Taro-Tofacitinib XR® Extended-Release Tablets for RA, PsA, and UC

What Taro-Tofacitinib XR® Is and How It Works

Taro-Tofacitinib XR is an extended-release tablet that contains tofacitinib, a Janus kinase (JAK) inhibitor. It helps reduce inflammation by blocking signaling inside immune cells. It is prescribed for adults with moderate to severe rheumatoid arthritis (RA) and psoriatic arthritis (PsA) who did not respond well to other treatments, and for certain patients with ulcerative colitis (UC). Many people compare Taro-Tofacitinib XR buy online options to manage out-of-pocket costs, and some seek Taro-Tofacitinib XR without insurance pricing.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

These XR tablets release medicine steadily over the day. Most adults take one tablet once daily as directed. For RA and PsA, the typical dose is 11 mg once daily. UC dosing can differ, including higher induction regimens or changes over time, based on your prescriber’s plan. Do not start or stop therapy without medical guidance. Avoid combining tofacitinib with biologic DMARDs or potent immunosuppressants.

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Dosage and Usage

• Follow the exact dose on your prescription label. Many adults take 11 mg XR once daily for RA or PsA.
• Swallow XR tablets whole with water. Do not split, crush, or chew the tablet.
• Take with or without food at the same time each day.
• If you miss a dose, take it when remembered the same day. Skip if it is almost time for the next dose. Do not double up.
• Do not use with strong immunosuppressants or biologic DMARDs. Confirm all medicines with your prescriber.
• Tell your care team about all drugs and supplements. Strong CYP3A4 inhibitors or inducers may require dose changes or avoidance.
• Avoid live vaccines during treatment. Ask about vaccinations before starting therapy.
• Your provider may order blood tests for lymphocytes, neutrophils, hemoglobin, liver enzymes, and lipids.

• Store tablets at 15–30 °C (59–86 °F) in a dry place.
• Keep in the original container with the label intact.
• Protect from moisture. Do not store in the bathroom.
• During travel, carry your supply in hand luggage with a copy of your prescription.
• Keep away from children and pets.
• Do not use tablets that are damaged or past the expiry date.

Benefits and Savings

Tofacitinib targets JAK pathways that drive inflammation. Many patients notice reduced joint pain and swelling, improved physical function, and lower disease activity. In UC, it can ease rectal bleeding and stool frequency and help maintain remission after induction.

XR tablets offer once-daily dosing. You take a single tablet each day, which can improve adherence. You do not need injections or infusion visits, which some patients prefer.

Ordering from a Canadian pharmacy can lower costs. Many customers see 60–80% savings versus typical US retail prices. This helps if you are comparing the Taro-Tofacitinib XR price or looking for Taro-Tofacitinib XR generic online options. Savings matter for those paying Taro-Tofacitinib XR out of pocket or Taro-Tofacitinib XR no insurance.

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Side Effects and Safety

• Upper respiratory infections, cough, sore throat
• Headache, dizziness, fatigue
• Diarrhea, nausea, abdominal pain
• Increased cholesterol or triglycerides
• Elevated liver enzymes
• Shingles (herpes zoster)
• High blood pressure
• Rash

Serious risks include severe infections (tuberculosis, fungal, opportunistic), malignancies, major adverse cardiovascular events (heart attack, stroke), blood clots in legs or lungs, and death. Risk may be higher in adults 50+ with cardiovascular risk factors compared with certain TNF blockers. Gastrointestinal perforation can occur, especially with diverticulitis or NSAID use. Your prescriber will weigh risks and benefits and monitor labs. Seek urgent care for symptoms of blood clots, chest pain, shortness of breath, persistent fever, or severe abdominal pain.

Onset Time

Some patients with RA or PsA report symptom relief within 2–4 weeks. Joint swelling, stiffness, and pain may continue to improve over 8–12 weeks as steady dosing continues. In UC, some patients notice improvement within the first week, though induction and maintenance timelines vary. Full benefit may take several months.

Compare With Alternatives

Xeljanz is the branded tofacitinib. It comes in immediate-release and XR forms. Taro-Tofacitinib XR offers a once-daily generic extended-release option, which can simplify dosing compared with twice-daily immediate-release tablets.

Rinvoq (upadacitinib) is another oral JAK inhibitor used for RA and other conditions. It has different selectivity and dosing schedules. Safety profiles overlap but are not identical. Your clinician will select based on disease severity, prior response, and risk factors.

Biologic DMARDs such as adalimumab or etanercept target cytokines outside the cell. They require injections and have their own risks and monitoring needs. Patients who prefer oral therapy may choose tofacitinib, while others stay with biologics depending on response and coverage.

Combination Therapy

• Often used with methotrexate for RA when monotherapy is not enough.
• May be combined with other nonbiologic DMARDs (e.g., sulfasalazine, leflunomide) under supervision.
• Do not combine with biologic DMARDs or potent immunosuppressants (e.g., azathioprine, cyclosporine).
• If taking strong CYP3A4 inhibitors (e.g., ketoconazole), your prescriber may reduce the dose or choose another therapy.
• Avoid strong CYP3A4 inducers (e.g., rifampin) which can lower drug levels and reduce effect.

Patient Suitability and Cost-Saving Tips

Tofacitinib may suit adults with moderate to severe RA or PsA after inadequate response to other DMARDs, and certain adults with UC. It may not suit those with active serious infections, a history of recurrent opportunistic infections, recent blood clots, severe liver problems, or certain cancers. Adults 65+, current or past smokers, and those with cardiovascular risk factors may have higher serious risks. Live vaccines should be avoided during treatment. Discuss pregnancy plans and breastfeeding with your clinician.

To lower your Taro-Tofacitinib XR cost, consider a multi-month supply if appropriate. Per-month pricing can be lower on larger fills. You can set simple reorder reminders in your account so you do not run out. Compare the Taro-Tofacitinib XR cash price with your plan’s options. This can help if you are uninsured or seeking Taro-Tofacitinib XR uninsured pricing.

Authoritative Sources

FDA Prescribing Information for Xeljanz/Xeljanz XR (tofacitinib)

Health Canada Drug Product Database: Tofacitinib

Pfizer Product Page for Xeljanz (tofacitinib)

Order Taro-Tofacitinib XR® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This page is educational and does not replace professional medical advice. Always follow your prescriber’s directions and the patient information that comes with your medicine.