Xigduo® (dapagliflozin/metformin) for Type 2 Diabetes Management

What Xigduo® Is and How It Works

Xigduo® combines dapagliflozin (an SGLT2 inhibitor) with metformin (a biguanide) for adults with type 2 diabetes. Xigduo is used for improving blood sugar when diet and exercise are not enough. It is available as immediate-release tablets and as Xigduo XR (extended-release metformin). Xigduo use targets fasting and post-meal glucose, and can support weight neutrality.

YouDrugstore is a licensed Canadian pharmacy in Manitoba that follows Canadian pharmacy standards. Prescriptions are reviewed by licensed pharmacists before dispensing, and our team is available to help with ordering and shipping questions.

We work with licensed, vetted partner pharmacies internationally to source authentic brand medicines, offering a broad selection at affordable prices. This supports access to Xigduo ingredients that meet quality expectations.

How it works: dapagliflozin reduces renal glucose reabsorption, which increases urinary glucose excretion. This lowers circulating glucose and may reduce blood pressure through mild diuresis. Metformin decreases hepatic glucose production and improves insulin sensitivity in peripheral tissues. Together, the combination lowers A1C more than either alone.

Xigduo XR uses extended-release metformin for once-daily dosing. Dapagliflozin metformin XR tablets should be swallowed whole. Immediate-release Xigduo is typically taken twice daily with meals.

Dosage and Usage

Dosing is individualized based on current therapy, A1C goals, kidney function, and tolerability. The total dapagliflozin dose generally does not exceed 10 mg daily. The typical metformin target is up to 2000 mg per day as tolerated.

• Immediate-release Xigduo: often given twice daily with meals to reduce stomach upset.
• Xigduo XR: once daily with a meal; swallow tablets whole without crushing, splitting, or chewing.
• Switching regimens: match the current dapagliflozin dose and the nearest effective metformin dose.
• Renal function guides metformin dosing. Assess eGFR before start and during therapy.

• Missed dose: take when remembered unless it is near the next scheduled dose. Skip if close to the next dose. Do not double up.
• Hydration: maintain fluid intake to lower the risk of dehydration.
• Temporary holds: consider holding around major surgery or iodinated contrast procedures as directed by a clinician.

• Storage: keep tablets at room temperature (15–30°C), dry, and away from direct heat and light.
• Travel: carry in original labeled container. Pack enough tablets for the trip and a few extra days.
• Security: keep out of reach of children and pets.

Do not use for type 1 diabetes or diabetic ketoacidosis. Review all medicines and supplements for interactions and overlapping side effects.

Benefits and Savings

Xigduo can reduce A1C, fasting glucose, and postprandial glucose. The combination has a low risk of hypoglycemia when used without insulin or a sulfonylurea. Many people see modest weight loss or stability, and some may see small blood pressure reductions due to dapagliflozin’s osmotic effect.

Cardiovascular and kidney outcomes with dapagliflozin are well studied. In appropriate patients, dapagliflozin has shown benefits for heart failure risk and slowing CKD progression. These benefits support Xigduo ingredients chosen for broad metabolic impact.

Buying from Canada can cut the xigduo cost. Customers often save 60–80% compared with typical US pharmacy prices. If comparing xigduo price or xigduo xr price, YouDrugstore offers transparent pricing at Canadian rates and attentive support.

Savings can improve adherence over time. We also offer multi-month supplies when appropriate, which reduces refill trips and may lower per-month costs. Ask customer service about reorder reminders and available bulk promotions for discount xigduo and cheap xigduo options.

Side Effects and Safety

Side effects of Xigduo XR 5/1000 and side effects of Xigduo 10/1000 are consistent with the dapagliflozin and metformin components.

• Common: nausea, diarrhea, stomach upset, gas, headache.
• Genitourinary: yeast infections, increased urination, urinary tract infections, thirst.
• Metabolic: decreased B12 with long-term metformin use; consider monitoring.

