Tobi® Inhalation Solution for Cystic Fibrosis

Tobi is a prescription inhaled antibiotic used in cystic fibrosis to manage chronic Pseudomonas aeruginosa lung infections. This page explains how it works, who it’s for, and how to use it safely. We outline ways to save if you need tobramycin without insurance. Ordering is available with US delivery from Canada.

What Tobi Is and How It Works

Tobi® contains tobramycin, an aminoglycoside antibiotic formulated for inhalation. It targets Pseudomonas in the airways by inhibiting bacterial protein synthesis. Delivering the medicine directly to the lungs helps concentrate therapy where it is needed while limiting systemic exposure.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Most patients use a nebulizer compatible with the medicine’s label. Your clinician may recommend a specific compressor and nebulizer set. Do not mix this treatment with other medicines in the nebulizer cup. With a valid prescription, you can buy tobramycin inhalation solution from YouDrugstore. Follow your care team’s instructions and the official patient information.

Who It’s For

This medicine is indicated for people with cystic fibrosis aged 6 years and older who have Pseudomonas aeruginosa present in sputum cultures. It may be used as part of long-term management alongside airway clearance and other therapies. People with a known aminoglycoside allergy should not use it. Those with kidney problems, hearing or balance disorders, or who are taking other ototoxic or nephrotoxic drugs should discuss risks with a clinician before starting.

Pregnant or breastfeeding individuals should review potential risks and benefits with their prescriber. Children require supervision to ensure correct setup and inhalation technique.

Dosage and Usage

Adults and children 6 years and older typically inhale one full single-use ampule twice daily, roughly 12 hours apart, for 28 days. Then they stop for 28 days and repeat the cycle as prescribed. Do not exceed the prescribed frequency or mix the solution with other nebulized medicines.

General sequencing often places a bronchodilator first, followed by airway clearance, then other inhaled medications, and finally this antibiotic. Always follow your clinician’s order of therapies if it differs. Sit upright during inhalation, breathe through the mouthpiece steadily, and continue until the nebulizer chamber is empty. Clean and dry all nebulizer parts after each dose according to the equipment manual.

If throat irritation or cough occurs, pause briefly and resume more slowly. Reach out to your healthcare professional if symptoms persist or worsen.

Strengths and Forms

The product is supplied as sterile, preservative-free solution in single-use plastic ampules sealed in foil to protect from light. Many patients know the labeled presentation as TOBI 300 mg/5 mL inhalation solution. Availability may vary by pack size and manufacturer lot. Your exact supply may come in a boxed kit with multiple foil pouches.

Missed Dose and Timing

If you miss a dose and there is plenty of time before the next one, take it when you remember. If it is close to your next scheduled time, skip the missed dose and resume your regular schedule. Do not take two doses at once to catch up. Try to keep doses about 12 hours apart during the 28-day on-cycle for consistent coverage.

Storage and Travel Basics

Store unopened ampules as directed on the label, usually refrigerated and protected from light. Keep ampules in the foil pouch until you are ready to use one. Do not use the solution if it becomes very cloudy or markedly darker than its usual pale yellow appearance. Once an ampule is opened, use it right away and discard any leftover solution.

When traveling, pack ampules in a sealed pouch within a carry-on bag, along with your nebulizer and a copy of your prescription. Protect from extreme temperatures. Keep medicines out of reach of children. If you need a travel letter, ask your prescriber in advance.

Benefits

This inhaled antibiotic helps reduce Pseudomonas bacterial load in the lungs. Patients may notice easier breathing, less sputum burden, and fewer exacerbations over time when used as part of a comprehensive regimen. Inhalation targets the airways directly, which can support effective local action while limiting systemic exposure compared with oral aminoglycosides.

Using a nebulized formulation also allows the treatment to reach lower airways where mucus can trap bacteria. Adherence to the 28-days-on/28-days-off cycle is important to maintain benefits and help manage resistance.

Side Effects and Safety

• Cough or throat irritation
• Hoarseness or voice changes
• Increased sputum or wheeze
• Chest discomfort or shortness of breath
• Bad taste in the mouth
• Headache

Serious risks can include bronchospasm, hearing changes or ringing in the ears, balance problems, and kidney effects. The risk may be higher in those using other ototoxic or nephrotoxic drugs or with prior ear or kidney disease. Stop the medicine and seek medical help for symptoms of significant bronchospasm, hearing loss, severe dizziness, or signs of kidney problems such as reduced urine output. Report persistent or severe side effects to your prescriber promptly.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements you take. Use caution with:

• Other aminoglycosides
• Loop diuretics such as furosemide or ethacrynic acid
• Strong diuretics or osmotic agents like mannitol or urea
• Neuromuscular blockers

Concurrent use with these agents may increase the risk of hearing, balance, kidney, or neuromuscular effects. Do not mix this solution with other nebulized drugs in the same chamber. If you use multiple inhaled therapies, follow your prescriber’s sequence.

What to Expect Over Time

During an on-cycle, many patients notice gradual respiratory comfort improvements as bacterial load decreases. Some throat irritation or hoarseness can occur early and may lessen with continued use. Cultures and clinical assessment guide ongoing therapy. Off-cycles help limit resistance while maintaining benefit through repeated courses as directed by your care team.

Adherence to the two daily doses and equipment cleaning improves consistency. If you experience new or worsening wheeze or reduced hearing, contact your clinician for guidance.

Compare With Alternatives

Other inhaled options for CF-related Pseudomonas include aztreonam lysine solution (Cayston) and colistimethate sodium for inhalation, depending on availability and prescriber judgment. Systemic agents may be used for acute exacerbations or when cultures guide a different approach. Your prescriber may consider Ciprofloxacin Hcl for systemic therapy when appropriate. Treatment choice depends on culture results, prior response, and tolerance.

Pricing and Access

Check the TOBI inhalation solution price by selecting your pack size and adding to cart to see current pricing and stock. We show Canadian pricing in USD for clarity. This item Ships from Canada to US. Savings vary by product and market conditions. For general education on airway care, explore our Respiratory category or visit Cystic Fibrosis and Pseudomonas Infection pages. Checkout uses encrypted checkout for your security. If you look for seasonal offers, see our Promotions.

Availability and Substitutions

Supply can vary. If this item is temporarily unavailable, your prescriber may recommend an alternative inhaled antibiotic or an oral regimen based on cultures. We cannot promise restock dates. Ask your clinician about interim options if needed.

Patient Suitability and Cost-Saving Tips

This therapy may suit people with CF who have Pseudomonas and can use a nebulizer reliably. It may not suit those with severe hearing loss history, significant kidney disease, or known aminoglycoside hypersensitivity. Share your medical history, including current medicines and supplements, with your healthcare professional.

To manage costs, consider larger fills when appropriate, align refills with clinic visits, and set reminders so you do not miss on-cycle starts. If you have a manufacturer or payer discount, apply a TOBI coupon during checkout when eligible. For CF digestive support needs, some patients also use pancreatic enzymes; learn more about Creon® and Viokace® with your care team.

Questions to Ask Your Clinician

• Is this inhaled antibiotic appropriate for my current culture results?
• Which nebulizer system and compressor should I use at home?
• How should I schedule this medicine with my other inhaled therapies?
• What signs of ear, balance, or kidney problems should I look for?
• How often should I have hearing tests or kidney function checks?
• What should I do if I experience bronchospasm during a dose?
• When should we repeat cultures to assess response?

Authoritative Sources

FDA DailyMed

Novartis

Health Canada DPD

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