vitamins, and herbal products to your prescriber to review for interactions and overlapping toxicities.

Patient Suitability and Cost-Saving Tips

Adults with mCRC previously treated with fluoropyrimidine, oxaliplatin, irinotecan, anti‑VEGF therapy, and, if RAS wild‑type, an anti‑EGFR therapy may be candidates. In GIST, suitability follows progression on or intolerance to imatinib and sunitinib. In HCC, it is considered after sorafenib if liver function and performance status allow. Severe hepatic impairment may limit use, and dose changes are common in moderate impairment.

To reduce out‑of‑pocket stivarga cost, consider longer supplies when appropriate, which can lower per‑month pricing. Set up gentle reorder reminders so your therapy is not interrupted. If you are looking for current deals, see our promotions page for any stivarga coupon options and bulk offers. Your order qualifies for US shipping, and our team can explain pack sizes like stivarga 40 mg tab online listings.

For background on cancer care topics, you may find our articles helpful. See Common Darzalex Side Effects And Tips To Manage Them and Understanding Calquence Medication For Cancer Treatment for practical insights you can discuss with your oncology team. To browse related conditions, visit our Cancer section.

Authoritative Sources

For full prescribing details, review the manufacturer and regulators:

• Bayer Stivarga official product page
• Health Canada Drug Product Database listing for regorafenib
• FDA Prescribing Information (US label)

YouDrugstore offers caring support, Canadian pricing, and secure delivery to the US. Place your order online, and our pharmacists will review your prescription before dispensing. We ship using prompt, express, cold‑chain shipping practices where required, with careful packaging.

This content is for general information and does not replace medical advice. Your prescriber is the best source for dosing, monitoring, and suitability. Product availability and pricing may change without notice.