• Serious: lactic acidosis (rare; higher risk with renal impairment, dehydration, hypoxia), ketoacidosis (including euglycemic), acute kidney injury, severe UTI including pyelonephritis, necrotizing fasciitis of the perineum.
• Hypotension and dehydration can occur, especially in older adults or with diuretics.
• Hypoglycemia risk increases when combined with insulin or sulfonylureas.
• Allergic reactions including angioedema are possible.

Contraindications include severe renal impairment (eGFR below product-specific threshold), metabolic acidosis, and hypersensitivity. Not for use in type 1 diabetes or active ketoacidosis. Assess renal function before start and regularly. Review alcohol intake because heavy use increases lactic acidosis risk with metformin. Discuss pregnancy and breastfeeding plans with a clinician.

Onset Time

Blood sugar lowering begins after the first doses. Fasting glucose may improve within days. Gastrointestinal tolerability with metformin usually improves over 1–2 weeks as the dose is adjusted. Expect A1C changes over 12–24 weeks as steady control is reached.

Compare With Alternatives

Other SGLT2/metformin combinations include Synjardy (empagliflozin/metformin) and Invokamet (canagliflozin/metformin). These share a class mechanism with differences in dosing, labeling, and outcome data. Choice depends on medical history, kidney function, and cost.

DPP-4 inhibitors can be used if metformin alone is not adequate. Options include Onglyza® or Nesina® Alogliptin. These are weight neutral and have low hypoglycemia risk, but generally offer smaller A1C reductions than GLP-1s.

Injectable combination therapy may be considered when oral therapy is not enough. Soliqua® Solostar Pens combine basal insulin with a GLP-1 receptor agonist, supporting stronger A1C reduction with careful titration.

Combination Therapy

Xigduo can be combined with other non-overlapping agents. GLP-1 receptor agonists, DPP-4 inhibitors, or basal insulin may be added based on goals and risk. When adding insulin or a secretagogue, dose reductions may be needed to limit hypoglycemia. Avoid duplicate SGLT2 therapy.

Monitor kidney function with any regimen that includes metformin. Ensure hydration. Educate patients on infection symptoms and when to seek care. Pause therapy as directed during acute illness, dehydration, or before contrast procedures.

Patient Suitability and Cost-Saving Tips

Xigduo is intended for adults with type 2 diabetes who need more than lifestyle changes or metformin alone. It may suit those who prefer oral therapy, seek modest weight effects, or have heart failure or CKD risk where dapagliflozin may help. It is not for type 1 diabetes or ketoacidosis.

Kidney function matters. Dose selection and continuation depend on eGFR. People with a history of recurrent genital infections, dehydration, or low blood pressure need careful assessment. Seniors or those using diuretics should review the plan closely with their prescriber.

To manage the cost of Xigduo, consider a longer supply. Multi-month fills often reduce the cost of xigduo on a per-month basis. The same approach can help when comparing xigduo xr price versus immediate-release. Our customer-service chat is available during posted office hours to discuss shipping and stock.

For current deals, see our xigduo coupon options, including promotions and bulk choices when available.

Learn more about type 2 diabetes care in our condition pages such as Type 2 Diabetes and Diabetes. If exploring GLP-1 therapy, this article may help: Thinking About Trulicity Weight Loss Read This First.

There is no generic dapagliflozin/metformin combination available at this time in many markets. Comparing xigduo cost to separate components may inform decisions, but single-tablet regimens can support adherence. We can also discuss xigduo xr 10 1000mg dose availability and packaging sizes when applicable.

Authoritative Sources

Xigduo XR Prescribing Information (AstraZeneca)

Health Canada Drug Product Database: Xigduo

FDA Label: Xigduo XR (dapagliflozin/metformin HCl)

Order from YouDrugstore for friendly service, pharmacists who review each prescription, and prompt, express, cold-chain shipping when temperature control is required. We stock brand and select generics at Canadian prices to support ongoing care.

This information is for educational purposes and does not replace your prescriber’s advice. Always follow the directions from your healthcare professional and the package insert for your specific product.