How is this cream different from topical steroids?

This therapy is a PDE4 inhibitor, not a corticosteroid. It works by targeting an inflammatory enzyme pathway to help reduce redness, scaling, and itch. Many people use it on thin-skin or fold areas where steroid use may be limited. Your clinician may still recommend short courses of topical steroids for flares. Discuss where each fits and how to layer or rotate them to reduce irritation and maintain control over time.

Can I use moisturizers with the treatment?

Yes, many patients use gentle emollients with this medicine. Your clinician may suggest applying the prescription cream at a different time than moisturizers to avoid dilution. Fragrance-free products can be easier on sensitive skin. Avoid harsh scrubs and acids on treated areas unless directed. If you notice more stinging, space products further apart or ask your prescriber for application timing tips.

How long should I use it before reassessment?

Your prescriber will set follow-up timing based on your skin and past treatments. Many people continue daily use while the clinician monitors progress and tolerability. If your symptoms are not improving or worsen, contact your healthcare professional. Do not change frequency or stop abruptly without guidance, as symptoms may rebound. Keep a simple routine and track any triggers or irritants.

What areas of the body can be treated?

The cream may be used on many body sites affected by plaque psoriasis, including intertriginous areas, when your clinician advises. Avoid eyes, mouth, and mucous membranes. Do not apply on infected or open wounds unless directed. If you have scalp involvement, your clinician may suggest other formulations or adjuncts that suit hair-bearing areas. Follow label directions for each specific area.

What if the skin burns or stings after applying?

Mild burning or stinging can occur, especially at the start. Use a thin layer on clean, dry skin. If it persists or becomes intense, contact your prescriber. They may recommend spacing other active topicals, using a bland moisturizer at a different time, or adjusting your plan. Severe irritation, spreading rash, or swelling should prompt medical advice and possible discontinuation until you are reviewed.

Can children use this medicine?

This cream is approved for plaque psoriasis in pediatric patients six years and older. Your clinician will decide if it is appropriate based on severity, location of plaques, and tolerability. Caregivers should supervise use to ensure thin, even application and handwashing after application unless treating the hands. Report any persistent side effects promptly. Keep the tube out of children’s reach when not in use.

Are there known interactions with other skin treatments?

Systemic interactions are unlikely due to low absorption. However, combining multiple active topicals may increase local irritation. Share your full list of creams, ointments, gels, and cleansers with your clinician. If you use salicylic acid, retinoids, or potent corticosteroids, you may need a timing plan. Ask about phototherapy schedules and whether to alternate days with other agents to reduce overlap.

Promotion

Zoryve

Zoryve® Cream for Plaque Psoriasis

Psoriasis

Please note: a valid prescription is required for all prescription medication.

Stock up and Save - Get 20% off when you buy 3 or more of any one product. Use code SAVE20 at checkout.

Coupon code cannot be combined with other offers. Sale applies to all products originating from Canada. Maximum allowable quantity equal to a 90 day supply per single order.

Price:

$430.99

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This prescription cream treats plaque psoriasis in patients six years and older. This page explains how it works, how it is used, and how to access it with US shipping from Canada. You can also review typical costs without insurance and see storage and safety basics.

What Zoryve® Is and How It Works

This medicine contains roflumilast, a phosphodiesterase-4 (PDE4) inhibitor. It helps reduce inflammation that drives scaling, redness, and itching. The cream is steroid-free, which may suit thin-skin areas. Roflumilast cream 0.3 is applied to affected skin once daily as directed by your prescriber.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

The treatment is for external use only. Avoid eyes, mouth, and mucous membranes. Wash hands after applying unless you are treating the hands. Do not cover with airtight dressings unless your clinician advises.

Learn more about the condition and options in our Psoriasis hub and browse related items in Dermatology.

Who It’s For

This therapy is indicated to manage plaque psoriasis in adults and in children six years of age and older. It can be used on many body areas, including folds, when a clinician considers it appropriate. People with known hypersensitivity to roflumilast or any cream component should avoid it. Discuss your medical history, including pregnancy or breastfeeding, with your healthcare professional.

