Triumeq® Tablets for HIV-1 Treatment in Adults and Adolescents

What Triumeq® Is and How It Works

Triumeq combines dolutegravir, abacavir, and lamivudine in one daily tablet for the treatment of HIV-1 in adults and adolescents weighing at least 25 kg. It belongs to the integrase inhibitor plus nucleoside reverse transcriptase inhibitor (NRTI) drug class and is used for initial therapy and switch maintenance. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. Many patients compare Triumeq cost with insurance to the cash price and discover that buying Triumeq without insurance at Canadian prices can lower costs.

Dolutegravir blocks the HIV integrase enzyme, preventing viral DNA from integrating into host DNA. Abacavir and lamivudine inhibit reverse transcriptase, which reduces viral replication. Combined, these actions lower viral load and support immune recovery. The usual route is oral tablets taken once daily with or without food. A pediatric dispersible formulation (Triumeq PD) exists for younger children; it is not interchangeable milligram-for-milligram with the tablet.

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Before abacavir-containing therapy, patients should be screened for the HLA-B*5701 allele due to the risk of serious hypersensitivity. Triumeq is a complete regimen and should not be taken with other antiretrovirals unless directed by a prescriber for a specific reason.

Dosage and Usage

• Standard Triumeq dose: one tablet (600 mg abacavir/50 mg dolutegravir/300 mg lamivudine) once daily.
• Take with or without food. Swallow tablets whole; do not crush or split.
• Antacids and mineral supplements: take Triumeq at least 2 hours before or 6 hours after aluminum/magnesium-containing products. Iron or calcium may be taken with food or separated as above.
• Missed dose: take as soon as remembered unless it is close to the next dose. Do not double up.
• Vomiting within 1 hour of a dose may reduce absorption; follow prescriber guidance for replacement dosing.
• Do not use with certain enzyme inducers (e.g., rifampin, carbamazepine, phenytoin, St. John’s wort) because dolutegravir exposure may be reduced and the fixed-dose tablet cannot be adjusted.
• Not recommended in moderate or severe hepatic impairment, or if creatinine clearance is below 50 mL/min due to the lamivudine component.
• Screen for HLA-B*5701 before starting; never restart abacavir after a suspected hypersensitivity reaction.

• Storage: store at 20–25 °C (68–77 °F); permitted excursions 15–30 °C (59–86 °F).
• Keep tablets in the original bottle with desiccant to protect from moisture.
• Travel: pack in carry-on, keep tightly closed, avoid heat and humidity. Bring extra doses for delays.
• Keep out of reach of children and pets.

Benefits and Savings

Triumeq offers a once-daily, single-tablet regimen that simplifies therapy and supports adherence. Many patients reach undetectable viral loads when they take it as prescribed. Integrase inhibitor–based regimens are well studied and generally well tolerated. The convenience of one pill can reduce pill fatigue compared with multi-drug combinations.

Canadian pharmacy pricing can offer typical 60–80% savings versus common U.S. pharmacy prices. Patients comparing Triumeq price online often find a lower Triumeq tablets price, and this can be especially helpful for those paying Triumeq cost without insurance. Multi-month supplies can further lower the per-month cost, and eligible orders may qualify for bulk promotions.

To view current promotions, see our triumeq coupon page.

We also offer reorder reminders by email so you can maintain steady treatment without last-minute rushes.

Side Effects and Safety

• Common side effects of Triumeq: nausea, diarrhea, headache, fatigue, insomnia, abnormal dreams.
• Other reported effects: dizziness, rash, increased liver enzymes, weight gain, and mood changes.
• Renal lab changes: dolutegravir can increase serum creatinine by inhibiting tubular secretion without reducing actual kidney function; providers monitor this when assessing Triumeq side effects on kidneys.
• Hypersensitivity: abacavir can cause a serious reaction involving fever, rash, gastrointestinal, and respiratory symptoms. This risk is strongly associated with HLA-B*5701 positivity.

Serious but less common risks include lactic acidosis and severe hepatomegaly with steatosis, immune reconstitution inflammatory syndrome (IRIS), severe liver problems, and rare depression or suicidal ideation. Do not restart abacavir after a suspected hypersensitivity reaction. In hepatitis B coinfection, stopping lamivudine can cause severe HBV flares. There is a precaution about neural tube defects with dolutegravir use near conception; discuss planning and risks with a qualified clinician. Some data suggest caution with abacavir in patients with high cardiovascular risk.

Onset Time

Viral load often begins to decline within 1–2 weeks of starting therapy. Many patients see substantial reductions by 4 weeks, with continued decreases toward undetectable levels over 8–24 weeks, depending on baseline viral load and adherence. CD4 counts usually rise over several months as viral suppression is maintained. Weight and laboratory changes, if they occur, are typically gradual across weeks to months.

Compare With Alternatives

Many first-line regimens use an integrase inhibitor backbone. Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) is another once-daily single-tablet option without abacavir; it can be suited to patients where abacavir is not preferred. Dovato (dolutegravir/lamivudine) is a two-drug regimen for select patients without HBV coinfection and with certain baseline criteria.

For maintenance in suppressed patients without resistance to its components, Juluca® (dolutegravir/rilpivirine) is an option, taken with a meal and separate from acid-lowering agents as directed. If a multi-pill regimen is used, raltegravir-based therapy is another route; see Isentress® for details on the integrase inhibitor component.

Choice depends on prior therapy, resistance profile, comorbidities, drug interactions, and patient preferences. A prescriber will tailor therapy to clinical needs.

Combination Therapy

• Triumeq is a complete antiretroviral regimen; do not coadminister with other HIV medications unless directed by a specialist.
• Avoid duplicated components (no additional abacavir or lamivudine).
• If rifampin is required for another condition, a different HIV regimen may be selected because Triumeq cannot be dose-adjusted.
• Separate from aluminum/magnesium antacids; take iron or calcium with food or separate by timing to maintain dolutegravir exposure.
• Coordinate dosing around treatments for opportunistic infections to avoid interactions.

Patient Suitability and Cost-Saving Tips

Triumeq may be appropriate for adults and adolescents weighing at least 25 kg who test negative for HLA-B*5701 and have no contraindications. It is not recommended for moderate to severe hepatic impairment. Because lamivudine needs renal dose adjustment, Triumeq is not advised when creatinine clearance is below 50 mL/min. In hepatitis B coinfection, additional active HBV therapy is usually required. Pregnancy planning requires individualized discussion due to precautions with dolutegravir near conception.

Those with significant cardiovascular risk should review abacavir’s risk profile with their prescriber. People taking enzyme inducers, polyvalent cation products, or certain anticonvulsants require careful interaction checks. Patients who cannot swallow tablets may ask about Triumeq PD dispersible tablets for appropriate pediatric weights.

For budgeting, compare Triumeq cash price options and Triumeq cost out of pocket across supply sizes. Multi-month quantities can lower the effective monthly price. Reorder reminders help prevent gaps in therapy. Some patients find that Triumeq cost without insurance from a Canadian pharmacy is still lower than typical U.S. retail costs.

Authoritative Sources

ViiV Healthcare Triumeq product information

Health Canada Drug Product Database: Triumeq

FDA Prescribing Information: Triumeq

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This content is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.