Tukysa® Tablets for HER2-Positive Breast Cancer

Tukysa® is a prescription HER2-directed tablet used with other medicines for certain advanced breast cancers. This page explains how it works, typical use, safety, and how to access Canadian options with US delivery from Canada. You can review Tukysa price without insurance and plan conversations with your clinician.

What Tukysa Is and How It Works

Tukysa contains tucatinib, a kinase inhibitor that targets the HER2 receptor. It is typically used with trastuzumab and capecitabine for adults with unresectable or metastatic HER2-positive breast cancer, including patients with brain metastases. By selectively inhibiting HER2 signaling, the treatment may help slow cancer cell growth and spread.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine is taken by mouth. It is designed for continuous dosing, as directed by your prescriber. Your care team may monitor your liver tests and manage diarrhea early, which supports continued therapy. When reading about combinations, remember each component has its own directions and precautions.

For background on related therapies and terms, you can browse our overview in Cancer Drugs List.

Who It’s For

This therapy is for adults with HER2-positive breast cancer that is unresectable or metastatic. It is commonly used after prior anti-HER2 treatment. Your oncologist decides if this combination is appropriate based on tumor markers, prior therapies, symptoms, and imaging.

It should not be used during pregnancy. Effective contraception is recommended during treatment and for a period after the last dose as directed on the official label. Do not breastfeed while taking this medicine. People with significant liver issues or severe uncontrolled diarrhea may need closer monitoring or another approach.

To read about the condition itself, see our category page for Her2 Positive Breast Cancer.

Dosage and Usage

Follow the directions on your prescription label and the official prescribing information. Tablets are swallowed whole with water. You may take doses with or without food. Do not chew, crush, or split the tablets. If you also receive capecitabine and trastuzumab, follow their schedules separately and keep a written plan so times stay clear.

Try to take the treatment at the same times each day. This helps maintain steady levels. If your clinician adjusts dosing because of liver test changes or other effects, follow their new instructions carefully. Keep a medication list with you at appointments and note any new symptoms, especially diarrhea, nausea, fatigue, or skin changes on the hands and feet.

Strengths and Forms

The product is supplied as film-coated tablets in commonly published strengths of 50 mg and 150 mg. Packaging and availability may vary by supplier and time. Your prescription will specify the strength and number of tablets needed for your regimen.

Missed Dose and Timing

If you miss a dose, take the next dose at the regular time. Do not double up to make up for a missed tablet. If you vomit after taking a dose, do not take an extra tablet; wait until the next scheduled time. Use a phone reminder or pill organizer to help keep your schedule consistent.

Storage and Travel Basics

Store tablets at room temperature in the original container. Keep the bottle closed tightly to protect from moisture. Place it out of reach of children and pets. Do not store in a bathroom cabinet where humidity can build up. Check the label for any additional handling instructions from the manufacturer.

When traveling, keep your medicine in carry-on luggage along with your prescription details. A simple medication list can help during security checks or unexpected care visits. Do not repack tablets into unlabeled bags. If your trip crosses time zones, align doses to your home schedule first, then gradually adjust at your clinician’s direction. Bring extra tablets in case plans change.

Benefits

This therapy adds a targeted HER2 inhibitor to established combination partners. It offers an oral option that you can take at home, which may simplify day-to-day routines compared with certain infusions. The class has evidence in patients with brain metastases when used as directed in the approved combination.

Having a consistent daily schedule and early side-effect management can support tolerability. Your team will track labs and symptoms to help you stay on treatment when appropriate. If adjustments are needed, they will guide you.

Side Effects and Safety

• Diarrhea
• Nausea or vomiting
• Fatigue
• Decreased appetite
• Hand–foot skin changes
• Stomatitis or mouth soreness
• Rash
• Elevations in liver enzymes

Serious or rare risks include severe diarrhea, significant liver injury, severe skin reactions, and embryo–fetal toxicity. The medicine may raise serum creatinine by affecting renal transporters without reducing kidney function; your clinician interprets these labs in context. Contact your healthcare professional for worsening symptoms such as persistent diarrhea, yellowing of the skin or eyes, severe abdominal pain, or signs of dehydration.

