Truqap® (capivasertib) tablets for HR+ HER2- advanced breast cancer

What Truqap® Is and How It Works

Truqap® contains capivasertib, a targeted cancer medicine. It is an oral AKT inhibitor used with fulvestrant to treat adults with hormone receptor–positive, HER2‑negative advanced or metastatic breast cancer that carries certain AKT1, PIK3CA, or PTEN alterations. Many patients search for truqap capivasertib without insurance, and YouDrugstore helps with access and clear pricing. The focused term Truqap (Capivasertib) often reflects interest in brand details and clinical use.

Capivasertib blocks AKT signaling (AKT1/2/3). This pathway drives tumor growth and survival. By inhibiting it, Truqap® can slow cancer cell proliferation and increase the effect of endocrine therapy like fulvestrant. The usual schedule follows a 4-days-on, 3-days-off pattern within 28‑day cycles.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba. Our pharmacists review every prescription before dispensing, and we offer brand and generic medicines at Canadian prices. We also carry OTC health products and provide friendly customer-service chat during posted office hours. We source through licensed, vetted partner pharmacies abroad to offer authentic brands, a wide selection, and fair pricing.

Dosage and Usage

Follow your oncology team’s instructions and the product insert. General guidance:

• Recommended adult dose: 400 mg by mouth twice daily on Days 1–4 of each week, then 3 days off, repeated in 28‑day cycles with fulvestrant.
• Swallow tablets whole with water. Take with or without food.
• Avoid strong CYP3A inhibitors or inducers and grapefruit products unless your prescriber adjusts therapy.
• Missed dose: take it if there are 4 hours or more before the next dose; otherwise skip. Do not double up.
• If you vomit after a dose, do not take an extra dose. Resume the next scheduled dose.
• Dose interruptions or reductions may be needed for side effects (for example, rash, diarrhea, or high blood sugar).
• Your care team may monitor glucose, skin, blood counts, and liver tests during treatment.
• Store tablets at room temperature in the original container, protected from moisture and heat.

Ask your pharmacy about safe handling at home. Keep away from children and pets.

Benefits and Savings

In a pivotal study (CAPItello‑291), Truqap® plus fulvestrant extended progression‑free survival compared with placebo plus fulvestrant. The benefit was notable in tumors with AKT‑pathway alterations. Many patients value the oral schedule and predictable “4‑days‑on/3‑days‑off” cadence.

Ordering through our Canadian pharmacy can lower the Truqap® capivasertib cost versus typical US pricing. Savings often fall in the 60–80% range, depending on strength and pack size. We serve patients who need Truqap® capivasertib without insurance or who face high copays, and we provide clear, itemized invoices.

Side Effects and Safety

Not all patients experience side effects, and severity varies. Known effects include:

• Diarrhea, nausea, vomiting, decreased appetite
• Rash or dermatitis, dry skin, pruritus
• Fatigue, mouth sores (stomatitis)
• Hyperglycemia (high blood sugar)
• Anemia or other lab changes

Serious risks can occur:

• Severe hyperglycemia or ketoacidosis
• Severe skin reactions
• Significant dehydration from gastrointestinal losses
• Liver enzyme elevations

Tell your healthcare provider about all medicines and supplements. Strong CYP3A inhibitors or inducers can change capivasertib levels. Avoid grapefruit or Seville oranges. Use effective contraception during treatment and for the period recommended after the last dose. Do not use in pregnancy. Breastfeeding is not recommended while on therapy.

Onset Time

Targeted therapies work over time. You may not feel changes right away. In studies, tumor assessments were scheduled every few weeks. Clinicians judge response with imaging, labs, and symptoms across multiple cycles. Keep all appointments and share any new or worsening effects with your care team.

Compare With Alternatives

For HR‑positive, HER2‑negative advanced breast cancer with pathway alterations, alternatives may include the PI3K inhibitor alpelisib (with fulvestrant) or the mTOR inhibitor everolimus (with endocrine therapy). Many patients also receive CDK4/6 inhibitors earlier in the treatment course, such as palbociclib, ribociclib, or abemaciclib with aromatase inhibitors or fulvestrant.

These options differ in targets, side‑effect profiles, and monitoring needs. For example, alpelisib often requires close glucose management, and CDK4/6 inhibitors may affect blood counts. Your oncology team selects therapy based on prior treatments, biomarkers, comorbidities, and goals of care.

YouDrugstore also carries other oncology medicines used for different cancers, such as Bavencio® and Zytiga®. Ask our team about availability and pricing for your prescription.

Combination Therapy

Truqap® is given with fulvestrant. Fulvestrant is administered by intramuscular injection on a set schedule. This combination targets hormone signaling and the AKT pathway together. In premenopausal patients, ovarian suppression may be part of the regimen as directed by the oncologist. Other supportive medicines may be used to help manage rash, diarrhea, or glucose changes when appropriate.

Patient Suitability and Cost-Saving Tips

Truqap® is intended for adults with HR‑positive, HER2‑negative advanced or metastatic breast cancer that has certain AKT‑pathway alterations and has progressed after endocrine‑based therapy. It may not suit patients with uncontrolled diabetes, severe hepatic impairment, or those who are pregnant or breastfeeding. Suitability and dosing are decided by the treating oncologist based on the full clinical picture.

If you are looking to reduce the Truqap® capivasertib price, consider these options:

• Ask your prescriber about a multi‑month supply. Larger fills can lower the per‑month cost.
• Use our reorder reminders so you do not run out between cycles.
• Compare strengths and pack sizes for the best unit price shown on the product page.
• Check our promotions page for bulk offers and seasonal deals.

See current offers, including any truqap capivasertib coupon, on our promotions page.

For condition education, browse our Cancer category. If you want general tips on managing oncology side effects, you may find practical ideas in articles like Common Darzalex Side Effects And Tips To Manage Them and insights on targeted therapy in Understanding Calquence Medication For Cancer Treatment. These are not substitutes for your care team’s guidance, but they can help frame good questions.

Authoritative Sources

Review full prescribing details on the manufacturer’s site at AstraZeneca’s Truqap page. You can also consult the Health Canada Drug Product Database and the FDA Prescribing Information for capivasertib.

You can order from YouDrugstore, a licensed Canadian pharmacy. Our pharmacists review your Truqap® prescription, and our team supports you with caring service. We offer discreet packing and prompt, express, cold-chain shipping to the US where required.

This information is educational and does not replace your oncologist’s advice. Always follow your prescriber’s instructions and the patient information leaflet for your specific product.