Ask your prescriber about Zoryve indication in the context of your diagnosis and past treatments. Some patients may use this alongside other topical agents under guidance.

Dosage and Usage

Follow your prescriber’s directions and the product label. Typically, apply a thin layer once daily to affected skin. Rub in gently until absorbed. If using other topicals, your prescriber may suggest a sequence to minimize irritation. Avoid use on broken skin unless instructed. Do not use more than recommended or more often than directed.

Label instructions guide frequency and area-specific directions. If you use moisturizers, apply them at a different time if advised by your clinician to reduce dilution. Refer to official labeling for full details on Zoryve dosing.

Strengths and Forms

This product is available as a topical cream in a 0.3% strength. Pack sizes and presentations may vary by supplier and availability.

Missed Dose and Timing

If you miss an application, use it when remembered. If it is close to the next scheduled time, skip the missed dose and resume your routine. Do not apply extra cream to make up for a missed dose. Consistent daily use as directed supports ongoing control.

Storage and Travel Basics

Store the cream at room temperature as directed on the label. Keep the cap tightly closed. Protect from excessive heat and keep out of reach of children and pets. Do not freeze. When traveling, keep it in your carry-on with the original label and your prescription or a copy of your medication list. Avoid leaving it in a hot car. If flying, pack it in a clear bag for security screening.

For broader skin-care context, see our overview on Eczema and the educational piece on Topical Steroids.

Pen Handling and Sharps Disposal

Not applicable. This product is a topical cream and does not use pens, needles, or sharps.

Benefits

This treatment offers non-steroidal control of plaque psoriasis signs and symptoms. It can be used on sensitive and intertriginous areas when appropriate. Once-daily use may fit routine skin care. The cream can be combined with other therapies as part of a plan designed by your prescriber.

Side Effects and Safety

Common effects are usually mild and can include application-site pain or discomfort, mild redness, and temporary irritation. Some people report headache or gastrointestinal symptoms. These typically lessen with continued use. Stop and seek medical help for signs of a serious reaction, such as widespread rash, hives, swelling, or breathing trouble.

Local irritation: burning, stinging, or itching
Headache or nausea: generally mild
Rare allergic reaction: stop use if suspected

Discuss other skin products you use, including salicylic acid, retinoids, or keratolytics, to reduce additive irritation. Contact your clinician if you develop severe diarrhea, persistent headaches, or worsening skin changes. For more context, review Zoryve cream side effects with your healthcare professional.

Drug Interactions and Cautions

Topical roflumilast has low systemic absorption; however, always list all medicines and supplements you use. Combining multiple strong skin treatments may increase local irritation. If you are pregnant, planning pregnancy, or breastfeeding, ask your clinician about risks and benefits. Avoid applying on infected skin unless specifically treated and cleared by your prescriber.

If you receive phototherapy or use potent topical steroids, your prescriber may time each product to avoid overlap. Do not start, stop, or change any medicine without professional guidance.

What to Expect Over Time

Many people notice gradual improvement in scaling and redness with regular use. It may take continued daily application for your skin to settle. Keep a simple routine and use gentle cleansers and moisturizers that suit your skin type. If you miss days or stop early, symptoms may return. Schedule check-ins with your clinician to review fit and adjustments.

For community insights and education, see World Psoriasis Day and Psoriasis Action Month 2025.

Compare With Alternatives

For moderate to severe disease or widespread involvement, prescribers may consider systemic options. Two prescription alternatives we offer include an oral PDE4 inhibitor and a biologic injection, when appropriate for the patient and severity.

Otezla: oral PDE4 inhibitor for plaque psoriasis and psoriatic arthritis
Skyrizi Cartridge: injectable biologic for plaque psoriasis

Your prescriber can also discuss topical steroids, calcineurin inhibitors, or vitamin D analogs when appropriate and how they compare to a PDE4 inhibitor cream.

Pricing and Access

See current Zoryve Canadian pricing on this page and compare options that fit your prescription. We provide transparent pricing and secure checkout. Orders are fulfilled by a licensed Canadian pharmacy and Ships from Canada to US with reliable parcel partners.

