Stivarga® (regorafenib) 40 mg Tablets for Advanced Cancers

What Stivarga® Is and How It Works

Stivarga (regorafenib) is an oral targeted cancer medicine used after prior treatments in metastatic colorectal cancer (mCRC), gastrointestinal stromal tumor (GIST), and hepatocellular carcinoma (HCC). It is supplied as a Stivarga 40 mg tablet and is taken in treatment cycles. Many people compare Stivarga without insurance options to manage costs while continuing therapy. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

Regorafenib blocks several kinases involved in tumor growth and blood-vessel formation, including VEGFR, PDGFR, KIT, RET, and RAF. By inhibiting these pathways, it can slow tumor progression. The usual regimen is 160 mg once daily (four 40 mg tablets) for 21 days, then 7 days off, in 28‑day cycles. It is taken after a low‑fat meal to improve absorption and reduce stomach upset. We source medicines through licensed, vetted international partner pharmacies so patients receive authentic brand products, a broad selection, and affordable pricing.

Stivarga is a Bayer Stivarga product. It is often started after standard therapies such as fluoropyrimidine-, oxaliplatin-, and irinotecan‑based regimens for mCRC; after imatinib and sunitinib for GIST; or after sorafenib for HCC. Oncology teams adjust dosing based on tolerance, lab results, and clinical response.

Dosage and Usage

• Typical starting dose: 160 mg once daily (four 40 mg tablets) for 21 days, followed by 7 days off, per 28‑day cycle.
• Tablets are swallowed whole with water after a low‑fat meal. Do not crush, split, or chew.
• Administration with a low‑fat meal helps reduce stomach irritation and supports consistent exposure.
• Missed dose: take the missed dose the same day when remembered; do not take two doses on the same day.
• Vomiting after a dose: the dose is not repeated; take the next scheduled dose at the usual time.
• Dose reductions or interruptions may be used for side effects such as hand‑foot skin reaction, high blood pressure, or liver‑test changes.
• Avoid strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John’s wort) and grapefruit products, which can alter exposure.
• Therapy is generally paused for major surgery and resumed when wounds have adequately healed.
• Effective contraception is advised during treatment and for the period specified in the product monograph; breastfeeding is not recommended.
• Common lab monitoring includes liver tests, blood pressure checks, and other tests directed by the oncology team.

Storage and travel

• Store at 20–25 °C (68–77 °F); permitted excursions 15–30 °C (59–86 °F).
• Keep tablets in the original bottle with the desiccant and the cap tightly closed to protect from moisture.
• Do not transfer tablets to pill organizers; moisture control in the bottle is important.
• Check the bottle for any discard‑after‑opening timeframe and follow that guidance.
• During travel, keep medicine in carry‑on luggage. Avoid heat, freezing, and direct sunlight.
• Keep out of reach of children and pets.

Benefits and Savings

Stivarga has demonstrated clinical benefit in its approved settings. Trials in mCRC (CORRECT) and GIST (GRID) showed improved progression‑free outcomes versus placebo. In HCC (RESORCE), regorafenib extended overall survival after prior sorafenib. Most patients receive it as later‑line therapy, so expectations focus on disease control and maintaining function.

Ordering from YouDrugstore helps patients compare Stivarga cost against local options. Many people buy Stivarga online to access Canadian pricing and manage Stivarga out of pocket expenses more predictably. Typical savings range from 60–80% versus common US prices, which can meaningfully lower the Stivarga 40 mg cost across multiple cycles—especially for those purchasing Stivarga without insurance. Multi‑month supplies may reduce per‑month costs.

For occasional promotions, see the latest Stivarga coupon information.

Side Effects and Safety

• Hand‑foot skin reaction (palmar‑plantar erythrodysesthesia), redness, or pain on the palms and soles
• Fatigue, weakness, or low energy
• Diarrhea, abdominal pain, nausea, vomiting
• Decreased appetite, weight loss, taste changes
• High blood pressure
• Mouth irritation or sores
• Rash or dry, itchy skin
• Hoarseness (dysphonia)
• Fever or infection

Serious risks include severe liver injury (hepatotoxicity), which can be fatal. Early and periodic liver tests are standard, especially during the first two months, then as directed. Other important risks are bleeding, gastrointestinal perforation or fistula, infections, heart or brain ischemia, reversible posterior leukoencephalopathy syndrome, severe hypertension, and impaired wound healing. Use is not recommended during pregnancy, and effective contraception is needed during and after treatment per label guidance. Patients with substantial liver dysfunction require careful assessment before therapy. For a broader look at kinase‑inhibitor safety, see Dasatinib 100 Mg Tablets How It Works In Cancer Therapy.

Onset Time

Regorafenib begins working at the cellular level soon after dosing, but clinical effects are assessed over weeks. Many oncology teams evaluate tolerance in the first 1–2 weeks and perform imaging after 1–2 cycles (about 4–8 weeks). Symptom changes may occur earlier, but radiologic assessments guide decisions on continuing or adjusting treatment. Liver tests are typically checked every two weeks for the first two months, then regularly thereafter.

Compare With Alternatives

When disease progresses after initial therapies, oncologists may consider other options. In GIST, alternatives include imatinib, sunitinib, or ripretinib depending on prior lines. In HCC, sorafenib or lenvatinib are frontline choices; cabozantinib or immunotherapy may be options later. In mCRC, trifluridine/tipiracil or targeted biologics may be considered depending on biomarkers.

YouDrugstore also carries other specialty oncology medicines. For example, Zytiga® (abiraterone) is used in advanced prostate cancer, and Bavencio® (avelumab) serves defined roles in urothelial and Merkel cell cancers. Explore our Cancer section for more therapies supplied through our pharmacy network.

Combination Therapy

• Stivarga is usually used as monotherapy in its approved indications, alongside best supportive care.
• Blood pressure medicines, skin‑care measures, and antidiarrheals are commonly used to help manage tolerability.
• Concomitant strong CYP3A4 inducers or inhibitors may necessitate adjustments or avoidance to maintain appropriate exposure.
• Use with anticoagulants or antiplatelet agents increases bleeding risk and calls for close clinical monitoring.
• For planned surgery, therapy is generally interrupted and resumed when wounds have healed.

Patient Suitability and Cost-Saving Tips

Stivarga may suit adults with mCRC, GIST, or HCC who have progressed after specified prior therapies and can attend regular monitoring. It may not be appropriate for those with severe hepatic impairment, uncontrolled hypertension, recent significant bleeding, poor wound healing, or during pregnancy or breastfeeding. Tablets must be swallowed whole and taken after a low‑fat meal.

To reduce overall Stivarga price, consider multi‑month shipments when appropriate. Per‑month costs often decrease with longer supplies, and periodic Stivarga discount offers or Stivarga deal periods may appear. Reorder reminders help time refills before the next cycle. For patients paying a Stivarga cash price or managing Stivarga out of pocket expenses, asking about Stivarga bulk options can further improve affordability. These points can make it easier to order Stivarga and maintain continuity of care.

Authoritative Sources

Bayer Stivarga official product site

Health Canada Drug Product Database: Regorafenib

FDA Prescribing Information and Medication Guide

Order Stivarga® from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This information is educational and not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional about medications and health conditions.