Xtandi® (enzalutamide) tablets for advanced prostate cancer

What Xtandi® Is and How It Works

Xtandi® (enzalutamide) is an oral androgen receptor inhibitor used for prostate cancer. It is approved for non-metastatic castration-resistant prostate cancer (nmCRPC), metastatic castration-resistant prostate cancer (mCRPC), and metastatic castration-sensitive disease (mCSPC). The usual route is once-daily tablets. Treatment is often given with ongoing androgen-deprivation therapy (ADT) or after surgical castration. Xtandi blocks androgen receptor signaling and reduces tumor growth.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Prescriptions are reviewed by licensed pharmacists before dispensing. You can order online and use our friendly customer-service chat during posted office hours. We ship brand and generic medicines at Canadian prices to the US.

We work with licensed, carefully vetted partner pharmacies abroad to offer authentic brands, a broad selection, and steady affordability. If you need Xtandi without insurance questions, our team can explain payment options and multi-month supplies.

Dosage and Usage

• Usual adult dose: 160 mg by mouth once daily (four 40 mg tablets).
• Take at the same time each day, with or without food.
• Swallow tablets whole. Do not crush, chew, or split.
• Given with ongoing ADT or after orchiectomy.
• Missed dose: take it as soon as remembered on the same day. Do not double up; take the next dose the following day.
• Strong CYP2C8 inhibitors or inducers can change exposure. The prescriber may adjust the dose or choose alternatives if such combinations cannot be avoided.
• Continue unless the prescriber advises stopping for lack of benefit or safety issues.

• Storage: store at 20–25°C (68–77°F). Keep in the original container. Protect from moisture. Keep out of reach of children and pets.
• Travel: keep tablets in your carry-on bag and in the labeled container. Bring enough for the trip plus extra. Follow time zones by taking it at your usual daily time.

Benefits and Savings

Xtandi decreases androgen receptor activity, which can slow disease progression. Many patients see PSA declines and delayed radiographic progression. It is taken once daily and does not require steroids. In trials, benefits included longer progression-free survival and improved outcomes across several prostate cancer settings.

Ordering through YouDrugstore can reduce costs. Typical savings are 60–80% compared with common US prices. You can view current Xtandi pricing and choose a multi-month supply to lower per-month costs. Our team can also set simple reorder reminders so you do not run short.

Side Effects and Safety

• Common: fatigue, hot flushes, back or joint pain, headache, decreased appetite, diarrhea or constipation, hypertension, falls.
• Other effects: edema, weight loss, dizziness, insomnia, cough.
• Serious: seizures (rare), posterior reversible encephalopathy syndrome (very rare), ischemic heart disease, severe hypertension, severe allergic reaction.
• Bone health: risk of falls and fractures may increase. Bone-protective measures may be considered.
• Reproductive risk: can harm an unborn baby. Men with partners who can become pregnant should use effective contraception during therapy and for a period after the last dose, as directed by the prescriber.
• Drug interactions: enzalutamide can induce CYP3A4, CYP2C9, and CYP2C19 and may reduce exposure to sensitive substrates (for example, warfarin, some statins, some antiepileptics). The prescriber may adjust other medicines or monitor closely.

Seek urgent care for signs of seizure, severe headache with confusion or vision changes, chest pain, or severe shortness of breath. Report persistent dizziness, falls, or high blood pressure readings.

Onset Time

Some patients see PSA declines within a few weeks, but timelines vary. Imaging responses and symptom changes often take longer. Clinical trials showed delayed progression over months compared with placebo or standard care. The care team will schedule labs and imaging to assess response.

Compare With Alternatives

Several agents treat advanced prostate cancer. Choice depends on disease state, prior therapies, comorbidities, biomarkers, and tolerance.

Abiraterone acetate is another oral option. It inhibits CYP17 and requires prednisone. It is used in mCRPC and mCSPC. You can compare with Zytiga®, which is the brand form of abiraterone acetate.

PARP inhibitors help selected patients with homologous recombination repair (HRR) gene alterations. Lynparza® (olaparib) is approved for mCRPC with certain gene mutations after progression on an androgen pathway inhibitor like enzalutamide or abiraterone.

Other androgen receptor pathway agents include apalutamide and darolutamide for nmCRPC and selected metastatic settings. Chemotherapy such as docetaxel or cabazitaxel remains important for some patients. Treatment sequencing is individualized by the oncology team.

Combination Therapy

Xtandi is usually given with ongoing ADT. It does not require routine steroids. In some settings, clinicians may combine or sequence therapy with chemotherapy, PARP inhibitors, or bone-strengthening agents like zoledronic acid or denosumab. Calcium, vitamin D, and exercise plans may support bone health. The oncology team will coordinate labs and imaging to monitor safety and benefit.

Patient Suitability and Cost-Saving Tips

Xtandi may be considered for adults with nmCRPC, mCRPC, or mCSPC. It is not used in women or children. Caution is needed with seizure history, significant cardiovascular disease, uncontrolled hypertension, or conditions that increase fall risk. The prescriber will review medicine lists for interactions and decide on monitoring. Patients with severe liver impairment generally do not need a starting dose change, but care teams follow labs as needed.

You can reduce costs by ordering a 90-day supply when appropriate, which often lowers the monthly average. Our pricing is in US dollars for US shipping, and we confirm prescriptions before dispensing. For extra value, see our xtandi coupon and bulk options on the promotions page.

You can browse our condition pages to learn more about Prostate Cancer and the advanced setting Metastatic Castration Resistant Prostate Cancer. For general oncology learning, you may find these articles helpful: tips on side effects in Common Darzalex Side Effects And Tips To Manage Them, a look at mechanisms in Darzalex Mechanism Of Action How It Treats Multiple Myeloma, and background reading in Understanding Calquence Medication For Cancer Treatment.

Authoritative Sources

For full details, review the manufacturer and regulator information. See the Official XTANDI patient website, the FDA Prescribing Information (enzalutamide), and the Health Canada Drug Product Database listing.

You can order Xtandi® from YouDrugstore with support from our pharmacy team. We offer prompt, express, cold-chain shipping for medicines that require it, with discreet packaging to the US.

Disclaimer: This page is informational and does not replace medical advice. Always follow the directions from your prescriber and the patient information that comes with your medicine. Report side effects to your healthcare provider.