Debridat® (Trimebutine) Uses, Dosing, and Availability

What Debridat® Is and How It Works

Trimebutine is an antispasmodic and gut motility modulator used for functional gastrointestinal disorders, including irritable bowel syndrome (IBS). It acts mainly on peripheral opioid receptors within the enteric nervous system to normalize motility and reduce visceral pain. It is taken by mouth as tablets. Many patients ask if trimebutine is over the counter; in many regions it is prescription only. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and our pharmacists review prescriptions before dispensing.

We partner with licensed, vetted international pharmacies so you can access authentic brands and generics at fair prices across a broad selection.

By dampening spasms when the bowel is overactive and supporting transit when it is sluggish, trimebutine can help abdominal cramping, bloating, and irregular bowel habits. It is not FDA-approved; searches for trimebutine FDA will confirm there is no US approval. That is why it can be hard to find trimebutine CVS or trimebutine Walgreens listings, and it is also uncommon at trimebutine Boots in the UK. You can read more in our overview, Trimebutine Uses Dosage And Side Effects Explained.

Products are usually labeled as trimebutine maleate. Some labels reference trimebutine base for strength equivalence. International names include trimebutina de maleato, trimebutina maleato 150 mg, and trimebutina maleato 300 mg. Common strengths include trimebutine 100mg, trimebutine 150 mg, and 200 mg tablets. You may also see brands like apo trimebutine or trimebutine mylan, and presentations such as trimebutine 200mg mylan.

In some countries, combination packs exist, such as omeprazole trimebutine or trimébutine et omeprazole for overlap with reflux or dyspepsia symptoms, and formulations that pair ruscogenin trimebutine. Evidence and availability vary by market.

Dosage and Usage

• The usual adult dose is 100–200 mg three times daily, taken before meals as prescribed.
• Some regimens use 300 mg twice daily where available.
• Tablets are swallowed with water. Crushing or splitting should follow the product’s instructions or pharmacist guidance.
• Treatment duration depends on symptom control and the prescriber’s plan.
• If a dose is missed, take it when remembered unless it is close to the next dose. Do not double up.
• Report persistent or worsening symptoms to the prescriber.

• Store tablets at 15–25 °C (59–77 °F), away from moisture and direct heat.
• Keep in the original blister or bottle with the label intact for security checks.
• When traveling, pack your medication in carry-on luggage with your prescription.
• Do not freeze. Avoid leaving tablets in a hot car or near windows.
• Use a pill organizer and set phone reminders to keep doses on schedule.

Benefits and Savings

Trimebutine helps reduce cramping, abdominal discomfort, and irregular bowel function in IBS and related functional disorders. A steady dosing schedule often brings fewer urgent bathroom trips and less bloating. Because it targets intestinal motility and sensation, it can help both diarrhea-predominant and constipation-predominant patterns when part of a guided treatment plan.

Convenience features include multiple strengths (such as trimebutine 100mg and trimebutine 150 mg) and widely used generics like trimebutine mylan. Patients who have searched for trimebutina en estados unidos or trimebutina USA often turn to cross-border pharmacies due to limited US retail supply.

Ordering from YouDrugstore can offer 60–80% savings versus typical US pricing benchmarks. Reorder reminders help you stay on schedule, and multi-month supplies can lower the effective per-month cost when permitted by your prescription.

Side Effects and Safety

• Nausea or upset stomach
• Constipation or diarrhea
• Abdominal discomfort or bloating
• Dry mouth
• Dizziness or drowsiness
• Headache
• Skin rash or itching

Serious reactions are uncommon. Seek urgent care for signs of severe allergy (swelling of the face or throat, trouble breathing), severe dizziness, fainting, or a widespread rash. Use is not advised in known bowel obstruction or perforation. Discuss all medicines you take to avoid duplication with other antispasmodics.

Onset Time

Symptom relief for cramping and urgency may begin within a few days of regular dosing. Bowel habit regularity often improves over 1–2 weeks. The full effect for IBS patterns generally stabilizes by 3–4 weeks as the dose and timing settle. If symptoms persist beyond several weeks, the treatment plan may need adjustment by the prescriber.

Compare With Alternatives

Antispasmodic options include dicyclomine and hyoscyamine. These agents can also reduce cramping but may cause more anticholinergic effects like dry mouth or blurred vision. Trimebutine modulates motility through enteric opioid receptors, which can be preferable for some patients.

For predominant upper GI motility symptoms such as nausea or gastroparesis, prescribers may consider prokinetic therapy like Domperidone. This targets dopamine receptors to enhance gastric emptying and can complement or replace antispasmodics depending on the case.

Inflammatory bowel disease requires anti-inflammatory therapy rather than motility agents. Mesalamine products such as Pentasa® help treat bowel inflammation in ulcerative colitis. These medicines are not interchangeable with trimebutine, which is intended for functional disorders like IBS without structural inflammation.

Combination Therapy

• With acid suppression (omeprazole trimebutine): used when reflux or dyspepsia overlaps with IBS. Monitor for additive side effects such as headache.
• With fiber or osmotic laxatives: may help constipation-predominant IBS; dosing is spaced to reduce gas.
• With antidiarrheals: used short term for flares of diarrhea-predominant IBS.
• With probiotics or dietary measures: supports gut comfort alongside symptom-directed medication.
• Avoid using two antispasmodics together unless directed by a clinician.

Patient Suitability and Cost-Saving Tips

Adults with IBS-related cramping and irregularity may be candidates for trimebutine. It is not intended for acute surgical abdomen, bowel obstruction, or active gastrointestinal bleeding. Caution is advised in severe hepatic impairment and in those prone to significant dizziness or sedation.

Pregnancy data are limited. Questions about trimebutine in pregnancy or use while breastfeeding should be directed to the prescriber, who will weigh potential benefits and risks. Pediatric use is not well established in many markets.

Product labeling varies by country. You may see apo trimebutine, trimebutine mylan 100 mg, or trimebutine mylan 200 mg in international listings. Spanish-language packaging often reads trimebutina de maleato with strengths such as trimebutina maleato 150 mg and trimebutina maleato 300 mg. Availability in the United States is limited; searches for trimebutina en estados unidos often return few local options.

To manage costs, consider a multi-month supply when your prescription allows. Set up a reminder in your account so you can reorder on time and avoid gaps in therapy. Prices may differ by strength and pack size; larger quantities can reduce the monthly average cost.

Authoritative Sources

WHO ATC classification for trimebutine (A03AA05)

PubChem compound summary: Trimebutine

International brand names and availability for trimebutine

Order Debridat® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This content is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s instructions and the product labeling.