Zoryve® Cream for Plaque Psoriasis

Zoryve is a prescription topical used to treat plaque psoriasis. It contains roflumilast, a PDE4 inhibitor that helps calm skin inflammation. This page explains how it works, safe use, storage, and practical ways to access treatment.

What Zoryve Is and How It Works

Zoryve® cream is a nonsteroidal PDE4 inhibitor for plaque psoriasis in adults and children 6 years and older. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing. Access may be straightforward, even without insurance, with US shipping from Canada available.

Roflumilast inhibits phosphodiesterase 4, which helps increase intracellular cAMP. This mechanism can reduce inflammatory mediators in skin and improve scaling and redness. The treatment is for external use only and is not for eyes, mouth, or vagina.

Because this medicine is steroid free, it may suit sensitive or intertriginous areas when prescribed. The cream can be used alone or as part of a broader routine under a clinician’s guidance.

Who It’s For

This treatment is indicated for the topical management of plaque psoriasis in adults and pediatric patients 6 years and older, including involvement of skin folds. Suitability depends on diagnosis, affected areas, and medical history.

Do not use if there is a known allergy to roflumilast or any component of the formulation. According to labeling, use is not recommended in moderate to severe hepatic impairment. If pregnant or breastfeeding, discuss potential benefits and risks with a clinician before starting therapy.

Dosage and Usage

Apply a thin layer once daily to affected skin as directed. Use on clean, dry areas and rub in gently until absorbed. Wash hands after handling unless treating the hands. Avoid occlusive dressings unless a prescriber advises otherwise. The medicine is for external dermal use only; do not use on eyes, mouth, or vagina. If irritation occurs, contact a healthcare professional.

Allow the cream to absorb before covering with clothing. If other topicals are part of the regimen, confirm the order of application with a clinician. Do not use more often than prescribed. Continue as directed even if lesions improve, unless a clinician instructs otherwise.

Strengths and Forms

• Cream 0.3% roflumilast for topical use
• Tubes; packaging options may vary by market and stock

Availability can differ by jurisdiction and dispensing pharmacy.

Missed Dose and Timing

If a dose is missed, use it when remembered the same day. If it is close to the next scheduled time, skip the missed dose and resume regular use. Do not double up. Aim for a consistent daily routine to support steady control.

Storage and Travel Basics

Store at room temperature and keep the cap tightly closed. Protect from excessive heat and freezing. Keep out of reach of children and pets. Do not use after the expiration date on the package. Discard if the tube is damaged or the cream changes appearance or smell.

When traveling, keep the tube in original packaging with the pharmacy label. Pack it in your carry-on to avoid heat extremes. Use a sealable bag to prevent leaks. If traveling internationally, bring a copy of the prescription. For road trips, avoid storing the tube in a hot vehicle. Follow local regulations for transporting prescription medicines.

Benefits

• Steroid-free option: helps limit corticosteroid exposure
• Once-daily routine: simple schedule supports adherence
• Sensitive area use: appropriate for folds when prescribed
• Non-occlusive wear: comfortable under clothing
• Compatible regimens: may fit combination plans
• Pediatric eligibility: includes patients 6 years and up

Side Effects and Safety

• Diarrhea: may occur, usually mild
• Headache: typically transient
• Nausea: less common with topical use
• Insomnia: reported in some patients
• Application site pain or burning: localized discomfort possible
• Upper respiratory symptoms: occasional

Serious reactions are uncommon but can include hypersensitivity or severe local irritation. Stop use and seek medical help if signs of allergy occur, such as rash, swelling, or trouble breathing. Avoid use on broken or infected skin unless specifically directed. Discuss use during pregnancy or while breastfeeding with a clinician. Patients with moderate to severe liver impairment should not use this medicine based on labeling guidance.

Drug Interactions and Cautions

Roflumilast is metabolized by CYP3A4 and CYP1A2. Strong inhibitors (for example, erythromycin, ketoconazole, or fluvoxamine) and strong inducers (such as rifampin, carbamazepine, or phenytoin) may affect systemic exposure. With topical use, overall exposure is low, and the clinical impact of interactions is uncertain. Share a full medication list, including herbal products, with the prescribing clinician. Avoid combining with other PDE4 inhibitors without medical supervision.

Use caution on thin or sensitive skin and avoid contact with eyes, mouth, or genital mucosa. Do not cover treated areas with tight bandages unless instructed. If significant irritation or worsening occurs, contact a healthcare professional promptly.

What to Expect Over Time

With consistent daily use, plaques may gradually appear less red and scaly, and skin comfort can improve. Response times vary between individuals and by body area. Keep using as directed even if improvement is gradual. If there is limited benefit or worsening after an appropriate trial, consult the prescriber about next steps. Symptoms may return after stopping therapy.

Compare With Alternatives

Several approved therapies can complement or provide alternatives, depending on disease severity and locations. Oral PDE4 inhibition is one option: Otezla® tablets and apremilast tablets. For systemic biologic therapy, options include IL-23 or IL-17 inhibitors, such as Skyrizi® injection, ixekizumab injection, and etanercept prefilled syringe. Explore our psoriasis condition page or browse the dermatology category for more options.

Pricing and Access

To view current options or place a request, sign in to your account. Transparent Canadian pharmacy pricing is available with US shipping from Canada. Checkout is protected with encrypted processing. If you are looking for seasonal deals, see our current promotions page.

Availability and Substitutions

Stock may vary. If this medicine is temporarily unavailable, a prescriber may recommend a suitable alternative from the same class or another approved psoriasis therapy. Our pharmacy team can coordinate with your clinician when a substitution is appropriate.

Patient Suitability and Cost-Saving Tips

Candidates include adults and children 6 years and older with plaque psoriasis who need a steroid-sparing topical for sensitive or fold areas. Those with moderate to severe hepatic impairment are generally not candidates. Tell the prescriber about all conditions and medicines before starting.

For savings and convenience, consider multi-month quantities if appropriate, set refill reminders in your account, and consolidate orders. Keep a treatment calendar and align reorders with follow-up visits. If your plan includes other therapies, coordinate refill timing to reduce separate parcels.

Questions to Ask Your Clinician

• Is this PDE4 inhibitor appropriate for my specific plaque locations?
• How should I coordinate this cream with moisturizers or other topicals?
• What signs of irritation mean I should pause and call the clinic?
• Are there medicines or supplements that I should avoid while using it?
• What goals should we track to judge response over time?
• Could a systemic option be better if plaques are widespread?
• How often should I schedule follow-up for monitoring?

Authoritative Sources

• US Prescribing Information (DailyMed)
• Arcutis Biotherapeutics (manufacturer)
• Health Canada Drug Product Database

Ready to proceed? Order with US shipping from Canada and benefit from prompt, express, cold-chain shipping when required. This information is not a substitute for professional medical advice. Always follow the directions from your prescriber and the official label.