Trulicity® (dulaglutide) once-weekly injection for type 2 diabetes

What Trulicity® Is and How It Works

Trulicity® (dulaglutide) is a once-weekly GLP-1 receptor agonist used to improve blood sugar control in adults with type 2 diabetes. It comes as a prefilled, single-dose pen for subcutaneous injection. Many people compare Trulicity price, dosing convenience, and outcomes when deciding on a weekly GLP-1. This page offers clear information to help you discuss options with your healthcare provider.

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GLP-1 medicines mimic a natural hormone that helps the body release insulin when blood sugar rises. Trulicity® slows stomach emptying and reduces appetite, which may reduce A1C and weight. It can be used alone or with other diabetes medicines. It is not insulin and is not for type 1 diabetes or diabetic ketoacidosis.

Dosage and Usage

Follow your prescriber’s directions. Typical schedules use once-weekly dosing on the same day each week. Pens are single-use and already contain the dose.

• Starting dose: 0.75 mg once weekly.
• Usual step-up: 1.5 mg once weekly after assessing tolerance and targets.
• Higher options: 3.0 mg or 4.5 mg once weekly for added A1C lowering when appropriate.
• Trulicity 1.5 mg 0.5 mL pen is a common maintenance strength.
• Missed dose: take as soon as possible if 3 days remain until the next dose; otherwise skip and resume the regular day.
• Injection sites: abdomen, thigh, or upper arm. Rotate sites.
• With or without food.

Storage and travel tips:

• Refrigerate at 2–8°C (36–46°F). Do not freeze.
• Keep in the original carton to protect from light.
• Before injecting, allow the pen to reach room temperature for comfortable use.
• At room temperature, pens may be stored up to 14 days. Do not expose above 30°C (86°F).
• Use a sharps container for used pens.

Benefits and Savings

Trulicity® can reduce A1C and help lower fasting and post-meal glucose. Many patients also see modest weight loss over time. The once-weekly schedule reduces daily injections. Pens require no mixing and have a hidden needle, which simplifies use.

Ordering through Youdrugstore is straightforward, and you can reorder by phone or online. You can set friendly reminders so you do not run out. Buying multi-month supplies often lowers the per-month cost, and we sometimes run bulk promotions. Many customers report 60–80% savings compared with typical US prices.

Side Effects and Safety

Common side effects often start when therapy begins or when the dose increases. They usually lessen over several weeks.

• Nausea, vomiting, diarrhea, or constipation
• Decreased appetite, abdominal pain, indigestion, or gas
• Fatigue or headache

Serious effects are uncommon but need urgent care:

• Signs of pancreatitis: severe abdominal pain that may spread to the back
• Gallbladder problems: persistent upper-right abdominal pain, fever, jaundice
• Severe allergic reaction: swelling of face or throat, trouble breathing
• Worsening kidney function, especially with dehydration from vomiting/diarrhea
• Low blood sugar when used with insulin or a sulfonylurea

Boxed warning: GLP-1 receptor agonists, including Trulicity®, caused thyroid C-cell tumors in rodents. The relevance to humans is unknown. Do not use if you or a family member has medullary thyroid carcinoma (MTC) or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Not for type 1 diabetes or DKA. Tell your prescriber about any history of pancreatitis, gallbladder disease, severe GI disease, or kidney problems. Discuss pregnancy and breastfeeding plans before starting.

Onset Time

Trulicity® starts working after the first injection. Blood sugar effects appear within the first week. Most people see meaningful A1C changes over 4 to 12 weeks as steady levels are reached. Weight changes generally take longer and vary by dose and diet.

Compare With Alternatives

Ozempic (semaglutide) is another weekly GLP-1 that may offer larger A1C and weight changes at higher doses, but tolerability and insurance coverage can differ. A daily GLP-1 option is Victoza® Prefilled Pen (liraglutide), which some prefer for smaller daily steps during titration. For those who want an oral GLP-1, Rybelsus® (oral semaglutide) avoids injections but needs strict timing before meals.

Other classes can be combined with GLP-1 therapy, such as SGLT2 inhibitors like Invokana® (canagliflozin) to support kidney and heart outcomes in appropriate patients. Choice depends on A1C goals, weight priorities, side-effect tolerance, and cost.

Combination Therapy

Trulicity® is often added to metformin when A1C remains above target. It can be used with SGLT2 inhibitors, thiazolidinediones, basal insulin, or sulfonylureas. Your prescriber may reduce doses of insulin or sulfonylureas to lower hypoglycemia risk. Do not combine two GLP-1 receptor agonists. Using a GLP-1 with a DPP-4 inhibitor usually offers little extra benefit.

Patient Suitability and Cost-Saving Tips

This medicine is for adults with type 2 diabetes who need A1C reduction and prefer weekly dosing. It is not for type 1 diabetes. People with a history of pancreatitis, severe GI disease, MTC, or MEN 2 should not use it. Dose selection and titration depend on glucose levels, tolerability, and goals. Ask your clinician how Trulicity® fits with your plan for Type 2 Diabetes and related risks like Obesity.

To manage budget, compare strengths and refill intervals to reduce waste. Multi-month orders can lower the trulicity monthly cost on a per-pen basis. Consider a reorder reminder before travel, and use cold packs to protect pens. For savings and bulk options, see our current offers and any trulicity coupon. We also share practical guidance in our articles, including Thinking About Trulicity Weight Loss Read This First and How To Break A Weight Loss Plateau And Stay Motivated.

Authoritative Sources

For detailed prescribing and safety information, review the manufacturer and regulator materials below:

• Eli Lilly Trulicity Prescribing Information (US)
• Health Canada Drug Product Database: Trulicity
• Official Trulicity Patient Site (Lilly)

You can order online or by phone with Youdrugstore. Our team supports your purchase from checkout to delivery. We use prompt, express, cold-chain shipping to protect temperature-sensitive medicines.

This content is for general education. It does not replace guidance from your healthcare professional. Always follow your prescriber’s directions and the pen Instructions for Use. All trademarks are the property of their owners.