Seroquel XR® Tablets for Schizophrenia and Bipolar Disorder

Quetiapine XR is an extended-release antipsychotic for schizophrenia and bipolar disorder. You can access US delivery from Canada, including Seroquel XR without insurance. This page explains how the medicine works, who it may suit, and safe use.

What Seroquel XR Is and How It Works

Seroquel XR® contains quetiapine, an atypical antipsychotic in an extended-release tablet. It gradually releases medicine over the day to support once-daily dosing. The treatment helps balance neurotransmitters such as dopamine and serotonin. That balance may reduce hallucinations, stabilize mood, and improve sleep quality when part of a full care plan. For background on the condition, see What Is Schizophrenia.

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Quetiapine XR can be prescribed for adults with schizophrenia, acute manic or mixed episodes in bipolar I disorder, bipolar depression, and maintenance therapy as directed. It is also used as adjunct therapy with an antidepressant for major depressive disorder in adults when approved by a prescriber.

Who It’s For

This medicine is intended for adults diagnosed with schizophrenia or bipolar disorder. It may also be considered as add-on therapy for major depression when an antidepressant alone has not been enough. Learn more about these conditions in our categories for Schizophrenia and Bipolar Disorder.

People with a history of severe allergic reaction to quetiapine should not take it. It is not approved for dementia-related psychosis in older adults because of an increased risk of death. Use caution with liver impairment, low blood pressure, seizures, glaucoma, or a history of metabolic issues. Discuss pregnancy or breastfeeding with your prescriber.

Dosage and Usage

The extended-release tablet is taken once daily, usually in the evening. Swallow tablets whole with water; do not split, crush, or chew them. Take it without food or with a light meal, as directed on the official label. Your healthcare professional will titrate to a target dose based on the condition being treated, your response, and tolerability.

Typical dosing ranges differ by indication. For schizophrenia, many adults use once-daily dosing within a prescriber-set range. For bipolar mania or mixed episodes, higher target ranges may be used, while bipolar depression often requires a different target. When used with an antidepressant for major depression, lower ranges are common. Follow your prescriber’s instructions and the approved labeling.

Consistency matters. Take doses at the same time each day. If your regimen changes, use the new schedule exactly as written by your clinician. Do not change your dose on your own. If you need more detail on mental health therapies, explore our Mental Health category.

Strengths and Forms

Extended-release tablets are commonly supplied in these strengths:

• 50 mg
• 150 mg
• 200 mg
• 300 mg
• 400 mg

Availability may vary by manufacturer and time. If your prescriber specifies a particular strength such as Seroquel XR 200 mg, your pharmacy team will dispense to match the prescription.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is close to the next scheduled time. If it is near your next dose, skip the missed dose. Do not double up. If you miss several doses, contact your healthcare professional for guidance on restarting, as titration may be needed again in some cases.

Storage and Travel Basics

Store tablets at room temperature away from moisture, heat, and direct light. Keep them in the original bottle with the label intact, and out of reach of children and pets. When you travel, pack your medication in carry-on luggage with a copy of your prescription. Use a daily reminder or travel-sized pill organizer to stay on schedule.

If you have special storage questions, your pharmacist can help. For safety, never share this prescription with anyone. Dispose of unused or expired tablets through local take-back programs.

Benefits

The extended-release design supports once-daily dosing, which can make routines simpler. This medicine affects multiple neurotransmitter pathways, which may help psychotic symptoms, mood stabilization, and sleep continuity in approved uses. Some people find a steady release easier to tolerate compared with multiple daily doses of immediate-release formulations. Your prescriber will evaluate how it fits into your overall plan.

Side Effects and Safety

• Sleepiness or sedation
• Dizziness or lightheadedness
• Dry mouth
• Constipation
• Increased appetite and weight gain
• Indigestion
• Orthostatic low blood pressure

Serious effects are less common but can include neuroleptic malignant syndrome, tardive dyskinesia, high blood sugar, cholesterol changes, severe allergic reaction, or heart rhythm issues. Antidepressant medicines carry a warning for suicidal thoughts and behaviors, particularly in young adults; monitoring is important. There is an increased risk of death in older patients with dementia-related psychosis. Contact your prescriber right away if you have severe restlessness, fever, muscle rigidity, fainting, or unusual heart symptoms.

Drug Interactions and Cautions

Strong CYP3A4 inhibitors such as ketoconazole, clarithromycin, and some HIV protease inhibitors can raise levels of this medicine. Strong CYP3A4 inducers such as carbamazepine, phenytoin, rifampin, and St. John’s wort can lower levels. Alcohol and other sedating agents may worsen drowsiness. Use care with blood pressure medicines and drugs that prolong the QT interval. Avoid grapefruit and grapefruit juice unless your prescriber says otherwise.

What to Expect Over Time

Many people notice sedation early in therapy; this may lessen after a few weeks. Mood and thought symptoms can change gradually. Regular follow-up helps your prescriber assess benefits, side effects, and any need for adjustments. Staying consistent with dosing, sleep, nutrition, and therapy supports long-term outcomes. If goals are not met, your clinician may consider an alternative strategy from our resources on Depression or related conditions.

Compare With Alternatives

Other atypical antipsychotics may be considered if you need a different profile. Two options include Aripiprazole and Latuda. Each has distinct dosing, interactions, and side effect patterns. Your prescriber will match the therapy to your diagnosis, medical history, and treatment goals.

Pricing and Access

Canadian pharmacy options may help with Seroquel XR price concerns. We also display Quetiapine XR Canadian pricing so you can compare authorized products before checkout. Final costs depend on manufacturer, strength, and quantity.

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Availability and Substitutions

Both brand and generics may be supplied depending on stock and your prescription. If a specific product is not available, your prescriber may recommend an equivalent approved alternative. Quetiapine XR generic options are often substituted when permitted by your clinician and local regulations.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults who need once-daily dosing for schizophrenia or bipolar disorder, or adjunct therapy for major depression under supervision. It may not suit people with severe liver disease, uncontrolled low blood pressure, or those at high risk for metabolic complications. Regular metabolic monitoring is recommended.

To manage budgets, ask your prescriber about multi-month supplies when appropriate. Setting refill reminders can prevent gaps that lead to urgent orders. If you pay cash, review your Quetiapine XR cash price and compare generic options. Consider discussing tablet strength consolidation only if your prescriber agrees it is clinically suitable. Never split or crush the extended-release form.

Questions to Ask Your Clinician

• Target symptoms: Which goals are we tracking first?
• Dosing plan: How will we titrate and monitor?
• Side effects: Which warning signs should prompt a call?
• Interactions: Are any current medicines or supplements a concern?
• Lifestyle: How should I manage sleepiness or weight changes?
• Monitoring: How often will labs or check-ins be scheduled?
• Alternatives: If this is not a fit, which options come next?

Authoritative Sources

DailyMed: Seroquel XR (quetiapine) Prescribing Information

Health Canada DPD: Quetiapine Extended-Release

Manufacturer PI: Seroquel XR

Ready to proceed? Checkout with prompt US shipping from Canada and temperature-controlled handling when required. This information is educational and does not replace medical advice from your healthcare professional.