Vosevi® Tablets for Hepatitis C

Vosevi® is a prescription antiviral for chronic hepatitis C. It combines three direct-acting agents in a single daily tablet. This page explains how it works, who it suits, and how to access US delivery from Canada, including options for Vosevi® without insurance.

What Vosevi Is and How It Works

Vosevi® contains sofosbuvir, velpatasvir, and voxilaprevir. These medicines target different steps in the hepatitis C virus life cycle. Sofosbuvir inhibits the NS5B polymerase. Velpatasvir blocks the NS5A protein. Voxilaprevir inhibits the NS3/4A protease. Together, they help stop viral replication.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

The combination is taken once daily with food. It is often used after certain prior hepatitis C treatments did not lead to cure. On-label use follows the official prescribing information. When in doubt, your clinician will rely on the approved instructions.

These sofosbuvir velpatasvir voxilaprevir tablets are approved for multiple genotypes. Your healthcare professional will confirm your genotype, liver status, and the right duration based on prior therapy.

Who It’s For

This treatment is indicated for adults and certain adolescents with chronic hepatitis C genotypes 1 through 6 who have received prior therapy. It is commonly chosen after a regimen containing an NS5A inhibitor or sofosbuvir has failed. People with decompensated cirrhosis should not use this medicine. Those with moderate to severe liver impairment may require a different approach.

Discuss past treatments, resistance testing, and hepatitis B status. Some patients with co-infection or complex histories need closer monitoring. For general condition guidance, see Hepatitis C.

Dosage and Usage

The standard regimen is one tablet by mouth once daily with food for 12 weeks. Swallow the tablet whole. Do not crush or split. If you use acid-reducing agents, follow label spacing and limits. Your prescriber will advise on antacids, H2-blockers, or proton pump inhibitors.

Tell your clinician about all medicines, vitamins, and herbal products. Avoid strong inducers that can lower antiviral levels. Your care team may schedule lab monitoring before, during, and after treatment to assess response and safety. If you have questions on instructions, defer to the official label and your prescriber’s guidance.

Strengths and Forms

The fixed-dose tablet contains sofosbuvir/velpatasvir/voxilaprevir 400/100/100 mg. Packaging and availability can vary by market and lot. Some packs include a 28-tablet bottle. Product availability may change; your pharmacist will confirm what is in stock.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember the same day. If it is almost time for the next dose, skip the missed dose and resume your usual schedule. Do not take two doses at the same time. If you vomit soon after dosing, consult the label or your prescriber for next steps. Consistent daily dosing supports treatment success.

Storage and Travel Basics

Store tablets at room temperature in the original container with the desiccant. Keep the bottle tightly closed and away from moisture. Protect from excessive heat and direct light. Keep out of reach of children. When traveling, carry the medicine in your hand luggage with a copy of your prescription. Keep the pharmacy label visible to ease security checks. Use a reminder system to help you take the dose at the same time every day while away from home.

Benefits

This therapy combines three direct-acting antivirals in one tablet. Once-daily dosing with food can simplify routines. The combination covers multiple genotypes and is used after some previous treatments have not worked. Your clinician may select it to address resistance concerns or prior exposure to NS5A or sofosbuvir-containing regimens. Fewer pills can support adherence compared to multi-bottle approaches.

Side Effects and Safety

• Headache
• Fatigue
• Diarrhea
• Nausea
• Abdominal discomfort

More serious risks are uncommon but can occur. Hepatitis B reactivation has been reported with direct-acting antivirals; screen for HBV before starting. Significant bradycardia can occur when sofosbuvir is used with amiodarone; avoid this combination. Severe liver issues require careful assessment. Seek urgent care for signs of severe allergic reaction, severe rash, yellowing of the skin or eyes, extreme fatigue, or dark urine.

Drug Interactions and Cautions

Avoid strong enzyme or transporter inducers such as rifampin, carbamazepine, phenobarbital, phenytoin, and St. John’s wort. Acid-reducing agents can decrease velpatasvir absorption; follow label spacing and dose limits if they must be used. Do not combine with amiodarone.

Review all prescriptions and over-the-counter products with your healthcare professional. For broader class context, see Antivirals. Some antivirals are used for other hepatitis viruses, such as Baraclude, or for herpes viruses, such as Valtrex. Your clinician will determine what is right for your diagnosis.

For background on liver and kidney considerations, read Drug Caveats. This information is not a substitute for medical advice.

What to Expect Over Time

Most people take the tablet daily with food for the full course. Your prescriber may check labs during therapy and after finishing. A sustained virologic response is confirmed with follow-up testing per guidelines. You may feel fine even before the virus is cleared, so continue exactly as prescribed. Using reminders, pairing dosing with a meal, and organizing travel plans can help you stay on track.

If you experience bothersome symptoms, speak with your healthcare professional. They can advise on supportive measures. For context on liver anatomy during evaluations, see Right Upper Quadrant.

Compare With Alternatives

Other approved direct-acting antiviral combinations for chronic hepatitis C include sofosbuvir/velpatasvir and glecaprevir/pibrentasvir. Selection depends on genotype, prior treatment, cirrhosis status, and potential interactions. Your prescriber will compare label-based options and choose the regimen that best fits your clinical history. To explore options by condition, review our Hepatitis C pages.

Pricing and Access

We provide Canadian pharmacy pricing with transparent checkout. To review the Vosevi price and your options, add the item to your cart and follow the prompts. US payers may choose cash-pay if plans do not cover this therapy. For current offers, see our Promotions. Ships from Canada to US with tracking. Your prescription is required and verified. We use encrypted checkout for your security.

Availability and Substitutions

Supply can vary. If a item is unavailable, your prescriber may recommend a suitable alternative based on genotype, past therapies, and clinical status. Packaging may include a Vosevi 28 tablets bottle depending on the lot. We cannot confirm restock dates in advance. Your pharmacist can help coordinate options with your clinician.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults and some adolescents with chronic hepatitis C after prior therapy. It may not suit people with decompensated cirrhosis or those taking contraindicated medicines. If you have kidney or liver conditions, your clinician will assess safety before starting.

To manage costs, consider a longer supply if approved by your prescriber. Setting refill reminders helps avoid gaps. If paying cash, compare the Vosevi cash price with any available assistance or payer options. Keep your prescriber’s plan aligned with your budget and travel schedule to maintain adherence.

Questions to Ask Your Clinician

• My genotype and stage: Which regimen is appropriate for me?
• Duration: How long should I take this tablet?
• Interactions: Are my heart, seizure, or stomach-acid medicines compatible?
• Monitoring: What labs will you check during and after therapy?
• HBV screening: Do I need hepatitis B testing before starting?
• Side effects: What symptoms should prompt a call or visit?
• Travel: How should I store and carry doses while away?

Authoritative Sources

Manufacturer Prescribing InformationFDA DailyMedHealth Canada DPD

Ready to proceed? Place your order with prompt, express, temperature-controlled handling when required. This information is educational and not a substitute for professional medical advice.