Tagrisso® Tablets for EGFR-Mutated NSCLC

What Tagrisso® Is and How It Works

Tagrisso® (osimertinib) is a third‑generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor used for certain types of non‑small cell lung cancer. It targets EGFR mutations such as exon 19 deletions and L858R substitutions, and it can treat tumors with the T790M resistance mutation. It comes as film‑coated tablets. Many people compare Tagrisso 80mg price when planning long‑term therapy for Lung Cancer.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. We also work with licensed, vetted international partner pharmacies to supply authentic brand medicines across a broad selection at competitive prices.

Tagrisso® is indicated for metastatic EGFR‑mutated NSCLC as first‑line treatment, for T790M‑positive disease after progression on earlier EGFR TKIs, and as adjuvant therapy after tumor resection in eligible patients. Osimertinib penetrates the central nervous system and treats brain metastases in many cases. It is taken once daily by mouth, with or without food.

Tagrisso targeted therapy works by irreversibly binding mutant EGFR and blocking signaling that drives tumor growth. It spares wild‑type EGFR more than earlier agents, which often reduces certain skin and gastrointestinal side effects. For exon 20 insertion tumors, sensitivity is limited; options other than osimertinib for lung cancer are often preferred in that setting.

Dosage and Usage

• The usual dose is 80 mg once daily. Tablets are available as 80 mg and 40 mg strengths.
• Take at the same time each day, with or without food.
• Swallow tablets whole. If swallowing is difficult, disperse the tablet in 50 mL of non‑carbonated water, stir until dispersed (do not crush), and drink immediately; rinse the glass and drink the rinse.
• Adjuvant Tagrisso lung cancer treatment also uses 80 mg once daily, typically for up to three years, as directed by the prescriber.
• If a dose is missed, take it as soon as remembered unless less than 12 hours remain before the next dose; if so, skip the missed dose. Do not double doses.
• Avoid strong CYP3A inducers (for example, rifampin, carbamazepine, St. John’s wort), which can lower osimertinib exposure.
• Use caution with drugs that prolong QT, and monitor as directed. Heart function may be checked during therapy.
• Contraception is recommended during treatment and for a period after the last dose; avoid breastfeeding during therapy and for a period after the last dose.

• Storage: store Tagrisso tablets at 20–25 °C (68–77 °F). Excursions 15–30 °C (59–86 °F) are generally permitted. Keep tablets dry and in the original container.
• Keep out of reach of children and pets.
• Travel: pack enough medication for the full trip plus extra days. Keep tablets in a carry‑on, with the labeled pharmacy container.
• Avoid heat and moisture. Do not store in a bathroom. Do not freeze.
• For mail‑order delivery, you can choose prompt, express shipping and track your package in your account.

Benefits and Savings

Osimertinib treatment can produce high response rates and longer progression‑free survival in EGFR‑mutated NSCLC, including activity against brain metastases. Many patients experience symptom relief within weeks, and adjuvant use reduces the risk of recurrence after surgery.

Ordering through YouDrugstore can lower the overall cost of care. Typical savings are 60–80% versus common US retail prices, which can help reduce Tagrisso cost per month over a full course of therapy. Patients often compare tagrisso price across pharmacies; our Canadian pricing for osimertinib 80mg tablets and other strengths is competitive. Multi‑month supplies and occasional bulk promotions can further lower the per‑month cost. You can also set gentle reorder reminders so treatment is not interrupted. If comparing osimertinib tablets price, check both single‑bottle and multi‑bottle options.

For those researching coverage, many Medicare enrollees still review cash options to manage tagrisso cost medicare alongside plan benefits. Pricing varies by strength and quantity.

For periodic offers, see our tagrisso coupon page.

Side Effects and Safety

• Common: diarrhea, rash or acneiform eruption, dry skin, pruritus, mouth sores, decreased appetite, fatigue, nail changes (paronychia), and cough.
• Less common: stomatitis, conjunctivitis, headache, musculoskeletal pain, and mild liver enzyme increases.
• Skin care and antidiarrheals are often used to manage tolerability.

Serious but less frequent risks include interstitial lung disease/pneumonitis, QT interval prolongation, cardiomyopathy or decreased ejection fraction, keratitis, and severe cutaneous reactions. New or worsening shortness of breath, vision changes, chest symptoms, or sudden skin blistering require urgent medical attention. Dose interruptions or reductions (for example, to 40 mg daily) may be used for toxicity per prescribing guidance.

Onset Time

Clinical improvement with Tagrisso® often emerges within 2–4 weeks, especially for cough or dyspnea. Radiographic responses are commonly assessed at the first follow‑up scan, typically around 6–8 weeks. Intracranial responses may occur on a similar timeline. In the adjuvant setting, benefit is measured by a reduced risk of recurrence over months to years rather than immediate symptom change.

Compare With Alternatives

First‑ and second‑generation EGFR inhibitors such as erlotinib (Tarceva) and gefitinib (Iressa), and the second‑generation agent afatinib (Gilotrif), are alternatives for EGFR‑mutated NSCLC. Many patients receive osimertinib first line because of improved outcomes and better central nervous system activity.

Dacomitinib (Vizimpro) is another option in some cases, though tolerability may differ. For EGFR exon 20 insertion–positive disease, other targeted approaches are usually preferred since tagrisso exon 20 activity is limited.

In unresectable stage III disease after chemoradiation, consolidation immunotherapy such as Imfinzi® may be used in appropriate patients. Care teams weigh mutation status, prior therapy, and goals when selecting regimens for Non Small Cell Lung Cancer Nsclc. For broader context on classes and uses, you can review our article Cancer Drugs List Common Medications And Their Uses.

Combination Therapy

• Osimertinib monotherapy is common first line for EGFR‑mutated metastatic NSCLC.
• Osimertinib plus platinum‑pemetrexed chemotherapy may be considered based on clinical trial data showing longer progression‑free survival; schedules vary by cycle.
• Supportive medications (for example, antidiarrheals, skin care) are often paired to manage tolerability.
• Avoid strong CYP3A inducers; consider alternative agents to maintain osimertinib exposure.
• Coordinate timing with radiation or stereotactic radiosurgery as directed by the oncology team.

Patient Suitability and Cost-Saving Tips

Tagrisso® is for adults whose tumors harbor sensitizing EGFR mutations such as exon 19 deletion or L858R, either metastatic or as adjuvant therapy after surgical resection. It also treats T790M‑positive tumors after progression on earlier EGFR inhibitors. It is not designed for EGFR exon 20 insertion–positive disease, where other targeted agents are often used.

Caution is advised in patients with a history of interstitial lung disease, heart failure, QT prolongation, or significant eye inflammation. Periodic ECGs and ejection fraction assessments may be part of monitoring. Discuss potential drug interactions, especially with agents that affect CYP3A or QT interval.

To manage ongoing costs, consider larger quantities when appropriate, because multi‑month supplies can reduce tagrisso cost per month. You can enable reorder reminders in your account so you keep a steady supply. Pricing for osimertinib 80mg price and other strengths varies by brand pack size and shipping method.

Authoritative Sources

AstraZeneca Tagrisso official site

Health Canada Drug Product Database: Osimertinib

FDA Prescribing Information for Tagrisso (osimertinib)

Order Tagrisso® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This content is for educational purposes and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and local regulations.