Verzenio® (abemaciclib) Tablets for HR+ HER2- Breast Cancer

What Verzenio® Is and How It Works

Verzenio® (abemaciclib) is an oral cancer medicine for adults with hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2-) advanced or metastatic breast cancer. It is a cyclin-dependent kinase (CDK) 4/6 inhibitor taken as tablets, usually twice daily. Many patients compare verzenio price to plan long-term therapy costs.

It works by blocking CDK4 and CDK6 enzymes that drive cell division. This slows the growth of HR+ breast cancer cells. Verzenio® is used alone or with endocrine therapy, such as an aromatase inhibitor or fulvestrant. Your oncology team decides the regimen and dosing schedule.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba. Our pharmacists review prescriptions before dispensing and support safe use. We offer brand and generic medicines at Canadian prices and ship to the US.

We source authentic brand medicines through licensed, vetted partner pharmacies and wholesalers, giving you a broad selection at competitive pricing.

Dosage and Usage

Dosing is individualized. Typical strengths include 50 mg, 100 mg, 150 mg, and 200 mg tablets. Common regimens include 150 mg twice daily with endocrine therapy, or 200 mg twice daily as monotherapy. Your prescriber may adjust your Verzenio® dosing for side effects or lab changes.

• Swallow tablets whole with water. Do not crush, chew, or split.
• Take with or without food. Avoid grapefruit and grapefruit juice.
• Take doses about 12 hours apart for steady levels.
• If you miss a dose and it is close to the next dose, skip the missed dose. Do not double up.
• If you vomit after a dose, do not take an extra tablet. Resume at the next scheduled time.
• Keep all scheduled blood tests. These check white blood cells, liver enzymes, and other safety markers.

Storage and travel

• Store Verzenio® tablets at room temperature (20–25°C / 68–77°F). Short excursions 15–30°C are acceptable.
• Keep tablets in the original container with the label.
• Protect from moisture and out of reach of children and pets.
• When you travel, pack enough tablets in your carry-on. Bring your Rx label for security checks.

Benefits and Savings

Verzenio® helps delay disease progression in HR+/HER2- advanced breast cancer. In clinical trials, adding abemaciclib to endocrine therapy improved progression-free survival compared with endocrine therapy alone. Continuous daily dosing avoids planned off-weeks common with other CDK4/6 inhibitors.

Patients value the oral pill format and flexible dosing schedule. Many also watch the cost of Verzenio per month over time. Ordering through YouDrugstore can offer 60–80% savings versus typical US retail prices, depending on strength and supply size.

We make ordering simple online or by phone. Friendly customer-service chat is available during posted office hours, and pharmacists can address medication questions.

Side Effects and Safety

Side effects vary. Your cancer team monitors you and may adjust your dose.

• Common: diarrhea, nausea, vomiting, decreased appetite, abdominal pain, fatigue, headache, mouth sores.
• Blood changes: neutropenia, leukopenia, anemia, thrombocytopenia. This may increase infection or bleeding risk.
• Liver effects: elevated AST/ALT; rare liver injury.
• Infections: upper respiratory or other infections.
• Serious but less common: dehydration from severe diarrhea, venous thromboembolism, interstitial lung disease/pneumonitis, severe neutropenia with fever.

Tell your healthcare provider about all medicines you take. Strong CYP3A inhibitors (for example, ketoconazole, clarithromycin) may raise abemaciclib levels. Strong CYP3A inducers (for example, rifampin, carbamazepine, St. John’s wort) may lower its levels. Avoid grapefruit products. Pregnancy should be avoided; use effective contraception during treatment and for a time after the last dose as directed by your clinician.

Onset Time

Diarrhea often starts early, sometimes within the first week, and is usually manageable with prompt care from your team. Tumor response and progression-free survival are assessed over weeks to months with imaging and labs. Your oncology plan may include periodic scans to track benefit.

Compare With Alternatives

Other CDK4/6 inhibitors include palbociclib (Ibrance) and ribociclib (Kisqali). Palbociclib and ribociclib are taken on a 3-weeks-on, 1-week-off schedule, while Verzenio® is dosed continuously. Neutropenia rates may be higher with palbociclib and ribociclib, while diarrhea is more frequent with abemaciclib.

Ribociclib may require ECG monitoring due to QT prolongation risk, while Verzenio® more often needs early diarrhea management and liver function checks. Choice depends on your medical history, concurrent medicines, and how you tolerate treatment. Endocrine backbones differ as well, such as aromatase inhibitors versus fulvestrant. Your oncology team selects and adjusts therapy based on your needs.

Combination Therapy

Verzenio® is used with endocrine therapy in many settings. With an aromatase inhibitor, it may be used as initial therapy for postmenopausal women and men with HR+/HER2- metastatic disease. With fulvestrant, it is an option after disease progression on endocrine therapy. Premenopausal patients typically add ovarian suppression when using endocrine agents. Your care team will detail the plan and monitoring schedule.

Patient Suitability and Cost-Saving Tips

Verzenio® is for adults with HR+/HER2- advanced or metastatic breast cancer. It is not for HER2-positive disease. People with significant liver impairment may need dose changes. Report breathing symptoms, blood clot symptoms, or signs of infection promptly to your care team.

To manage costs, consider a multi-month supply when appropriate. Multi-pack orders often lower the per-month price. You can set simple reorder reminders in your account so you do not run out. For current deals and bulk options, see our verzenio coupon page.

You can order online at Verzenio or by phone during office hours. Explore our Cancer category for more treatments and support products. For background reading on cancer medicines and side-effect care, you may find Common Darzalex Side Effects And Tips To Manage Them and Understanding Calquence Medication For Cancer Treatment helpful.

Authoritative Sources

Review official prescribing details in these resources:

• Eli Lilly Verzenio product information
• FDA Prescribing Information for abemaciclib
• Health Canada Drug Product Database listing

Ready to get started? YouDrugstore offers caring service, pharmacist review, and secure checkout. We ship to the US with prompt, express, cold-chain shipping where needed, and keep you informed from checkout to delivery.

This content is for general education and does not replace medical advice. Always consult your oncology team for diagnosis, treatment decisions, and dosing. Verzenio® requires a valid prescription from your healthcare provider.