Stivarga® Tablets for Colorectal Cancer

Stivarga is an oral cancer medicine used in several advanced tumors. It contains regorafenib, a targeted kinase inhibitor taken as tablets. This page explains what it treats, how to use it safely, and how to arrange US delivery from Canada even without insurance.

What Stivarga Is and How It Works

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Stivarga® is the brand name for regorafenib, a multikinase inhibitor. It blocks signals that help tumors grow and form blood vessels. By inhibiting targets such as VEGFR, PDGFR, FGFR, and RAF kinases, this treatment may slow cancer progression in specific settings. It is taken by mouth and used in cycles as directed by your prescriber.

Approved uses include metastatic colorectal cancer after prior standard therapies, unresectable or metastatic gastrointestinal stromal tumor after imatinib and sunitinib, and hepatocellular carcinoma previously treated with sorafenib. Use is based on official labeling. Always follow your healthcare professional’s instructions.

Who It’s For

This medicine is for adults who have specific advanced cancers. It is indicated for metastatic colorectal cancer after prior treatments. It is also used for unresectable or metastatic gastrointestinal stromal tumor after two prior tyrosine kinase inhibitors. In liver cancer, it is for patients previously treated with sorafenib.

People with severe liver impairment should avoid this therapy. Those with moderate liver issues may need close monitoring. It is not for use during pregnancy or while breastfeeding. Effective contraception is advised during treatment and for a period after the last dose. Talk with your prescriber if you have uncontrolled blood pressure, recent surgery, or a history of significant bleeding.

Some patients ask about regorafenib 40 mg tablets as part of their care plan. Your prescriber decides if this class fits your situation based on cancer type, prior treatments, and overall health.

Dosage and Usage

The typical schedule is once daily for three weeks, followed by one week off, in 28‑day cycles. Many patients take it at the same time each day with a low‑fat meal. Swallow tablets whole with water. Do not crush or chew. If your prescriber gives different instructions, follow those directions.

Eating a low‑fat meal helps control how much medicine your body absorbs. Avoid grapefruit or grapefruit juice due to interaction potential. Your care team may check blood pressure and blood tests regularly. Report severe fatigue, worsening skin changes on hands and feet, persistent diarrhea, or yellowing of the skin or eyes. These can be signs that need medical attention.

Some people search for Stivarga tablets 40 mg when reviewing schedules and cycles. Use only the dose and timing your clinician prescribes; do not change your dose on your own.

Strengths and Forms

This product is supplied as film‑coated tablets, commonly in the 40 mg strength. Packaging and bottle sizes may vary by market and supplier.

Tablets are designed to be swallowed whole. Availability can differ based on your location and prescriber’s authorization. If you have trouble swallowing, ask your clinician about options; do not split or crush unless your prescriber specifically advises otherwise.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember on the same day. If it is the next day already, skip the missed dose and take the next scheduled dose. Do not double up to make up for a missed tablet. If vomiting occurs after a dose, do not take an extra dose; resume at the next scheduled time. Keep a simple calendar or set phone reminders to help you stay on track.

Storage and Travel Basics

Store tablets at room temperature in the original bottle with the desiccant. Keep the container tightly closed and protected from moisture. Many labels instruct discarding tablets seven weeks after opening the bottle; check your package insert and follow your pharmacist’s directions. Keep out of reach of children and pets.

For travel, carry medicine in your hand luggage in the original labeled bottle. Bring a copy of your prescription and your prescriber’s contact information. If flying, allow extra time for security screening. Avoid storing tablets in a bathroom or other humid place. Do not transfer tablets to pill organizers unless advised by your pharmacist, as moisture control is important.

Benefits

This therapy offers an oral option when certain cancers progress on prior treatments. It can be used at home on a repeating cycle, which many patients find convenient. The class targets pathways linked to tumor growth and blood vessel formation. Your care team monitors labs and side effects and may adjust therapy if needed.

