Trulance® for Chronic Idiopathic Constipation and IBS‑C (Plecanatide)

What Trulance® Is and How It Works

Trulance® (plecanatide) is a prescription pill used in adults for chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS‑C). It is taken once daily as 3 mg plecanatide tablets. Many people search for trulance price when comparing options for long‑term constipation care. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and prescriptions are reviewed by licensed pharmacists before dispensing.

We also source through licensed, vetted international partner pharmacies to offer authentic brand medications, a broad selection, and affordable pricing.

Plecanatide is a guanylate cyclase‑C (GC‑C) agonist that works on the surface of the intestinal lining. It increases levels of cyclic GMP, which stimulates chloride and bicarbonate secretion via CFTR channels. This draws water into the bowel, softens stools, and promotes regular movement. GC‑C activation may also reduce visceral pain signaling, which can help abdominal discomfort in IBS‑C.

Indications include adult CIC and IBS‑C. The route is oral, once daily, with or without food. The recommended strength is 3 mg. Tablets act locally in the gut with minimal systemic absorption.

Dosage and Usage

• Usual adult dose for CIC or IBS‑C: 3 mg (one tablet) once daily.
• May be taken with or without food, at any time of day.
• Swallow tablets whole. For those who cannot swallow, tablets may be crushed and mixed with applesauce or dissolved in water for immediate use.
• Do not cut the tablet to “split a dose.” The only approved strength is 3 mg.
• Missed dose: if the next dose is near, skip the missed dose. Do not take two doses at once.
• Not for pediatric use. Contraindicated in children under 6 years; avoid use in ages 6–17 years due to dehydration risk.
• Do not use in known or suspected mechanical gastrointestinal obstruction.
• Consult the product leaflet for tube administration instructions if needed.

• Store at room temperature, 20–25 °C (68–77 °F); short excursions 15–30 °C (59–86 °F) are acceptable.
• Keep tablets dry. Store in the original bottle with the desiccant. Close the cap tightly after each use.
• Avoid humidity (bathrooms) and direct heat or sunlight.
• When you travel, keep Trulance in your carry‑on in the original labeled container.
• Do not leave medicine in a parked car. Use a small pill case only if it stays dry and cool.
• If crushed and mixed for administration, use the mixture right away and do not store it.

Benefits and Savings

Trulance can increase complete spontaneous bowel movements and improve stool consistency. Many patients with IBS‑C also report less straining and reduced abdominal discomfort over time. The once‑daily dosing is simple, and the trulance pill has very low drug‑interaction potential because it acts locally in the gut.

Buying from Canada can reduce trulance cost. Typical savings are 60–80% compared with many US pharmacy prices, depending on quantity. Multi‑month supplies and bulk promotions can lower the per‑month price further, and you may turn on reorder reminders in your account so you do not run out.

There is currently no widely available plecanatide generic. If you are evaluating the cost of trulance or comparing trulance medication cost with alternatives, our site lists current pricing transparently by quantity and strength. For extra savings, see our promotions page; some customers look for a trulance coupon to check seasonal offers.

Side Effects and Safety

• Diarrhea
• Abdominal distension or discomfort
• Gas (flatulence)
• Nausea
• Dizziness or headache

Diarrhea is the most common side effect and can sometimes be severe, leading to dehydration. Stop treatment and contact a healthcare professional if severe diarrhea occurs. Trulance is contraindicated in children under 6 years because of serious dehydration risk, and use is not recommended from 6 to 17 years. Do not use with known or suspected GI obstruction. Discuss use in pregnancy or breastfeeding with a clinician; plecanatide has minimal systemic absorption, but data are limited.

Onset Time

Some people notice softer stools and easier passage within the first week. Bowel movement frequency often improves during the initial 1–2 weeks as dosing stabilizes. Abdominal symptoms in IBS‑C may take several weeks to improve. A steady response is typically assessed over 4–12 weeks; prescribers may adjust the care plan based on symptom tracking.

Compare With Alternatives

Linaclotide is another GC‑C agonist with once‑daily dosing for CIC and IBS‑C. In Canada, brand linaclotide is available as Constella®. It has a similar mechanism and side‑effect profile, with diarrhea also the most frequent adverse effect. Some people tolerate one GC‑C agonist better than the other.

Lubiprostone (Amitiza) is a chloride channel activator indicated for CIC and some other constipation conditions. It is taken twice daily with food and may cause nausea. It uses a different mechanism than plecanatide and may be considered when GC‑C agonists are not suitable.

If you are exploring broader care for constipation, review our Chronic Idiopathic Constipation category or read guidance such as IBS What Is IBS Causes Symptoms Treatment to learn about adjunct strategies.

Combination Therapy

• Dietary fiber and hydration strategies alongside plecanatide to support stool form.
• Short courses of osmotic laxatives (e.g., polyethylene glycol) during flares; stop if diarrhea develops.
• Stool softeners or gentle stimulant laxatives only under clinician guidance to avoid over‑correction.
• Antispasmodics for cramping in IBS‑C, as appropriate.
• Review all therapies if diarrhea or dehydration occurs; adjust doses or stop add‑on laxatives.

Patient Suitability and Cost-Saving Tips

Adults with CIC or IBS‑C who need a once‑daily option may be candidates for Trulance. It should not be used in children under 6 years, and use is not recommended in ages 6–17 years. Avoid use in mechanical GI obstruction. Because plecanatide works locally, systemic interactions are unlikely, but medical history still matters.

Saving on therapy helps adherence over time. Prices vary by quantity, and larger fills can reduce the per‑tablet rate. Consider ordering a multi‑month supply if your prescriber issues an extended prescription. You can set in‑account reminders to reorder before traveling or holidays. We offer prompt, express shipping across the US from Canada.

Authoritative Sources

Trulance manufacturer product information (Salix/Bausch Health)

Health Canada Product Monograph: Plecanatide (Trulance)

FDA Prescribing Information: Trulance (plecanatide)

Order Trulance® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This material is educational and not a substitute for professional medical advice, diagnosis, or treatment. Always speak with a qualified healthcare professional about your specific situation.