Drug Interactions and Cautions

Tucatinib is metabolized mainly by CYP2C8, with a contribution from CYP3A. Strong inhibitors or inducers of these enzymes can change drug levels. Certain antifungals, antibiotics, anticonvulsants, and herbal products such as St. John’s wort may interact. Your prescriber and pharmacist will review your full medication list, including over-the-counter products and supplements.

This medicine can affect transporters involved in creatinine handling. You may see a small rise in creatinine without an actual drop in kidney filtration. Your care team may advise baseline and periodic liver tests. Avoid starting or stopping interacting medicines unless your prescriber agrees. Alcohol intake can worsen dehydration or liver strain; ask about limits appropriate for you.

What to Expect Over Time

The first weeks often focus on getting into a steady rhythm and preventing diarrhea. Keep antidiarrheal guidance from your care team close at hand, and stay hydrated. Many people find a simple log of doses and symptoms helpful at follow-up visits. Imaging and lab results guide ongoing decisions rather than how you feel day to day.

If treatment is continued, your pharmacy schedule will settle into predictable refills. You can order tucatinib online from our pharmacy once your prescription is on file, or request a refill reminder before you run low. For added education, see our article on Breast Cancer Management.

Compare With Alternatives

Other oral options for breast cancer include CDK4/6 inhibitors used in specific subtypes. For hormone receptor–positive disease, your clinician may consider Ibrance or Verzenio with endocrine therapy when appropriate. These are not direct substitutes for HER2-directed regimens, but they illustrate how modern targeted therapies differ by tumor biology. Your oncology team will match the right class to your cancer profile.

Pricing and Access

We list current options so you can compare tucatinib price with other sourcing routes. If you are paying cash, you will also see Tukysa Canadian pricing alongside dispensing details. US shipping from Canada is available to eligible states once your prescription is verified. For occasional offers, check our promotions page. Our checkout is encrypted to help protect your information.

To view what you will pay at checkout, add the quantity your prescriber recommends and continue to the cart. If you need help matching bottle sizes to your regimen, contact our team before placing an order. You can browse broader oncology options under Cancer for context and planning.

Availability and Substitutions

Supply can vary. If this product is temporarily unavailable, your prescriber may recommend another regimen that fits your tumor type and prior therapies. We cannot suggest changes to your treatment plan; discuss all adjustments with your oncology team to ensure clinical fit.

Patient Suitability and Cost-Saving Tips

Adults with confirmed HER2-positive disease who have received prior HER2 therapy are typical candidates. People who are pregnant or planning pregnancy should avoid treatment. If your clinician clears you for therapy and you prefer a mail-service pharmacy, you can buy Tukysa tablets after your prescription is received. Consider aligning refills with clinic visits so lab results and questions are reviewed together.

To reduce costs over time, ask your prescriber whether a multi-month fill is appropriate. Larger quantities can reduce per-shipment fees. Set refill reminders so you never rush orders. If insurance coverage is limited, your care team may direct you to assistance resources. For general learning on endocrine and targeted options, you can also read Fulvestrant Injection guides and related topics.

Questions to Ask Your Clinician

• Is this HER2-directed combination right for my cancer stage?
• How will you monitor my liver tests during treatment?
• What should I do at the first sign of diarrhea?
• Do any of my current medicines interact with tucatinib?
• How long should I use contraception after the last dose?
• How will we coordinate scans and refills to avoid gaps?
• What symptoms should prompt a call between visits?

Authoritative Sources

FDA Prescribing Information

Health Canada Drug Product Database

Manufacturer Site

Ready to proceed? Ships from Canada to US with prompt, express, cold-chain shipping and temperature-controlled handling when required. Our team can help with Tukysa US shipping, ordering steps, and storage basics. This page is informational and does not replace medical advice from your healthcare professional.