Side Effects and Safety

Common side effects include:

• Hand‑foot skin reaction with redness or pain
• Tiredness and weakness
• Diarrhea or abdominal discomfort
• Decreased appetite and weight loss
• High blood pressure or headache
• Rash or mouth irritation

Serious risks can include liver problems, bleeding, gastrointestinal perforation or fistula, heart ischemia, severe infections, and a rare brain condition called PRES. Wound‑healing complications may occur; your prescriber may advise holding therapy before and after surgery. Contact your healthcare professional right away with yellowing of the skin or eyes, dark urine, chest pain, sudden severe headache, unusual bleeding, or severe abdominal pain. This medicine can harm an unborn baby; use effective birth control and discuss timing if planning surgery.

Drug Interactions and Cautions

Regorafenib is affected by CYP3A4 and UGT1A9 pathways. Strong CYP3A4 inhibitors or inducers can change levels and may raise side‑effect risk or reduce benefit. Avoid St. John’s wort and grapefruit products. Tell your prescriber about all medicines, vitamins, and herbal supplements. Blood thinners and antiplatelets may increase bleeding risk. Your team may monitor blood pressure and liver tests more often when starting or changing other medicines.

Alcohol can worsen liver strain and blood pressure control. If you smoke, discuss cessation, as it may complicate overall care. Do not start new supplements without asking your prescriber or pharmacist.

What to Expect Over Time

During the first cycles, your clinician may check labs and blood pressure to guide safe use. Skin care for hands and feet, staying hydrated, and using gentle moisturizers may help manage common reactions. Some people need dose adjustments to balance tolerability and benefit. Keep a simple symptom log to discuss at visits. If side effects feel worse, contact your care team; do not stop or restart therapy without their guidance.

Compare With Alternatives

Other targeted therapies may be considered based on tumor type and mutation status. For GIST in earlier lines, your prescriber may use Gleevec in appropriate settings. In BRAF V600E‑mutant metastatic colorectal cancer, combinations using Braftovi with other agents may be options under specialist care. Your choice depends on cancer features, prior therapies, and tolerability.

Pricing and Access

We offer Canadian pricing with transparent checkout for eligible prescriptions. You can review Stivarga 40 mg price and compare options for your budget. Many customers also look at regorafenib 40 mg price when discussing coverage and financial support. YouDrugstore provides US shipping from Canada with clear tracking. If you pay cash, ask our team about documentation for reimbursement or savings without insurance. See current offers on our Promotions page. Our site uses encrypted checkout for added security.

Availability and Substitutions

Supply can vary. If this item is unavailable, your prescriber may recommend a comparable alternative based on your diagnosis and prior treatments. We cannot suggest changes to your therapy; reach out to your healthcare professional for medical guidance. Our team can coordinate with your clinic or pharmacist to fulfill an approved alternative when appropriate.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults whose cancer has progressed after specific prior therapies. It may not be a good choice for people with severe liver impairment, uncontrolled hypertension, or certain bleeding risks. Pregnancy and breastfeeding are not compatible with this medicine.

Cost‑saving ideas include discussing a multi‑month supply if your prescriber supports it, aligning refills with clinic visits, and setting reminder alerts so you do not miss cycles. Ask your prescriber or insurer about assistance programs. If paying out of pocket, you can compare the Stivarga 40 mg cash price with your coverage options and request itemized receipts for possible reimbursement. Keep all paperwork in one folder for tax and insurance records.

Questions to Ask Your Clinician

• Is this therapy appropriate for my cancer type and prior treatments?
• How will we monitor my liver health and blood pressure?
• What side effects should prompt a call versus an urgent visit?
• Which foods, supplements, or medicines should I avoid?
• How long should contraception be used after stopping this medicine?
• If I need surgery, when should I pause and restart treatment?
• What support resources can help with costs or side‑effect management?

Authoritative Sources

Manufacturer Site

FDA DailyMed

Health Canada DPD

Explore Related Topics

Learn more about conditions and therapies: Colorectal Cancer, Gastrointestinal Stromal Tumor, Liver Cancer, and our broader Cancer category. For background reading, see Braftovi Uses for targeted therapy context.

Ready to proceed? You can order Stivarga 40 mg online with prompt, express shipping and temperature-controlled handling when required. This information is not a substitute for medical advice; always consult your healthcare professional.