Tivicay® Tablets for HIV-1 Treatment

What Tivicay® Is and How It Works

Tivicay is the brand name for dolutegravir, an integrase strand transfer inhibitor used with other antiretrovirals to treat HIV‑1. It comes as tablets, often taken once daily. Many people ask about Tivicay coupon options and paying tivicay without insurance, and this page explains costs, benefits, and safe use.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and prescriptions are reviewed by licensed pharmacists before dispensing. We also partner with vetted, licensed international pharmacies so you can access authentic brand medicines across a wide selection at affordable prices.

Dolutegravir blocks the HIV integrase enzyme. This prevents viral DNA from inserting into human DNA, which lowers viral replication. Tivicay is indicated for adults and pediatric patients when used in combination therapy. It is not used alone. Most adults who are integrase‑inhibitor naive take 50 mg once daily. Some interactions and resistance patterns require 50 mg twice daily.

You can take Tivicay with or without food. Separate doses from products containing aluminum, magnesium, calcium, iron, or zinc, because these reduce absorption. If needed, take supplements with food at the same time as Tivicay, or separate by hours when fasting. Ask your prescriber about the dispersible pediatric formulation if swallowing tablets is hard.

Dosage and Usage

• Typical adult dose: 50 mg once daily with other antiretrovirals.
• Adults taking rifampin or certain enzyme inducers: 50 mg twice daily if appropriate.
• Documented or suspected integrase resistance: 50 mg twice daily under specialist guidance.
• Pediatric dosing is weight‑based. Follow the exact plan from your prescriber.
• Take with or without food.
• Avoid taking with aluminum/magnesium antacids. Separate by 2 hours before or 6 hours after if fasting.
• Calcium or iron supplements may be taken with Tivicay if taken together with a meal.
• Swallow tablets whole. If you have difficulty, discuss alternatives or dispersible tablets.
• Missed dose: take as soon as you remember unless it is close to the next dose. If it is within about 4 hours of the next dose, skip the missed dose. Do not double up.

• Store at 20–25 °C (68–77 °F); excursions 15–30 °C (59–86 °F).
• Keep in the original bottle with desiccant and the cap tightly closed.
• Protect from moisture. Do not store in bathrooms.
• For travel, keep medicine in your hand luggage with a copy of your prescription.
• Carry extra tablets for delays, and use a daily reminder to avoid missed doses.

Benefits and Savings

Tivicay helps lower viral load quickly and supports immune recovery when combined with a complete regimen. Once‑daily dosing for most adults makes adherence simpler. It can be paired with many backbones, giving flexibility when planning therapy. Brand Tivicay is widely used and well studied, supporting confidence in long‑term treatment.

Ordering from YouDrugstore can reduce your Tivicay cost by about 60–80% versus typical US prices. Options are available if you need to purchase tivicay without insurance. Multi‑month supplies and bulk promotions can lower your per‑month expense. You can also set gentle reorder reminders so you do not run out.

To check current promotions, see our Tivicay coupon.

Side Effects and Safety

• Common: headache, insomnia, fatigue, nausea, diarrhea.
• Less common: dizziness, abdominal pain, rash, elevated liver enzymes.
• Weight gain has been reported with integrase inhibitors.
• Mood changes, including depression or anxiety, can occur in some patients.
• Increases in serum creatinine without affecting actual kidney function may be seen.

Serious reactions are rare but include hypersensitivity with rash, fever, and organ involvement; severe skin reactions; and liver problems, especially with hepatitis B or C. Do not use with dofetilide due to life‑threatening interactions. Dolutegravir raises metformin levels; dose adjustment and monitoring may be needed. Separate from aluminum/magnesium antacids and other polyvalent cations as directed. If pregnant or planning, discuss risks and benefits, as data around periconception exposure have evolved.

Onset Time

Many patients see a clear drop in viral load within 2–4 weeks when doses are taken consistently with a complete regimen. Most achieve viral suppression within 8–24 weeks, depending on baseline viral load, adherence, and companion drugs. CD4 counts often improve over months. Individual timelines vary, and your clinician will monitor labs and adjust therapy if needed.

Compare With Alternatives

Raltegravir (Isentress) is another integrase inhibitor used with a backbone. It is well tolerated and effective, but often requires twice‑daily dosing, which may affect convenience compared to once‑daily Tivicay in many patients.

Fixed‑dose combinations simplify therapy. For example, Stribild® combines an integrase inhibitor with two nucleoside analogs and a booster in one tablet. It can be convenient, but may have specific renal and drug‑interaction considerations that differ from dolutegravir‑based regimens.

Backbone agents such as tenofovir disoproxil fumarate are commonly paired with integrase inhibitors. Viread® is a brand of tenofovir disoproxil fumarate, often combined with emtricitabine or lamivudine. Your clinician selects the backbone based on kidney health, hepatitis B status, and resistance testing.

Combination Therapy

• Tivicay with two nucleos(t)ide reverse transcriptase inhibitors (NRTIs), such as tenofovir plus emtricitabine or abacavir plus lamivudine.
• Rifampin co‑administration may require increasing Tivicay to 50 mg twice daily.
• Do not combine with dofetilide. Avoid strong inducers unless managed by a specialist.
• Dolutegravir increases metformin levels; adjust metformin dose and monitor as needed.
• If chronic hepatitis B is present, include HBV‑active agents to prevent flare or resistance.

Patient Suitability and Cost-Saving Tips

Tivicay is suitable for adults and eligible pediatric patients as part of a complete regimen. It is not used as monotherapy. Those with prior integrase inhibitor exposure or resistance may still use it, often at higher doses, under specialist care. People with active liver disease need monitoring. Severe hepatic impairment may limit use.

Avoid Tivicay with dofetilide. Review all medicines and supplements with your care team, including antacids, multivitamins, iron, calcium, magnesium, rifampin, carbamazepine, phenytoin, St. John’s wort, and metformin. If you are pregnant, planning to conceive, or breastfeeding, discuss benefits and risks to choose the right regimen.

To reduce your Tivicay price, compare 30‑, 60‑, and 90‑day fills; longer supplies often lower the per‑month cost. Plan refills ahead of travel. If you pay out of pocket or need tivicay no insurance options, check promotions and watch for bulk pricing that can reduce your cash spend.

Authoritative Sources

ViiV Healthcare Tivicay product information

FDA Prescribing Information for dolutegravir (Tivicay)

Health Canada Drug Product Database: Tivicay

Order Tivicay® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This content is for educational purposes only and does not replace advice from your healthcare professional. Always follow your prescriber’s directions for your specific treatment.