Zyprexa Zydis® (Olanzapine ODT) for Schizophrenia and Bipolar I Disorder

What Zyprexa Zydis® Is and How It Works

Zyprexa Zydis® contains olanzapine as an orally disintegrating tablet (ODT) used for schizophrenia and bipolar I disorder. Zyprexa Zydis buy options are available at Canadian prices through YouDrugstore. You can order Zyprexa Zydis without insurance and have it shipped to the US. YouDrugstore is a licensed Canadian pharmacy based in Manitoba that meets Canadian standards of practice, and our pharmacists review prescriptions before dispensing.

Olanzapine is an atypical antipsychotic. It helps balance brain neurotransmitters, including dopamine and serotonin. Clinically, this can reduce hallucinations, delusions, agitation, and mood swings. The ODT format dissolves on the tongue without water, which helps people who have trouble swallowing tablets or need discreet dosing.

We source medicines through licensed, vetted partner pharmacies and wholesalers so you receive authentic brands at fair prices and with a broad selection.

Approved uses vary by region. Common indications include treatment of schizophrenia in adults and adolescents, and treatment of acute manic or mixed episodes in bipolar I disorder, as monotherapy or with mood stabilizers. Dosing is once daily. Take as directed by your prescriber.

Dosage and Usage

Your prescriber will set your dose. Typical starting doses are 5–10 mg once daily for schizophrenia, and 10–15 mg once daily for bipolar mania. Target doses often range from 10–20 mg daily. Older adults or those with liver impairment may start lower. Follow your specific instructions.

• With dry hands, peel back the foil (do not push the tablet through the foil).
• Gently remove the ODT and place it on the tongue to dissolve.
• You may swallow with or without water after it dissolves.
• Take once daily at the same time each day.
• If you miss a dose, take it when remembered unless it is close to the next dose. Do not double up.

Storage and travel:

• Store at 20–25°C (68–77°F); keep tablets dry and in the original blister until use.
• Protect from moisture and light; do not store in the bathroom.
• When traveling, keep medicine in your carry-on, in original packaging, and away from heat above 30°C (86°F).

Benefits and Savings

Zyprexa Zydis® can reduce positive symptoms of schizophrenia and help with negative symptoms such as social withdrawal. In bipolar I disorder, it helps stabilize mood and control acute mania. The ODT format supports adherence for people who prefer not to swallow tablets. Once-daily dosing is convenient.

Buying from Canada can lower your costs. Many patients pay 60–80% less than typical US retail. We also help people paying without insurance by offering competitive Canadian pricing and a choice of brand and alternatives where available.

Side Effects and Safety

Common effects include sleepiness, weight gain, increased appetite, dry mouth, constipation, dizziness, and lightheadedness when standing. Metabolic changes are possible, including higher blood sugar and lipids. Some people may see increased liver enzymes or prolactin.

• Common: drowsiness, weight gain, increased appetite, dry mouth, constipation, dizziness, fatigue.
• Metabolic: hyperglycemia, dyslipidemia, increased triglycerides and cholesterol.
• Less common: orthostatic hypotension, tremor, edema, rash, blurred vision.
• Serious (seek care): signs of high blood sugar (excess thirst/urination), severe confusion, persistent fever/rigidity (possible NMS), uncontrollable movements (tardive dyskinesia), severe allergic reaction, thoughts of self-harm.

Do not use for dementia-related psychosis in elderly patients due to increased risk of stroke and death. Tell your clinician about diabetes, high cholesterol, liver disease, glaucoma, bowel obstruction, prostate issues, seizure history, or low white blood cells. Alcohol and other sedatives can increase drowsiness. Smoking can lower olanzapine levels. Fluvoxamine can raise levels; carbamazepine may reduce them. Ask about interactions with your full medication list.

Onset Time

Some symptom relief, such as reduced agitation or improved sleep, may appear within several days. It can take two to six weeks to see the full effect on mood or psychotic symptoms. Your prescriber may adjust the dose to reach a steady response.

Compare With Alternatives

Olanzapine also comes as standard film-coated tablets such as Zyprexa®. These offer the same active ingredient and dosing ranges but require swallowing a tablet and may be better for those who do not need an ODT format.

Quetiapine Fumarate is another atypical antipsychotic used for schizophrenia and bipolar disorder. It often causes less weight gain than olanzapine but can be more sedating at some doses and requires multiple daily dosing in some regimens.

Trifluoperazine is an older (typical) antipsychotic. It may control positive symptoms but has a higher risk of movement-related side effects compared to atypicals like olanzapine.

Combination Therapy

Olanzapine can be combined with mood stabilizers such as lithium or valproate for acute mania. Some patients use olanzapine with an antidepressant under close supervision. A fixed-dose olanzapine/fluoxetine combination exists in some markets for bipolar depression, but product availability varies. Your prescriber will decide if combination therapy is appropriate based on your history, current symptoms, and tolerability.

Patient Suitability and Cost-Saving Tips

Zyprexa Zydis® may suit adults needing reliable control of schizophrenia or acute manic symptoms who prefer an ODT. It may not suit those with uncontrolled diabetes, significant metabolic syndrome, or high stroke risk. Children and adolescents need specialist oversight and tailored doses.

To manage costs, consider a multi-month supply if your prescriber is stable on a dose, as larger fills can reduce the per-month price. You can turn on reorder reminders in your account so you never run short. For current promotions or bulk options, see our Zyprexa Zydis coupon page.

Browse condition guides such as Schizophrenia and Bipolar Disorder to learn more about treatments and support. For related reading, you may find Fluoxetine For Anxiety How It Boosts Mood And Reduces Worry helpful if your clinician has discussed antidepressants, and Abilify And Alcohol Risks And Safety Tips for guidance about alcohol with antipsychotics. If you pay out of pocket, you can also ask our team about ways to compare strengths or pack sizes that fit your budget, including one more option for those purchasing without insurance.

Authoritative Sources

For full product details, review the manufacturer information on Eli Lilly’s Zyprexa Zydis prescribing information. You can also check the Health Canada Drug Product Database entry for olanzapine ODT and the FDA label and Medication Guide for olanzapine.

YouDrugstore offers caring support from our customer-service team during posted office hours, with pharmacists available to address medication questions. Order online or by phone where available, and we will arrange prompt, express, cold-chain shipping to the US.

This content does not replace professional medical advice. Always follow your prescriber’s directions and the patient information that comes with your medicine.