How does the orally disintegrating tablet differ from regular tablets?

The orally disintegrating tablet dissolves on the tongue within seconds and can be swallowed with saliva. This can help people who have trouble swallowing standard tablets. The active ingredient is the same as regular olanzapine tablets. Administration differs: you peel back the blister foil with dry hands, place the tablet on the tongue, and allow it to dissolve. Do not split or crush the ODT. Always follow your prescriber’s directions and the official patient information.

Can I drink water or eat with this medicine?

You can take the orally disintegrating tablet with or without water, since it dissolves quickly in saliva. Food does not meaningfully change absorption for most people. If your clinician gives timing guidance for meals or other medicines, follow those instructions. Avoid alcohol because it may increase drowsiness and impair judgment. Stay consistent with daily timing, and ask your healthcare professional if you need help coordinating doses with meals or other therapies.

What are the most common side effects?

Common effects include drowsiness, dizziness, dry mouth, increased appetite, constipation, and weight gain. Some people experience changes in blood sugar and lipids, which is why periodic labs may be recommended. Less common effects can include restlessness or tremor. Serious but rare problems include high fever with rigidity, severe rash, low white blood cell counts, seizures, or liver enzyme elevations. Contact your clinician promptly if you notice severe or worsening symptoms.

Does smoking affect how it works?

Yes. Cigarette smoking can induce CYP1A2, an enzyme that metabolizes olanzapine. That induction may lower olanzapine exposure. Do not change smoking habits solely for medication reasons without discussing with your prescriber, as adjustments may be needed. Also tell your clinician about caffeine intake and other medicines, because some drugs (like fluvoxamine) can increase levels, while others (like carbamazepine) can reduce them. A complete medication list helps manage interactions.

What should I know about missed doses and stopping?

If you miss a dose, take it when remembered unless it is near the next scheduled dose; if so, skip the missed dose. Do not double up. Do not stop suddenly without medical advice, as symptoms may return or worsen. If you have missed several doses, ask your clinician how to restart. Keep regular appointments to review benefits, side effects, and lab tests, and to make any adjustments safely and gradually when needed.

Is it safe for older adults with dementia-related psychosis?

Antipsychotics, including olanzapine, carry an increased risk of death in elderly patients with dementia-related psychosis. This is a boxed warning on the label. It is not approved for this use. If behavioral symptoms occur in dementia, clinicians usually consider non-drug approaches first and may explore alternative strategies tailored to the person’s medical history and goals of care. Discuss risks and benefits thoroughly with the healthcare team.

Does the ODT contain phenylalanine?

Some orally disintegrating olanzapine products contain aspartame, which provides phenylalanine. People with phenylketonuria (PKU) should check the patient information and discuss with a clinician before use. If phenylalanine is a concern, a standard film-coated tablet may be considered instead when appropriate. Always read the specific product insert you receive, as inactive ingredients can vary by manufacturer and strength.

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Zyprexa Zydis

Zyprexa Zydis® Orally Disintegrating Tablets for Schizophrenia

Bipolar Disorder, Schizophrenia

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Zyprexa Zydis is an orally disintegrating version of olanzapine used to manage schizophrenia and bipolar I disorder. This page explains what it treats, how to take it, and key safety points. It also outlines ordering steps with US delivery from Canada and options if you pay Zyprexa Zydis without insurance.

What Zyprexa Zydis Is and How It Works

Zyprexa Zydis® contains olanzapine, an atypical antipsychotic. It helps balance certain brain neurotransmitters implicated in psychosis and mood symptoms. The tablet dissolves on the tongue within seconds and can be swallowed with saliva. This formulation may support people who have difficulty swallowing regular tablets.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Olanzapine affects dopamine and serotonin receptors. This activity can reduce hallucinations, delusions, agitation, and disorganized thinking in Schizophrenia. It can also help stabilize mood in bipolar I disorder, including acute manic or mixed episodes. Learn more about the class in Antipsychotics.

Who It’s For

This medicine is used in adults for schizophrenia and for acute manic or mixed episodes of bipolar I disorder. It may be continued as maintenance therapy in bipolar I disorder alone or with lithium or valproate when clinically appropriate. It is not approved for treating dementia-related psychosis due to an increased risk of death in elderly patients.

