Xigduo® (Dapagliflozin–Metformin XR) for Type 2 Diabetes

What Xigduo® Is and How It Works

Xigduo combines dapagliflozin and extended-release metformin (dapagliflozin metformin XR). It is used for adults with type 2 diabetes to improve blood glucose control when diet and exercise are not enough. As interest grows around xigduo xr cost and value, many people compare pricing across strengths like 5/1000 mg and 10/1000 mg, including without insurance options.

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Dapagliflozin is an SGLT2 inhibitor. It helps the kidneys remove excess glucose in the urine. Metformin decreases hepatic glucose production and improves insulin sensitivity. Together, these two medicines work through complementary pathways. The XR formulation is designed for once-daily dosing and steadier gastrointestinal tolerance.

Xigduo’s class is a fixed-dose combination: SGLT2 inhibitor plus biguanide. Typical strengths include 5/1000 mg and 10/1000 mg (also written as xigduo 5 1000 mg and xigduo 10 1000 mg). Common reasons for use include reducing A1C, fasting glucose, and post-meal spikes. Xigduo used for patients with established cardiovascular disease may also offer heart-failure and kidney benefits driven by dapagliflozin.

Dosage and Usage

• Start based on current metformin dose to reduce stomach upset. Physicians may begin at 5/1000 mg once daily with food.
• Swallow XR tablets whole; do not split, crush, or chew.
• Take once daily with the evening meal or as directed to improve GI tolerance.
• Titrate at intervals to a maximum strength such as 10/1000 mg if needed and tolerated.
• If a dose is missed, take it when remembered unless it is near the next dose; do not double.
• Stop before iodinated contrast or certain surgeries as advised by a clinician, then restart when safe.
• Do not use for type 1 diabetes or diabetic ketoacidosis.

• Store tablets at 20–25°C (68–77°F); brief excursions 15–30°C (59–86°F).
• Keep in the original, tightly closed container; protect from moisture.
• For travel, carry in hand luggage with a copy of the prescription.
• Use a pill organizer only if it stays dry and labeled.
• When crossing time zones, keep the once-daily schedule roughly 24 hours apart.
• Do not leave in a hot car; heat and humidity can damage tablets.

Benefits and Savings

This dual therapy targets several metabolic defects. Many patients see meaningful A1C reductions, improved fasting glucose, and modest weight loss with dapagliflozin. SGLT2 inhibition may lower blood pressure slightly through mild diuresis. In higher-risk patients, dapagliflozin has shown benefits in heart failure and kidney outcomes.

XR dosing is convenient and may limit GI side effects versus immediate-release metformin. The once-daily schedule can simplify complex regimens.

Youdrugstore offers Canadian pricing with typical 60–80% savings versus many US cash prices. We display xigduo xr price by strength, including xigduo xr 5 1000 price and xigduo xr 10 1000 price, so you can compare options even without insurance. If you track total spend, the cost of xigduo may be lower with larger fills.

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Side Effects and Safety

• Very common: gastrointestinal upset from metformin (nausea, diarrhea, gas, stomach pain).
• Genital yeast infections and urinary tract infections.
• Increased urination and thirst; dehydration or dizziness.
• Headache, fatigue, or back pain.
• Metallic taste and appetite changes.
• Skin rash or pruritus.
• xigduo 5 1000 side effects and xigduo xr 10 1000 side effects are similar; intensity can vary by dose and tolerance.

Serious risks are uncommon but include lactic acidosis from metformin (higher risk with severe kidney or liver disease) and euglycemic diabetic ketoacidosis with SGLT2 inhibitors. Rare events include Fournier’s gangrene, severe dehydration, and acute kidney injury. Hypoglycemia is more likely if combined with insulin or sulfonylureas, so dose adjustments may be needed.

Onset Time

Many people notice lower fasting glucose within 1–2 weeks as the dapagliflozin effect begins. A1C changes build over 8–12 weeks after a stable dose. GI side effects, if present, usually improve after the first few weeks. Modest weight reduction often appears over 1–3 months, with results varying by diet, activity, and dose.

Compare With Alternatives

Metformin alone remains first-line for many patients. Xigduo adds dapagliflozin for stronger A1C reduction and cardio-renal benefits with once-daily dosing. Those who need a different mechanism may consider a DPP-4 inhibitor such as Onglyza®, which is weight-neutral and generally well tolerated.

Some patients benefit from a basal insulin plus GLP-1 option. Soliqua® Solostar Pens combine insulin glargine with lixisenatide and can lower A1C further than many oral agents. Individual goals, kidney function, and side-effect profiles guide the choice.

DPP-4 inhibitors such as alogliptin (see also Nesina® products) are alternatives for those who cannot take SGLT2 inhibitors or who prefer once-daily oral treatments with low hypoglycemia risk.

Combination Therapy

• With insulin: consider reducing insulin dose to lower hypoglycemia risk.
• With sulfonylureas: dose reductions may be needed to prevent lows.
• With GLP-1 receptor agonists: complementary effects on weight and A1C are possible.
• With antihypertensives or diuretics: monitor volume status due to dapagliflozin’s diuretic effect.
• Avoid routine pairing with another SGLT2 inhibitor or duplicating metformin.

Patient Suitability and Cost-Saving Tips

Xigduo is intended for adults with type 2 diabetes. It is not for type 1 diabetes or diabetic ketoacidosis. Kidney function matters: do not start in severe renal impairment or dialysis. People with a history of lactic acidosis, significant liver disease, hypoxia, or heavy alcohol use may not be candidates. Recurrent UTIs, genital infections, or severe dehydration also require caution.

Pregnancy and breastfeeding data are limited, so discuss options with a healthcare professional. Hold metformin-containing products before iodinated contrast and certain surgeries as directed. Review all medicines, including diuretics and ACE inhibitors, to manage volume and kidney safety.

For budget planning, check xigduo price across strengths, such as xigduo xr 10 1000 mg and xigduo xr 5 1000 mg. A 90-day supply may lower the per-month cost. You can turn on reorder reminders in your account so you do not run out, even when paying without insurance. Multi-pack promotions can also reduce the average xigduo xr 10 1000 price.

Authoritative Sources

Xigduo XR Prescribing Information (FDA)

Xigduo Product Monograph (Health Canada)

AstraZeneca Xigduo XR Full Prescribing Information

Order Xigduo® from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This page is educational and does not replace medical advice. Always consult your healthcare professional about diagnosis, treatment, and medication decisions.