Trulicity® once-weekly injection pens for adults with type 2 diabetes

What Trulicity® Is and How It Works

Trulicity (dulaglutide) is a once-weekly glucagon-like peptide-1 (GLP-1) receptor agonist used to improve blood sugar in adults with type 2 diabetes. It is supplied as a single-use prefilled pen. Many shoppers compare Trulicity price options to manage ongoing therapy, especially when purchasing without insurance. Trulicity helps the body release insulin when glucose is high, reduces glucagon, and slows gastric emptying. These actions lower fasting and post-meal glucose.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. We work with vetted, licensed partner pharmacies to source authentic brand medications across a broad range at competitive, affordable pricing.

Trulicity is injected subcutaneously in the abdomen, thigh, or upper arm once every 7 days. Typical starting therapy uses the 0.75 mg/0.5 mL pen, with stepwise increases to 1.5 mg/0.5 mL, 3.0 mg/0.5 mL, and 4.5 mg/0.5 mL as tolerated to reach goals. It can be used alone or with other diabetes medicines such as metformin, SGLT2 inhibitors, or basal insulin. It is not for type 1 diabetes or diabetic ketoacidosis.

Dosage and Usage

• Initiation: Many patients start at 0.75 mg once weekly to limit stomach side effects.
• Titration: Increase to 1.5 mg after at least 4 weeks if more glucose lowering is needed. Some may advance to 3.0 mg, then 4.5 mg based on response and tolerability.
• Weekly schedule: Inject the same day each week, any time of day, with or without food.
• Missed dose: If the next scheduled dose is 3 or more days away, take the missed dose as soon as possible. If fewer than 3 days remain, skip the missed dose and resume on the next scheduled day.
• Injection sites: Abdomen, thigh, or upper arm. Rotate sites to reduce irritation.
• Device steps: Wash hands. Check the pen label and expiration. Remove the base cap. Place the base flat against the skin at the chosen site. Unlock if applicable. Press and hold the green injection button until a second click is heard and the indicator shows completion. Dispose of the pen in a sharps container.

• Storage: Refrigerate pens at 2–8 °C (36–46 °F). Do not freeze. Keep in the original carton to protect from light.
• Room temperature option: If needed, a pen may be kept at up to 30 °C (86 °F) for a single period of up to 14 days.
• Handling: Do not use if the pen has been frozen, dropped on a hard surface, or appears damaged or cloudy.
• Travel: Keep pens in an insulated bag with cold packs. Do not place pens directly on ice. Carry a backup pen and needles as directed. Keep a copy of your prescription for airport security.
• Shipping: Orders are packed with prompt, express, cold-chain shipping to protect temperature-sensitive items.

Benefits and Savings

Trulicity improves A1C and fasting glucose, and many patients see modest weight reductions. Weekly dosing simplifies routines compared with daily injections. Higher strengths such as the 3.0 mg and 4.5 mg pens can deliver additional A1C lowering in some patients when stepped up gradually. Many adults also value fewer mealtime dose decisions.

Buying from Canada can lower costs. Typical savings are about 60–80% versus many US retail prices, which can help with Trulicity monthly cost planning. Patients often ask about Trulicity out of pocket expenses; ordering through YouDrugstore may reduce the Trulicity cash price compared with local options. These savings matter when paying without insurance.

Looking for ways to save? See current offers; if available, a simple page may mention a Trulicity coupon: https://youdrugstore.com/promotions.

We stock multiple strengths, including Trulicity 0.75 mg 0.5 mL pen for starting therapy, the Trulicity 1.5 mg 0.5 mL pen for common maintenance, and higher-dose options up to the Trulicity 4.5 mg pen for intensified control as directed. This selection supports smooth titration without switching brands.

Side Effects and Safety

• Common: Nausea, vomiting, diarrhea, decreased appetite, stomach pain, indigestion.
• Other: Fatigue, constipation, burping, injection-site redness or itch.
• Usually transient: Gastrointestinal effects often lessen over several weeks after each dose increase.
• Hypoglycemia: Risk increases when used with insulin or a sulfonylurea; dose adjustments of those agents may be needed.

Serious but less common risks include pancreatitis, gallbladder issues, kidney problems from dehydration, and allergic reactions. Trulicity carries a boxed warning about thyroid C-cell tumors observed in rodents. Do not use if you or a family member has a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2). Seek urgent care for severe abdominal pain or signs of an allergic reaction.

Onset Time

Some glucose improvement may appear within the first 1–2 weeks, particularly after meals. A1C changes build over 8–12 weeks as weekly dosing stabilizes. Weight shifts often begin over 4–12 weeks and may continue gradually with sustained therapy and lifestyle changes. If a dose increase is made, allow several weeks for the new dose to show full effect.

Compare With Alternatives

Liraglutide is a daily GLP-1 analog. It offers similar benefits but requires more frequent injections. If a once-weekly schedule is preferred, Trulicity may be more convenient. You can review daily liraglutide details here: Victoza® Prefilled Pen.

Oral semaglutide provides GLP-1 therapy in tablet form. It can suit those avoiding injections but has strict dosing on an empty stomach. Compare here: Rybelsus®.

SGLT2 inhibitors such as canagliflozin are another class that lowers glucose by increasing urinary glucose excretion. These agents complement GLP-1 therapy for broader cardiometabolic benefits in appropriate patients.

Combination Therapy

• With metformin: Common first-line base; complementary mechanisms.
• With SGLT2 inhibitors: May improve A1C, weight, and cardiorenal outcomes.
• With basal insulin: Consider reducing basal dose to lower hypoglycemia risk; monitor closely.
• With sulfonylureas: Lower the sulfonylurea dose if hypoglycemia occurs.
• Not for type 1 diabetes or diabetic ketoacidosis.

Patient Suitability and Cost-Saving Tips

Good candidates often include adults with type 2 diabetes who need better glycemic control or who prefer a weekly pen. Trulicity injection is not recommended for those with a personal or family history of MTC or MEN 2, a prior serious hypersensitivity to dulaglutide, or a history suggesting pancreatitis risk. Use caution with severe gastrointestinal disease, such as gastroparesis.

Discuss use during pregnancy or breastfeeding with a qualified professional. Those with kidney problems should monitor hydration during gastrointestinal side effects. Vision changes should be reported promptly. Always follow the prescriber’s plan for Trulicity pen dosage and ongoing monitoring.

To lower ongoing costs, consider multi-month supplies when appropriate; larger fills can reduce the Trulicity cost per month. Set simple reorder reminders so you do not miss a weekly dose. There is no generic dulaglutide, so comparing dulaglutide price sources can help. Many patients also compare Trulicity for sale listings to evaluate reputable suppliers when paying without insurance.

Authoritative Sources

Eli Lilly Trulicity Full Prescribing Information (US)

FDA Label and Medication Guide for Dulaglutide

Health Canada Drug Product Database: Trulicity

Order Trulicity® from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This content is for educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Always speak with a qualified healthcare professional about your health and medications.