People with known hypersensitivity to olanzapine should avoid this treatment. Discuss use with your prescriber if you have liver disease, a history of low white blood cell counts, seizures, glaucoma, or significant cardiovascular disease. For bipolar education, see Bipolar Disorder. For broader context, see Psychosis.

Dosage and Usage

Follow your prescriber’s directions and the official patient information. Zydis tablets come individually sealed in aluminum blisters. Do not push tablets through the foil. With dry hands, peel back the foil, remove the tablet gently, place it on the tongue, and allow it to dissolve. You may swallow with saliva; water is optional.

Typical starting doses are once daily, with or without food. The dose may be adjusted by your clinician based on response and tolerability. Do not change your dose or stop the medicine without professional guidance. If you are also taking lithium or valproate, your prescriber will consider that when selecting a schedule.

Because the tablet dissolves quickly, avoid chewing or breaking it. If the tablet cracks during removal, discard it safely and open a new blister.

Strengths and Forms

The orally disintegrating form is supplied as blister-packed tablets in several strengths, including 5 mg, 10 mg, 15 mg, and 20 mg. Availability can vary by pack size and manufacturer.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is close to the next scheduled dose. In that case, skip the missed dose and resume your regular schedule. Do not double up. If you miss multiple doses, contact your prescriber for advice.

Storage and Travel Basics

Store the blisters at room temperature and protect them from moisture. Keep each tablet in its blister until use. Handle with dry hands to avoid crumbling. Keep out of reach of children and pets.

When traveling, carry the medicine in original packaging along with a copy of your prescription. Pack it in your hand luggage to prevent loss or extreme temperatures. If crossing time zones, ask your clinician how to adjust the timing so doses remain evenly spaced.

Benefits

The treatment can reduce positive symptoms of schizophrenia and support mood stabilization in bipolar I disorder. The orally disintegrating format may help with swallowability and convenience. Once-daily schedules can simplify routines and support adherence alongside a comprehensive care plan.

Side Effects and Safety

Common: drowsiness, dizziness, dry mouth, increased appetite
Weight gain and changes in blood sugar or lipids
Constipation or mild orthostatic lightheadedness
Tremor or restlessness in some patients

Serious effects can include neuroleptic malignant syndrome, severe allergic reactions including rare DRESS, significant metabolic changes, tardive dyskinesia, low white blood cell counts, seizures, and liver enzyme elevations. Elderly patients with dementia-related psychosis have an increased risk of death. Seek immediate help for high fever, rigidity, confusion, severe rash, uncontrolled movements, or signs of high blood sugar. For foundational reading, see What Is Schizophrenia.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements. Fluvoxamine may increase olanzapine levels, while carbamazepine or smoking can reduce them through CYP1A2 induction. Caution with CNS depressants, antihypertensives, and medications that affect QT interval. Alcohol can intensify sedation and impair judgment. If you have phenylketonuria, note that some orally disintegrating formulations contain phenylalanine. Learn about class considerations in Psychosis And Antipsychotics.

What to Expect Over Time

Some people may notice calmer thinking and improved organization as treatment continues. Mood may become steadier when used for bipolar symptoms. Sedation and appetite changes can occur early and may lessen with time. Regular follow-up helps track benefits, side effects, weight, and metabolic parameters. Consistent daily timing, pill organizers, and reminders can support adherence.

Compare With Alternatives

Other atypical antipsychotics may be considered if this option is not suitable. Aripiprazole offers a different receptor profile and may be activating for some; see Aripiprazole. Risperidone is another common choice with broad evidence for psychotic and mood symptoms; see Risperidone. Your prescriber can advise based on your history, response, and tolerability.

Pricing and Access

We provide Canadian pricing with transparent options and private-pay checkout. You can Buy Zyprexa Zydis online after your prescription is verified. We support US shipping from Canada with clear status updates and encrypted checkout.

Many people compare copays with the Zyprexa Zydis cash price to decide how to proceed. If you are combining treatments, consider consolidating refills to reduce handling fees. For mental health categories and options, explore Mental Health.