Looking for ways to save? Check our rotating offers on the Promotions page. We support encrypted checkout and can coordinate with your prescriber when needed. If you are using a health spending account, keep invoices for reimbursement.

Availability and Substitutions

Stock may vary. If this cream is not available, your prescriber may recommend another topical or an interim alternative that suits your skin and severity. We do not provide timelines for restock; please check back or ask your clinician about substitutes.

Patient Suitability and Cost-Saving Tips

This cream may suit adults and children six years and older with plaque psoriasis, especially in areas where non-steroidal options are preferred. It may not suit those with ingredient sensitivities. Review your full medication list with your clinician before starting.

Refill planning: set reminders to avoid gaps
Multi-month fills: ask your prescriber if appropriate
Bundle needs: combine dermatology items in one order
Travel ready: keep a copy of your prescription

To keep your routine simple, apply at the same time each day. If irritation occurs, speak with your prescriber about spacing other topicals. For reference in discussions, the phrase Roflumilast cream 0.3 refers to the labeled strength.

Questions to Ask Your Clinician

Placement plan: which areas should I treat first?
Layering tips: how should I time moisturizers and other topicals?
Irritation control: what signs mean I should pause and call?
Long-term plan: when should we reassess my regimen?
Combination use: can this be paired with phototherapy or other agents?

Authoritative Sources

FDA Prescribing Information Health Canada DPD Manufacturer Site

Ready when your prescription is? Place your order with prompt US shipping from Canada. This information is not a substitute for medical advice; always follow your prescriber’s guidance and the official label.

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Shipping Countries:

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Standard Shipping - $15.00

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Prices:

Dry-Packed Products $15.00
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View All FAQs

How is this cream different from topical steroids?
This therapy is a PDE4 inhibitor, not a corticosteroid. It works by targeting an inflammatory enzyme pathway to help reduce redness, scaling, and itch. Many people use it on thin-skin or fold areas where steroid use may be limited. Your clinician may still recommend short courses of topical steroids for flares. Discuss where each fits and how to layer or rotate them to reduce irritation and maintain control over time.
Can I use moisturizers with the treatment?
Yes, many patients use gentle emollients with this medicine. Your clinician may suggest applying the prescription cream at a different time than moisturizers to avoid dilution. Fragrance-free products can be easier on sensitive skin. Avoid harsh scrubs and acids on treated areas unless directed. If you notice more stinging, space products further apart or ask your prescriber for application timing tips.
How long should I use it before reassessment?
Your prescriber will set follow-up timing based on your skin and past treatments. Many people continue daily use while the clinician monitors progress and tolerability. If your symptoms are not improving or worsen, contact your healthcare professional. Do not change frequency or stop abruptly without guidance, as symptoms may rebound. Keep a simple routine and track any triggers or irritants.
What areas of the body can be treated?
The cream may be used on many body sites affected by plaque psoriasis, including intertriginous areas, when your clinician advises. Avoid eyes, mouth, and mucous membranes. Do not apply on infected or open wounds unless directed. If you have scalp involvement, your clinician may suggest other formulations or adjuncts that suit hair-bearing areas. Follow label directions for each specific area.
What if the skin burns or stings after applying?
Mild burning or stinging can occur, especially at the start. Use a thin layer on clean, dry skin. If it persists or becomes intense, contact your prescriber. They may recommend spacing other active topicals, using a bland moisturizer at a different time, or adjusting your plan. Severe irritation, spreading rash, or swelling should prompt medical advice and possible discontinuation until you are reviewed.
Can children use this medicine?
This cream is approved for plaque psoriasis in pediatric patients six years and older. Your clinician will decide if it is appropriate based on severity, location of plaques, and tolerability. Caregivers should supervise use to ensure thin, even application and handwashing after application unless treating the hands. Report any persistent side effects promptly. Keep the tube out of children’s reach when not in use.
Are there known interactions with other skin treatments?
Systemic interactions are unlikely due to low absorption. However, combining multiple active topicals may increase local irritation. Share your full list of creams, ointments, gels, and cleansers with your clinician. If you use salicylic acid, retinoids, or potent corticosteroids, you may need a timing plan. Ask about phototherapy schedules and whether to alternate days with other agents to reduce overlap.