Verzenio® Tablets for HR+ HER2- Breast Cancer

Verzenio is a prescription CDK4/6 inhibitor for certain breast cancers. This page explains how it works, safety considerations, and access options with US delivery from Canada. If comparing Verzenio price without insurance, the sections below outline key points to discuss with a prescriber.

What Verzenio Is and How It Works

Verzenio® contains abemaciclib, a cyclin-dependent kinase 4 and 6 inhibitor. It helps slow cancer cell growth by blocking cell cycle progression in tumors that are hormone receptor positive and HER2 negative. It is used alone or with endocrine therapy, depending on the treatment setting and prior therapies.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine is FDA- and Health Canada-approved for adults with HR+, HER2- advanced or metastatic breast cancer. It may be combined with an aromatase inhibitor or fulvestrant, or used as monotherapy when appropriate. For early, high-risk disease, it may be prescribed in combination with adjuvant endocrine therapy. See the official label for full indications and limitations of use. For condition context, explore Hormone Receptor Positive Breast Cancer.

Who It’s For

This treatment is for adults with HR+, HER2- breast cancer in two main settings:

• Advanced or metastatic disease, typically with endocrine therapy
• High-risk early disease, alongside adjuvant endocrine therapy

It is not for people with a known hypersensitivity to abemaciclib or tablet components. Use during pregnancy can harm an unborn baby. Breastfeeding is generally not recommended during therapy and for a period after the last dose per the label. Those with significant liver impairment, a history of blood clots, or lung inflammation need careful evaluation by a prescriber. For broader topics, see Metastatic Breast Cancer.

Dosage and Usage

Typical regimens follow the product label. Abemaciclib is commonly taken twice daily, usually in combination with endocrine therapy for most indications. When used as monotherapy, a different dose may apply. Tablets can be taken with or without food. Swallow tablets whole; do not crush, chew, or split.

Gastrointestinal effects can occur early. Anti-diarrheal measures may be needed as directed by a clinician. Adequate hydration is important. Strong CYP3A modulators can affect drug levels; grapefruit and grapefruit juice should be avoided. Blood tests are routinely checked for neutropenia and liver function. Follow the official label and prescriber guidance for dose holds or adjustments when necessary.

Strengths and Forms

Abemaciclib is available as film-coated tablets in multiple strengths, commonly published as 50 mg, 100 mg, 150 mg, and 200 mg. Availability can vary by market and manufacturer packaging.

Missed Dose and Timing

If a dose is missed or vomiting occurs after dosing, do not take an extra tablet. Resume with the next scheduled dose at the usual time. Avoid doubling doses. Consistent timing helps maintain steady exposure over days and weeks, but precise instructions should follow the official label.

Storage and Travel Basics

Store tablets at room conditions in the original container with the desiccant. Keep the bottle closed tightly and protect it from moisture. Place out of reach of children and pets. Do not store in a bathroom or any humid space.

When traveling, keep the prescription label visible and carry the medicine in hand luggage. Pack enough supply for the trip plus a small buffer. A copy of the prescription and the prescriber’s contact details can simplify security checks and refills away from home. Use a reminder system for regular dosing, especially across time zones.

Pen Handling and Sharps Disposal

Abemaciclib is an oral tablet. No pen assembly is required, and no sharps disposal is needed.

Benefits

This therapy targets a key signaling pathway involved in tumor cell proliferation. It offers an oral option that can be combined with endocrine agents in appropriate settings. Twice-daily dosing provides steady exposure. Ongoing therapy may continue while clinical benefit persists and side effects remain manageable, as guided by the prescriber and label.

Side Effects and Safety

• Diarrhea, nausea, vomiting, abdominal pain
• Decreased appetite, weight loss, fatigue
• Neutropenia and infections
• Anemia and thrombocytopenia
• Elevated liver enzymes
• Headache and dizziness

Serious risks can include severe neutropenia with infection, interstitial lung disease or pneumonitis, liver injury, and venous thromboembolism. Treatment may be interrupted or adjusted if significant toxicity occurs. Routine blood work is standard. Seek urgent care for fever, chest pain, shortness of breath, or signs of clotting or severe infection. Review the Medication Guide and full Prescribing Information for complete safety details.

Drug Interactions and Cautions

Strong CYP3A inhibitors may raise abemaciclib levels, while strong inducers can lower exposure. Examples include certain antifungals, macrolides, antivirals, and anticonvulsants. Avoid grapefruit products. Anticoagulants and antiplatelet agents may increase bleeding risk. St. John’s wort is not recommended. Alcohol may worsen dizziness or stomach upset. Provide a full medication list, including over-the-counter products and supplements, to the healthcare professional managing therapy.

What to Expect Over Time

Gastrointestinal symptoms often appear early and may improve with supportive care. Blood counts and liver tests are assessed regularly. The prescriber evaluates response over time using clinical exams and imaging when appropriate. Treatment continues while benefit outweighs risks, consistent with label guidance. Keeping a symptom diary and bringing it to clinic visits can help guide adjustments if needed.

Compare With Alternatives

Other CDK4/6 inhibitors include Ibrance® and Kisqali®. These agents share a class mechanism but differ in dosing schedules, monitoring, and certain adverse-effect profiles. Endocrine backbones may include aromatase inhibitors or fulvestrant, selected based on prior treatments and menopausal status. For broader oncology options, browse our Cancer category and read the overview in Cancer Drugs List.

Pricing and Access

Canadian sourcing can help patients evaluate Abemaciclib price alongside local options. This store lists current availability and formats when in stock. We provide transparent details so patients and caregivers can compare pharmacy pathways responsibly.

US shipping from Canada is available where permitted. Many patients review Verzenio monthly cost, copay programs, and financial assistance offered by manufacturers or third parties. You can review product pages, add items to the cart, and save quotes for discussion with a prescriber. For periodic deals, visit Promotions. Checkout uses encrypted processing to protect personal data.

Availability and Substitutions

Supply can vary by strength and package configuration. If a particular presentation is not available, a prescriber may recommend another strength or an alternative therapy in the same class. We do not provide medical advice; clinical substitutions require a valid prescription and clinician oversight.

Patient Suitability and Cost-Saving Tips

Good candidates typically have HR+, HER2- disease and are appropriate for combination therapy or monotherapy per label. Those with prior intolerance to CDK4/6 inhibitors, poor marrow reserve, uncontrolled infections, or severe hepatic impairment may need careful risk assessment. Contraception is advised during treatment and for a time after the last dose; consult the label for specifics.

To manage expenses, consider multi-month fills when appropriate, discuss generic and brand options with the prescriber, and coordinate lab schedules to avoid unnecessary visits. Use refill reminders and calendar alerts to prevent gaps during travel. Keep medicines in original packaging to simplify customs checks and pharmacy transfers.

Questions to Ask Your Clinician

• How will this therapy be combined with my current endocrine plan?
• Which lab tests and how often will monitoring occur?
• What are early signs of diarrhea or infection that require attention?
• Do any of my medicines interact through CYP3A pathways?
• What steps should I take if I develop shortness of breath or chest pain?
• How long might treatment continue if it remains tolerable?

Authoritative Sources

• FDA Prescribing Information (DailyMed/FDA)
• Health Canada Drug Product Database
• Manufacturer Product Site

Learn More

For endocrine therapy context, explore Anastrozole For Breast Cancer and Afinitor Uses. These resources outline mechanisms, administration, and common safety considerations relevant to breast oncology.

Ready to proceed? Add the medicine to your cart, upload the prescription, and choose prompt US shipping from Canada. This information is not medical advice; always follow the official label and your prescriber’s directions.