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Tukysa

Breast Cancer, Cancer

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Tukysa is a targeted oral therapy used to treat HER2-positive breast cancer that has spread to other parts of the body, including the brain. It is typically used in combination with trastuzumab and capecitabine in patients who have received prior treatments. Tukysa works by blocking the HER2 protein, which fuels the growth of certain breast cancer cells.

Benefits

  • Specifically targets HER2-positive breast cancer cells, helping to slow or stop their growth.
  • Effective even in patients with brain metastases.
  • Used in combination therapy to enhance treatment results.
  • Oral medication that can be taken at home.
  • May extend survival and delay disease progression in advanced stages.

Dosage

  • The usual dose is 300 mg twice daily (two 150 mg tablets per dose).
  • Taken in combination with trastuzumab and capecitabine.
  • Should be taken approximately 12 hours apart, with or without food.
  • Swallow tablets whole with water — do not crush, chew, or split them.

Warnings and Precautions

  • May cause liver problems — liver function should be monitored regularly.
  • Can cause diarrhea — patients should be monitored for dehydration and treated promptly.
  • May affect kidney function or alter electrolyte levels.
  • Should not be used during pregnancy or breastfeeding.
  • Inform your doctor about any other medications, as Tukysa can interact with several drugs.

Usage Instructions

  • Take twice daily, at the same times each day.
  • Swallow tablets whole with water.
  • Continue treatment as prescribed unless your doctor advises otherwise.
  • If you miss a dose and it has been less than 8 hours, take it. If more than 8 hours, skip it.
  • Follow your doctor’s instructions carefully and attend all monitoring appointments.

Storage Information

  • Store at room temperature (20°C to 25°C).
  • Keep tablets in their original bottle with the lid tightly closed.
  • Protect from moisture and heat.
  • Keep out of reach of children and pets.

Common Side Effects

  • Mild to moderate effects: diarrhea, fatigue, nausea, vomiting, mouth sores, loss of appetite, or redness and swelling of the hands and feet.
  • Serious (seek medical attention): signs of liver damage (yellowing of the skin or eyes, dark urine), severe or persistent diarrhea, or symptoms of allergic reaction such as rash, itching, or difficulty breathing.

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