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Product Information

Prolensa is an ophthalmic solution used to treat postoperative inflammation. It also helps relieve ocular pain after a cataract surgery. Prolensa is developed by the New Jersey-based Bausch + Lomb, which operates under Valeant Pharmaceuticals.

This medication is also known under the following names in Canada and the USA:

Brand medications: BromSite, Prolensa

Generic medications: Bromfenac

Active ingredients

Prolensa contains 0.07% of bromfenac as its medicinal ingredient.  Bromfenac belongs to a group of drugs known as a nonsteroidal anti-inflammatory drugs (NSAIDs). Having anti-inflammatory properties, it inhibits cyclooxygenase enzymes (including COX-1 and COX-2) to prevent the biosynthesis of prostaglandin. As a result, ocular inflammation is reduced.

Conditions treated

Prolensa is used to treat:

• Postoperative inflammation and pain.

Dosage information

Side effects

Some of the common adverse events associated with Prolensa include:

• "Floaters" in vision/flashes of light;
• Mild eye irritation;
• Headache;
• Worsened photosensitivity;
• Sensation of something in the eye.

This list does not include all the possible side effects of Prolensa. Some patients may experience side effects other than the ones listed above. Speak with your doctor if you have any question about the side effects of Prolensa.

Warnings and precautions

Please refer to the product pamphlet for more information on precautions and contraindications related to Prolensa. The below is not a complete list of precautions, warnings, or contraindications.

Contraindications

Do not use if you are allergic to any of the ingredients.

Precautions

• Prolensa can potentially cause keratitis and corneal epithelial breakdown. You should stop using the eye drop if these occur.
• Before using these eye drops, remove your contact lenses. Do not use Prolensa while you are wearing contact lenses. You may use the lenses 10 minutes after administering the eye drops.
• Unless directed otherwise, do not use Prolensa concurrently with other eye medicines.
• Use the ophthalmic solution cautiously in patients who are on anticoagulants. Prolensa may result in a prolonged bleeding time.
• Cross-sensitivity may occur between NSAIDs (e.g. bromfenac), aspirin and phenylacetic acid derivatives. Use Prolensa cautiously in patients who are hypersensitive to these medicines.
• Prolensa contains a NSAID, which may slow/delay healing. Using the eye drop concurrently with topical steroids (which also impede healing) may aggravate its healing-impeding effects.
• While you are on the drug, drive cautiously. Prolensa may cause an impairment in thinking/reaction. It may also result in blurred vision.
• The drug contains sodium sulfite, which may lead to allergic reactions. Use cautiously in patients with sulfite sensitivities.

Drug interactions

Being a topical ophthalmic solution, Prolensa is unlikely to interact with other drugs.

Frequently asked questions

How does Prolensa work?

The active ingredient in Prolensa ophthalmic solution is bromfenac. Acting as a NSAID, bromfenac effectively reduces the production of prostaglandin by blocking the actions of COX-1 and COX-2. Prostaglandin is a substance responsible for a range of inflammatory activities, including leukocytosis, vasodilation and an elevated intraocular pressure. Through the inhibition of these inflammatory events, ocular inflammation becomes attenuated.

How to store it

Keep Prolensa at room temperature in a cool, dry place. Protect from heat, moisture, and freezing. Close the bottle securely after use. Keep out of reach of children.

Is there an alternative generic brand to Prolensa?

A generic alternative to Prolensa is available as bromfenac 0.07%.

What is postoperative inflammation?

Surgeries typically involve an incision. Regardless of its size, surgical incision will stimulate the release of inflammatory mediators, resulting in inflammation. For example, cataract surgery will lead to inflammation in the iris, anterior chamber, and cornea. After an eye surgery, it is essential to use topical anti-inflammatory drugs (e.g. Prolensa) to reduce inflammation and clear the vision.

What is ocular pain?

Ocular pain is type of ophthalmalgia that occurs on the eye surface. The condition is characterized by itching and scratching. It may also be accompanied by a burning sensation. Some of the common causes of ocular pain include surgery, injury, blepharitis and the presence of a foreign object. While most of the symptoms are self-limiting, medications such as eye drops can be used for symptomatic relief.

What if I overdose on Prolensa?

An overdose of the drug (i.e. instilling too many drops) is unlikely to cause harm.

Prolensa eye drops are intended for ophthalmic use only. It may be harmful to ingest the solution orally. If accidentally ingested, go to the nearest hospital or call a regional Poison Information Center immediately.

What if I miss a dose of Prolensa?

If you forget to use Prolensa, apply it as soon as you remember. However, if it is time or close to the time for the next dose, you should skip the missed dose and take the next dose as you normally would. Do not double up your dose for Prolensa.

If you miss your first dose on the day before surgery, tell the doctor right away.