Availability and Substitutions

Supply may vary by pack size and manufacturer. At our Canadian pharmacy Zyprexa Zydis supply can vary, and your prescriber may suggest an appropriate substitution if needed. If the orally disintegrating format is temporarily unavailable, a standard tablet or another atypical antipsychotic may be considered when clinically suitable. Questions about Olanzapine ODT buy should be discussed with your healthcare professional.

Patient Suitability and Cost-Saving Tips

This medicine may fit adults who need an antipsychotic and prefer an orally disintegrating format. It may not be suitable for those with severe liver impairment, a history of major allergic reactions to olanzapine, or elderly patients with dementia-related psychosis. Monitor weight, glucose, and lipids as advised.

Plan ahead by using multi-month refills when approved, setting calendar reminders, and coordinating lab checks with follow-up appointments. People who Zyprexa Zydis pay out of pocket can compare options and consider generic alternatives if advised by their prescriber. If your schedule varies, ask how to align dose timing to maintain steady daily use.

Questions to Ask Your Clinician

Starting dose goals and how progress will be monitored
Expected side effects and when to contact the clinic
Lab checks for glucose, lipids, and liver enzymes
Whether weight or sleep changes should prompt a visit
How smoking or certain medicines may change levels
Plans if symptoms persist or adverse effects emerge

Authoritative Sources

FDA Prescribing Information

Health Canada DPD

UK SmPC (Reference)

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View All FAQs

How does the orally disintegrating tablet differ from regular tablets?
The orally disintegrating tablet dissolves on the tongue within seconds and can be swallowed with saliva. This can help people who have trouble swallowing standard tablets. The active ingredient is the same as regular olanzapine tablets. Administration differs: you peel back the blister foil with dry hands, place the tablet on the tongue, and allow it to dissolve. Do not split or crush the ODT. Always follow your prescriber’s directions and the official patient information.
Can I drink water or eat with this medicine?
You can take the orally disintegrating tablet with or without water, since it dissolves quickly in saliva. Food does not meaningfully change absorption for most people. If your clinician gives timing guidance for meals or other medicines, follow those instructions. Avoid alcohol because it may increase drowsiness and impair judgment. Stay consistent with daily timing, and ask your healthcare professional if you need help coordinating doses with meals or other therapies.
What are the most common side effects?
Common effects include drowsiness, dizziness, dry mouth, increased appetite, constipation, and weight gain. Some people experience changes in blood sugar and lipids, which is why periodic labs may be recommended. Less common effects can include restlessness or tremor. Serious but rare problems include high fever with rigidity, severe rash, low white blood cell counts, seizures, or liver enzyme elevations. Contact your clinician promptly if you notice severe or worsening symptoms.
Does smoking affect how it works?
Yes. Cigarette smoking can induce CYP1A2, an enzyme that metabolizes olanzapine. That induction may lower olanzapine exposure. Do not change smoking habits solely for medication reasons without discussing with your prescriber, as adjustments may be needed. Also tell your clinician about caffeine intake and other medicines, because some drugs (like fluvoxamine) can increase levels, while others (like carbamazepine) can reduce them. A complete medication list helps manage interactions.
What should I know about missed doses and stopping?
If you miss a dose, take it when remembered unless it is near the next scheduled dose; if so, skip the missed dose. Do not double up. Do not stop suddenly without medical advice, as symptoms may return or worsen. If you have missed several doses, ask your clinician how to restart. Keep regular appointments to review benefits, side effects, and lab tests, and to make any adjustments safely and gradually when needed.
Is it safe for older adults with dementia-related psychosis?
Antipsychotics, including olanzapine, carry an increased risk of death in elderly patients with dementia-related psychosis. This is a boxed warning on the label. It is not approved for this use. If behavioral symptoms occur in dementia, clinicians usually consider non-drug approaches first and may explore alternative strategies tailored to the person’s medical history and goals of care. Discuss risks and benefits thoroughly with the healthcare team.
Does the ODT contain phenylalanine?
Some orally disintegrating olanzapine products contain aspartame, which provides phenylalanine. People with phenylketonuria (PKU) should check the patient information and discuss with a clinician before use. If phenylalanine is a concern, a standard film-coated tablet may be considered instead when appropriate. Always read the specific product insert you receive, as inactive ingredients can vary by manufacturer and strength.